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1. 发明专利

CH677886A5 未知
公开(公告)号：CH677886A5
公开(公告)日：1991-07-15
申请号：CH237489
申请日：1989-06-26
申请人： HANS GEORG WEDER PROF DR
发明人： WEDER HANS GEORG PROF DR , MUETSCH MATTHIAS
IPC分类号： C12N1/00 , A61K8/06 , A61K8/37 , A61K8/64 , A61K8/66 , A61K9/107 , B01J13/00 , C09K23/00 , C09K23/14 , C12N5/00

2. 发明授权

US08158134B1 Microemulsion preconcentrate, microemulsion and use thereof 有权
标题翻译：微乳液预浓缩液，微乳液及其用途
公开(公告)号：US08158134B1
公开(公告)日：2012-04-17
申请号：US10110212
申请日：2000-10-20
申请人： Andreas Supersaxo , Marc Antoine Weder , Hans Georg Weder
发明人： Andreas Supersaxo , Marc Antoine Weder , Hans Georg Weder
IPC分类号： A61K9/00 , A61K9/46 , C11D17/00
CPC分类号： A61K9/1075 , A61K9/4858 , A61K38/13
摘要： The invention relates to compositions in the form of microemulsion preconcentrates that contain (a) a mixture that consists of a medium-chain triglyceride and an omega-9 fatty acid and/or an omega-6 fatty acid; and (b) a surface-active component that contains a polyoxethylene tenside. When contacted with water or with an aqueous medium these microemulsion preconcentrates form microemulsions. The microemulsions of the O/W type have an average particle size below 150 nm, preferably below 100 nm. The inventive microemulsion preconcentrates and microemulsions are suitable for use as vehicles for substances, namely active agents, that are hardly soluble in water, but soluble in components (a) and/or (b). In the aqueous phase, said microemulsions may contain water-soluble substances.
摘要翻译：本发明涉及微乳液预浓缩物形式的组合物，其含有（a）由中链甘油三酯和ω-9脂肪酸和/或ω-6脂肪酸组成的混合物; 和（b）含有聚氧乙烯表面活性剂的表面活性成分。当与水或水介质接触时，这些微乳液预浓缩物形成微乳液。 O / W型的微乳液的平均粒度小于150nm，优选低于100nm。本发明的微乳液预浓缩物和微乳液适用于难溶于水但可溶于组分（a）和/或（b）的物质即活性剂的载体。在水相中，所述微乳液可含有水溶性物质。

3. 发明授权

US5997888A Cosmetic preparations 失效
标题翻译：化妆品
公开(公告)号：US5997888A
公开(公告)日：1999-12-07
申请号：US989763
申请日：1997-12-12
申请人： Hans Georg Weder , Marc Antoine Weder
发明人： Hans Georg Weder , Marc Antoine Weder
IPC分类号： A61K8/04 , A61K8/49 , A61K8/55 , A61Q19/00 , A61K7/00
CPC分类号： A61K8/044 , A61K8/4993 , A61K8/553 , A61Q19/00 , B82Y5/00 , A61K2800/413 , Y10S514/844 , Y10S514/846 , Y10S514/847 , Y10S514/848 , Y10S514/937 , Y10S514/938
摘要： The cosmetic preparation contains: (a) an oil-soluble active ingredient that is suitable for skin cosmetics, (b) a partial fatty acid ester of polyoxyethylene sorbitan, (c) at least one phospholipid, (d) ethanol, and (e) water as a carrier liquid. The phospholipid is dissolved in ethanol, and then the partial fatty acid esters of polyoxyethylene sorbitan and the active ingredient are added. The oil phase that is obtained is added to water and stirred. The preparation is obtained in the form of a nanodispersion.
摘要翻译：化妆品包含：（a）适用于皮肤化妆品的油溶性活性成分，（b）聚氧乙烯脱水山梨糖醇的部分脂肪酸酯，（c）至少一种磷脂，（d）乙醇和（e）水作为载体液体。将磷脂溶于乙醇中，然后加入聚氧乙烯失水山梨糖醇的部分脂肪酸酯和活性成分。将得到的油相加入到水中并搅拌。制备以纳米分散体的形式获得。

