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1. 发明授权

US07183056B2 Method for performing multiplex PCR with cyclic changes of PCR parameters 失效
标题翻译：用PCR参数循环变化进行多重PCR的方法
公开(公告)号：US07183056B2
公开(公告)日：2007-02-27
申请号：US10697295
申请日：2003-10-31
申请人： Se Ho Park , Hae Sik Yang , Dae Sik Lee , Yong Beom Shin , Kyu Won Kim , Tae Hwan Yoon , Sung Jin Kim , Yun Tae Kim
发明人： Se Ho Park , Hae Sik Yang , Dae Sik Lee , Yong Beom Shin , Kyu Won Kim , Tae Hwan Yoon , Sung Jin Kim , Yun Tae Kim
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q2537/143 , C12Q2527/113 , C12Q2527/101
摘要： The present invention is directed to an improved multiplex PCR method for obtaining at least two PCR products from one PCR solution. In the multiplex PCR method for having at least two DNA amplified products from a sample positioned in a PCR equipment, the object of the present invention is to provide a novel multiplex PCR method characterized in that a primer annealing temperature and an extension time be changed per cycle with constant periods. When a multiplex PCR is performed in accordance with the present invention, limitations in determining PCR conditions due to a various sizes of PCR products or dimers caused by primers can be eliminated, and time and efforts required for determining the PCR conditions to various samples can also be reduced. Further, not only refined DNAs like cDNA, genomic DNA, vector, etc, but blood can be directly used as a multiplex PCR sample, and PCR amplification reaction can be performed even with a sample having the smallest amounts.
摘要翻译：本发明涉及一种用于从一种PCR溶液获得至少两种PCR产物的改进的多重PCR方法。本发明的目的是提供一种新的多重PCR方法，其特征在于，引物退火温度和延长时间根据周期不变的周期。当根据本发明进行多重PCR时，可以消除由于由引物引起的各种大小的PCR产物或二聚体导致的PCR条件的限制的限制，并且确定各种样品的PCR条件所需的时间和努力也可以减少此外，不仅可以将cDNA，基因组DNA，载体等精制DNA与血液直接用作多重PCR样品，即使使用量少的样品也能进行PCR扩增反应。

2. 发明授权

US06901963B2 Micro fluidic device for controlling flow time of micro fluid 有权
标题翻译：用于控制微流体流动时间的微流体装置
公开(公告)号：US06901963B2
公开(公告)日：2005-06-07
申请号：US10731211
申请日：2003-12-08
申请人： Sung Jin Kim , Yong Beom Shin , HaeSik Yang , Dae Sik Lee , Kyu Won Kim , Se Ho Park , Yun Tae Kim
发明人： Sung Jin Kim , Yong Beom Shin , HaeSik Yang , Dae Sik Lee , Kyu Won Kim , Se Ho Park , Yun Tae Kim
IPC分类号： B01J19/00 , G05D7/01 , F15B21/00
CPC分类号： G05D7/0186 , Y10T137/2076 , Y10T137/2224
摘要： Provided is a micro fluidic device that can control a flow time of micro fluid by using a capillary phenomenon. The micro fluidic device includes: a flow channel for flowing fluid, the flow channel being formed between a top substrate and a bottom substrate or between a top substrate, a bottom substrate, and a middle substrate; a flow blocking surface for stopping a flow of the fluid in the flow channel temporarily; and a hump for delaying the flow formed in the line of continuity with the flow blocking surface. The micro fluidic device of the present research can control the flow time in a simple manner.
摘要翻译：提供了一种微流体装置，其可以通过使用毛细管现象来控制微流体的流动时间。微流体装置包括：用于流动流体的流动通道，流动通道形成在顶部基板和底部基板之间，或者在顶部基板，底部基板和中间基板之间; 用于暂停流道中的流体流动的阻流表面; 以及用于延迟在与阻流表面连续的线中形成的流动的隆起。本研究的微流体装置可以以简单的方式控制流动时间。

