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1. 发明授权

US07872057B2 Dual cure composition 有权
标题翻译：双重治疗组合物
公开(公告)号：US07872057B2
公开(公告)日：2011-01-18
申请号：US12090824
申请日：2006-10-02
申请人： David James , Kent Sörensen , Henrik Bernquist
发明人： David James , Kent Sörensen , Henrik Bernquist
IPC分类号： C09D4/00 , C08G18/04 , C08G69/00 , C08G73/00
CPC分类号： C09D175/16 , C08G18/68 , C08J3/243 , C08L2312/06
摘要： A liquid radiation and thermally curing composition characterized in, that said composition comprises at least one ester between at least one tri or polyalcohol and acrylic and/or methacrylic acid, which ester has at least two hydroxyl groups, at least one acrylic or methacrylic double bond, a hydroxyl value of 50-500 mg KOH/g and a double bond concentration of 1-10 mmoles/g, at least one crosslinking agent for hydroxyl functional compounds, which crosslinking agent optionally has at least one olefinic double bond, and an additive package comprising at least one photoinitiator, radical scavenger, light stabilizer, wetting agent and/or leveling agent, and optionally at least one monomeric or oligomeric reactive diluent.
摘要翻译：一种液体辐射和热固化组合物，其特征在于，所述组合物包含至少一种三醇或多元醇与丙烯酸和/或甲基丙烯酸之间的酯，该酯具有至少两个羟基，至少一个丙烯酸或甲基丙烯酸双键，羟基值为50-500mg KOH / g，双键浓度为1-10mmoles / g，至少一种用于羟基官能化合物的交联剂，该交联剂任选具有至少一个烯属双键，以及添加剂包含至少一种光引发剂，自由基清除剂，光稳定剂，润湿剂和/或流平剂，以及任选的至少一种单体或低聚反应性稀释剂。

2. 发明申请

US20090069459A1 DUAL CURE COMPOSITION 有权
标题翻译：双重固化组合物
公开(公告)号：US20090069459A1
公开(公告)日：2009-03-12
申请号：US12090824
申请日：2006-10-02
申请人： David James , Kent Sorensen , Henrik Bernquist
发明人： David James , Kent Sorensen , Henrik Bernquist
IPC分类号： C08L67/00 , C08L67/02 , C08L79/00
CPC分类号： C09D175/16 , C08G18/68 , C08J3/243 , C08L2312/06
摘要： A liquid radiation and thermally curing composition characterized in, that said composition comprises at least one ester between at least one tri or polyalcohol and acrylic and/or methacrylic acid, which ester has at least two hydroxyl groups, at least one acrylic or methacrylic double bond, a hydroxyl value of 50-500 mg KOH/g and a double bond concentration of 1-10 mmoles/g, at least one crosslinking agent for hydroxyl functional compounds, which crosslinking agent optionally has at least one olefinic double bond, and an additive package comprising at least one photoinitiator, radical scavenger, light stabilizer, wetting agent and/or leveling agent, and optionally at least one monomeric or oligomeric reactive diluent.
摘要翻译：一种液体辐射和热固化组合物，其特征在于，所述组合物包含至少一种三醇或多元醇与丙烯酸和/或甲基丙烯酸之间的酯，该酯具有至少两个羟基，至少一个丙烯酸或甲基丙烯酸双键，羟基值为50-500mg KOH / g，双键浓度为1-10mmoles / g，至少一种用于羟基官能化合物的交联剂，该交联剂任选具有至少一个烯属双键，以及添加剂包含至少一种光引发剂，自由基清除剂，光稳定剂，润湿剂和/或流平剂，以及任选的至少一种单体或低聚反应性稀释剂。

