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1. 发明申请

WO2005019795A3 ELECTROCHEMICAL SENSORS INCLUDING ELECTRODE SYSTEMS WITH INCREASED OXYGEN GENERATION 审中-公开
标题翻译：包括电极系统在内的电化学传感器与增加的氧气发生
公开(公告)号：WO2005019795A3
公开(公告)日：2006-03-16
申请号：PCT/US2004023650
申请日：2004-07-21
申请人： DEXCOM INC , SIMPSON PETER C , GOODE PAUL , TAPSAK MARK A , CARR-BRENDEL VICTORIA
发明人： SIMPSON PETER C , GOODE PAUL , TAPSAK MARK A , CARR-BRENDEL VICTORIA
IPC分类号： A61B5/00 , C12Q1/00 , G01N33/487 , G01N27/327
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14546 , C12Q1/003 , G01N27/3272
摘要： The present invention relates generally to systems and methods for increasing oxygen generation in electrochemical sensors (10) in order to overcome the oxygen limitations. The preferred embodiments employ electrode systems (16b) with at least two electrodes in relatively close proximity to each other; wherein at least one electrode is configured to generate oxygen and at least one other electrode is configured to sense an analyte or a product of a reaction indicative of the concentration of analyte. The oxygen generated by the oxygen-generating electrode is available to the catalyst within a membrane system and/or the counter electrode, thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. The electrochemical sensor (10) can include a body with a sensing region (14), and a membrane system (18) disposed over the electroactive surfaces of the electrode system (16b).
摘要翻译：本发明一般涉及用于增加电化学传感器（10）中的氧气产生的系统和方法，以克服氧的限制。优选实施例采用电极系统（16b），其中至少两个电极彼此相对靠近; 其中至少一个电极被配置为产生氧，并且至少一个其它电极被配置为感测分析物或指示分析物浓度的反应的产物。由氧发生电极产生的氧气可用于膜系统和/或对电极中的催化剂，从而使得优选实施方案的电化学传感器能够在缺血条件下起作用。电化学传感器（10）可以包括具有感测区域（14）的主体和设置在电极系统（16b）的电活性表面之上的膜系统（18）。

2. 发明申请

WO2006073453A2 IMPLANTABLE ANALYTE SENSOR 审中-公开
标题翻译：可植入分析传感器
公开(公告)号：WO2006073453A2
公开(公告)日：2006-07-13
申请号：PCT/US2005014696
申请日：2005-05-02
申请人： DEXCOM INC , GOODE JR PAUL V , HOLMQUIST ARNOLD L , TAPSAK MARK A , SHULTS MARK , CARR-BRENDEL VICTORIA , BRAUKER JAMES H , NEALE PAUL V , MCCLURE JASON D , BRISTER MARK , SIMPSON PETER C , RHODES RATHBUN K
发明人： GOODE JR PAUL V , HOLMQUIST ARNOLD L , TAPSAK MARK A , SHULTS MARK , CARR-BRENDEL VICTORIA , BRAUKER JAMES H , NEALE PAUL V , MCCLURE JASON D , BRISTER MARK , SIMPSON PETER C , RHODES RATHBUN K
IPC分类号： A61B5/07 , A61B5/00 , A61B5/05 , H04B1/03
CPC分类号： A61B5/0031 , A61B5/076 , A61B5/14532 , A61B5/14865 , A61B2560/04 , A61B2560/0462 , H04B1/03 , Y10T29/49117
摘要： An implantable analyte sensor (12) including a sensor body substantially formed from a water vapor permeable material and electrical components encapsulated within the sensor body, wherein the electrical components comprise RF circuitry (38) and an antenna (42) adapted for RF transmission from the sensor (12) in vivo to a receiver (14) ex vivo, wherein the RF circuitry (38) is spaced a fixed distance from the sensor body so as to support a dielectric constant that enables RF transmission between the sensor (12) in vivo to the receiver (14) ex vivo.
摘要翻译：一种可植入分析物传感器（12），其包括基本由水蒸气可渗透材料形成的传感器主体和封装在传感器主体内的电子部件，其中电子部件包括RF电路（38）和适于从传感器（12）在体内与接收器（14）离体接触，其中所述RF电路（38）与所述传感器主体间隔固定距离，以支持介电常数，所述介电常数使所述传感器（12）能够在体内到体外的接收器（14）。