3. 发明申请

US20130264221A1 MEMBRANE PHASE ELECTRODE USING PRINTING AND BIO-MOLECULE DETECTION USING SAME 有权
标题翻译：使用相同的印刷和生物分子检测的膜相电极
公开(公告)号：US20130264221A1
公开(公告)日：2013-10-10
申请号：US13994348
申请日：2011-12-16
申请人： Min Gon Kim , Jun Hyoung Ahn , Yun Ju Sung , Yong Beom Shin , Hyo Arm Joung
发明人： Min Gon Kim , Jun Hyoung Ahn , Yun Ju Sung , Yong Beom Shin , Hyo Arm Joung
IPC分类号： G01N27/327 , A61B5/1486
CPC分类号： G01N27/3278 , A61B5/1486 , B82Y5/00 , B82Y15/00 , G01N27/3275 , G01N33/54346 , G01N33/54366
摘要： A membrane electrode includes a novel sensor combining a filtering function of a membrane and a signal measuring ability of an electrode. A target material may be measured by filtration through the membrane. A small amount of target materials may be detected with high sensitivity using an amplified electrical signal by increasing electrical conductivity by reducing metal ions on the membrane, and thus the target material may be subject to quantitative analysis. In addition, only a target material selectively binding to a receptor may be filtrated by passing a sample through the membrane after a receptor material is fixed to the electrode, and thus may be used to detect an electrical signal. In addition, the sensor may measure a signal in various methods such as electrical conductivity, impedance, etc.
摘要翻译：膜电极包括结合膜的过滤功能和电极的信号测量能力的新型传感器。目标材料可以通过膜过滤来测量。使用放大的电信号，可以通过降低膜上的金属离子来提高导电性，可以以高灵敏度检测少量的目标材料，因此可以对靶材进行定量分析。此外，只有选择性地结合受体的靶材料可以在将受体材料固定到电极之后通过样品通过膜来过滤，因此可以用于检测电信号。此外，传感器可以以各种方法测量信号，例如导电性，阻抗等。

4. 发明授权

US09315796B2 Method for activating catalyst using photothermal nanomaterials 有权
标题翻译：使用光热纳米材料活化催化剂的方法
公开(公告)号：US09315796B2
公开(公告)日：2016-04-19
申请号：US13817305
申请日：2011-08-18
申请人： Min Gon Kim , Taihua Li , Yong Beom Shin
发明人： Min Gon Kim , Taihua Li , Yong Beom Shin
IPC分类号： B82Y30/00 , C12N9/96 , B01J21/18 , B01J31/00 , B01J35/00 , C11C3/04 , C12N11/14 , C11C3/10 , B01J27/02 , B01J37/04
CPC分类号： C12N9/96 , B01J21/185 , B01J27/02 , B01J31/003 , B01J35/0013 , B01J35/004 , B01J37/04 , B82Y30/00 , C11C3/04 , C11C3/10 , C12N11/14 , Y10S977/742
摘要： Disclosed is a method for activating a catalyst using the photothermal effects of photothermal nanomaterials, and more particularly to a method of activating a catalyst at a temperature, at which the catalyst has low or no activity, by irradiating a catalyst-photothermal nanomaterial composite with light. The method can activate the catalyst by increasing only the temperature around the nanomaterials without substantially changing the temperature of the reaction medium. A catalyst that generally has high activity at room temperature can be activated even at low temperature. Catalysts having high activity only under mild conditions are immobilized on photothermal nanomaterials so that they have activity even under low temperature and extreme conditions. The invention is useful when a catalyst substrate unstable at room temperature is used or a catalytic product unstable at room temperature is produced.
摘要翻译：公开了使用光热纳米材料的光热效应来活化催化剂的方法，更具体地说，涉及在催化剂 - 光热纳米材料复合材料与光照射下在催化剂活性低或无活性的温度下活化催化剂的方法。该方法可以通过仅增加纳米材料周围的温度来激活催化剂，而基本上不改变反应介质的温度。通常在室温下通常具有高活性的催化剂即使在低温也可以被活化。仅在温和条件下具有高活性的催化剂固定在光热纳米材料上，使得即使在低温和极端条件下它们也具有活性。当使用在室温下不稳定的催化剂基材或在室温下产生不稳定的催化剂时，本发明是有用的。

