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1. 发明申请

US20050214233A1 Stabilization of body-care and household products 有权
标题翻译：稳定身体护理和家庭用品
公开(公告)号：US20050214233A1
公开(公告)日：2005-09-29
申请号：US11133532
申请日：2005-05-20
申请人： Dietmar Huglin , Thomas Ehlis , Erich Kramer , Joseph Lupia , Oliver Reich
发明人： Dietmar Huglin , Thomas Ehlis , Erich Kramer , Joseph Lupia , Oliver Reich
IPC分类号： A61K8/49 , A61Q1/02 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q3/02 , A61Q5/02 , A61Q5/06 , A61Q9/02 , A61Q13/00 , A61Q15/00 , C11D3/28 , C11D3/42 , A61K7/42
CPC分类号： C11D3/28 , A61K8/496 , A61K8/4966 , A61K2800/52 , A61Q1/02 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q3/02 , A61Q5/02 , A61Q5/06 , A61Q9/02 , A61Q13/00 , A61Q15/00
摘要： A description is given of the use of light stabilizers of formulae (1) and/or (2) for protecting body-care and household products from photolytic degradation.
摘要翻译：给出了使用式（1）和/或（2）的光稳定剂用于保护身体护理和家用产品免受光解降解的描述。

2. 发明申请

US20070092460A1 Silylated compounds as precursors for self-tanning compositions 审中-公开
标题翻译：甲硅烷基化合物作为自鞣组合物的前体
公开(公告)号：US20070092460A1
公开(公告)日：2007-04-26
申请号：US11637322
申请日：2006-12-12
申请人： Thomas Ehlis , Dietmar Huglin , Joachim Roding
发明人： Thomas Ehlis , Dietmar Huglin , Joachim Roding
IPC分类号： A61K8/89
CPC分类号： A61Q19/04 , A61K8/585 , C07F7/1804
摘要： The use of silylated compounds as precursors of skin self-tanning substances in self-tanning compositions is described.
摘要翻译：描述了在自鞣组合物中使用甲硅烷基化合物作为皮肤自鞣物质的前体。

3. 发明申请

US20060153783A1 Triazine derivatives as uv absorbers 有权
标题翻译：三嗪衍生物作为紫外线吸收剂
公开(公告)号：US20060153783A1
公开(公告)日：2006-07-13
申请号：US10542467
申请日：2004-01-13
申请人： Thomas Ehlis , Dietmar Huglin , Elek Borsos
发明人： Thomas Ehlis , Dietmar Huglin , Elek Borsos
IPC分类号： A61K8/49 , C07D251/18 , C07D403/02
CPC分类号： C07D251/18 , C07D251/20
摘要： The present invention relates to new compounds of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, and R8 independently from each other are hydrogen; C1-C18alkyl; C2-C18alkenyl; C5-C7, cycloalkyl; C1-C6alkylene-C5-C7, cycloalkyl; R9 is hydrogen; C1-C18alkyl; C2-C18alkenyl; C5-C7cycloalkyl; C1-C6alkylene-C5-C7cycloalkyl; C6-C10aryl; A is —S—; —O— or —NR10—, wherein R10 has the same meanings as R9; X is COOR11; CONR12R13; SO3, R14; or SO2NR15R16, wherein R11, R12, R13, R14, R15, and R16, have independently from each other the same meanings as R9; to their preparation and to their use as UV absorbers in cosmetic and pharmaceutical formulations.
摘要翻译：本发明涉及新的式（I）化合物，其中R 1，R 2，R 3，R 4， R 5，R 6，R 7和R 8彼此独立地是氢 ; C 1 -C 18烷基; C 2 -C 18链烯基; C 5 -C 7环烷基，环烷基， C 1 -C 6亚烷基-C 5 -C 7亚烷基，环烷基; R 9是氢; C 1 -C 18烷基; C 2 -C 18链烯基; C 5 -C 7环烷基; C 1 -C 6亚烷基-C 5 -C 7环烷基; C 6 -C 10芳基; A是-S-; -O-或-NR 10 - ，其中R 10具有与R 9相同的含义; X是COOR 11; CONR 12 R 13; SO 3，R 14; 或其中R 11，R 12，R 12，R 12，R 12， R 13，R 14，R 15和R 16，彼此独立地具有与 R 9; 用于制备和用作化妆品和药物制剂中的UV吸收剂。

