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1. 发明申请

US20090192396A1 Apparatus and method for detecting a fetal heart rate 审中-公开
标题翻译：用于检测胎儿心率的装置和方法
公开(公告)号：US20090192396A1
公开(公告)日：2009-07-30
申请号：US12385068
申请日：2009-03-30
申请人： Barrie Hayes-Gill , David James , John Crowe , Jean-Francois Pieri
发明人： Barrie Hayes-Gill , David James , John Crowe , Jean-Francois Pieri
IPC分类号： A61B5/0444
CPC分类号： A61B5/4362 , A61B5/02411 , A61B5/0444
摘要： An apparatus and method for detecting the heart rate of a fetus. The apparatus includes three detectors detecting heart beats of the fetus, each detector including at least two electrodes detecting ECG signals, the detectors being positioned on an abdomen of a mother in use. The apparatus also includes a processor coupled to the detectors, the processor being adapted to process the ECG signals received from the detectors and determine a heart rate of the fetus. The method of determining the heart rate of the fetus includes determining a position of the fetus within a womb, placing the detectors on an abdomen of the mother, monitoring the ECG signals obtained from the detectors for a predetermined length of time, and processing the ECG signals obtained from the detectors positioned on the abdomen of the mother to determine heart beats of the mother.
摘要翻译：一种用于检测胎儿心率的装置和方法。该装置包括检测胎儿心跳的三个检测器，每个检测器包括检测ECG信号的至少两个电极，检测器位于正在使用的母亲的腹部上。该装置还包括耦合到检测器的处理器，该处理器适于处理从检测器接收的ECG信号并确定胎儿的心率。确定胎儿心率的方法包括确定胎儿在子宫内的位置，将检测器放置在母体的腹部上，监测从检测器获得的ECG信号达预定时间长度，以及处理ECG 从位于母亲腹部的检测器获得的信号，以确定母亲的心跳。

2. 发明授权

US07532923B1 Apparatus and method for detecting a fetal heart rate 有权
标题翻译：用于检测胎儿心率的装置和方法
公开(公告)号：US07532923B1
公开(公告)日：2009-05-12
申请号：US10089997
申请日：2000-10-06
申请人： Barrie Hayes-Gill , David James , John Crowe , Jean-Francois Pieri
发明人： Barrie Hayes-Gill , David James , John Crowe , Jean-Francois Pieri
IPC分类号： A61B5/0444
CPC分类号： A61B5/4362 , A61B5/02411 , A61B5/0444
摘要： The present invention relates to apparatus for detecting the heart rate of a fetus. The apparatus includes at least two detectors for detecting heart beats of the fetus, each detector comprising at least two electrodes for detecting ECG signals. A processor, which is coupled to the detectors, is used to process the ECG signals received from each detector and determine the heart rate of the fetus.
摘要翻译：本发明涉及用于检测胎儿心率的装置。该装置包括用于检测胎儿心跳的至少两个检测器，每个检测器包括用于检测ECG信号的至少两个电极。耦合到检测器的处理器用于处理从每个检测器接收的ECG信号并确定胎儿的心率。

3. 发明申请

US20070213627A1 FETAL SURVEILLANCE 有权
标题翻译： FETAL监视
公开(公告)号：US20070213627A1
公开(公告)日：2007-09-13
申请号：US10595378
申请日：2004-10-13
申请人： David James , John Crowe , Barrie Hayes-Gill , Carl Barratt , Jean-Francois Pieri
发明人： David James , John Crowe , Barrie Hayes-Gill , Carl Barratt , Jean-Francois Pieri
IPC分类号： A61B5/0444
CPC分类号： A61B5/4362 , A61B5/02411 , A61B5/0444
摘要： Fetal behaviour is monitored by receiving ECG data from a set of electrodes attached to a materrial body. A waveform pre-processor identifies a succession of fetal ECG complex waveforms within the received data and a waveform processor determines differences in the processor succession of fetal ECG complex waveforms over time. An event logger determines from the determined differences a number of fetal movements during the period of time. Fetal spatial presentation and/or position within the uterus may also be determined from fetal ECG data acquired from a plurality of electrodes positioned on the maternal abdomen in a predetermined configuration. A number of fetal ECG complex waveforms are identified within the data, and each of the waveforms is compared with a set of predetermined fetal ECG complex templates ascribed to the predetermined electrode configuration to determine a template that best matches the identified fetal ECG waveforms.
摘要翻译：通过从连接到物质体的一组电极接收ECG数据来监测胎儿行为。波形预处理器识别接收到的数据中的一系列胎儿ECG复杂波形，并且波形处理器确定随着时间的推移，胎儿ECG复杂波形的处理器连续性的差异。事件记录器根据所确定的差异确定一段时间内的胎动。胎儿空间呈现和/或子宫内的位置也可以从以预定配置从位于母体腹部的多个电极获取的胎儿ECG数据确定。在数据内识别出许多胎儿ECG复杂波形，并且将每个波形与归因于预定电极配置的一组预定胎儿ECG复合模板进行比较，以确定与所识别的胎儿ECG波形最佳匹配的模板。

