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1. 发明申请

WO2007120442A3 DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR 审中-公开
标题翻译：用于连续分析仪传感器的双电极系统
公开(公告)号：WO2007120442A3
公开(公告)日：2008-11-06
申请号：PCT/US2007007612
申请日：2007-03-27
申请人： DEXCOM INC , SIMPSON PETER C , BRAUKER JAMES H , GOODE PAUL V , KAMATH APURV U , PETISCE JAMES R , WOO KUM MING , NICHOLAS MELISSA A , BOOCK ROBERT J , RIXMAN MONICA A , BURD JOHN , RHODES RATHBUN K , TAPSAK MARK A
发明人： SIMPSON PETER C , BRAUKER JAMES H , GOODE PAUL V , KAMATH APURV U , PETISCE JAMES R , WOO KUM MING , NICHOLAS MELISSA A , BOOCK ROBERT J , RIXMAN MONICA A , BURD JOHN , RHODES RATHBUN K , TAPSAK MARK A
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/14865 , B33Y70/00
摘要： Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor (10b). One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain. The sensor (10b) can include a glucose-measuring working electrode (16), an optional auxiliary working electrode (18), and at least one additional electrode (20), which may function as a counter and/or reference electrode.
摘要翻译：本文公开了用于连续分析物传感器的系统和方法，例如连续葡萄糖传感器（10b）。一个这样的系统利用第一和第二工作电极来测量分析物或非分析物相关的信号，这两个电极都包括干扰域。传感器（10b）可以包括葡萄糖测量工作电极（16），可选的辅助工作电极（18）和至少一个可用作计数器和/或参考电极的附加电极（20）。

2. 发明申请

WO2005082436A9 INTEGRATED DELIVERY DEVICE FOR CONTINUOUS GLUCOSE SENSOR 审中-公开
标题翻译：用于连续葡萄糖传感器的集成传送装置
公开(公告)号：WO2005082436A9
公开(公告)日：2006-11-16
申请号：PCT/US2005006301
申请日：2005-02-24
申请人： DEXCOM INC , BRAUKER JAMES H , TAPSAK MARK A , SAINT SEAN T , KAMATH APURV U , NEALE PAUL V , SIMPSON PETER C , MENSINGER MICHAEL ROBERT , MARKOVIC DUBRAVKA
发明人： BRAUKER JAMES H , TAPSAK MARK A , SAINT SEAN T , KAMATH APURV U , NEALE PAUL V , SIMPSON PETER C , MENSINGER MICHAEL ROBERT , MARKOVIC DUBRAVKA
IPC分类号： A61M1/00 , A61B5/00 , A61M31/00
CPC分类号： A61M5/31525 , A61B5/0002 , A61B5/14532 , A61B5/1486 , A61B5/14865 , A61B5/4839 , A61B2560/0443 , A61M5/1723 , A61M11/00 , A61M15/0001 , A61M2005/1726 , A61M2205/18 , A61M2205/3303 , A61M2205/502 , A61M2205/52 , A61M2230/201 , G06F19/3468 , G16H40/63
摘要： Systems and methods for integrating a continuous glucose sensor (12), including a receiver (14), a medicament delivery device (16), and optionally a single point glucose monitor 18 are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.
摘要翻译：提供了用于集成包括接收器（14），药物输送装置（16）和任选的单点葡萄糖监测器18的连续葡萄糖传感器（12）的系统和方法。手动集成提供了用户（例如，患者或医生）手动选择数量，类型和/或递送时间的设备之间的物理关联。设备的半自动化集成包括集成，其中集成组件之间的可操作连接有助于用户（例如患者或医生）在选择，输入，计算或验证葡萄糖值的药物递送量，类型或时间例如，通过将数据发送到另一个组件，从而减少所需的用户输入量。设备之间的自动集成包括集成，其中集成组件之间的可操作连接提供对系统的完全控制，而不需要用户交互。

