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1. 发明申请

US20130252824A1 SYSTEM AND METHOD FOR CLEANING NOISY GENETIC DATA FROM TARGET INDIVIDUALS USING GENETIC DATA FROM GENETICALLY RELATED INDIVIDUALS 有权
标题翻译：使用遗传资料从遗传相关个体清除目标个体的噪声遗传数据的系统和方法
公开(公告)号：US20130252824A1
公开(公告)日：2013-09-26
申请号：US13793186
申请日：2013-03-11
申请人： Matthew Rabinowitz , Milena Banjevic , Zachary Demko , David Johnson
发明人： Matthew Rabinowitz , Milena Banjevic , Zachary Demko , David Johnson
IPC分类号： G06F19/20
CPC分类号： G06F19/20 , G06F19/18
摘要： A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available, are disclosed. Genetic data for the target individual is acquired and amplified using known methods, and poorly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related subjects. In accordance with one embodiment of the invention, incomplete genetic data is acquired from embryonic cells, fetal cells, or cell-free fetal DNA isolated from the mother's blood, and the incomplete genetic data is reconstructed using the more complete genetic data from a larger sample diploid cells from one or both parents, with or without genetic data from haploid cells from one or both parents, and/or genetic data taken from other related individuals.
摘要翻译：公开了一种用于确定一个或一小组细胞遗传数据的系统和方法，或从有限数量的遗传数据获得的片段DNA。使用已知方法获取和扩增目标个体的遗传数据，并且使用目标基因组与基因相关受试者的基因组之间的预期相似性重建差测量的碱基对，缺失的等位基因和缺失区域。根据本发明的一个实施方案，从母体血液中分离的胚胎细胞，胎儿细胞或无细胞胎儿DNA获得不完整的遗传数据，并且使用更大的样本的更完整的遗传数据来重建不完整的遗传数据来自一个或两个父母的二倍体细胞，具有或不具有来自一个或两个亲本的单倍体细胞的遗传数据和/或从其他相关个体获取的遗传数据。

2. 发明申请

US20110288780A1 Methods for Non-Invasive Prenatal Ploidy Calling 有权
标题翻译：非侵入性产前倍性调用方法
公开(公告)号：US20110288780A1
公开(公告)日：2011-11-24
申请号：US13110685
申请日：2011-05-18
申请人： Matthew Rabinowitz , George Gemelos , Milena Banjevic , Allison Ryan , Zachary Demko , Matthew Hill , Bernhard Zimmermann , Johan Baner
发明人： Matthew Rabinowitz , George Gemelos , Milena Banjevic , Allison Ryan , Zachary Demko , Matthew Hill , Bernhard Zimmermann , Johan Baner
IPC分类号： G06F19/00 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q1/6869 , C12Q2537/161 , C12Q2537/165 , C12Q2600/112 , C12Q2600/156 , C12Q2600/16 , C12Q2600/172 , G06F19/00 , G06F19/12 , G06F19/18 , G06F19/22 , G06F19/34 , G16H50/30
摘要： Methods for non-invasive prenatal ploidy calling are disclosed herein. Methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a sample of DNA from the mother of the fetus and from the fetus, and from genotypic data from the mother and optionally also from the father are disclosed herein. The ploidy state is determined by using a joint distribution model to create a set of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. In an embodiment, the mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias.
摘要翻译：本文公开了非侵入性产前倍性呼叫的方法。本文公开了从胎儿母体和胎儿的DNA样本以及来自母亲和任选也来自父亲的基因型数据测量的基因型数据中确定妊娠胎儿染色体倍性状态的方法。通过使用联合分布模型来确定给定父母基因型数据的不同可能胎儿倍性状态的一组预期等位基因分布，并将预期等位基因分布与在混合样品中测量的测量等位基因分布的模式进行比较来确定倍性状态，并选择其预期等位基因分布模式与观察到的等位基因分布模式最接近的倍性状态。在一个实施方案中，DNA的混合样品可以以使等位基因偏倚最小化的方式优先富集在多个多态位点。

3. 发明申请

US20110105483A1 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY 有权
标题翻译：调节HSP90活性的三唑化合物
公开(公告)号：US20110105483A1
公开(公告)日：2011-05-05
申请号：US12526491
申请日：2008-02-08
申请人： Dinesh U. Chimmanamada , Joseph A. Burlison , Weiwen Ying , Lijun Sun , Stefan Michael Schweizer , Shijie Zhang , Zachary Demko , David James , Teresa Przewloka
发明人： Dinesh U. Chimmanamada , Joseph A. Burlison , Weiwen Ying , Lijun Sun , Stefan Michael Schweizer , Shijie Zhang , Zachary Demko , David James , Teresa Przewloka
IPC分类号： A61K31/4196 , C07D403/10 , C07D403/14 , C07D413/10 , C07D413/14 , C07D417/10 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P37/00 , A61P31/10 , A61P7/00
CPC分类号： C07D417/14 , C07D249/08 , C07D249/10 , C07D249/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to the use of a substituted triazole compound of the invention, or a composition comprising such a compound in the preparation of a medicament for preventing or treating hyperprolif erative disorders, such as cancer, in a subject in need thereof.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及本发明的取代的三唑化合物或包含这种化合物的组合物在制备用于预防或治疗有需要的受试者中的多药耐药性疾病如癌症的药物中的用途。