4. 发明授权

US09090569B2 Triazone compounds that modulate HSP90 activity 有权
标题翻译：调节HSP90活性的三嗪类化合物
公开(公告)号：US09090569B2
公开(公告)日：2015-07-28
申请号：US12604970
申请日：2009-10-23
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号： A61K31/4196 , C07D249/08 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物，或包含这种化合物的组合物。

5. 发明申请

US20130296378A1 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY 有权
公开(公告)号：US20130296378A1
公开(公告)日：2013-11-07
申请号：US13857665
申请日：2013-04-05
申请人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Prezewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Paul Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Prezewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Paul Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： C07D401/04 , A61K45/06 , A61K31/4439 , C07D401/14
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

6. 发明申请

US20130169234A1 METHOD AND SYSTEM FOR CONTROLLING ENERGY STORAGE DEVICE 有权
标题翻译：控制能量储存装置的方法和系统
公开(公告)号：US20130169234A1
公开(公告)日：2013-07-04
申请号：US13338380
申请日：2011-12-28
申请人： Christopher James Chuah , Roger Bull , James Sudworth , Vincent Boccanfuso , David James
发明人： Christopher James Chuah , Roger Bull , James Sudworth , Vincent Boccanfuso , David James
IPC分类号： H02J7/00
CPC分类号： H01M10/44 , G01R31/3624 , G01R31/3679 , H01M10/443 , H01M10/448 , H01M10/48 , H01M10/486
摘要： A system and method of use including a controller responsive to a deviation in absolute value or relative slope and operable to terminate a discharge operation in an energy storage device is provided. The absolute value or relative slope is determined at sampling frequency based upon a combination of measured operating parameters, for example, potential and current. Any deviation in the absolute value or relative slope indicates that a threshold limit in the available energy of the system has been reached, for example when active materials in the device are at a point of depletion, indicating a need to cease the discharge operation. The system and method operate on a real-time basis, providing instantaneous SOH information with regard to the device.
摘要翻译：提供了一种系统和使用方法，其包括响应于绝对值或相对斜率的偏差并可操作以终止能量存储装置中的放电操作的控制器。基于测量的操作参数（例如电位和电流）的组合，以采样频率确定绝对值或相对斜率。绝对值或相对斜率的任何偏差表示已经达到系统可用能量的阈限，例如当器件中的活性材料处于耗尽点时，表示需要停止放电操作。该系统和方法在实时的基础上运行，提供关于设备的即时SOH信息。

7. 发明授权

US08299107B2 Triazole compounds that modulate HSP90 activity 有权
标题翻译：调节HSP90活性的三唑化合物
公开(公告)号：US08299107B2
公开(公告)日：2012-10-30
申请号：US12526491
申请日：2008-02-08
申请人： Dinesh U. Chimmanamada , Joseph A. Burlison , Weiwen Ying , Lijun Sun , Stefan Michael Schweizer , Shijie Zhang , Zachary Demko , David James , Teresa K. Przewloka
发明人： Dinesh U. Chimmanamada , Joseph A. Burlison , Weiwen Ying , Lijun Sun , Stefan Michael Schweizer , Shijie Zhang , Zachary Demko , David James , Teresa K. Przewloka
IPC分类号： A61K31/41 , C07D249/00
CPC分类号： C07D417/14 , C07D249/08 , C07D249/10 , C07D249/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to the use of a substituted triazole compound of the invention, or a composition comprising such a compound in the preparation of a medicament for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及本发明的取代的三唑化合物或包含这种化合物的组合物在制备用于预防或治疗有需要的受试者中的过度增殖性疾病如癌症的药物中的用途。