3. 发明申请

WO2006073453A2 IMPLANTABLE ANALYTE SENSOR 审中-公开
标题翻译：可植入分析传感器
公开(公告)号：WO2006073453A2
公开(公告)日：2006-07-13
申请号：PCT/US2005014696
申请日：2005-05-02
申请人： DEXCOM INC , GOODE JR PAUL V , HOLMQUIST ARNOLD L , TAPSAK MARK A , SHULTS MARK , CARR-BRENDEL VICTORIA , BRAUKER JAMES H , NEALE PAUL V , MCCLURE JASON D , BRISTER MARK , SIMPSON PETER C , RHODES RATHBUN K
发明人： GOODE JR PAUL V , HOLMQUIST ARNOLD L , TAPSAK MARK A , SHULTS MARK , CARR-BRENDEL VICTORIA , BRAUKER JAMES H , NEALE PAUL V , MCCLURE JASON D , BRISTER MARK , SIMPSON PETER C , RHODES RATHBUN K
IPC分类号： A61B5/07 , A61B5/00 , A61B5/05 , H04B1/03
CPC分类号： A61B5/0031 , A61B5/076 , A61B5/14532 , A61B5/14865 , A61B2560/04 , A61B2560/0462 , H04B1/03 , Y10T29/49117
摘要： An implantable analyte sensor (12) including a sensor body substantially formed from a water vapor permeable material and electrical components encapsulated within the sensor body, wherein the electrical components comprise RF circuitry (38) and an antenna (42) adapted for RF transmission from the sensor (12) in vivo to a receiver (14) ex vivo, wherein the RF circuitry (38) is spaced a fixed distance from the sensor body so as to support a dielectric constant that enables RF transmission between the sensor (12) in vivo to the receiver (14) ex vivo.
摘要翻译：一种可植入分析物传感器（12），其包括基本由水蒸气可渗透材料形成的传感器主体和封装在传感器主体内的电子部件，其中电子部件包括RF电路（38）和适于从传感器（12）在体内与接收器（14）离体接触，其中所述RF电路（38）与所述传感器主体间隔固定距离，以支持介电常数，所述介电常数使所述传感器（12）能够在体内到体外的接收器（14）。

4. 发明申请

WO2007120381A3 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2007120381A3
公开(公告)日：2008-03-27
申请号：PCT/US2007003881
申请日：2007-02-14
申请人： DEXCOM INC , BOOCK ROBERT , RIXMAN MONICA , BRAUKER JAMES H , PETISCE JAMES R , SIMPSON PETER , BRISTER MARK , TAPSAK MARK A , CARR-BRENDEL VICTORIA
发明人： BOOCK ROBERT , RIXMAN MONICA , BRAUKER JAMES H , PETISCE JAMES R , SIMPSON PETER , BRISTER MARK , TAPSAK MARK A , CARR-BRENDEL VICTORIA
IPC分类号： A61B5/05
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532 , A61B5/418 , B33Y70/00
摘要： The present invention relates generally to membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel silicone-hydrophilic polymer blend membranes, and to devices and implantable devices including these membranes, for example, a continuous analyte needle-type sensor (34) including a reference electrode (30) helically wound around the working electrode (38), and covered by a membrane system (32) including a silicone-hydrophilic polymer blend membrane.
摘要翻译：本发明一般涉及与可植入装置一起使用的膜，例如用于检测生物样品中分析物浓度的装置。更具体地说，本发明涉及新颖的硅氧烷亲水性聚合物共混膜，以及包括这些膜的装置和可植入装置，例如连续的分析物针型传感器（34），其包括在工作中螺旋缠绕的参比电极（30）电极（38），并被包括硅氧烷亲水聚合物共混膜的膜系统（32）覆盖。

