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1. 发明授权

US07682571B2 Micro-fluidic heating system 有权
标题翻译：微流体加热系统
公开(公告)号：US07682571B2
公开(公告)日：2010-03-23
申请号：US10899143
申请日：2004-07-27
申请人： Sung Jin Kim , Hae Sik Yang , Dae Sik Lee , Yong Taik Lim , Kwang Hyo Chung , Kyu Won Kim , Se Ho Park , Yun Tae Kim
发明人： Sung Jin Kim , Hae Sik Yang , Dae Sik Lee , Yong Taik Lim , Kwang Hyo Chung , Kyu Won Kim , Se Ho Park , Yun Tae Kim
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , B01J2219/00286 , B01J2219/00389 , B01J2219/00495 , B01J2219/00783 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/00869 , B01J2219/00873 , B01L7/00 , B01L2300/1827 , C40B60/14 , H05B3/26 , H05B2203/003 , H05B2203/013 , H05B2203/017
摘要： Provided is a micro-fluidic heating system, which comprises a micro-fluidic control element for providing a chamber, a flow path and a valve, and a main body for heating the inside of the chamber in contact with the micro-fluidic control element, wherein the micro-fluidic control element consists of an upper substrate for providing the chamber, the flow path and the valve, and a lower substrate as a thin film bonded to the upper substrate, and the main body consists of a membrane in which heating means and suction holes are formed, and support member for supporting the membrane, and the heating means is partially in contact with the lower substrate of the chamber to heat the inside of the chamber, so that thermal transfer efficiency becomes maximized and temperature of each chamber may be independently controlled in the case of configuration having chambers arranged in array.
摘要翻译：提供了一种微流体加热系统，其包括用于提供腔室，流路和阀门的微流控制元件和用于加热与微流控制元件接触的腔室内部的主体，其特征在于，所述微流体控制元件由用于提供所述室，所述流路和所述阀的上基板以及与所述上基板接合的薄膜的下基板构成，所述主体由膜构成，加热单元并且形成吸入孔，并且用于支撑膜的支撑构件，并且加热装置部分地与室的下基板接触以加热室的内部，使得热传递效率变得最大，并且每个室的温度可以在配置有排列成阵列的腔室的情况下，可独立控制。

2. 发明授权

US07652370B2 Plastic microfabricated structure for biochip, microfabricated thermal device, microfabricated reactor, microfabricated reactor array, and micro array using the same 有权
标题翻译：用于生物芯片，微制造热装置，微制造反应堆，微制造反应堆阵列和使用其的微阵列的塑料微制造结构
公开(公告)号：US07652370B2
公开(公告)日：2010-01-26
申请号：US10899177
申请日：2004-07-27
申请人： Dae Sik Lee , Hae Sik Yang , Yong Taik Lim , Kwang Hyo Chung , Sung Jin Kim , Se Ho Park , Kyu Won Kim , Yun Tae Kim
发明人： Dae Sik Lee , Hae Sik Yang , Yong Taik Lim , Kwang Hyo Chung , Sung Jin Kim , Se Ho Park , Kyu Won Kim , Yun Tae Kim
IPC分类号： H01L29/06
CPC分类号： B01J19/0093 , B01J2219/00495 , B01J2219/00605 , B01J2219/0061 , B01J2219/00619 , B01J2219/00621 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00783 , B01J2219/00804 , B01J2219/00833 , B01J2219/00853 , B01J2219/00858 , B01J2219/00873 , B01J2219/00961 , B01L3/502707 , B01L3/50851 , B01L2200/12 , B01L2200/147 , B01L2300/0819 , B01L2300/12 , B01L2300/1827 , B33Y80/00 , C40B60/14 , G01N27/128
摘要： Provided are a plastic microfabricated structure, and a microfabricated thermal device, a microfabricated reactor, a microfabricated reactor array and a micro array using the same, which may be applied to a bio chip, and the present invention may fabricate the plastic microfabricated structure for providing a heating region by means of insulating plastic, which has a thin thickness, flatness enough to allow a photolithography process to be performed, thermal isolation in its some or total area, and a small thermal mass, and on top of the heating region of the plastic microfabricated structure, a heater, a temperature sensor for sensing a temperature, an electrode, and an electrode pad are formed to thereby fabricate the microfabricated heating device, whereby element may be readily fabricated at a low cost, and the heating region is formed of a plastic thin layer, so that uniform temperature control is possible even with a low power, and various samples may be thermally treated at a fast speed to obtain their reaction and analysis.
摘要翻译：本发明提供一种塑料微制造结构，微制造热装置，微制造反应器，微制造反应器阵列和使用其的微阵列，其可以应用于生物芯片，并且本发明可以制造塑料微制造结构以提供通过绝缘塑料的加热区域，其具有薄的厚度，足够的平坦度，以允许执行光刻工艺，其一些或总面积的热隔离和小的热质量，以及在形成塑料微加工结构，加热器，用于感测温度的温度传感器，电极和电极焊盘，从而制造微制造加热装置，从而可以以低成本容易地制造元件，并且加热区域由塑料薄层，使得即使在低功率下也能进行均匀的温度控制，并且各种样品可以在fa处进行热处理速度获得反应和分析。

