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1. 发明授权

US08607615B2 Microfabricated thermal modulator for comprehensive 2D gas chromatography 失效
标题翻译：用于综合2D气相色谱的微型热调节剂
公开(公告)号：US08607615B2
公开(公告)日：2013-12-17
申请号：US12906357
申请日：2010-10-18
申请人： Sung Jin Kim , Katsuo Kurabayashi , Kensall D. Wise , Edward T. Zellers , Bruce P. Block
发明人： Sung Jin Kim , Katsuo Kurabayashi , Kensall D. Wise , Edward T. Zellers , Bruce P. Block
IPC分类号： G01N30/30
CPC分类号： G01N30/463 , G01N30/465 , G01N30/6095
摘要： A two-dimensional gas chromatography system having first and second separation columns, a thermal modulator disposed between the first and second columns and having a plurality of stage channels, and a micro heater monolithically integrated in the thermal modulator. The thermal modulator is operable to trap and focus gas/vapor species within the plurality of stage channels upon cooling and release the gas/vapor species to the second column upon heating by the micro heater.
摘要翻译：一种具有第一和第二分离柱的二维气相色谱系统，设置在第一和第二列之间并具有多个级通道的热调节器，以及整体地集成在热调制器中的微加热器。热调节器可操作以在冷却时捕获并聚焦在多个级通道内的气体/蒸汽物质，并且通过微加热器加热将气体/蒸气物质释放到第二塔。

2. 发明申请

US20110125029A1 Targeted Dual-Axes Confocal Imaging Apparatus with Vertical Scanning Capabilities 有权
标题翻译：具有垂直扫描能力的目标双轴共聚焦成像仪
公开(公告)号：US20110125029A1
公开(公告)日：2011-05-26
申请号：US12916159
申请日：2010-10-29
申请人： Thomas D. Wang , Katsuo Kurabayashi , Kenn Oldham , Zhen Qiu
发明人： Thomas D. Wang , Katsuo Kurabayashi , Kenn Oldham , Zhen Qiu
IPC分类号： A61B6/00
CPC分类号： G02B26/101 , A61B5/0068 , A61B5/0073 , A61B5/4255 , A61B2503/40 , G01N21/6458 , G02B21/0028 , G02B21/0036 , G02B21/0076 , G02B26/0841
摘要： An optical device is described that may be used as a microscope system for real-time, three-dimensional optical imaging. The device includes a miniature, fiber optic, intra-vital probe microscope that uses a dual-axes confocal architecture to allow for vertical scanning perpendicular to a surface of the sample (e.g., a tissue surface). The optical device can use off-axis illumination and collection of light to achieve sub-cellular resolution with deep tissue penetration. The optical device may be used as part of an integrated molecular imaging strategy using fluorescence-labeled peptides to detect cell surface targets that are up-regulated by the epithelium and/or endothelium of colon and breast tumors in small animal models of cancer.
摘要翻译：描述了可用作用于实时三维光学成像的显微镜系统的光学装置。该装置包括使用双轴共焦结构以允许垂直于样品表面（例如，组织表面）的垂直扫描的微型光纤，生物质内探针显微镜。光学装置可以使用离轴照明和光的收集来实现具有深层组织穿透的亚细胞分辨率。光学装置可以被用作使用荧光标记的肽来检测小癌动物模型中由结肠和乳腺肿瘤的上皮和/或内皮上调的细胞表面靶的整合分子成像策略的一部分。

3. 发明申请

US20110088452A1 MICROFABRICATED THERMAL MODULATOR FOR COMPREHENSIVE 2D GAS CHROMATOGRAPHY 失效
标题翻译：用于全面2D气相色谱的微晶热调制器
公开(公告)号：US20110088452A1
公开(公告)日：2011-04-21
申请号：US12906357
申请日：2010-10-18
申请人： Sung Jin Kim , Katsuo Kurabayashi , Kensall D. Wise , Edward T. Zellers , Bruce P. Block
发明人： Sung Jin Kim , Katsuo Kurabayashi , Kensall D. Wise , Edward T. Zellers , Bruce P. Block
IPC分类号： G01N30/30
CPC分类号： G01N30/463 , G01N30/465 , G01N30/6095
摘要： A two-dimensional gas chromatography system having first and second separation columns, a thermal modulator disposed between the first and second columns and having a plurality of stage channels, and a micro heater monolithically integrated in the thermal modulator. The thermal modulator is operable to trap and focus gas/vapor species within the plurality of stage channels upon cooling and release the gas/vapor species to the second column upon heating by the micro heater.
摘要翻译：一种具有第一和第二分离柱的二维气相色谱系统，设置在第一和第二列之间并具有多个级通道的热调节器，以及整体地集成在热调制器中的微加热器。热调节器可操作以在冷却时捕获并聚焦在多个级通道内的气体/蒸汽物质，并且通过微加热器加热将气体/蒸气物质释放到第二塔。

