专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

2. 发明授权

US08415377B2 Triazole compounds that modulate HSP90 activity 有权
公开(公告)号：US08415377B2
公开(公告)日：2013-04-09
申请号：US13229178
申请日：2011-09-09
申请人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： C07D401/14 , C07D403/04 , A61K31/4196 , A61K31/4709
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

3. 发明授权

US08362055B2 Triazole compounds that modulate HSP90 activity 有权
公开(公告)号：US08362055B2
公开(公告)日：2013-01-29
申请号：US12815322
申请日：2010-06-14
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号： A61K31/41 , C07D249/08
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

4. 发明授权

US07825148B2 Triazole compounds that modulate Hsp90 activity 有权
标题翻译：调节Hsp90活性的三唑化合物
公开(公告)号：US07825148B2
公开(公告)日：2010-11-02
申请号：US11282119
申请日：2005-11-17
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号： A61K31/41 , C07D249/04
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物，或包含这种化合物的组合物。

5. 发明申请

US20090253694A1 Fused hetrocyclic compounds 有权
标题翻译：稠合的杂环化合物
公开(公告)号：US20090253694A1
公开(公告)日：2009-10-08
申请号：US12380007
申请日：2009-02-20
申请人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Teresa Przewloka , Hao Li , Zachary Demko , Dinesh Chimmanamada
发明人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Teresa Przewloka , Hao Li , Zachary Demko , Dinesh Chimmanamada
IPC分类号： A61K31/5377 , C12N5/00 , A61P37/06 , A61P19/08 , A61P29/00 , A61P25/00
CPC分类号： C07D239/95 , C04B35/632 , C07D215/40 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D409/04 , C07D413/14 , C07D471/04 , C07D475/06 , C07D491/04
摘要： This invention provides fused heterocyclic compounds, pharmaceutical compositions of the compounds, and methods of using the compounds for the treatment of, inter alia, IL-12 related disease and disorders.
摘要翻译：本发明提供稠合杂环化合物，化合物的药物组合物，以及使用该化合物治疗特别是IL-12相关疾病和病症的方法。

6. 发明授权

US06255323B1 Cyanoguanidine compounds 失效
标题翻译：氰基胍化合物
公开(公告)号：US06255323B1
公开(公告)日：2001-07-03
申请号：US09545430
申请日：2000-04-07
申请人： Tai-Nang Huang , Guiqing Liang , Weimin Liu , Teresa Przewloka , Ming Shen , Shijie Zhang
发明人： Tai-Nang Huang , Guiqing Liang , Weimin Liu , Teresa Przewloka , Ming Shen , Shijie Zhang
IPC分类号： C07D21375
CPC分类号： C07D213/75 , C07D213/81 , C07D215/38 , C07D401/12 , C07D405/12 , C07D409/12
摘要： A cyanoguanidine compound of the following formula: is disclosed. A cyanoguanidine compound of the present invention possess a high specificity for tumor cells. Also disclosed are methods for preparing a cyanoguanidine compound.
摘要翻译：公开了下式的氰基胍化合物。本发明的氰基胍化合物对肿瘤细胞具有高特异性。还公开了制备氰基胍化合物的方法。

7. 发明授权

US5874412A Bis-anthracyclines with high activity against doxorubicin resistant tumors 失效
标题翻译：具有高抗阿霉素抗性肿瘤活性的双蒽环类抗生素
公开(公告)号：US5874412A
公开(公告)日：1999-02-23
申请号：US828198
申请日：1997-03-21
申请人： Waldemar Priebe , Jonathan B. Chaires , Teresa Przewloka , Izabela Fokt , Roman Perez-Soler
发明人： Waldemar Priebe , Jonathan B. Chaires , Teresa Przewloka , Izabela Fokt , Roman Perez-Soler
IPC分类号： C07H15/252 , A61K31/00 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P35/00 , C07H15/24 , C07H17/08
CPC分类号： A61K31/704 , A61K47/481 , C07H15/24 , C07H15/252
摘要： The present invention discloses new and novel bisanthracyclines linked through the saccharide portions. These compounds show high activity against two clinically relevant mechanisms of resistance. A novel approach of the invention produces compounds that are as active or more so than the parent compounds. Furthermore, the inventor's discovery is also for the design of effective DNA-binding bisanthracyclines as well as anthracyclines mixed with other intercalators and groove binders.
摘要翻译：本发明公开了通过糖部分连接的新型和新型的抗坏血酸。这些化合物对抗两种临床相关的抵抗机制显示出高活性。本发明的新方法产生与母体化合物一样活性或更多的化合物。此外，发明人的发现也是为了设计有效的DNA结合性中性抗环素以及与其它嵌入剂和沟槽结合剂混合的蒽环类。