4. 发明申请

US20050129632A1 Uv absorber compositions comprising a hydroxyphenyltriazine compound 有权
标题翻译：包含羟基苯基三嗪化合物的Uv吸收剂组合物
公开(公告)号：US20050129632A1
公开(公告)日：2005-06-16
申请号：US10507295
申请日：2003-03-04
申请人： Jurg Haase , Thomas Ehlis , Elek Borsos , Dietmar Huglin , Bernd Herzog
发明人： Jurg Haase , Thomas Ehlis , Elek Borsos , Dietmar Huglin , Bernd Herzog
IPC分类号： C07D249/20 , A61K8/00 , A61K8/35 , A61K8/49 , A61Q5/02 , A61Q17/04 , C07D251/16 , C09K3/00 , A61K7/42
CPC分类号： A61K8/4966 , A61Q17/04
摘要： UV absorber compositions are described, comprising (a) from 1 to 99% by weight of a hydroxyphenyltriazine compound of formula (I) wherein R1, R2 and R3 are each independently of the others C1-C18 alkyl; C2-C10,alkenyl; or phenyl-C1-C4 alkyl; R4 is hydrogen; or C1-C5alkyl; and (b) from 99 to 1% by weight of a further UV absorber selected from the group of (b) hydroxyphenyltriazines that are different from component (a), (b2) benzotriazoles, (b3) dibenzoylmethane derivatives and (b4) camphor derivatives. The compositions are suitable as UV filters in cosmetic compositions.
摘要翻译：描述了UV吸收剂组合物，其包含（a）1至99重量％的式（I）的羟基苯基三嗪化合物，其中R 1，R 2和R 2 > 3 各自独立地为C 1 -C 12烷基; C 2 -C 10，烯基; 或苯基-C 1 -C 4烷基; R 4是氢; 或C 1 -C 5烷基; （b）99〜1重量％的另外的紫外线吸收剂，其选自（b）不同于组分（a），（b-2）苯并三唑的（b）羟基苯基三嗪，（b < （3/4）二苯甲酰甲烷衍生物和（b 4 S）樟脑衍生物。该组合物适用于化妆品组合物中的UV过滤器。