5. 发明授权

US08894871B2 Lithography method using tilted evaporation 有权
标题翻译：使用倾斜蒸发的平版印刷方法
公开(公告)号：US08894871B2
公开(公告)日：2014-11-25
申请号：US13500834
申请日：2010-11-10
申请人： Yong Beom Shin , Seung Woo Lee
发明人： Yong Beom Shin , Seung Woo Lee
IPC分类号： H01L21/00 , H01L21/027 , G03F7/00 , G03F7/40
CPC分类号： H01L21/0272 , B82Y20/00 , G02B2207/101 , G03F7/0035 , G03F7/40
摘要： The present invention relates to a lithography method using tilted evaporation, and includes: (1) coating a resist on top of a substrate; (2) patterning the resist using a lithography process; (3) tilt-evaporating a first thin film material on an upper layer of the patterned resist to form a modified pattern mask; (4) evaporating a second thin film material on the top of the substrate with the modified pattern mask; and (5) removing the resist coated on the top of the substrate.
摘要翻译：本发明涉及使用倾斜蒸发的光刻方法，并且包括：（1）在基板的顶部涂覆抗蚀剂; （2）使用光刻工艺构图抗蚀剂; （3）在图案化的抗蚀剂的上层上倾斜蒸发第一薄膜材料以形成改性图案掩模; （4）用修改后的图案掩模在衬底的顶部蒸发第二薄膜材料; 和（5）去除涂覆在基材顶部上的抗蚀剂。

6. 发明申请

US20130210115A1 Method for Activating Catalyst Using Photothermal Nanomaterials 有权
标题翻译：使用光热纳米材料活化催化剂的方法
公开(公告)号：US20130210115A1
公开(公告)日：2013-08-15
申请号：US13817305
申请日：2011-08-18
申请人： Min Gon Kim , Taihua Li , Yong Beom Shin
发明人： Min Gon Kim , Taihua Li , Yong Beom Shin
IPC分类号： C12N9/96 , B01J27/02
CPC分类号： C12N9/96 , B01J21/185 , B01J27/02 , B01J31/003 , B01J35/0013 , B01J35/004 , B01J37/04 , B82Y30/00 , C11C3/04 , C11C3/10 , C12N11/14 , Y10S977/742
摘要： Disclosed is a method for activating a catalyst using the photothermal effects of photothermal nanomaterials, and more particularly to a method of activating a catalyst at a temperature, at which the catalyst has low or no activity, by irradiating a catalyst-photothermal nanomaterial composite with light. The method can activate the catalyst by increasing only the temperature around the nanomaterials without substantially changing the temperature of the reaction medium. A catalyst that generally has high activity at room temperature can be activated even at low temperature. Catalysts having high activity only under mild conditions are immobilized on photothermal nanomaterials so that they have activity even under low temperature and extreme conditions. The invention is useful when a catalyst substrate unstable at room temperature is used or a catalytic product unstable at room temperature is produced.
摘要翻译：公开了使用光热纳米材料的光热效应来活化催化剂的方法，更具体地说，涉及在催化剂 - 光热纳米材料复合物与光照射下在催化剂活性低或无活性的温度下活化催化剂的方法。该方法可以通过仅增加纳米材料周围的温度来激活催化剂，而基本上不改变反应介质的温度。通常在室温下通常具有高活性的催化剂即使在低温也可以被活化。仅在温和条件下具有高活性的催化剂固定在光热纳米材料上，使得即使在低温和极端条件下它们也具有活性。当使用在室温下不稳定的催化剂基材或在室温下产生不稳定的催化剂时，本发明是有用的。