4. 发明申请

US20060177937A1 Flow cytometers and detection system of lesser size 有权
公开(公告)号：US20060177937A1
公开(公告)日：2006-08-10
申请号：US11384477
申请日：2006-03-20
申请人： Katsuo Kurabayashi , Shuichi Takayama , Steven Skerlos , Dongeun Huh , James Grotberg , Yi-Chung Tung
发明人： Katsuo Kurabayashi , Shuichi Takayama , Steven Skerlos , Dongeun Huh , James Grotberg , Yi-Chung Tung
IPC分类号： G01N33/48
CPC分类号： G01N33/491 , G01N15/1404 , G01N15/1484 , G01N2015/1006 , G01N2015/1413 , G01N2015/149 , Y10T436/2575
摘要： Gas focusing flow cytometers are fabricatable employing simple and inexpensive manufacturing techniques. When such cytometers or conventional cytometers are combined with fiber optical light paths and laser diode and semiconductor photodetectors, light weight and handheld, optionally disposable devices which maintain high performance are possible.

5. 发明申请

US20060063207A1 Reconfigurable protein patterning using electrowetting microelectrodes 失效
公开(公告)号：US20060063207A1
公开(公告)日：2006-03-23
申请号：US11233975
申请日：2005-09-22
申请人： Chih-Tin Lin , Amaya Frost , Edgar Meyhofer , Katsuo Kurabayashi , Chao Fan
发明人： Chih-Tin Lin , Amaya Frost , Edgar Meyhofer , Katsuo Kurabayashi , Chao Fan
IPC分类号： G01N33/53
CPC分类号： G01N33/5438 , G01N33/54306
摘要： A protein patterning electrode device consisting of capacitor microelectrode arrays coated with a protein non-adherent layer is provided. Operation of the electrode is based on a phenomenon called “electrowetting,” where surface wettability can dynamically be controlled by varying the voltage across the device electrodes. When an electric field is applied across the electrode layers, the surface accumulates charge and becomes hydrophilic, binding the proteins to the surface via ionic bonding. Electrically controlling the amount of the surface charge permits controlled protein surface affinity. The device provides a means for reconfigurable protein patterning.

6. 发明授权

US06748818B2 High-performance fully-compliant micro-mechanisms for force/displacement amplification 失效
标题翻译：用于强制/位移放大的高性能完全兼容的微机构
公开(公告)号：US06748818B2
公开(公告)日：2004-06-15
申请号：US10144239
申请日：2002-05-13
申请人： Brian D. Jensen , Michael Farina , Katsuo Kurabayashi
发明人： Brian D. Jensen , Michael Farina , Katsuo Kurabayashi
IPC分类号： G05G100
CPC分类号： B81B3/0062 , B81B3/0037 , B81B2201/0235 , G01P15/00 , H01Q3/01 , H01Q9/14 , Y10T74/20006 , Y10T74/20207 , Y10T74/20305 , Y10T74/20329
摘要： A device for amplifying mechanical and geometrical advantage having a base structure, a first link member having a first end and a second end, and a first compliant flexural joint pivotally interconnects the first end of the first link member to the base structure. A second link member is also provided having a first end and a second end. A second compliant flexural joint pivotally interconnects the first end of the second link member to the base structure. Furthermore, a third link member is provided having a first end and a second end. A third compliant flexural joint pivotally interconnects the first end of the third link member to the second end of the first link member and a fourth compliant flexural joint pivotally interconnects the second end of the third link member to the second end of the second link member. The base structure, first link member, second link member, and third link member cooperate to define a four-bar linkage for receiving an input force and providing an amplified force or displacement output in response thereto.
摘要翻译：一种用于放大具有基座结构的机械和几何优点的装置，具有第一端和第二端的第一连杆构件以及第一柔性弯曲接头将第一连杆构件的第一端枢转地互连到基座结构。还提供了具有第一端和第二端的第二连杆构件。第二顺从弯曲接头将第二连杆构件的第一端枢转地互连到基部结构。此外，提供具有第一端和第二端的第三连杆构件。第三顺从弯曲接头将第三连杆构件的第一端枢转地互连到第一连杆构件的第二端，并且第四顺从弯曲接头将第三连杆构件的第二端枢转地互连到第二连杆构件的第二端。基座结构，第一连杆构件，第二连杆构件和第三连杆构件协作以限定用于接收输入力的四杆联动装置，并响应于此而提供放大的力或位移输出。