5. 发明授权

US6015575A Liposomogenic UV absorbers 失效
标题翻译：脂质体紫外线吸收剂
公开(公告)号：US6015575A
公开(公告)日：2000-01-18
申请号：US913531
申请日：1997-09-15
申请人： Helmut Luther , Dietmar Huglin , Bernd Herzog
发明人： Helmut Luther , Dietmar Huglin , Bernd Herzog
IPC分类号： A61K8/00 , A61K8/14 , A61K8/34 , A61K8/35 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/46 , A61K8/49 , A61Q17/04 , C07C69/734 , C07C219/06 , C07C219/10 , C07C229/12 , C07C235/34 , C07D249/20 , C07D251/54 , C07D251/70 , C09K3/00
CPC分类号： C07D251/70 , A61K8/14 , A61K8/37 , A61K8/4966 , A61Q17/04 , B82Y30/00 , B82Y5/00 , C07C219/10 , C07C229/12 , C07C235/34 , C07C69/734 , C07D249/20 , A61K2800/57
摘要： There are described liposomogenic UV absorbers, comprising a hydrophilic head group (.dbd.Z), a spacer (.dbd.W), a UV chromophore (Q) having an absorption in the range from 285 to 400 nm and at least one hydrophobic tail group (.dbd.A) of the formula (1), in which A.sub.1 and A.sub.2, independently of one another, are a hydrophobic radical, Q is a UV chromophore, W is an organic radical, Z.sub.1 and Z.sub.2, independently of one another, are a hydrophilic radical, n.sub.1 and n.sub.2, independently of one another, are a number from 0 to 4, n.sub.1 =n.sub.2 =0 not being additionally included, p is 1 or 2, q is a number from 0 to 3, r.sub.1 is 1 or 2, r.sub.2 is 0 or 1, and s.sub.1 is a number from 1 to 3. The liposomogenic UV absorbers according to the invention are preferably used as sunscreen agents in cosmetic preparations. They are capable of self-organization into bimolecular layers, and can thereby penetrate into the stratum corneum to a high extent and behave there in an extremely wash-resistant manner. ##STR1##
摘要翻译： PCT No.PCT / EP96 / 00959 Sec。 371日期：1997年9月15日 102（e）1997年9月15日PCT PCT 1996年3月7日PCT公布。公开号WO96 / 29302 PCT。日本1996年9月26日描述了脂质体生成紫外线吸收剂，其包含亲水性头基（= Z），间隔物（= W），紫外发色团（Q），其吸收范围为285-400nm，至少一个其中A1和A2彼此独立地是疏水性基团，Q是UV发色团，W是有机基团，Z 1和Z 2彼此独立地是通式（1）的疏水性尾基（= A）是亲水基团，n1和n2彼此独立地为0至4的数，n1 = n2 = 0，不包括其中，p为1或2，q为0至3的数，r1为 1或2，r2为0或1，s1为1至3的数。根据本发明的脂质体生成的UV吸收剂优选用作化妆品制剂中的防晒剂。它们能够自组织成双分子层，并且因此可以高度渗透到角质层中，并以非常耐洗涤的方式在那里表现。

6. 发明授权

US5688995A o-Hydroxyphenyl-s-triazines 失效
标题翻译：邻羟基苯基-s-三嗪
公开(公告)号：US5688995A
公开(公告)日：1997-11-18
申请号：US649940
申请日：1996-05-15
申请人： Helmut Luther , Dietmar Huglin , Bernd Herzog
发明人： Helmut Luther , Dietmar Huglin , Bernd Herzog
IPC分类号： A61K8/00 , A61K8/42 , A61K8/49 , A61Q17/04 , C07D251/24 , C08K5/3477 , C08K5/3492 , C09K3/00 , C07C229/00
CPC分类号： A61K8/4966 , A61Q17/04 , C07D251/24
摘要： A description is given of o-hydroxyphenyl-s-triazines containing at least two alkoxyphenyl-substituents. They have the formula (1). The compounds according to the invention are particularly suitable as sunscreen agents in cosmetic preparations.
摘要翻译：给出了含有至少两个烷氧基苯基取代基的邻羟基苯基-s-三嗪的描述。他们有公式（1）。根据本发明的化合物特别适合作为化妆品制剂中的防晒剂。