5. 发明申请

WO2005011520A3 OXYGEN ENHANCING MEMBRANE SYSTEMS FOR IMPLANTABLE DEVICES 审中-公开
标题翻译：用于可植入设备的氧气增强膜系统
公开(公告)号：WO2005011520A3
公开(公告)日：2005-12-15
申请号：PCT/US2004023454
申请日：2004-07-21
申请人： DEXCOM INC , PETISCE JAMES R , TAPSAK MARK A , SIMPSON PETER C , CARR-BRENDEL VICTORIA
发明人： PETISCE JAMES R , TAPSAK MARK A , SIMPSON PETER C , CARR-BRENDEL VICTORIA
IPC分类号： A61B5/00 , A61B5/05 , A61F20060101 , G01N27/327
CPC分类号： A61B5/1473 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/14735 , A61B5/14865
摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system (18) configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. The membrane system (18) can include a cell disruptive domain (40), a cell impermeable domain (42), a resistance domain (44), an enzyme domain (46), an interference domain (48), and an electrolyte domain (50) adjacent to the electrochemically reactive surfaces. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
摘要翻译：本发明一般涉及用于增加可植入装置的氧气可用性的系统和方法。优选的实施方案提供了一种膜系统（18），其被配置为提供该装置与生物环境的保护和/或用于实现酶反应的催化剂，其中所述膜系统包括由高氧可溶性材料形成的聚合物。高氧可溶性聚合物材料与可植入装置上的氧气源相邻设置，以便在缺氧期间动态地保持氧利用源的高氧可利用性。膜系统（18）可以包括细胞破碎结构域（40），细胞不可渗透结构域（42），电阻结构域（44），酶结构域（46），干扰结构域（48）和电解质结构域邻近电化学反应的表面。优选实施方案的膜系统对于具有氧利用源的可植入装置和/或在低氧环境中起作用，例如基于酶的电化学传感器和细胞移植装置是有用的。

6. 发明申请

WO03011354A3 MEMBRANE FOR USE WITH IMPLANTABLE DEVICES 审中-公开
标题翻译：膜与可植入器件的使用
公开(公告)号：WO03011354A3
公开(公告)日：2003-08-14
申请号：PCT/US0223902
申请日：2002-07-26
申请人： DEXCOM INC , BRAUKER JAMES H , SHULTS MARK C , TAPSAK MARK A
发明人： BRAUKER JAMES H , SHULTS MARK C , TAPSAK MARK A
IPC分类号： G01N27/327 , A61B5/145 , A61B5/1473 , A61L31/10 , A61L31/14 , C12M1/34 , C12M1/40 , C12Q1/26 , C12Q1/54 , G01N27/416 , A61L27/44
CPC分类号： A61B5/14735 , A61B5/076 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2562/02 , A61L31/10 , A61L31/14 , Y10T428/249921
摘要： The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer and instead forms a foreign body response (FBR) layer including: an innermost FBR layer (40) composed generally of macrophages and foreign body giant cells (41) that forms over the entire surface (48a) of the membrane (48); an intermediate FBR layer (42) composed primarily of fibroblasts (43) and fibrous matrix (44); and an outermost FBR layer (46) is loose connective granular tissue containing new blood vessels (45); wherein the innermost layer (40) is resistant to cellular attachment and is impermeable to cells and wherein the outermost layer (46) supports tissue attachment and interferes with barrier cell layer formation. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.
摘要翻译：本发明提供了一种用于与可植入装置一起使用的生物界面膜，该生物界面膜干扰阻挡细胞层的形成，并形成异物反应（FBR）层，其包括：最内层的FBR层（40），其通常由巨噬细胞和异物在膜（48）的整个表面（48a）上形成的巨细胞（41）; 主要由成纤维细胞（43）和纤维基质（44）组成的中间FBR层（42）; 最外面的FBR层（46）是含有新血管的松散结缔组织颗粒组织（45）; 其中最内层（40）抵抗细胞附着并且对细胞是不可渗透的，并且其中最外层（46）支持组织附着并干扰阻挡细胞层形成。此外，本发明提供了包括生物界面膜，包括这些传感器或生物界面膜的可植入装置的传感器，以及利用本发明的分析物检测可植入装置监测宿主中的葡萄糖水平的方法。还提供了包括本发明的生物界面膜的其它可植入装置，例如用于细胞移植的装置，药物递送装置和电信号传递或测量装置。