8. 发明申请

US20110105483A1 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY 有权
标题翻译：调节HSP90活性的三唑化合物
公开(公告)号：US20110105483A1
公开(公告)日：2011-05-05
申请号：US12526491
申请日：2008-02-08
申请人： Dinesh U. Chimmanamada , Joseph A. Burlison , Weiwen Ying , Lijun Sun , Stefan Michael Schweizer , Shijie Zhang , Zachary Demko , David James , Teresa Przewloka
发明人： Dinesh U. Chimmanamada , Joseph A. Burlison , Weiwen Ying , Lijun Sun , Stefan Michael Schweizer , Shijie Zhang , Zachary Demko , David James , Teresa Przewloka
IPC分类号： A61K31/4196 , C07D403/10 , C07D403/14 , C07D413/10 , C07D413/14 , C07D417/10 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P37/00 , A61P31/10 , A61P7/00
CPC分类号： C07D417/14 , C07D249/08 , C07D249/10 , C07D249/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to the use of a substituted triazole compound of the invention, or a composition comprising such a compound in the preparation of a medicament for preventing or treating hyperprolif erative disorders, such as cancer, in a subject in need thereof.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及本发明的取代的三唑化合物或包含这种化合物的组合物在制备用于预防或治疗有需要的受试者中的多药耐药性疾病如癌症的药物中的用途。

9. 发明授权

US07615552B2 Fused heterocyclic compounds 有权
标题翻译：稠合杂环化合物
公开(公告)号：US07615552B2
公开(公告)日：2009-11-10
申请号：US10985627
申请日：2004-11-10
申请人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Teresa Przewloka , Hao Li , Zachary Demko , Dinesh Chimmanamada
发明人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Teresa Przewloka , Hao Li , Zachary Demko , Dinesh Chimmanamada
IPC分类号： A61K31/517 , A61K31/5377 , C07D265/30 , C07D413/04
CPC分类号： C07D239/95 , C04B35/632 , C07D215/40 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D409/04 , C07D413/14 , C07D471/04 , C07D475/06 , C07D491/04
摘要： This invention provides fused heterocyclic compounds, pharmaceutical compositions of the compounds, and methods of using the compounds for the treatment of, inter alia, IL-12 related disease and disorders.
摘要翻译：本发明提供稠合杂环化合物，化合物的药物组合物，以及使用该化合物治疗特别是IL-12相关疾病和病症的方法。

10. 发明申请

US20080125587A1 Synthesis of triazole compounds that modulate HSP90 activity 审中-公开
标题翻译：合成调节HSP90活性的三唑化合物
公开(公告)号：US20080125587A1
公开(公告)日：2008-05-29
申请号：US11807333
申请日：2007-05-25
申请人： Dinesh U. Chimmanamada , Chi-Wan Lee , David James , Shijie Zhang , Weiwen Ying , Junghyun Chae , Teresa Przewloka
发明人： Dinesh U. Chimmanamada , Chi-Wan Lee , David James , Shijie Zhang , Weiwen Ying , Junghyun Chae , Teresa Przewloka
IPC分类号： C07D249/12 , C07D407/02 , C07D403/02 , C07D401/02 , C07D401/04 , C07D403/10 , C07D417/02 , C07D487/04 , C07D413/12 , C07D413/02
CPC分类号： C07D403/04 , C07D249/12 , C07D249/14 , C07D401/04 , C07D401/10 , C07D403/10 , C07D413/04 , C07D417/04
摘要： The present invention provides novel methods of preparing triazole compounds which inhibit the activity of Hsp90. One embodiment of the invention is directed to methods for preparing a triazole compound represented by the following Structural Formula: or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising the steps of: a) reacting an amide represented by the following Structural Formula: with a thionation reagent to form a thioamide; b) reacting the thioamide of step a) with hydrazine to form a hydrazonamide; c) reacting the hydrazonamide of step b) with a carbonylation or a thiocarbonylation reagent.In one embodiment, the present invention is a method of synthesis of a compound of formula (IA) or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising reacting a compound of formula (IIA) with an oxidizing agent, thereby producing a compound of formula (IA).The present invention is also directed to a method of preparing a compound or a tautomer thereof represented by the following Structural Formula: or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof. The method comprises the step of reacting a first starting compound represented by the following Structural Formula: in the presence of a mercuric salt, with a second starting compound represented by the following Structural Formula:
摘要翻译：本发明提供抑制Hsp90活性的三唑化合物的新方法。本发明的一个实施方案涉及制备由以下结构式表示的三唑化合物或互变异构体，药学上可接受的盐，溶剂化物或包合物或其前药的方法，其包括以下步骤：a）使酰胺由以下结构式表示：用硫化试剂形成硫代酰胺; b）使步骤a）的硫代酰胺与肼反应形成腙酰胺; c）使步骤b）的腙与羰基化或硫代羰基化试剂反应。在一个实施方案中，本发明是合成式（IA）化合物或互变异构体，其药学上可接受的盐，溶剂化物或包合物或其前药的方法，包括使式（IIA）化合物与氧化剂，从而制备式（IA）化合物。本发明还涉及制备由以下结构式表示的化合物或其互变异构体的方法：或其互变异构体，药学上可接受的盐，溶剂化物或包合物或其前药。该方法包括使由以下结构式表示的第一起始化合物在汞盐存在下与由以下结构式表示的第二起始化合物反应的步骤：

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式