4. 发明申请

US20100279410A1 COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS 审中-公开
标题翻译：用于治疗增生性疾病的化合物
公开(公告)号：US20100279410A1
公开(公告)日：2010-11-04
申请号：US12768164
申请日：2010-04-27
申请人： Zachary Demko , Christopher Borella , Shoujun Chen , Lijun Sun
发明人： Zachary Demko , Christopher Borella , Shoujun Chen , Lijun Sun
IPC分类号： C12N5/09
CPC分类号： C07F9/6518 , A61K31/4192 , A61K31/422 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/501 , A61K31/506 , A61K31/675 , C07D249/06 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/10
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
摘要翻译：本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂化物，包合物和前药，其中R a，R b和R 2在本文中定义。这些化合物抑制微管蛋白聚合和/或靶向脉管系统，并且可用于治疗增殖性疾病如癌症。

5. 发明授权

US07615552B2 Fused heterocyclic compounds 有权
标题翻译：稠合杂环化合物
公开(公告)号：US07615552B2
公开(公告)日：2009-11-10
申请号：US10985627
申请日：2004-11-10
申请人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Teresa Przewloka , Hao Li , Zachary Demko , Dinesh Chimmanamada
发明人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Teresa Przewloka , Hao Li , Zachary Demko , Dinesh Chimmanamada
IPC分类号： A61K31/517 , A61K31/5377 , C07D265/30 , C07D413/04
CPC分类号： C07D239/95 , C04B35/632 , C07D215/40 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D409/04 , C07D413/14 , C07D471/04 , C07D475/06 , C07D491/04
摘要： This invention provides fused heterocyclic compounds, pharmaceutical compositions of the compounds, and methods of using the compounds for the treatment of, inter alia, IL-12 related disease and disorders.
摘要翻译：本发明提供稠合杂环化合物，化合物的药物组合物，以及使用该化合物治疗特别是IL-12相关疾病和病症的方法。

6. 发明申请

US20080243398A1 System and method for cleaning noisy genetic data and determining chromosome copy number 有权
标题翻译：清除嘈杂遗传数据和确定染色体拷贝数的系统和方法
公开(公告)号：US20080243398A1
公开(公告)日：2008-10-02
申请号：US12076348
申请日：2008-03-17
申请人： Matthew Rabinowitz , Milena Banjevic , Zachary Demko , David Scott Johnson , Dusan Kijacic , Dimitri Petrov , Josh Sweetkind-Singer , Jing Xu
发明人： Matthew Rabinowitz , Milena Banjevic , Zachary Demko , David Scott Johnson , Dusan Kijacic , Dimitri Petrov , Josh Sweetkind-Singer , Jing Xu
IPC分类号： G01N33/48
CPC分类号： G06F19/16 , C12Q1/6855 , C12Q1/6874 , G06F19/18 , G06F19/24 , G06Q50/22
摘要： Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Genetic material from the target individual is acquired, amplified and the genetic data is measured using known methods. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment of the invention, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment of the invention, the chromosome copy number can be determined from the measured genetic data of a single or small number of cells, with or without genetic information from one or both parents. In another embodiment of the invention, these determinations are made for the purpose of embryo selection in the context of in-vitro fertilization. In another embodiment of the invention, the genetic data can be reconstructed for the purposes of making phenotypic predictions.
摘要翻译：本文公开了一种系统和方法，用于增加测量的遗传数据的保真度，进行等位基因调用，并确定在一组或一组细胞中或从片段DNA中确定非整倍体的状态，其中有限数量的遗传数据是可用的获取，扩增来自目标个体的遗传物质，并使用已知方法测量遗传数据。使用目标基因组与遗传相关个体的基因组之间的预期相似性来重建差或不正确测量的碱基对，缺失的等位基因和缺失区域。根据本发明的一个实施方案，使用来自一个或两个亲本的二倍体细胞的较大样本的更完整的遗传数据，在多个基因座重建来自胚胎细胞的不完全遗传数据，具有或不具有来自一个的单倍体遗传数据或双亲。在本发明的另一个实施方案中，染色体拷贝数可以从单个或少数细胞的测量的遗传数据确定，具有或不具有来自一个或两个亲本的遗传信息。在本发明的另一个实施方案中，这些确定是为了在体外受精的背景下进行胚胎选择的目的。在本发明的另一个实施方案中，为了进行表型预测的目的，可以重建遗传数据。