7. 发明授权

US5516938A Immunological detection method 失效
标题翻译：免疫检测方法
公开(公告)号：US5516938A
公开(公告)日：1996-05-14
申请号：US369241
申请日：1995-01-06
申请人： Jean-Marc Schlaeppi , Dietmar Huglin
发明人： Jean-Marc Schlaeppi , Dietmar Huglin
IPC分类号： C12N5/10 , C07C311/51 , C07K16/44 , C12N5/20 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577
CPC分类号： C07K16/44 , C07C311/51
摘要： The present invention relates to monoclonal antibodies that are distinguished by a high degree of selectivity and affinity towards herbicides from the group of the sulfonylureas, especially towards sulfonylurea herbicides of formula (A) ##STR1## wherein X is a mono- or di-substituted 6-membered heterocycle having from one to three nitrogen atoms and bonded via carbon, but is preferably mono- or di-substituted s-triazine or pyrimidine; andn is an integer from 0 to 4, preferably the number 1, and that are therefore outstandingly suitable for use in an immunoassay for the rapid and effective detection of the said sulfonylurea herbicides in soil, water or air samples or in plant extracts, and to methods for the production of said monoclonal antibodies.The present invention relates also to hybridoma cell lines that produce said monoclonal antibodies and to immunological detection methods using said monoclonal antibodies, and to test kits that may be used in those detection methods.
摘要翻译：本发明涉及通过高度选择性和对来自磺酰脲类的除草剂的亲和性，特别是对式（A）的磺酰脲除草剂（A）的区别的单克隆抗体，其中X是单或二具有1至3个氮原子并通过碳键合的取代的6元杂环，但优选为单取代或二取代的s-三嗪或嘧啶; 并且n是0至4的整数，优选数字1，因此非常适合用于在土壤，水或空气样品或植物提取物中快速和有效检测所述磺酰脲除草剂的免疫测定中，以及涉及产生所述单克隆抗体的方法。本发明还涉及产生所述单克隆抗体的杂交瘤细胞系和使用所述单克隆抗体的免疫检测方法，以及可用于这些检测方法的试剂盒。

8. 发明授权

US6017556A Liposomogenic UV absorbers 失效
标题翻译：脂质体紫外线吸收剂
公开(公告)号：US6017556A
公开(公告)日：2000-01-25
申请号：US931392
申请日：1997-09-16
申请人： Helmut Luther , Dietmar Huglin , Robert Hochberg
发明人： Helmut Luther , Dietmar Huglin , Robert Hochberg
IPC分类号： C07D249/20 , A61K8/00 , A61K8/14 , A61K8/37 , A61K8/40 , A61K8/49 , A61Q5/00 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/08 , A61Q5/10 , A61Q17/00 , A61Q17/04 , C07D251/14 , C07D251/24 , C09K3/00 , A61K9/127 , A61K7/06
CPC分类号： B82Y30/00 , A61K8/14 , A61K8/37 , A61K8/496 , A61K8/4966 , A61Q17/04 , A61Q5/00 , B82Y5/00 , C07D251/24 , A61K2800/57 , Y10S514/88 , Y10S514/881 , Y10S514/944 , Y10S514/972
摘要： The use of liposomogenic UV absorbers for protecting human hair from the damaging effect of UV radiation is described. The liposomogenic UV absorbers comprise a hydrophilic head group (=Z), a spacer (=W), a UV chromophore (Q) having an absorption in the range from 285 to 400 nm and at least one hydrophobic tail group (=A). They have the formula ##STR1## in which A.sub.1 and A.sub.2 independently of one another are a hydrophobic radical;Q is a UV chromophore;W is an organic radical;Z.sub.1 and Z.sub.2 independently of one another are a hydrophilic radical; n.sub.1 and n.sub.2 independently of one another are a number from 0 to 4, where n.sub.1 =n.sub.2 = is not included;p is 1 or 2;q is a number from 0 to 3;r.sub.1 is 1 or 2;r.sub.2 is 0 or 1; ands.sub.1 is a number from 1 to 3.The liposomogenic UV absorbers are capable of self-organization into bimolecular layers, and can as a result penetrate into the stratum corneum to a high degree and are extremely resistant to washing out there.
摘要翻译：描述了使用脂质体UV吸收剂来保护人的头发免受UV辐射的破坏作用。脂质体UV吸收剂包括亲水性头基（= Z），间隔基（= W），具有285至400nm范围内的吸收的UV发色团（Q）和至少一个疏水性尾基（= A）。它们具有其中A1和A2彼此独立的是疏水基团的式子; Q是紫外发色团; W是有机基团; Z 1和Z 2彼此独立地是亲水基团; n1和n2彼此独立的是0至4的数，其中n1 = n2 =不包括在内; p为1或2; q是从0到3的数字; r1为1或2; r2为0或1; s1是从1到3的数字。脂质体UV吸收剂能够自组织成双分子层，并且因此可以高度渗透到角质层中并且非常耐洗涤。