4. 发明授权

US07871642B2 Use of nanodispersions in pharmaceutical end formulations 有权
标题翻译：在药物末端制剂中使用纳米分散体
公开(公告)号：US07871642B2
公开(公告)日：2011-01-18
申请号：US11446844
申请日：2006-06-05
申请人： Andreas Werner Supersaxo , Hans Georg Weder , Dietmar Hüglin , Joachim Friedrich Röding
发明人： Andreas Werner Supersaxo , Hans Georg Weder , Dietmar Hüglin , Joachim Friedrich Röding
IPC分类号： A61K9/127 , A61K9/107
CPC分类号： A61K9/1075 , A61K9/4858 , A61K9/4866 , Y10S514/846 , Y10S514/937 , Y10S514/938 , Y10S514/941 , Y10S514/947
摘要： A nanodispersion comprises (a) a membrane-forming molecule, (b) a coemulsifier and (c) a lipophilic component, in pharmaceutical end formulations, the nanodispersion being obtainable by (α) mixing the components (a), (b) and (c) until a homogeneous clear liquid is obtained, and (β) adding the liquid obtained in step (α) to the water phase of the pharmaceutical end formulations, where steps (α) and (β) may be carried out without high energy mixing or homogenization. The nanodispersions prepared according to this invention are suitable as transport vehicles for pharmaceutical active agents.
摘要翻译：纳米分散体包含（a）在药物末端制剂中的成膜分子（b）共乳化剂和（c）亲脂性组分，所述纳米分散体可通过（α）混合组分（a），（b）和（ c）直到获得均匀的透明液体，并且将（步骤（α）中获得的液体）添加到药物末端制剂的水相中，其中步骤（α）和（＆bgr）可以在不高的情况下进行能量混合或均质化。根据本发明制备的纳米分散体适合用作药物活性剂的运输工具。

5. 发明授权

US07008638B2 Use of nanodispersions in cosmetic end formulations 有权
公开(公告)号：US07008638B2
公开(公告)日：2006-03-07
申请号：US10016903
申请日：2001-12-14
申请人： Dietmar Hüglin , Joachim Friedrich Röding , Andreas Werner Supersaxo , Hans Georg Weder
发明人： Dietmar Hüglin , Joachim Friedrich Röding , Andreas Werner Supersaxo , Hans Georg Weder
IPC分类号： A61K9/127 , A61K7/00
CPC分类号： A61K8/04 , A61K8/553 , A61K8/68 , A61K2800/21 , A61Q1/02 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/10 , B82Y5/00
摘要： A description is given of the use of a nanodispersion, which comprises (a) a membrane-forming molecule, (b) a coemulsifier and (c) a lipophilic component, in cosmetic end formulation, which nanodispersion is obtainable by (α) mixing the components (a), (b) and (c) until a homogeneous clear liquid is obtained, and (β) adding the liquid obtained in step (α) to the water phase of the cosmetic end formulations, steps (α) and (β) being carried out without any additional supply of energy. The nanodispersions used according to this invention can be easily prepared and are suitable as carrier systems for a very wide range of cosmetic active agents and oil-soluble dyes.