3. 发明授权

US07412990B2 Microfluidic control device and method for controlling microfluid 失效
标题翻译：微流控制装置及微流体控制方法
公开(公告)号：US07412990B2
公开(公告)日：2008-08-19
申请号：US10898964
申请日：2004-07-27
申请人： Kwang Hyo Chung , Hae Sik Yang , Dae Sik Lee , Yong Taek Lim , Sung Jin Kim , Se Ho Park , Kyu Won Kim , Yun Tae Kim
发明人： Kwang Hyo Chung , Hae Sik Yang , Dae Sik Lee , Yong Taek Lim , Sung Jin Kim , Se Ho Park , Kyu Won Kim , Yun Tae Kim
IPC分类号： F15C1/06
CPC分类号： B01F13/0086 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0406 , B01L2400/0622 , B01L2400/0688 , B33Y70/00 , B33Y80/00 , Y10T137/2082 , Y10T137/2224
摘要： Provided is a microfluidic control device and method for controlling the microfluid, and a fine amount of fluid is controlled even with natural fluid flow and solution injection, wherein a pressure barrier of a capillary is removed by a surface tension change resulted from the solution injection to thereby obtain transport, interflow, mixing, and time delay of the microfluid, and to detail this, solution is injected to meet the boundary surface of the stopped fluid when the fluid is stopped by the stop valve, so that a function of the stop valve is removed to obtain the transport, interflow, and mixing of the fluid, and the method for controlling the microfluid may be applied to the microfluidic control device for biochemical reaction, and it uses only the capillary force change resulted from solution injection to thereby have its structure simplified.
摘要翻译：提供了一种用于控制微流体的微流控制装置和方法，并且即使使用天然流体流动和溶液注入也能控制微量的流体，其中毛细管的压力屏障由于溶液注入导致的表面张力变化而被去除从而获得微流体的运输，流动，混合和时间延迟，并且为了详细说明，当流体被截止阀停止时，溶液被注入以满足停止的流体的边界表面，使得截止阀被移除以获得流体的输送，流动和混合，并且用于控制微流体的方法可以应用于用于生物化学反应的微流控制装置，并且其仅使用由溶液注入引起的毛细管力变化，从而使其结构简化。