3. 发明申请

WO2005011520A3 OXYGEN ENHANCING MEMBRANE SYSTEMS FOR IMPLANTABLE DEVICES 审中-公开
标题翻译：用于可植入设备的氧气增强膜系统
公开(公告)号：WO2005011520A3
公开(公告)日：2005-12-15
申请号：PCT/US2004023454
申请日：2004-07-21
申请人： DEXCOM INC , PETISCE JAMES R , TAPSAK MARK A , SIMPSON PETER C , CARR-BRENDEL VICTORIA
发明人： PETISCE JAMES R , TAPSAK MARK A , SIMPSON PETER C , CARR-BRENDEL VICTORIA
IPC分类号： A61B5/00 , A61B5/05 , A61F20060101 , G01N27/327
CPC分类号： A61B5/1473 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/14735 , A61B5/14865
摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system (18) configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. The membrane system (18) can include a cell disruptive domain (40), a cell impermeable domain (42), a resistance domain (44), an enzyme domain (46), an interference domain (48), and an electrolyte domain (50) adjacent to the electrochemically reactive surfaces. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
摘要翻译：本发明一般涉及用于增加可植入装置的氧气可用性的系统和方法。优选的实施方案提供了一种膜系统（18），其被配置为提供该装置与生物环境的保护和/或用于实现酶反应的催化剂，其中所述膜系统包括由高氧可溶性材料形成的聚合物。高氧可溶性聚合物材料与可植入装置上的氧气源相邻设置，以便在缺氧期间动态地保持氧利用源的高氧可利用性。膜系统（18）可以包括细胞破碎结构域（40），细胞不可渗透结构域（42），电阻结构域（44），酶结构域（46），干扰结构域（48）和电解质结构域邻近电化学反应的表面。优选实施方案的膜系统对于具有氧利用源的可植入装置和/或在低氧环境中起作用，例如基于酶的电化学传感器和细胞移植装置是有用的。

4. 发明申请

WO2007120381A3 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2007120381A3
公开(公告)日：2008-03-27
申请号：PCT/US2007003881
申请日：2007-02-14
申请人： DEXCOM INC , BOOCK ROBERT , RIXMAN MONICA , BRAUKER JAMES H , PETISCE JAMES R , SIMPSON PETER , BRISTER MARK , TAPSAK MARK A , CARR-BRENDEL VICTORIA
发明人： BOOCK ROBERT , RIXMAN MONICA , BRAUKER JAMES H , PETISCE JAMES R , SIMPSON PETER , BRISTER MARK , TAPSAK MARK A , CARR-BRENDEL VICTORIA
IPC分类号： A61B5/05
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532 , A61B5/418 , B33Y70/00
摘要： The present invention relates generally to membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel silicone-hydrophilic polymer blend membranes, and to devices and implantable devices including these membranes, for example, a continuous analyte needle-type sensor (34) including a reference electrode (30) helically wound around the working electrode (38), and covered by a membrane system (32) including a silicone-hydrophilic polymer blend membrane.
摘要翻译：本发明一般涉及与可植入装置一起使用的膜，例如用于检测生物样品中分析物浓度的装置。更具体地说，本发明涉及新颖的硅氧烷亲水性聚合物共混膜，以及包括这些膜的装置和可植入装置，例如连续的分析物针型传感器（34），其包括在工作中螺旋缠绕的参比电极（30）电极（38），并被包括硅氧烷亲水聚合物共混膜的膜系统（32）覆盖。

5. 发明申请

WO2005112741A2 IMPLANTABLE ANALYTE SENSOR 审中-公开
标题翻译：可分析传感器
公开(公告)号：WO2005112741A2
公开(公告)日：2005-12-01
申请号：PCT/US2005014708
申请日：2005-05-02
申请人： DEXCOM INC , BRAUKER JAMES H , TAPSAK MARK A , SHULTS MARK , CARR-BRENDEL VICTORIA , FISHER JACK G , SEARE WILLIAM J JR , NEALE PAUL V
发明人： BRAUKER JAMES H , TAPSAK MARK A , SHULTS MARK , CARR-BRENDEL VICTORIA , FISHER JACK G , SEARE WILLIAM J JR , NEALE PAUL V
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532 , A61B5/6882
摘要： An implantable analyte sensor (12) including a sensing region (16) for measuring the analyte and a non-sensing region (18) for immobilizing the sensor body in the host (10). The sensor (12) is implanted in a precisely dimensioned pocket to stabilize the analyte sensor (12) in vivo and enable measurement of the concentration of the analyte in the host (10) before and after formation of a foreign body capsule around the sensor (12). The sensor (12) further provides a transmitter (38) for RF transmission through the sensor body, electronic circuitry (22), and a power source (34) optimized for long-term use in the miniaturized sensor body.
摘要翻译：一种可植入分析物传感器（12），包括用于测量分析物的感测区域（16）和用于将传感器主体固定在主机（10）中的非感测区域（18）。将传感器（12）植入在精确尺寸的口袋中以在体内稳定分析物传感器（12），并且能够在传感器周围形成异物胶囊之前和之后测量主体（10）中分析物的浓度（ 12）。传感器（12）还提供用于通过传感器主体进行射频传输的发射器（38），电子电路（22）和为小型化传感器主体中长期使用而优化的电源（34）。