6. 发明申请

US20050191330A1 Use of nanodispersions in cosmetic end formulations 有权
标题翻译：在化妆品末端制剂中使用纳米分散体
公开(公告)号：US20050191330A1
公开(公告)日：2005-09-01
申请号：US11103208
申请日：2005-04-11
申请人： Dietmar Huglin , Joachim Friedrich Roding , Andreas Werner Supersaxo , Hans Georg Weder
发明人： Dietmar Huglin , Joachim Friedrich Roding , Andreas Werner Supersaxo , Hans Georg Weder
IPC分类号： A61K8/04 , A61K8/55 , A61Q1/02 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/10 , A61K7/00
CPC分类号： A61K8/553 , A61K8/04 , A61K2800/413 , A61Q1/02 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/10 , B82Y5/00 , Y10S514/937 , Y10S514/938
摘要： A description is given of the use of a nanodispersion, which comprises (a) a membrane-forming molecule, (b) a coemulsifier and (c) a lipophilic component, in cosmetic end formulation, which nanodispersion is obtainable by (α) mixing the components (a), (b) and (c) until a homogeneous clear liquid is obtained, and (β) adding the liquid obtained in, step (α) to the water phase of the cosmetic end formulations, steps (α) and (β) being carried out without any additional supply of energy. The nanodispersions used according to this invention can be easily prepared and are suitable as carrier systems for a very wide range of cosmetic active agents and oil-soluble dyes.
摘要翻译：描述了纳米分散体的使用，其包括（a）成膜分子，（b）化妆品末端制剂中的共乳化剂和（c）亲脂性组分，所述纳米分散体可通过（α）将组分（a），（b）和（c），直到获得均匀的透明液体，和（β）将在步骤（α）中获得的液体加入到化妆品末端制剂的水相中，步骤（α）和 beta）在没有任何额外的能量供应的情况下进行。根据本发明使用的纳米分散体可以容易地制备并且适合作为用于非常宽范围的美容活性剂和油溶性染料的载体体系。

7. 发明授权

US5658898A Intravenous solutions for a derivative of staurosporine 失效
标题翻译：星形孢菌素衍生物的静脉溶液
公开(公告)号：US5658898A
公开(公告)日：1997-08-19
申请号：US553126
申请日：1995-11-07
申请人： Hans Georg Weder , Ute Isele
发明人： Hans Georg Weder , Ute Isele
IPC分类号： A61K9/127 , A61K9/107 , A61K31/55 , A61K31/553 , A61K47/14 , A61K47/24 , A61P9/00 , A61P9/10 , A61P31/04 , A61P35/00 , C07D498/22
CPC分类号： A61K31/553 , A61K9/1075 , A61K9/127 , Y10S514/937
摘要： The invention relates to a novel advantageous dosage form for sparingly soluble staurosporin derivatives, especially N-benzoyl-staurosporin. The dosage form is administrable intravenously in the form of a nanoemulsion and comprises as solubilisers a combination of phospholipids, triglycerides and partial fatty acid esters of polyoxyethylene sorbitan.
摘要翻译：本发明涉及一种新颖的微溶型星形孢菌素衍生物，特别是N-苯甲酰基星形孢菌素的有利剂型。剂型以纳米乳剂的形式静脉内施用，并且包含作为增溶剂的是聚氧乙烯脱水山梨糖醇的磷脂，甘油三酸酯和部分脂肪酸酯的组合。

8. 发明授权

US07381423B2 Use of nanodispersions in cosmetic end formulations 有权
标题翻译：在化妆品末端制剂中使用纳米分散体
公开(公告)号：US07381423B2
公开(公告)日：2008-06-03
申请号：US11103208
申请日：2005-04-11
申请人： Dietmar Hüglin , Joachim Friedrich Röding , Andreas Werner Supersaxo , Hans Georg Weder
发明人： Dietmar Hüglin , Joachim Friedrich Röding , Andreas Werner Supersaxo , Hans Georg Weder
IPC分类号： A61K9/127 , A61K7/00
CPC分类号： A61K8/553 , A61K8/04 , A61K2800/413 , A61Q1/02 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/10 , B82Y5/00 , Y10S514/937 , Y10S514/938
摘要： A description is given of the use of a nanodispersion, which comprises (a) a membrane-forming molecule, (b) a coemulsifier and (c) a lipophilic component, in cosmetic end formulation, which nanodispersion is obtainable by (α) mixing the components (a), (b) and (c) until a homogeneous clear liquid is obtained, and (β) adding the liquid obtained in, step (α) to the water phase of the cosmetic end formulations, steps (α) and (β) being carried out without any additional supply of energy. The nanodispersions used according to this invention can be easily prepared and are suitable as carrier systems for a very wide range of cosmetic active agents and oil-soluble dyes.
摘要翻译：描述了纳米分散体的使用，其包括（a）成膜分子，（b）化妆品末端制剂中的共乳化剂和（c）亲脂性组分，所述纳米分散体可通过（α）将组分（a），（b）和（c），直到获得均匀的透明液体，和（β）将在步骤（α）中获得的液体加入到化妆品末端制剂的水相中，步骤（α）和 beta）在没有任何额外的能量供应的情况下进行。根据本发明使用的纳米分散体可以容易地制备并且适合作为用于非常宽范围的美容活性剂和油溶性染料的载体体系。