4. 发明授权

US07183056B2 Method for performing multiplex PCR with cyclic changes of PCR parameters 失效
标题翻译：用PCR参数循环变化进行多重PCR的方法
公开(公告)号：US07183056B2
公开(公告)日：2007-02-27
申请号：US10697295
申请日：2003-10-31
申请人： Se Ho Park , Hae Sik Yang , Dae Sik Lee , Yong Beom Shin , Kyu Won Kim , Tae Hwan Yoon , Sung Jin Kim , Yun Tae Kim
发明人： Se Ho Park , Hae Sik Yang , Dae Sik Lee , Yong Beom Shin , Kyu Won Kim , Tae Hwan Yoon , Sung Jin Kim , Yun Tae Kim
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q2537/143 , C12Q2527/113 , C12Q2527/101
摘要： The present invention is directed to an improved multiplex PCR method for obtaining at least two PCR products from one PCR solution. In the multiplex PCR method for having at least two DNA amplified products from a sample positioned in a PCR equipment, the object of the present invention is to provide a novel multiplex PCR method characterized in that a primer annealing temperature and an extension time be changed per cycle with constant periods. When a multiplex PCR is performed in accordance with the present invention, limitations in determining PCR conditions due to a various sizes of PCR products or dimers caused by primers can be eliminated, and time and efforts required for determining the PCR conditions to various samples can also be reduced. Further, not only refined DNAs like cDNA, genomic DNA, vector, etc, but blood can be directly used as a multiplex PCR sample, and PCR amplification reaction can be performed even with a sample having the smallest amounts.
摘要翻译：本发明涉及一种用于从一种PCR溶液获得至少两种PCR产物的改进的多重PCR方法。本发明的目的是提供一种新的多重PCR方法，其特征在于，引物退火温度和延长时间根据周期不变的周期。当根据本发明进行多重PCR时，可以消除由于由引物引起的各种大小的PCR产物或二聚体导致的PCR条件的限制的限制，并且确定各种样品的PCR条件所需的时间和努力也可以减少此外，不仅可以将cDNA，基因组DNA，载体等精制DNA与血液直接用作多重PCR样品，即使使用量少的样品也能进行PCR扩增反应。

5. 发明授权

US07238324B2 Microfluidic device for the controlled movement of fluid 失效
标题翻译：用于流体控制运动的微流体装置
公开(公告)号：US07238324B2
公开(公告)日：2007-07-03
申请号：US10615441
申请日：2003-07-07
申请人： Jong Soo Ko , Hyun Chul Yoon , Hae Sik Yang , Dae-Sik Lee , Kwang Hyo Chung , Hyeon Bong Pyo , Sung Jin Kim , Yun Tae Kim
发明人： Jong Soo Ko , Hyun Chul Yoon , Hae Sik Yang , Dae-Sik Lee , Kwang Hyo Chung , Hyeon Bong Pyo , Sung Jin Kim , Yun Tae Kim
IPC分类号： B01L3/02
CPC分类号： B01L3/502707 , B01L3/50273 , B01L3/502746 , B01L2200/16 , B01L2300/0645 , B01L2300/0867 , B01L2400/0406 , B01L2400/0442 , B01L2400/0487 , B01L2400/0688 , B01L2400/086 , B01L2400/088 , B33Y70/00 , B33Y80/00 , Y10T436/25
摘要： A microfluidic device for controlling the flow of a micro amount of fluid is provided. The microfluidic device is manufactured by binding a sensing substrate including a sensing electrode, an electrode interconnect, and a electrode pad, with a channel substrate including at least two fluid inlet ports, a chamber, and a channel, wherein a first fluid injected via one of the fluid inlet ports flows by natural capillary force, and a second fluid injected via another fluid inlet port is forced to flow by an external pump. The microfluidic device controls fluid flow and flow stoppage by a combination of natural capillary flow and an externally applied pressure as a result of the action of a pump.
摘要翻译：提供了用于控制微量流体流动的微流体装置。微流体装置通过将包括感测电极，电极互连和电极焊盘的感测衬底与包括至少两个流体入口端口，腔室和通道的通道衬底结合来制造，其中通过一个注入的第一流体的流体入口端口通过天然毛细管力流动，并且通过另一流体入口喷射的第二流体被迫使外部泵流动。由于泵的作用，微流体装置通过天然毛细管流动和外部施加的压力的组合来控制流体流动和流动停止。