7. 发明申请

US20130065220A1 METHOD OF RAPIDLY DETECTING MICROORGANISMS USING NANOPARTICLES 有权
标题翻译：使用纳米颗粒快速检测微生物的方法
公开(公告)号：US20130065220A1
公开(公告)日：2013-03-14
申请号：US13511574
申请日：2010-11-24
申请人： Min Gon Kim , Yong Beom Shin , Yoon Joo Sung
发明人： Min Gon Kim , Yong Beom Shin , Yoon Joo Sung
IPC分类号： G01N33/569 , C12M1/34 , G01N21/25 , C12Q1/70 , B82Y15/00
CPC分类号： G01N33/569 , B82Y15/00 , G01N33/54346
摘要： The present invention relates to a method of rapidly detecting microorganisms using nanoparticles, and more particularly to a method and device of rapidly detecting microorganisms by adding, to the microorganisms to be detected, nanoparticles having immobilized thereon an antibody that binds specifically to the microorganisms to be detected, subjecting the mixture to an immune reaction to form a reaction solution, passing the reaction solution through a microorganism-concentrating film to concentrate the microorganisms, capturing microorganisms, which was immune-reacted with the antibody-immobilized nanoparticles, by a microorganism-capturing filtration membrane, and determining the presence and concentration of the microorganisms.The present invention detects microorganisms using nanoparticles having immobilized thereon an antibody that binds specifically to the microorganisms to be detected, so that the presence and concentration of the microorganisms can be determined in a more effective and simpler manner than a conventional detection method, and the inventive method is effective in detecting a small amount of microorganisms owing to high sensitivity.
摘要翻译：本发明涉及使用纳米颗粒快速检测微生物的方法，更具体地说，涉及通过向被检测微生物添加特异性地与微生物结合的抗体的纳米颗粒来快速检测微生物的方法和装置。检测到，使混合物进行免疫反应以形成反应溶液，使反应溶液通过微生物浓缩膜以浓缩微生物，通过微生物捕获捕获与抗体固定的纳米颗粒免疫反应的微生物过滤膜，并确定微生物的存在和浓度。本发明使用其上固定有特异性地与待检测微生物结合的抗体的纳米颗粒来检测微生物，从而可以以比现有的检测方法更有效和更简单的方式确定微生物的存在和浓度。方法由于高灵敏度而有效地检测少量的微生物。

8. 发明申请

US20110189784A1 Immunochromatography Detection Sensor Comprising Optical Waveguide and a Detection Method Using the Same 审中-公开
标题翻译：包含光波导的免检色谱检测传感器及使用其的检测方法
公开(公告)号：US20110189784A1
公开(公告)日：2011-08-04
申请号：US13054168
申请日：2009-07-17
申请人： Yong Beom Shin , Min Gon Kim , Byeong Woo Bae
发明人： Yong Beom Shin , Min Gon Kim , Byeong Woo Bae
IPC分类号： G01N30/00
CPC分类号： G01N33/54373 , G01N21/7703 , G01N30/95 , G01N33/558 , G01N2021/7766
摘要： The present invention relates to an immunochromatographic detection sensor comprising optical waveguides and a detection method using the same, and more particularly, to an immunochromatographic detection sensor comprising optical waveguides, in which the optical waveguides are provided under the membrane, probe beams transmitted through the optical waveguide maximize the interaction frequency between evanescent wave generated on the surface of optical waveguide and the colored conjugate in the band formed on the membrane, and thus the absorbance signal from the colored conjugate is greatly amplified to improve the sample detection sensitivity, and a detection method using the same.
摘要翻译：本发明涉及包含光波导的免疫色谱检测传感器和使用其的检测方法，更具体地，涉及包括光波导的免疫色谱检测传感器，其中光波导设置在膜下方，透射通过光学的探测光束波导最大化在光波导表面上产生的ev逝波与膜上形成的带中的着色共轭之间的相互作用频率，从而大大放大来自着色共轭的吸光度信号，提高样品检测灵敏度，检测方法使用相同