9. 发明授权

US07081253B2 Use of nanodispersions in pharmaceutical end formulations 有权
标题翻译：在药物末端制剂中使用纳米分散体
公开(公告)号：US07081253B2
公开(公告)日：2006-07-25
申请号：US09306006
申请日：1999-05-06
申请人： Andreas Werner Supersaxo , Hans Georg Weder , Dietmar Hüglin , Joachim Friedrich Röding
发明人： Andreas Werner Supersaxo , Hans Georg Weder , Dietmar Hüglin , Joachim Friedrich Röding
IPC分类号： A61K9/127 , A61K9/133 , A61K9/10
CPC分类号： A61K9/1075 , A61K9/4858 , A61K9/4866 , Y10S514/846 , Y10S514/937 , Y10S514/938 , Y10S514/941 , Y10S514/947
摘要： A description is given of the use of a nanodispersion, which comprises (a) a membrane-forming molecule, (b) a coemulsifier and (c) a lipophilic component, in pharmaceutical end formulations, the nanodispersion being obtainable by (α) mixing the components (a), (b) and (c) until a homogeneous clear liquid is obtained, and (β) adding the liquid obtained in step (α) to the water phase of the pharmaceutical end formulations, steps (α) and (β) being carried out without any additional supply of energy. The nanodispersions used according to this invention are suitable as transport vehicles for pharmaceutical active agents.
摘要翻译：给出了使用纳米分散体的描述，该纳米分散体包含（a）在药物末端制剂中的成膜分子，（b）共乳化剂和（c）亲脂性组分，纳米分散体可通过（α）混合组分（a），（b）和（c），直到获得均匀的透明液体，和（β）将步骤（α）中获得的液体加入到药物末端制剂的水相中，步骤（α）和）在没有任何额外的能量供应的情况下进行。根据本发明使用的纳米分散体适合用作药物活性剂的运输载体。

10. 发明授权

US5726164A Nanosuspensions for intravenous administration 失效
标题翻译：用于静脉内给药的纳米悬浮液
公开(公告)号：US5726164A
公开(公告)日：1998-03-10
申请号：US619068
申请日：1996-03-20
申请人： Hans Georg Weder , Peter van Hoogevest
发明人： Hans Georg Weder , Peter van Hoogevest
IPC分类号： C07D498/22 , A61K9/08 , A61K9/10 , A61K31/55 , A61K31/553 , A61K47/10 , A61K47/24 , A61K47/26 , A61K47/32 , A61P9/00 , A61P25/00 , A61P35/00 , A61K31/35 , A61K31/40
CPC分类号： A61K31/553 , A61K47/10 , A61K47/24 , A61K9/0019 , A61K9/10
摘要： The present invention relates to a pharmaceutical composition for the intravenous administration of the sparingly soluble staurosporin derivative N-benzoyl-staurosporin. The composition comprises the following preferred components: a) the therpeutic agent N-benzoyl-staurosporin; b) a polyoxyethylene/polyoxypropylene block copolymer; c) ethanol and water as carrier liquids; and d) purified lecithin from soybeans and e) as water-soluble excipients glycerol and sorbitol.
摘要翻译：本发明涉及用于静脉内施用微溶性星形孢菌素衍生物N-苯甲酰基星形孢菌素的药物组合物。该组合物包含以下优选的组分：a）治疗剂N-苯甲酰基星形孢菌素; b）聚氧乙烯/聚氧丙烯嵌段共聚物; c）乙醇和水作为载体液体; 和d）来自大豆的纯化卵磷脂，和e）作为水溶性赋形剂甘油和山梨糖醇。

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