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1. 发明授权

US5576188A Immunological detection of metolachlor 失效
标题翻译：异丙甲草胺的免疫检测
公开(公告)号：US5576188A
公开(公告)日：1996-11-19
申请号：US359689
申请日：1994-12-20
申请人： Jean-Marc Schlaeppi , Klaus Ramsteiner , Hans Moser
发明人： Jean-Marc Schlaeppi , Klaus Ramsteiner , Hans Moser
IPC分类号： C07C217/84 , C07C233/25 , C07C323/12 , C07K16/44 , C12N5/10 , C12N5/20 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577
CPC分类号： C07C233/25 , C07C323/12 , C07K16/44 , Y10S436/815 , Y10S530/807
摘要： The present invention relates to monoclonal antibodies which are distinguished by high selectivity and affinity for metolachlor and which are therefore outstandingly suitable for use in an immunoassay for the rapid and efficient detection of metolachlor. Another aspect of the present invention relates to hybridoma cell lines which produce said monoclonal antibodies and to immunological methods for detecting metolachlor in samples of soil, water or air using said monoclonal antibodies and to the test kits which can be used within the scope of these detection methods.
摘要翻译：本发明涉及以对异丙甲草胺的高选择性和亲和力为特征的单克隆抗体，因此非常适合用于快速有效检测异丙甲草胺的免疫测定。本发明的另一方面涉及产生所述单克隆抗体的杂交瘤细胞系和使用所述单克隆抗体在土壤，水或空气样品中检测异丙甲草胺的免疫学方法，以及可在这些检测范围内使用的测试试剂盒方法。

2. 发明申请

US20050165218A1 Crystal structure of the ligand binding domain of the retinoic acid-related orphan receptor alpha (ror-alpha) 审中-公开
标题翻译：视黄酸相关孤儿受体α（ror-α）的配体结合结构域的晶体结构
公开(公告)号：US20050165218A1
公开(公告)日：2005-07-28
申请号：US10509316
申请日：2003-04-28
申请人： Rene Beerli , Brigitte Fournier , Jorg Kallen , Jean-Marc Schlaeppi
发明人： Rene Beerli , Brigitte Fournier , Jorg Kallen , Jean-Marc Schlaeppi
IPC分类号： C07K14/705 , A61K38/47 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C07K14/70567 , C07K2299/00
摘要： The present invention relates RORa in crystallized form and methods for the preparation thereof. The invention also provides a three-dimensional model of RORa and means for the design of RORa modulators. Ligands binding to RORa are also provided.
摘要翻译：本发明涉及结晶形式的RORa及其制备方法。本发明还提供了RORa的三维模型和用于设计RORa调制器的装置。还提供了与RORa结合的配体。

3. 发明申请

US20050176062A1 Method of identifying ligands for nuclear receptors 审中-公开
标题翻译：识别核受体配体的方法
公开(公告)号：US20050176062A1
公开(公告)日：2005-08-11
申请号：US10512891
申请日：2003-04-28
申请人： Reiner Aichholz , Francis Bitsch , Sabine Geisse , Jean-Marc Schlaeppi
发明人： Reiner Aichholz , Francis Bitsch , Sabine Geisse , Jean-Marc Schlaeppi
IPC分类号： G01N27/62 , C07K14/705 , C12N15/85 , C12N15/866 , G01N27/64 , G01N33/00 , G01N33/15 , G01N33/483 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/68
CPC分类号： G01N33/6848 , C12N15/86 , C12N2710/14143 , G01N33/566 , G01N33/6851 , G01N33/6875 , G01N2500/00
摘要： The present invention provides a method of identifying a ligand to a nuclear receptor protein comprising wherein said nuclear receptor protein is first expressed in an eukaryotic expression system in the presence of at least one candidate ligand. The nuclear receptor protein is then purified, isolated and mass spectrometry is used to determine the presence of a bound ligand. The ligand is finally isolated and the measured spectra is compared with the spectra of known ligands in compound libraries to identify the ligand.
摘要翻译：本发明提供鉴定核受体蛋白的配体的方法，其包括其中所述核受体蛋白首先在真核表达系统中在至少一种候选配体存在下表达。然后纯化，分离核受体蛋白，并使用质谱法测定结合的配体的存在。最后分离配体，并将测量的光谱与化合物文库中已知配体的光谱进行比较，以鉴定配体。