7. 发明申请

WO2005112741A2 IMPLANTABLE ANALYTE SENSOR 审中-公开
标题翻译：可分析传感器
公开(公告)号：WO2005112741A2
公开(公告)日：2005-12-01
申请号：PCT/US2005014708
申请日：2005-05-02
申请人： DEXCOM INC , BRAUKER JAMES H , TAPSAK MARK A , SHULTS MARK , CARR-BRENDEL VICTORIA , FISHER JACK G , SEARE WILLIAM J JR , NEALE PAUL V
发明人： BRAUKER JAMES H , TAPSAK MARK A , SHULTS MARK , CARR-BRENDEL VICTORIA , FISHER JACK G , SEARE WILLIAM J JR , NEALE PAUL V
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532 , A61B5/6882
摘要： An implantable analyte sensor (12) including a sensing region (16) for measuring the analyte and a non-sensing region (18) for immobilizing the sensor body in the host (10). The sensor (12) is implanted in a precisely dimensioned pocket to stabilize the analyte sensor (12) in vivo and enable measurement of the concentration of the analyte in the host (10) before and after formation of a foreign body capsule around the sensor (12). The sensor (12) further provides a transmitter (38) for RF transmission through the sensor body, electronic circuitry (22), and a power source (34) optimized for long-term use in the miniaturized sensor body.
摘要翻译：一种可植入分析物传感器（12），包括用于测量分析物的感测区域（16）和用于将传感器主体固定在主机（10）中的非感测区域（18）。将传感器（12）植入在精确尺寸的口袋中以在体内稳定分析物传感器（12），并且能够在传感器周围形成异物胶囊之前和之后测量主体（10）中分析物的浓度（ 12）。传感器（12）还提供用于通过传感器主体进行射频传输的发射器（38），电子电路（22）和为小型化传感器主体中长期使用而优化的电源（34）。

8. 发明申请

WO03011131A3 SENSOR HEAD FOR MONITORING GLUCOSE FOR USE WITH IMPLANTABLE DEVICES 审中-公开
标题翻译：用于监视葡萄糖的传感器头用于可移植设备
公开(公告)号：WO03011131A3
公开(公告)日：2003-08-21
申请号：PCT/US0223903
申请日：2002-07-26
申请人： DEXCOM INC , BRAUKER JAMES H , SHULTS MARK C , TAPSAK MARK A , RHODES RATHBUN
发明人： BRAUKER JAMES H , SHULTS MARK C , TAPSAK MARK A , RHODES RATHBUN
IPC分类号： G01N27/416 , A61B5/00 , A61B5/145 , A61B5/1473 , A61B5/1486 , C12Q1/00 , G01N27/327
CPC分类号： G01N27/3272 , A61B5/14532 , A61B5/14865 , C12Q1/002 , C12Q1/006 , G01N33/48707 , G01N33/48785
摘要： The present invention provides a sensor head (10) for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode (21), a reference electrode (20) and a counter electrode (22), wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode (22) is greater than the surface area of the working electrode (21); and a multi-region membrane having a first region (33), a second region (31), and a third region (32), wherein the membrane is affixed to the nonconductive body and covering the working electrode (21), reference electrode (20) and counter electrode (22). In addition, the present application provides an implantable device including at least one of the sensor heads (10). A method of monitoring glucose levels in a host utilizing the implantable device is also disclosed.
摘要翻译：本发明提供一种在可植入装置中使用的传感器头（10），其用于测量生物流体中的分析物的浓度，其包括：非导电体; 工作电极（21），参比电极（20）和对电极（22），其中电极通过非导电体，在身体的一个位置形成电化学反应性表面，并在另一位置形成电子连接其中所述对电极（22）的电化学反应性表面大于所述工作电极（21）的表面积; 以及具有第一区域（33），第二区域（31）和第三区域（32）的多区域膜，其中所述膜固定到所述非导电体并覆盖所述工作电极（21），参考电极 20）和对电极（22）。此外，本申请提供了包括至少一个传感器头（10）的可植入装置。还公开了利用可植入装置监测主机中的葡萄糖水平的方法。