3. 发明申请

US20100222448A1 AQUEOUS POLYURETHANE DISPERSION 有权
标题翻译：水性聚氨酯分散体
公开(公告)号：US20100222448A1
公开(公告)日：2010-09-02
申请号：US11909606
申请日：2006-03-16
申请人： Göran Ziegler , David James , Kent Sörensen
发明人： Göran Ziegler , David James , Kent Sörensen
IPC分类号： C08F2/46 , C08L75/04
CPC分类号： C08G18/672 , C08G18/0823 , C08G18/12 , C08G18/44 , C09D175/16 , C08G18/3228 , C08G18/6659
摘要： Disclosed is an aqueous polyurethane dispersion obtained by dispersing in water a reaction product obtained by reacting a reaction mixture comprising at least one organic, aliphatic, cycloaliphatic or aromatic di, tri or poryisocyanate, at least one isocyanate reactive polycarbonate diol, triol or polyol, at least one compound comprising at least one isocyanate reactive group and at least one free radically polymerisable unsaturated group, and at least one compound comprising at least one isocyanate reactive group and at least one at least dispersing active group, and optionally at least one compound comprising at least two isocyanate reactive groups and having a molecular weight of less than 1000 g/mol.
摘要翻译：公开了一种水性聚氨酯分散体，其通过将包含至少一种有机，脂族，脂环族或芳族二，三或异氰酸酯的反应混合物，至少一种异氰酸酯反应性聚碳酸酯二醇，三醇或多元醇的反应混合物分散在水中而得到的反应产物，至少一种包含至少一种异氰酸酯反应性基团和至少一种可自由基聚合的不饱和基团的化合物和至少一种包含至少一种异氰酸酯反应性基团和至少一种至少分散的活性基团的化合物，以及任选的至少一种包含至少两个异氰酸酯反应性基团，分子量小于1000g / mol。

4. 发明授权

US09034981B2 Aqueous polyurethane dispersion 有权
标题翻译：水性聚氨酯分散体
公开(公告)号：US09034981B2
公开(公告)日：2015-05-19
申请号：US11909606
申请日：2006-03-16
申请人： Göran Ziegler , David James , Kent Sörensen
发明人： Göran Ziegler , David James , Kent Sörensen
IPC分类号： C08F2/46 , C08L75/04 , C08G18/67 , C08G18/08 , C08G18/12 , C08G18/44 , C09D175/16
CPC分类号： C08G18/672 , C08G18/0823 , C08G18/12 , C08G18/44 , C09D175/16 , C08G18/3228 , C08G18/6659
摘要： Disclosed is an aqueous polyurethane dispersion obtained by dispersing in water a reaction product obtained by reacting a reaction mixture comprising at least one organic, aliphatic, cycloaliphatic or aromatic di, tri or poryisocyanate, at least one isocyanate reactive polycarbonate diol, triol or polyol, at least one compound comprising at least one isocyanate reactive group and at least one free radically polymerizable unsaturated group, and at least one compound comprising at least one isocyanate reactive group and at least one at least dispersing active group, and optionally at least one compound comprising at least two isocyanate reactive groups and having a molecular weight of less than 1000 g/mol.
摘要翻译：公开了一种水性聚氨酯分散体，其通过将包含至少一种有机，脂族，脂环族或芳族二，三或异氰酸酯的反应混合物，至少一种异氰酸酯反应性聚碳酸酯二醇，三醇或多元醇的反应混合物分散在水中而得到的反应产物，至少一种包含至少一种异氰酸酯反应性基团和至少一种可自由基聚合的不饱和基团的化合物，和至少一种包含至少一种异氰酸酯反应性基团和至少一种至少分散的活性基团的化合物，以及任选的至少一种包含至少两个异氰酸酯反应性基团，分子量小于1000g / mol。

5. 发明授权

US09090569B2 Triazone compounds that modulate HSP90 activity 有权
标题翻译：调节HSP90活性的三嗪类化合物
公开(公告)号：US09090569B2
公开(公告)日：2015-07-28
申请号：US12604970
申请日：2009-10-23
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号： A61K31/4196 , C07D249/08 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物，或包含这种化合物的组合物。

6. 发明申请

US20130296378A1 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY 有权
公开(公告)号：US20130296378A1
公开(公告)日：2013-11-07
申请号：US13857665
申请日：2013-04-05
申请人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Prezewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Paul Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Prezewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Paul Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： C07D401/04 , A61K45/06 , A61K31/4439 , C07D401/14
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