6. 发明申请

WO2005012873A3 ELECTRODE SYSTEMS FOR ELECTROCHEMICAL SENSORS 审中-公开
标题翻译：电化学传感器电极系统
公开(公告)号：WO2005012873A3
公开(公告)日：2006-04-13
申请号：PCT/US2004024178
申请日：2004-07-21
申请人： DEXCOM INC , SIMPSON PETER C , PETISCE JAMES R , CARR-BRENDEL VICTORIA , BRAUKER JAMES H
发明人： SIMPSON PETER C , PETISCE JAMES R , CARR-BRENDEL VICTORIA , BRAUKER JAMES H
IPC分类号： G01N20060101 , G01N27/26 , G01N27/416 , G01N27/327
CPC分类号： G01N27/3274 , A61B5/14532 , A61B5/14865 , C12Q1/001
摘要： The present invention relates generally to systems and methods for improved electrochemical measurement of analytes. The preferred embodiments employ electrode systems including an analyte-measuring electrode (16a) for measuring the analyte or the product of an enzyme reaction with the analyte and an auxiliary electrode (36) configured to generate oxygen and/or reduce electrochemical interferants. Oxygen generation by the auxiliary electrode (36) advantageously improves oxygen availability to the enzyme (38) and/or counter electrode; thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. Interferant modification by the auxiliary electrode (36) advantageously renders them substantially non-reactive at the analyte-measuring electrode, thereby reducing or eliminating inaccuracies in the analyte signal due to electrochemical interferants.
摘要翻译：本发明一般涉及用于改进分析物的电化学测量的系统和方法。优选实施例采用电极系统，包括分析物测量电极（16a），用于测量分析物或与分析物的酶反应产物以及被配置为产生氧和/或减少电化学干扰剂的辅助电极（36）。通过辅助电极（36）产生的氧有利地提高了对酶（38）和/或对电极的氧可用性; 从而使得优选实施例的电化学传感器能够在缺血状况下起作用。辅助电极（36）的干扰修饰有利地使它们在分析物测量电极处基本上不反应，从而减少或消除由于电化学干扰剂引起的分析物信号的不准确性。

7. 发明申请

WO2005079257A2 BIOINTERFACE WITH MACRO- AND MICRO- ARCHITECTURE 审中-公开
标题翻译：具有宏观和微观结构的生物界
公开(公告)号：WO2005079257A2
公开(公告)日：2005-09-01
申请号：PCT/US2005004058
申请日：2005-02-09
申请人： DEXCOM INC , CARR-BRENDEL VICTORIA , SIMPSON PETER C , BRAUKER JAMES H
发明人： CARR-BRENDEL VICTORIA , SIMPSON PETER C , BRAUKER JAMES H
IPC分类号： A61F13/00 , A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/10 , B33Y80/00
摘要： Disclosed herein are biointerface membranes including a macro-architecture and a micro-architecture co-continuous with and bonded to and/or located within at least a portion of the macro-architecture.The macro- and micro-architectures work together to manage and manipulate the high-level tissue organization and the low-level cellular organization of the foreign body response in vivo, thereby increasing neovascularization close to a device-tissue interface, interfering with barrier cell layer formation, and providing good tissue anchoring, while reducing the effects of motion artifact, and disrupting the organization and/or contracture of the foreign body capsule. The biointerface membranes of the preferred embodiments can be utilized with implantable devices such as devices for the detection of analyte concentrations in a biological sample (for example, from a body), cell transplantation devices, drug delivery devices, electrical signal delivering or measuring devices, and/or combinations thereof.
摘要翻译：这里公开的是生物界面膜，其包括宏观架构和与宏结构共同连接并结合到宏结构和/或位于宏观架构的至少一部分内的微架构。宏观和微观架构一起工作以管理和操纵高水平组织组织和体内异物反应的低水平细胞组织，从而增加靠近器官组织界面的新生血管形成，干扰屏障细胞层形成，并提供良好的组织锚定，同时降低运动神器，并扰乱异物胶囊的组织和/或挛缩。优选实施方案的生物界面膜可以与可植入装置一起使用，例如用于检测生物样品（例如，来自身体），细胞移植装置，药物递送装置，电信号传递或测量装置中的分析物浓度的装置，和/或其组合。