9. 发明申请

WO2005019795A3 ELECTROCHEMICAL SENSORS INCLUDING ELECTRODE SYSTEMS WITH INCREASED OXYGEN GENERATION 审中-公开
标题翻译：包括电极系统在内的电化学传感器与增加的氧气发生
公开(公告)号：WO2005019795A3
公开(公告)日：2006-03-16
申请号：PCT/US2004023650
申请日：2004-07-21
申请人： DEXCOM INC , SIMPSON PETER C , GOODE PAUL , TAPSAK MARK A , CARR-BRENDEL VICTORIA
发明人： SIMPSON PETER C , GOODE PAUL , TAPSAK MARK A , CARR-BRENDEL VICTORIA
IPC分类号： A61B5/00 , C12Q1/00 , G01N33/487 , G01N27/327
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14546 , C12Q1/003 , G01N27/3272
摘要： The present invention relates generally to systems and methods for increasing oxygen generation in electrochemical sensors (10) in order to overcome the oxygen limitations. The preferred embodiments employ electrode systems (16b) with at least two electrodes in relatively close proximity to each other; wherein at least one electrode is configured to generate oxygen and at least one other electrode is configured to sense an analyte or a product of a reaction indicative of the concentration of analyte. The oxygen generated by the oxygen-generating electrode is available to the catalyst within a membrane system and/or the counter electrode, thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. The electrochemical sensor (10) can include a body with a sensing region (14), and a membrane system (18) disposed over the electroactive surfaces of the electrode system (16b).
摘要翻译：本发明一般涉及用于增加电化学传感器（10）中的氧气产生的系统和方法，以克服氧的限制。优选实施例采用电极系统（16b），其中至少两个电极彼此相对靠近; 其中至少一个电极被配置为产生氧，并且至少一个其它电极被配置为感测分析物或指示分析物浓度的反应的产物。由氧发生电极产生的氧气可用于膜系统和/或对电极中的催化剂，从而使得优选实施方案的电化学传感器能够在缺血条件下起作用。电化学传感器（10）可以包括具有感测区域（14）的主体和设置在电极系统（16b）的电活性表面之上的膜系统（18）。

10. 发明申请

WO2005045394A2 SILICONE COMPOSITION FOR BIOCOMPATIBLE MEMBRANE 审中-公开
标题翻译：生物易燃膜的硅酮组合物
公开(公告)号：WO2005045394A2
公开(公告)日：2005-05-19
申请号：PCT/US2004035499
申请日：2004-10-26
申请人： DEXCOM INC , TAPSAK MARK A , VALINT PAUL JR
发明人： TAPSAK MARK A , VALINT PAUL JR
IPC分类号： B05D3/02 , B32B27/28 , C08G77/14 , C08G77/16 , C08G77/46 , C08L83/00 , C08L83/12 , C12Q1/00 , G01N20060101 , G01N
CPC分类号： C12Q1/002 , C08G77/46 , C08L83/12
摘要： The present invention relates generally to biosensor materials. More specifically, this invention relates to a novel polymeric material that can be useful as a biocompatible membrane (18) for use in biosensor applications.
摘要翻译：本发明一般涉及生物传感器材料。更具体地，本发明涉及可用作用于生物传感器应用的生物相容性膜（18）的新型聚合物材料。

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