6. 发明授权

US06901963B2 Micro fluidic device for controlling flow time of micro fluid 有权
标题翻译：用于控制微流体流动时间的微流体装置
公开(公告)号：US06901963B2
公开(公告)日：2005-06-07
申请号：US10731211
申请日：2003-12-08
申请人： Sung Jin Kim , Yong Beom Shin , HaeSik Yang , Dae Sik Lee , Kyu Won Kim , Se Ho Park , Yun Tae Kim
发明人： Sung Jin Kim , Yong Beom Shin , HaeSik Yang , Dae Sik Lee , Kyu Won Kim , Se Ho Park , Yun Tae Kim
IPC分类号： B01J19/00 , G05D7/01 , F15B21/00
CPC分类号： G05D7/0186 , Y10T137/2076 , Y10T137/2224
摘要： Provided is a micro fluidic device that can control a flow time of micro fluid by using a capillary phenomenon. The micro fluidic device includes: a flow channel for flowing fluid, the flow channel being formed between a top substrate and a bottom substrate or between a top substrate, a bottom substrate, and a middle substrate; a flow blocking surface for stopping a flow of the fluid in the flow channel temporarily; and a hump for delaying the flow formed in the line of continuity with the flow blocking surface. The micro fluidic device of the present research can control the flow time in a simple manner.
摘要翻译：提供了一种微流体装置，其可以通过使用毛细管现象来控制微流体的流动时间。微流体装置包括：用于流动流体的流动通道，流动通道形成在顶部基板和底部基板之间，或者在顶部基板，底部基板和中间基板之间; 用于暂停流道中的流体流动的阻流表面; 以及用于延迟在与阻流表面连续的线中形成的流动的隆起。本研究的微流体装置可以以简单的方式控制流动时间。

7. 发明授权

US07445754B2 Device for controlling fluid using surface tension 失效
标题翻译：用于使用表面张力控制流体的装置
公开(公告)号：US07445754B2
公开(公告)日：2008-11-04
申请号：US10671490
申请日：2003-09-29
申请人： Kwang Hyo Chung , Jong Soo Ko , Hyun Chul Yoon , Hae Sik Yang , Hyeon Bong Pyo , Sung Jin Kim , Yun Tae Kim
发明人： Kwang Hyo Chung , Jong Soo Ko , Hyun Chul Yoon , Hae Sik Yang , Hyeon Bong Pyo , Sung Jin Kim , Yun Tae Kim
IPC分类号： B01L3/02
CPC分类号： B01L3/5027 , B01J2219/00837 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2200/0684 , B01L2400/0688 , B33Y70/00 , B33Y80/00 , Y10T137/2076 , Y10T436/2575
摘要： Disclosed is to a device for exchanging minimum amount of the fluid only by using surface tension of the fluid instead of external force like a pump. According to the device, an additional pump and power supply is not needed, thereby the device can be small sized and portable, and not only manufacturing cost decreases and yield increases but the device is hardly out of order.
摘要翻译：公开了仅通过使用流体的表面张力而不是像泵这样的外力来交换最小量的流体的装置。根据该装置，不需要附加的泵和电源，因此该装置可以小型化且便于携带，不仅制造成本降低并且产量增加，而且装置几乎不会出现故障。

8. 发明授权

US09368667B1 Plasmon field effect transistor 有权
标题翻译：等离子场效应晶体管
公开(公告)号：US09368667B1
公开(公告)日：2016-06-14
申请号：US14171342
申请日：2014-02-03
申请人： Sung Jin Kim , Juhyung Yun
发明人： Sung Jin Kim , Juhyung Yun
IPC分类号： H01L31/062 , H01L31/113 , H01L31/0352
CPC分类号： H01L31/1136 , H01L31/02327
摘要： A field effect transistor (FET) is provided. The FET includes a first material layer, second material layer and a third material layer. The third material layer includes an n-type silicon substrate layer and a gate electrode. The gate electrode includes an insulating substrate with at least one conducting metal. The second material layer is disposed on the third material layer. The first material layer is disposed on the second material layer. A source electrode is disposed on the first material layer. A drain electrode is disposed on the first material layer. A plurality of gold nanostructures are disposed on an active channel of the FET. The plurality of gold nanostructures are electrically isolated from the source electrode, drain electrode and gate electrode. The plurality of gold nanostructures contribute to a drain current of the FET based at least in part on plasmonic absorption of photons.
摘要翻译：提供场效应晶体管（FET）。 FET包括第一材料层，第二材料层和第三材料层。第三材料层包括n型硅衬底层和栅电极。栅电极包括具有至少一个导电金属的绝缘衬底。第二材料层设置在第三材料层上。第一材料层设置在第二材料层上。源电极设置在第一材料层上。漏电极设置在第一材料层上。多个金纳米结构设置在FET的有源沟道上。多个金纳米结构与源电极，漏电极和栅电极电隔离。至少部分地基于光子的等离子体吸收，多个金纳米结构有助于FET的漏极电流。