8. 发明申请

WO2005057173A3 SYSTEMS AND METHODS FOR IMPROVING ELECTROCHEMICAL ANALYTE SENSORS 审中-公开
标题翻译：改进电化学分析仪传感器的系统和方法
公开(公告)号：WO2005057173A3
公开(公告)日：2006-04-13
申请号：PCT/US2004040913
申请日：2004-12-07
申请人： DEXCOM INC , SIMPSON PETER C , BRAUKER JAMES H , CARR-BRENDEL VICTORIA , GOODE JR PAUL V , TAPSAK MARK
发明人： SIMPSON PETER C , BRAUKER JAMES H , CARR-BRENDEL VICTORIA , GOODE JR PAUL V , TAPSAK MARK
IPC分类号： A61B5/00 , G01N20060101 , G01N27/26 , G01N27/327
CPC分类号： A61B5/14532 , A61B5/1486 , A61B5/14865 , C12Q1/006 , G01N27/3274
摘要： An analyte-measuring device, particularly an electrochemical sensor, is provided for measuring current values at multiple bias potential settings to assess the quality of the analyte measurement, identify interference in the signal, and calculate substantially interference-free analyte concentration measurements. The device and method are suitable for calculating substantially interference-free analyte concentration measurements when glucose is the analyte and acetaminophen is an interfering species.
摘要翻译：提供分析物测量装置，特别是电化学传感器，用于在多个偏置电位设置下测量电流值，以评估分析物测量的质量，识别信号中的干扰，并计算基本无干扰的分析物浓度测量。当葡萄糖是分析物和对乙酰氨基酚是干扰物质时，该装置和方法适用于计算基本无干扰的分析物浓度测量。

9. 发明申请

WO2005057175A3 SIGNAL PROCESSING FOR CONTINUOUS ANALYTE SENSOR 审中-公开
标题翻译：连续分析传感器的信号处理
公开(公告)号：WO2005057175A3
公开(公告)日：2005-09-01
申请号：PCT/US2004041095
申请日：2004-12-08
申请人： DEXCOM INC , BRAUKER JAMES H , CARR-BRENDEL VICTORIA , GOODE JR PAUL V , KAMATH APURV , THROWER JAMES , XAVIER BEN
发明人： BRAUKER JAMES H , CARR-BRENDEL VICTORIA , GOODE JR PAUL V , KAMATH APURV , THROWER JAMES , XAVIER BEN
IPC分类号： A61B5/00 , A61B5/05 , G01N20060101
CPC分类号： A61B5/14532 , A61B5/145 , A61B5/14503 , A61B5/1451 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/7257 , A61B5/726 , A61B5/7264 , A61B5/7275 , A61B5/742 , A61B5/7455 , A61B5/746 , A61B5/7475 , A61M5/1723 , Y02A90/22 , Y02A90/26
摘要： Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk. The methods can be employed in a medical device including a continuous analyte sensor (10) that provides an output signal indicative of a concentration of an analyte, a receiver to which the signal is sent (12), and an input module (14) that receives the signal.
摘要翻译：用于动态和智能地估计来自连续分析物传感器的分析物数据的系统和方法，包括接收数据流，选择多个算法中的一个，以及使用选择的算法估计分析物值。估计可用于补偿时间滞后，将传感器数据与相应的参考数据相匹配，警告即将出现的临床风险，更换错误的传感器数据信号，并提供更及时的分析信息，鼓励积极行为并抢占临床风险。该方法可用于医疗装置中，该医疗装置包括提供指示分析物浓度的输出信号的连续分析物传感器（10），发送信号的接收器（12）和输入模块（14）接收信号。

10. 发明申请

WO2005025634A3 BIOINTERFACE MEMBRANES INCORPORATING BIOACTIVE AGENTS 审中-公开
标题翻译：含有生物活性剂的生物膜面膜
公开(公告)号：WO2005025634A3
公开(公告)日：2005-10-06
申请号：PCT/US2004015846
申请日：2004-05-19
申请人： DEXCOM INC , SHULTS MARK , BRAUKER JAMES H , CARR-BRENDEL VICTORIA , TAPSAK MARK , MARKOVIC DUBRAVKA
发明人： CARR-BRENDEL VICTORIA , TAPSAK MARK , MARKOVIC DUBRAVKA
IPC分类号： A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A61B5/14865 , A61B5/14532 , A61L31/10 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/00 , B33Y80/00 , G01N33/48707
摘要： A biointerface membrane (30) for an implantable device including a nonresorbable solid portion (36) with a plurality of interconnected cavities (38) therein adapted to support tissue ingrowth in vivo, and a bioactive agent incorporated into the biointerface membrane and adapted to modify the tissue response is provided. The bioactive agents can be chosen to induce vascularization and/or prevent barrier cell layer formation in vivo, and are advantageous when used with implantable devices wherein solutes are transported across the device-tissue interface (42).
摘要翻译：一种用于可植入装置的生物界面膜（30），包括其中具有适于支持体内组织向内生长的多个互连空腔（38）的不可吸收固体部分（36），以及掺入生物界面膜并适于修改提供组织反应。可以选择生物活性剂以在体内诱导血管形成和/或防止屏障细胞层形成，并且当与其中溶质通过装置 - 组织界面（42）传输的可植入装置一起使用时，生物活性剂是有利的。

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