7. 发明授权

US08969256B2 Solution microarrays and uses thereof 有权
标题翻译：溶液微阵列及其用途
公开(公告)号：US08969256B2
公开(公告)日：2015-03-03
申请号：US13825721
申请日：2011-09-22
申请人： Shuichi Takayama , Arlyne Simon , Nien-Tsu Huang , Katsuo Kurabayashi
发明人： Shuichi Takayama , Arlyne Simon , Nien-Tsu Huang , Katsuo Kurabayashi
IPC分类号： G01N33/536 , G01N33/53 , C40B30/04 , C40B40/10 , G01N33/543 , G01N33/68
CPC分类号： G01N33/536 , G01N33/54313 , G01N33/54393 , G01N33/6845
摘要： The present invention relates to solution microarrays. In particular, the present invention relates to an aqueous 2-phase system for solution microarrays and uses thereof. The present invention further relates to systems and methods for performing assays within the solution microarrays (e.g., diagnostic assays).
摘要翻译：本发明涉及溶液微阵列。特别地，本发明涉及用于溶液微阵列的水性二相体系及其应用。本发明还涉及用于在溶液微阵列内进行测定的系统和方法（例如，诊断测定）。

8. 发明授权

US07381565B2 Flow cytometers and detection system of lesser size 有权
标题翻译：流式细胞仪检测体系较小
公开(公告)号：US07381565B2
公开(公告)日：2008-06-03
申请号：US11384477
申请日：2006-03-20
申请人： Katsuo Kurabayashi , Shuichi Takayama , Steven J. Skerlos , Dongeun Huh , James B. Grotberg , Yi-Chung Tung
发明人： Katsuo Kurabayashi , Shuichi Takayama , Steven J. Skerlos , Dongeun Huh , James B. Grotberg , Yi-Chung Tung
IPC分类号： G01N21/03 , G01N21/63
CPC分类号： G01N33/491 , G01N15/1404 , G01N15/1484 , G01N2015/1006 , G01N2015/1413 , G01N2015/149 , Y10T436/2575
摘要： Gas focusing flow cytometers are fabricatable employing simple and inexpensive manufacturing techniques. When such cytometers or conventional cytometers are combined with fiber optical light paths and laser diode and semiconductor photodetectors, light weight and handheld, optionally disposable devices which maintain high performance are possible.
摘要翻译：气体聚焦流式细胞仪是可制造的，采用简单而廉价的制造技术。当这种细胞计数器或常规细胞计数器与光纤光路和激光二极管和半导体光电探测器组合时，重量轻和手持式，可选的一次性装置可保持高性能。

9. 发明授权

US07105355B2 Flow cytometers and detection system of lesser size 有权
公开(公告)号：US07105355B2
公开(公告)日：2006-09-12
申请号：US10198378
申请日：2002-07-18
申请人： Katsuo Kurabayashi , Shuichi Takayama , Steven J. Skerlos , Dongeun Huh , James B. Grotberg , Yi-Chung Tung
发明人： Katsuo Kurabayashi , Shuichi Takayama , Steven J. Skerlos , Dongeun Huh , James B. Grotberg , Yi-Chung Tung
IPC分类号： G01N21/03 , G01N21/63
CPC分类号： G01N33/491 , G01N15/1404 , G01N15/1484 , G01N2015/1006 , G01N2015/1413 , G01N2015/149 , Y10T436/2575
摘要： Gas focusing flow cytometers are fabricatable employing simple and inexpensive manufacturing techniques. When such cytometers or conventional cytometers are combined with fiber optical light paths and laser diode and semiconductor photodetectors, light weight and handheld, optionally disposable devices which maintain high performance are possible.

10. 发明授权

US09921406B2 Targeted dual-axes confocal imaging apparatus with vertical scanning capabilities 有权
公开(公告)号：US09921406B2
公开(公告)日：2018-03-20
申请号：US12916159
申请日：2010-10-29
申请人： Thomas D. Wang , Katsuo Kurabayashi , Kenn Oldham , Zhen Qiu
发明人： Thomas D. Wang , Katsuo Kurabayashi , Kenn Oldham , Zhen Qiu
IPC分类号： A61B5/00 , G02B26/10 , G01N21/64 , G02B21/00 , G02B26/08
CPC分类号： G02B26/101 , A61B5/0068 , A61B5/0073 , A61B5/4255 , A61B2503/40 , G01N21/6458 , G02B21/0028 , G02B21/0036 , G02B21/0076 , G02B26/0841
摘要： An optical device is described that may be used as a microscope system for real-time, three-dimensional optical imaging. The device includes a miniature, fiber optic, intra-vital probe microscope that uses a dual-axes confocal architecture to allow for vertical scanning perpendicular to a surface of the sample (e.g., a tissue surface). The optical device can use off-axis illumination and collection of light to achieve sub-cellular resolution with deep tissue penetration. The optical device may be used as part of an integrated molecular imaging strategy using fluorescence-labeled peptides to detect cell surface targets that are up-regulated by the epithelium and/or endothelium of colon and breast tumors in small animal models of cancer.

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