4. 发明授权

US5756683A Immunological detection method 失效
公开(公告)号：US5756683A
公开(公告)日：1998-05-26
申请号：US470529
申请日：1995-06-06
申请人： Jean-Marc Schlaeppi , Dietmar Huglin
发明人： Jean-Marc Schlaeppi , Dietmar Huglin
IPC分类号： C12N5/10 , C07C311/51 , C07K16/44 , C12N5/20 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577 , C12N5/18
CPC分类号： C07K16/44 , C07C311/51
摘要： The present invention relates to monoclonal antibodies that are distinguished by a high degree of selectivity and affinity towards herbicides from the group of the sulfonylureas, especially towards sulfonylurea herbicides of formula (A) ##STR1## wherein X is a mono- or di-substituted 6-membered heterocycle having from one to three nitrogen atoms and bonded via carbon, but is preferably mono- or di-substituted s-triazine or pyrimidine; and n is an integer from 0 to 4, preferably the number 1, and that are therefore outstandingly suitable for use in an immunoassay for the rapid and effective detection of the said sulfonylurea herbicides in soil, water or air samples or in plant extracts, and to methods for the production of said monoclonal antibodies. The present invention relates also to hybridoma cell lines that produce said monoclonal antibodies and to immunological detection methods using said monoclonal antibodies, and to test kits that may be used in those detection methods.

5. 发明授权

US5563074A Immunological detection methods 失效
标题翻译：免疫检测方法
公开(公告)号：US5563074A
公开(公告)日：1996-10-08
申请号：US275567
申请日：1994-07-15
申请人： Jean-Marc Schlaeppi , Klaus Ramsteiner , Willy Meyer
发明人： Jean-Marc Schlaeppi , Klaus Ramsteiner , Willy Meyer
IPC分类号： A01N47/36 , C07D251/16 , C07K1/113 , C07K14/76 , C07K16/00 , C07K16/44 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/531 , G01N33/577
CPC分类号： C07K16/44 , C07D251/16 , G01N33/5308 , Y10S436/815
摘要： The present invention relates to monoclonal antibodies that are distinguished by a high degree of selectivity and affinity towards triasulfurone and that are therefore outstandingly suitable for use in an immunoassay for the rapid and effective detection of triasulfurone. The present invention relates also to hybridoma cell lines that produce the said monoclonal antibodies and to immunological methods for the detection of triasulfurone in soil, water or air samples using the said monoclonal antibodies and to test kits that may be used in those detection methods.
摘要翻译：本发明涉及通过高度选择性和对三氯嘧磺隆的亲和力而区分的单克隆抗体，因此非常适合用于免疫测定以快速有效地检测三氯磺隆。本发明还涉及产生所述单克隆抗体的杂交瘤细胞系和使用所述单克隆抗体在土壤，水或空气样品中检测三氯嘧磺隆的免疫学方法以及可用于这些检测方法的测试试剂盒。

6. 发明授权

US5272059A Monoclonal antibodies specific for hirudin 失效
标题翻译：水蛭素特异性单克隆抗体
公开(公告)号：US5272059A
公开(公告)日：1993-12-21
申请号：US920025
申请日：1992-07-27
申请人： Jean-Marc Schlaeppi , Dietmar G. Braun
发明人： Jean-Marc Schlaeppi , Dietmar G. Braun
IPC分类号： A61K38/00 , C07K16/38 , C12Q1/00 , C07K15/28 , G01N33/53
CPC分类号： C07K16/38 , A61K38/00
摘要： The invention concerns a process for the preparation of hybridoma cells which secrete monoclonal antibodies specific for hirudin, the hybridoma cells themselves, the monoclonal antibodies specific for hirudin secreted by these hybridoma cells, derivatives thereof, and a process for the preparation of said antibodies and derivatives. These monoclonal anti-hirudin antibodies and their derivatives are useful for the determination of hirudin and as an antidote to hirudin. The invention also concerns test kits and pharmaceutical compositions comprising said monoclonal antibodies and/or derivatives.
摘要翻译：本发明涉及制备分泌水蛭素特异性单克隆抗体的杂交瘤细胞的方法，杂交瘤细胞本身，由这些杂交瘤细胞分泌的水蛭素特异性的单克隆抗体及其衍生物，以及制备所述抗体和衍生物的方法。这些单克隆抗水蛭素抗体及其衍生物可用于测定水蛭素和水蛭素的解毒剂。本发明还涉及包含所述单克隆抗体和/或衍生物的测试试剂盒和药物组合物。