8. 发明授权

US07919487B2 Heteroaryl compounds 有权
标题翻译：杂芳基化合物
公开(公告)号：US07919487B2
公开(公告)日：2011-04-05
申请号：US11271704
申请日：2005-11-10
申请人： Lijun Sun , Shijie Zhang , Keizo Koya , Dinesh Chimmanamada , Hao Li , David James , Elena Kostik
发明人： Lijun Sun , Shijie Zhang , Keizo Koya , Dinesh Chimmanamada , Hao Li , David James , Elena Kostik
IPC分类号： A61K31/397 , A61K31/5377 , A61K31/50 , A61K31/53 , A61K31/505 , C07D413/14 , C07D251/02 , C07D401/14
CPC分类号： C07D213/75 , C07D213/77 , C07D239/47 , C07D239/48 , C07D239/50 , C07D239/56 , C07D251/42 , C07D251/52 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07D491/10
摘要： This invention relates to compounds of formula (I): their compositions and methods of use thereof. The compounds (and compositions) are useful in modulating IL-12 production and processes mediated by IL-12.
摘要翻译：本发明涉及式（I）化合物：它们的组成及其使用方法。化合物（和组合物）可用于调节由IL-12介导的IL-12产生和过程。

9. 发明申请

US20100222448A1 AQUEOUS POLYURETHANE DISPERSION 有权
标题翻译：水性聚氨酯分散体
公开(公告)号：US20100222448A1
公开(公告)日：2010-09-02
申请号：US11909606
申请日：2006-03-16
申请人： Göran Ziegler , David James , Kent Sörensen
发明人： Göran Ziegler , David James , Kent Sörensen
IPC分类号： C08F2/46 , C08L75/04
CPC分类号： C08G18/672 , C08G18/0823 , C08G18/12 , C08G18/44 , C09D175/16 , C08G18/3228 , C08G18/6659
摘要： Disclosed is an aqueous polyurethane dispersion obtained by dispersing in water a reaction product obtained by reacting a reaction mixture comprising at least one organic, aliphatic, cycloaliphatic or aromatic di, tri or poryisocyanate, at least one isocyanate reactive polycarbonate diol, triol or polyol, at least one compound comprising at least one isocyanate reactive group and at least one free radically polymerisable unsaturated group, and at least one compound comprising at least one isocyanate reactive group and at least one at least dispersing active group, and optionally at least one compound comprising at least two isocyanate reactive groups and having a molecular weight of less than 1000 g/mol.
摘要翻译：公开了一种水性聚氨酯分散体，其通过将包含至少一种有机，脂族，脂环族或芳族二，三或异氰酸酯的反应混合物，至少一种异氰酸酯反应性聚碳酸酯二醇，三醇或多元醇的反应混合物分散在水中而得到的反应产物，至少一种包含至少一种异氰酸酯反应性基团和至少一种可自由基聚合的不饱和基团的化合物和至少一种包含至少一种异氰酸酯反应性基团和至少一种至少分散的活性基团的化合物，以及任选的至少一种包含至少两个异氰酸酯反应性基团，分子量小于1000g / mol。

10. 发明申请

US20090100057A1 Organization System for Distributed Items 有权
标题翻译：分布式项目组织系统
公开(公告)号：US20090100057A1
公开(公告)日：2009-04-16
申请号：US11870805
申请日：2007-10-11
申请人： Peter Francis Martone , Gaurav Dhawan , David James , Jeff Liu , Richard Xia , Jun Wang , Joshua Pointer , Sobia Tariq
发明人： Peter Francis Martone , Gaurav Dhawan , David James , Jeff Liu , Richard Xia , Jun Wang , Joshua Pointer , Sobia Tariq
IPC分类号： G06F17/30
CPC分类号： G06F17/30212 , G06F17/30176
摘要： An item grouping mechanism may be applied to files or other computer objects to allow the files or objects to be accessed according to the group definition. The group definition may be defined in a table with other group definitions and distributed across an organization so that each device using the group definition may have files or other items presented in a consistent manner. The group definition may be distributed through a different mechanism than for the files or other items. If a device determines that a file defined in the group definition is missing from a local store, the device may retrieve the file from a distribution server.
摘要翻译：项目分组机制可以应用于文件或其他计算机对象，以允许根据组定义来访问文件或对象。组定义可以在具有其他组定义的表中定义并且分布在组织中，使得使用组定义的每个设备可以具有以一致方式呈现的文件或其他项目。组定义可以通过与文件或其他项目不同的机制来分发。如果设备确定在本地存储中缺少组定义中定义的文件，则设备可以从分发服务器检索该文件。

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