9. 发明申请

US20060292191A1 Use of nanodispersions in pharmaceutical end formulations 有权
标题翻译：在药物末端制剂中使用纳米分散体
公开(公告)号：US20060292191A1
公开(公告)日：2006-12-28
申请号：US11446844
申请日：2006-06-05
申请人： Andreas Supersaxo , Hans Weder , Dietmar Huglin , Joachim Roding
发明人： Andreas Supersaxo , Hans Weder , Dietmar Huglin , Joachim Roding
IPC分类号： A61K9/00
CPC分类号： A61K9/1075 , A61K9/4858 , A61K9/4866 , Y10S514/846 , Y10S514/937 , Y10S514/938 , Y10S514/941 , Y10S514/947
摘要： A nanodispersion comprises (a) a membrane-forming molecule, (b) a coemulsifier and (c) a lipophilic component, in pharmaceutical end formulations, the nanodispersion being obtainable by (α) mixing the components (a), (b) and (c) until a homogeneous clear liquid is obtained, and (β) adding the liquid obtained in step (α) to the water phase of the pharmaceutical end formulations, where steps (α) and (β) may be carried out without high energy mixing or homogenization. The nanodispersions prepared according to this invention are suitable as transport vehicles for pharmaceutical active agents.
摘要翻译：纳米分散体包含（a）在药物末端制剂中的成膜分子，（b）共乳化剂和（c）亲脂性组分，所述纳米分散体可通过（α）混合组分（a），（b）和（ c）直到获得均匀的透明液体，和（β）将步骤（α）中获得的液体加入到药物末端制剂的水相中，其中步骤（α）和（β）可以在没有高能量混合的情况下进行或均质化。根据本发明制备的纳米分散体适合用作药物活性剂的运输工具。

10. 发明申请

US20050191330A1 Use of nanodispersions in cosmetic end formulations 有权
标题翻译：在化妆品末端制剂中使用纳米分散体
公开(公告)号：US20050191330A1
公开(公告)日：2005-09-01
申请号：US11103208
申请日：2005-04-11
申请人： Dietmar Huglin , Joachim Friedrich Roding , Andreas Werner Supersaxo , Hans Georg Weder
发明人： Dietmar Huglin , Joachim Friedrich Roding , Andreas Werner Supersaxo , Hans Georg Weder
IPC分类号： A61K8/04 , A61K8/55 , A61Q1/02 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/10 , A61K7/00
CPC分类号： A61K8/553 , A61K8/04 , A61K2800/413 , A61Q1/02 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/10 , B82Y5/00 , Y10S514/937 , Y10S514/938
摘要： A description is given of the use of a nanodispersion, which comprises (a) a membrane-forming molecule, (b) a coemulsifier and (c) a lipophilic component, in cosmetic end formulation, which nanodispersion is obtainable by (α) mixing the components (a), (b) and (c) until a homogeneous clear liquid is obtained, and (β) adding the liquid obtained in, step (α) to the water phase of the cosmetic end formulations, steps (α) and (β) being carried out without any additional supply of energy. The nanodispersions used according to this invention can be easily prepared and are suitable as carrier systems for a very wide range of cosmetic active agents and oil-soluble dyes.
摘要翻译：描述了纳米分散体的使用，其包括（a）成膜分子，（b）化妆品末端制剂中的共乳化剂和（c）亲脂性组分，所述纳米分散体可通过（α）将组分（a），（b）和（c），直到获得均匀的透明液体，和（β）将在步骤（α）中获得的液体加入到化妆品末端制剂的水相中，步骤（α）和 beta）在没有任何额外的能量供应的情况下进行。根据本发明使用的纳米分散体可以容易地制备并且适合作为用于非常宽范围的美容活性剂和油溶性染料的载体体系。

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