7. 发明授权

US5516938A Immunological detection method 失效
标题翻译：免疫检测方法
公开(公告)号：US5516938A
公开(公告)日：1996-05-14
申请号：US369241
申请日：1995-01-06
申请人： Jean-Marc Schlaeppi , Dietmar Huglin
发明人： Jean-Marc Schlaeppi , Dietmar Huglin
IPC分类号： C12N5/10 , C07C311/51 , C07K16/44 , C12N5/20 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577
CPC分类号： C07K16/44 , C07C311/51
摘要： The present invention relates to monoclonal antibodies that are distinguished by a high degree of selectivity and affinity towards herbicides from the group of the sulfonylureas, especially towards sulfonylurea herbicides of formula (A) ##STR1## wherein X is a mono- or di-substituted 6-membered heterocycle having from one to three nitrogen atoms and bonded via carbon, but is preferably mono- or di-substituted s-triazine or pyrimidine; andn is an integer from 0 to 4, preferably the number 1, and that are therefore outstandingly suitable for use in an immunoassay for the rapid and effective detection of the said sulfonylurea herbicides in soil, water or air samples or in plant extracts, and to methods for the production of said monoclonal antibodies.The present invention relates also to hybridoma cell lines that produce said monoclonal antibodies and to immunological detection methods using said monoclonal antibodies, and to test kits that may be used in those detection methods.
摘要翻译：本发明涉及通过高度选择性和对来自磺酰脲类的除草剂的亲和性，特别是对式（A）的磺酰脲除草剂（A）的区别的单克隆抗体，其中X是单或二具有1至3个氮原子并通过碳键合的取代的6元杂环，但优选为单取代或二取代的s-三嗪或嘧啶; 并且n是0至4的整数，优选数字1，因此非常适合用于在土壤，水或空气样品或植物提取物中快速和有效检测所述磺酰脲除草剂的免疫测定中，以及涉及产生所述单克隆抗体的方法。本发明还涉及产生所述单克隆抗体的杂交瘤细胞系和使用所述单克隆抗体的免疫检测方法，以及可用于这些检测方法的试剂盒。

8. 发明授权

US5359135A Triasulfurone compounds 失效
标题翻译：三噻吩化合物
公开(公告)号：US5359135A
公开(公告)日：1994-10-25
申请号：US159030
申请日：1993-11-29
申请人： Jean-Marc Schlaeppi , Klaus Ramsteiner , Willy Meyer
发明人： Jean-Marc Schlaeppi , Klaus Ramsteiner , Willy Meyer
IPC分类号： A01N47/36 , C07D251/16 , C07K1/113 , C07K14/76 , C07K16/00 , C07K16/44 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/531 , G01N33/577 , C07C311/51
CPC分类号： C07K16/44 , C07D251/16 , G01N33/5308 , Y10S436/815
摘要： The present invention relates to monoclonal antibodies that are distinguished by a high degree of selectivity and affinity towards triasulfurone and that are therefore outstandingly suitable for use in an immunoassay for the rapid and effective detection of triasulfurone. The present invention relates also to hybridoma cell lines that produce the said monoclonal antibodies and to immunological methods for the detection of triasulfurone in soil, water or air samples using the said monoclonal antibodies and to test kits that may be used in those detection methods.
摘要翻译：本发明涉及通过高度选择性和对三氯嘧磺隆的亲和力而区分的单克隆抗体，因此非常适合用于免疫测定以快速有效地检测三氯磺隆。本发明还涉及产生所述单克隆抗体的杂交瘤细胞系和使用所述单克隆抗体在土壤，水或空气样品中检测三氯嘧磺隆的免疫学方法以及可用于这些检测方法的测试试剂盒。

9. 发明授权

US5296352A Monoclonal antibodies directed against complexes formed by thrombin and hirudin 失效
标题翻译：针对由凝血酶和水蛭素形成的复合物的单克隆抗体
公开(公告)号：US5296352A
公开(公告)日：1994-03-22
申请号：US763860
申请日：1991-09-23
申请人： Jean-Marc Schlaeppi
发明人： Jean-Marc Schlaeppi
IPC分类号： C12N5/10 , C07K16/36 , C07K16/38 , C07K16/44 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577 , A61K35/14 , C07K15/00
CPC分类号： C07K16/38 , C07K16/36
摘要： The invention concerns monoclonal antibodies which are directed against the thrombin/hirudin-complex and derivatives thereof, processes for their preparation, hybridoma cell lines secreting said monoclonal antibodies, and processes for the preparation of the hybridoma cell lines. Furthermore, the invention relates to the use of the monoclonal antibodies and/or their derivatives for the determination of the thrombin/hirudin-complex as well as to test kits comprising said monoclonal antibodies and/or their derivatives.
摘要翻译：本发明涉及针对凝血酶/水蛭素 - 复合物及其衍生物，其制备方法，分泌所述单克隆抗体的杂交瘤细胞系以及杂交瘤细胞系的制备方法的单克隆抗体。此外，本发明涉及单克隆抗体和/或其衍生物用于测定凝血酶/水蛭素 - 复合物以及测试包含所述单克隆抗体和/或其衍生物的试剂盒的用途。

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