7. 发明申请

US20130169234A1 METHOD AND SYSTEM FOR CONTROLLING ENERGY STORAGE DEVICE 有权
标题翻译：控制能量储存装置的方法和系统
公开(公告)号：US20130169234A1
公开(公告)日：2013-07-04
申请号：US13338380
申请日：2011-12-28
申请人： Christopher James Chuah , Roger Bull , James Sudworth , Vincent Boccanfuso , David James
发明人： Christopher James Chuah , Roger Bull , James Sudworth , Vincent Boccanfuso , David James
IPC分类号： H02J7/00
CPC分类号： H01M10/44 , G01R31/3624 , G01R31/3679 , H01M10/443 , H01M10/448 , H01M10/48 , H01M10/486
摘要： A system and method of use including a controller responsive to a deviation in absolute value or relative slope and operable to terminate a discharge operation in an energy storage device is provided. The absolute value or relative slope is determined at sampling frequency based upon a combination of measured operating parameters, for example, potential and current. Any deviation in the absolute value or relative slope indicates that a threshold limit in the available energy of the system has been reached, for example when active materials in the device are at a point of depletion, indicating a need to cease the discharge operation. The system and method operate on a real-time basis, providing instantaneous SOH information with regard to the device.
摘要翻译：提供了一种系统和使用方法，其包括响应于绝对值或相对斜率的偏差并可操作以终止能量存储装置中的放电操作的控制器。基于测量的操作参数（例如电位和电流）的组合，以采样频率确定绝对值或相对斜率。绝对值或相对斜率的任何偏差表示已经达到系统可用能量的阈限，例如当器件中的活性材料处于耗尽点时，表示需要停止放电操作。该系统和方法在实时的基础上运行，提供关于设备的即时SOH信息。

8. 发明授权

US08299107B2 Triazole compounds that modulate HSP90 activity 有权
标题翻译：调节HSP90活性的三唑化合物
公开(公告)号：US08299107B2
公开(公告)日：2012-10-30
申请号：US12526491
申请日：2008-02-08
申请人： Dinesh U. Chimmanamada , Joseph A. Burlison , Weiwen Ying , Lijun Sun , Stefan Michael Schweizer , Shijie Zhang , Zachary Demko , David James , Teresa K. Przewloka
发明人： Dinesh U. Chimmanamada , Joseph A. Burlison , Weiwen Ying , Lijun Sun , Stefan Michael Schweizer , Shijie Zhang , Zachary Demko , David James , Teresa K. Przewloka
IPC分类号： A61K31/41 , C07D249/00
CPC分类号： C07D417/14 , C07D249/08 , C07D249/10 , C07D249/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to the use of a substituted triazole compound of the invention, or a composition comprising such a compound in the preparation of a medicament for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及本发明的取代的三唑化合物或包含这种化合物的组合物在制备用于预防或治疗有需要的受试者中的过度增殖性疾病如癌症的药物中的用途。

9. 发明授权

US07919487B2 Heteroaryl compounds 有权
标题翻译：杂芳基化合物
公开(公告)号：US07919487B2
公开(公告)日：2011-04-05
申请号：US11271704
申请日：2005-11-10
申请人： Lijun Sun , Shijie Zhang , Keizo Koya , Dinesh Chimmanamada , Hao Li , David James , Elena Kostik
发明人： Lijun Sun , Shijie Zhang , Keizo Koya , Dinesh Chimmanamada , Hao Li , David James , Elena Kostik
IPC分类号： A61K31/397 , A61K31/5377 , A61K31/50 , A61K31/53 , A61K31/505 , C07D413/14 , C07D251/02 , C07D401/14
CPC分类号： C07D213/75 , C07D213/77 , C07D239/47 , C07D239/48 , C07D239/50 , C07D239/56 , C07D251/42 , C07D251/52 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07D491/10
摘要： This invention relates to compounds of formula (I): their compositions and methods of use thereof. The compounds (and compositions) are useful in modulating IL-12 production and processes mediated by IL-12.
摘要翻译：本发明涉及式（I）化合物：它们的组成及其使用方法。化合物（和组合物）可用于调节由IL-12介导的IL-12产生和过程。

10. 发明授权

US07532923B1 Apparatus and method for detecting a fetal heart rate 有权
标题翻译：用于检测胎儿心率的装置和方法
公开(公告)号：US07532923B1
公开(公告)日：2009-05-12
申请号：US10089997
申请日：2000-10-06
申请人： Barrie Hayes-Gill , David James , John Crowe , Jean-Francois Pieri
发明人： Barrie Hayes-Gill , David James , John Crowe , Jean-Francois Pieri
IPC分类号： A61B5/0444
CPC分类号： A61B5/4362 , A61B5/02411 , A61B5/0444
摘要： The present invention relates to apparatus for detecting the heart rate of a fetus. The apparatus includes at least two detectors for detecting heart beats of the fetus, each detector comprising at least two electrodes for detecting ECG signals. A processor, which is coupled to the detectors, is used to process the ECG signals received from each detector and determine the heart rate of the fetus.
摘要翻译：本发明涉及用于检测胎儿心率的装置。该装置包括用于检测胎儿心跳的至少两个检测器，每个检测器包括用于检测ECG信号的至少两个电极。耦合到检测器的处理器用于处理从每个检测器接收的ECG信号并确定胎儿的心率。

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