9. 发明授权

US09588111B2 Membrane biosensor having multi-hole film attached thereto and method for measuring immunological reaction or enzymatic reaction using the same 有权
标题翻译：附着有多孔膜的膜生物传感器及使用其的免疫反应或酶反应的测定方法
公开(公告)号：US09588111B2
公开(公告)日：2017-03-07
申请号：US13511962
申请日：2010-11-24
申请人： Min Gon Kim , Yong Beom Shin , Young Kyeng O , Hyo Arm Joung
发明人： Min Gon Kim , Yong Beom Shin , Young Kyeng O , Hyo Arm Joung
IPC分类号： C12M1/34 , G01N33/538 , G01N33/543
CPC分类号： G01N33/538 , G01N33/54366
摘要： The present invention relates to a membrane sensor having a multi-hole film attached thereto and a method for measuring immunological reactions or enzymatic reactions using the same. More specifically, the present invention relates to a membrane sensor in which a multi-hole film is joined to the top of a membrane on which receptors are immobilized, and a method for measuring immunological reactions or enzymatic reactions using the same. The present invention makes it possible to adjust the sensitivity of membrane biosensors by adjusting the hole size in the multi-hole film and so makes it possible to measure analytes with a high degree of sensitivity using just a small amount of sample, and makes it possible to simultaneously measure diverse types of analyte by attaching various types of receptor on the membrane sensor.
摘要翻译：本发明涉及一种具有附着于其上的多孔膜的膜传感器，以及使用该膜传感器的免疫反应或酶反应的方法。更具体地，本发明涉及一种膜传感器，其中多孔膜与固定有受体的膜的顶部接合，以及使用该膜传感器测量免疫反应或酶反应的方法。本发明可以通过调整多孔膜中的孔尺寸来调节膜生物传感器的灵敏度，因此可以仅使用少量的样品来测量具有高灵敏度的分析物，并且使其成为可能通过在膜传感器上附加各种类型的受体来同时测量不同类型的分析物。

10. 发明授权

US09465003B2 Membrane phase electrode using printing and bio-molecule detection using same 有权
标题翻译：使用相同的印刷和生物分子检测膜相电极
公开(公告)号：US09465003B2
公开(公告)日：2016-10-11
申请号：US13994348
申请日：2011-12-16
申请人： Min Gon Kim , Jun Hyoung Ahn , Yun Ju Sung , Yong Beom Shin , Hyo Arm Joung
发明人： Min Gon Kim , Jun Hyoung Ahn , Yun Ju Sung , Yong Beom Shin , Hyo Arm Joung
IPC分类号： G01N27/327 , G01N33/543 , A61B5/1486 , B82Y5/00 , B82Y15/00
CPC分类号： G01N27/3278 , A61B5/1486 , B82Y5/00 , B82Y15/00 , G01N27/3275 , G01N33/54346 , G01N33/54366
摘要： A membrane electrode includes a novel sensor combining a filtering function of a membrane and a signal measuring ability of an electrode. A target material may be measured by filtration through the membrane. A small amount of target materials may be detected with high sensitivity using an amplified electrical signal by increasing electrical conductivity by reducing metal ions on the membrane, and thus the target material may be subject to quantitative analysis. In addition, only a target material selectively binding to a receptor may be filtrated by passing a sample through the membrane after a receptor material is fixed to the electrode, and thus may be used to detect an electrical signal. In addition, the sensor may measure a signal in various methods such as electrical conductivity, impedance, etc.
摘要翻译：膜电极包括结合膜的过滤功能和电极的信号测量能力的新型传感器。目标材料可以通过膜过滤来测量。使用放大的电信号，可以通过降低膜上的金属离子来提高导电性，可以以高灵敏度检测少量的目标材料，因此可以对靶材进行定量分析。此外，只有选择性地结合受体的靶材料可以在将受体材料固定到电极之后通过样品通过膜来过滤，因此可以用于检测电信号。此外，传感器可以以各种方法测量信号，例如导电性，阻抗等。

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