9. 发明授权

US08684016B2 Dish washing machine 有权
标题翻译：洗碗机
公开(公告)号：US08684016B2
公开(公告)日：2014-04-01
申请号：US12458839
申请日：2009-07-23
申请人： Jung Chan Ryu , Sung Jin Kim , Jeon Suk Wee , Young Ho Kwon
发明人： Jung Chan Ryu , Sung Jin Kim , Jeon Suk Wee , Young Ho Kwon
IPC分类号： A47L15/02
CPC分类号： A47L15/4219 , A47L15/23 , A47L15/4225 , A47L15/4285
摘要： Disclosed herein is a dish washing machine including a sump unit capable of supplying, to an injection nozzle, wash water flowing in accordance with operation of an impeller, without using a separate channel member. The dish washing machine includes a body provided with a washing tub, a sump unit arranged in the washing tub, and at least one injection nozzle to inject wash water into the washing tub. The sump unit includes a sump housing, an impeller arranged in the sump housing, to pump wash water from the sump housing, and a guide member, to which the sump housing is mounted. The guide member guides the wash water pumped by the impeller directly to the injection nozzle.
摘要翻译：本文公开了一种洗碗机，其包括可以在不使用单独的通道构件的情况下向喷射喷嘴提供根据叶轮的操作流动的洗涤水的贮槽单元。洗碗机包括设置有洗涤桶的本体，设置在洗涤桶中的集尘单元，以及至少一个注入喷嘴，用于将洗涤水注入到洗涤桶中。贮槽单元包括贮槽壳体，布置在贮槽壳体中的叶轮，用于从贮槽壳体泵送洗涤水，以及引导构件，其中安装有贮槽壳体。引导构件将由叶轮泵送的洗涤水直接引导到喷嘴。

10. 发明授权

US08607615B2 Microfabricated thermal modulator for comprehensive 2D gas chromatography 失效
标题翻译：用于综合2D气相色谱的微型热调节剂
公开(公告)号：US08607615B2
公开(公告)日：2013-12-17
申请号：US12906357
申请日：2010-10-18
申请人： Sung Jin Kim , Katsuo Kurabayashi , Kensall D. Wise , Edward T. Zellers , Bruce P. Block
发明人： Sung Jin Kim , Katsuo Kurabayashi , Kensall D. Wise , Edward T. Zellers , Bruce P. Block
IPC分类号： G01N30/30
CPC分类号： G01N30/463 , G01N30/465 , G01N30/6095
摘要： A two-dimensional gas chromatography system having first and second separation columns, a thermal modulator disposed between the first and second columns and having a plurality of stage channels, and a micro heater monolithically integrated in the thermal modulator. The thermal modulator is operable to trap and focus gas/vapor species within the plurality of stage channels upon cooling and release the gas/vapor species to the second column upon heating by the micro heater.
摘要翻译：一种具有第一和第二分离柱的二维气相色谱系统，设置在第一和第二列之间并具有多个级通道的热调节器，以及整体地集成在热调制器中的微加热器。热调节器可操作以在冷却时捕获并聚焦在多个级通道内的气体/蒸汽物质，并且通过微加热器加热将气体/蒸气物质释放到第二塔。

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