7. 发明申请

US20070238699A1 Compounds for the treatment of proliferative disorders 有权
标题翻译：用于治疗增殖性疾病的化合物
公开(公告)号：US20070238699A1
公开(公告)日：2007-10-11
申请号：US11492692
申请日：2006-07-24
申请人： Zachary Demko , Christopher Borella , Shoujun Chen , Lijun Sun
发明人： Zachary Demko , Christopher Borella , Shoujun Chen , Lijun Sun
IPC分类号： A61K31/724 , A61K31/506 , A61K31/501 , A61K31/4439 , A61K31/4192 , C07D403/04
CPC分类号： C07F9/6518 , A61K31/4192 , A61K31/422 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/501 , A61K31/506 , A61K31/675 , C07D249/06 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/10
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
摘要翻译：本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂化物，包合物和前药，其中R a，R b，R b， SUB> 2 在本文中定义。这些化合物抑制微管蛋白聚合和/或靶向脉管系统，并且可用于治疗增殖性疾病如癌症。

8. 发明申请

US20050250774A1 Pyridine compounds 有权
标题翻译：吡啶化合物
公开(公告)号：US20050250774A1
公开(公告)日：2005-11-10
申请号：US10985696
申请日：2004-11-10
申请人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Teresa Przewloka , Hao Li , Howard Ng , Zachary Demko
发明人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Teresa Przewloka , Hao Li , Howard Ng , Zachary Demko
IPC分类号： A61K20060101 , A61K31/5375 , A61K31/5377 , C07D213/77 , C07D401/12 , C07D405/12 , C07D413/02 , C07D413/04 , C07D413/12
CPC分类号： C07D413/12 , C04B35/632 , C07D213/77 , C07D401/12 , C07D405/12
摘要： This invention features compounds of formula (I): pharmaceutical compositions of the compounds, and methods of using the compounds for the treatment of, inter alia, IL-12-related diseases and disorders.
摘要翻译：本发明的特征在于式（I）化合物：化合物的药物组合物，以及使用该化合物治疗特别是IL-12相关疾病和病症的方法。

9. 发明授权

US10113196B2 Prenatal paternity testing using maternal blood, free floating fetal DNA and SNP genotyping 有权
公开(公告)号：US10113196B2
公开(公告)日：2018-10-30
申请号：US13335043
申请日：2011-12-22
申请人： Allison Ryan , Styrmir Sigurjonsson , Milena Banjevic , George Gemelos , Matthew Hill , Johan Baner , Matthew Rabinowitz , Zachary Demko
发明人： Allison Ryan , Styrmir Sigurjonsson , Milena Banjevic , George Gemelos , Matthew Hill , Johan Baner , Matthew Rabinowitz , Zachary Demko
IPC分类号： C12Q1/6869 , C12Q1/6876 , G06F19/14
摘要： Methods for non-invasive prenatal paternity testing are disclosed herein. The method uses genetic measurements made on plasma taken from a pregnant mother, along with genetic measurements of the alleged father, and genetic measurements of the mother, to determine whether or not the alleged father is the biological father of the fetus. This is accomplished by way of an informatics based method that can compare the genetic fingerprint of the fetal DNA found in maternal plasma to the genetic fingerprint of the alleged father.

10. 发明申请

US20150232938A1 METHODS FOR INCREASING FETAL FRACTION IN MATERNAL BLOOD 审中-公开
标题翻译：用于增加母体中的胎儿分数的方法
公开(公告)号：US20150232938A1
公开(公告)日：2015-08-20
申请号：US14704314
申请日：2015-05-05
申请人： Ravi Mhatre , Johan Baner , Bernhard Zimmermann , Matthew Micah Hill , Zachary Demko
发明人： Ravi Mhatre , Johan Baner , Bernhard Zimmermann , Matthew Micah Hill , Zachary Demko
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A23D9/00 , C12Q2600/118 , C12Q2600/156
摘要： The invention provides methods of increasing the fetal fraction in maternal blood and plasma. This increase in fetal fraction improves the accuracy and decreases the “no call” rate for prenatal testing that measures fetal DNA in maternal blood.
摘要翻译：本发明提供了增加母体血液和血浆中胎儿分数的方法。胎儿分数的这种增加提高了准确性，降低了测量母体血液胎儿DNA的产前测试的“无呼叫”率。

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