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1. 发明申请

WO2007120381A3 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2007120381A3
公开(公告)日：2008-03-27
申请号：PCT/US2007003881
申请日：2007-02-14
申请人： DEXCOM INC , BOOCK ROBERT , RIXMAN MONICA , BRAUKER JAMES H , PETISCE JAMES R , SIMPSON PETER , BRISTER MARK , TAPSAK MARK A , CARR-BRENDEL VICTORIA
发明人： BOOCK ROBERT , RIXMAN MONICA , BRAUKER JAMES H , PETISCE JAMES R , SIMPSON PETER , BRISTER MARK , TAPSAK MARK A , CARR-BRENDEL VICTORIA
IPC分类号： A61B5/05
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532 , A61B5/418 , B33Y70/00
摘要： The present invention relates generally to membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel silicone-hydrophilic polymer blend membranes, and to devices and implantable devices including these membranes, for example, a continuous analyte needle-type sensor (34) including a reference electrode (30) helically wound around the working electrode (38), and covered by a membrane system (32) including a silicone-hydrophilic polymer blend membrane.
摘要翻译：本发明一般涉及与可植入装置一起使用的膜，例如用于检测生物样品中分析物浓度的装置。更具体地说，本发明涉及新颖的硅氧烷亲水性聚合物共混膜，以及包括这些膜的装置和可植入装置，例如连续的分析物针型传感器（34），其包括在工作中螺旋缠绕的参比电极（30）电极（38），并被包括硅氧烷亲水聚合物共混膜的膜系统（32）覆盖。

2. 发明申请

WO2007120442A3 DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR 审中-公开
标题翻译：用于连续分析仪传感器的双电极系统
公开(公告)号：WO2007120442A3
公开(公告)日：2008-11-06
申请号：PCT/US2007007612
申请日：2007-03-27
申请人： DEXCOM INC , SIMPSON PETER C , BRAUKER JAMES H , GOODE PAUL V , KAMATH APURV U , PETISCE JAMES R , WOO KUM MING , NICHOLAS MELISSA A , BOOCK ROBERT J , RIXMAN MONICA A , BURD JOHN , RHODES RATHBUN K , TAPSAK MARK A
发明人： SIMPSON PETER C , BRAUKER JAMES H , GOODE PAUL V , KAMATH APURV U , PETISCE JAMES R , WOO KUM MING , NICHOLAS MELISSA A , BOOCK ROBERT J , RIXMAN MONICA A , BURD JOHN , RHODES RATHBUN K , TAPSAK MARK A
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/14865 , B33Y70/00
摘要： Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor (10b). One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain. The sensor (10b) can include a glucose-measuring working electrode (16), an optional auxiliary working electrode (18), and at least one additional electrode (20), which may function as a counter and/or reference electrode.
摘要翻译：本文公开了用于连续分析物传感器的系统和方法，例如连续葡萄糖传感器（10b）。一个这样的系统利用第一和第二工作电极来测量分析物或非分析物相关的信号，这两个电极都包括干扰域。传感器（10b）可以包括葡萄糖测量工作电极（16），可选的辅助工作电极（18）和至少一个可用作计数器和/或参考电极的附加电极（20）。

3. 发明申请

WO2005012873A3 ELECTRODE SYSTEMS FOR ELECTROCHEMICAL SENSORS 审中-公开
标题翻译：电化学传感器电极系统
公开(公告)号：WO2005012873A3
公开(公告)日：2006-04-13
申请号：PCT/US2004024178
申请日：2004-07-21
申请人： DEXCOM INC , SIMPSON PETER C , PETISCE JAMES R , CARR-BRENDEL VICTORIA , BRAUKER JAMES H
发明人： SIMPSON PETER C , PETISCE JAMES R , CARR-BRENDEL VICTORIA , BRAUKER JAMES H
IPC分类号： G01N20060101 , G01N27/26 , G01N27/416 , G01N27/327
CPC分类号： G01N27/3274 , A61B5/14532 , A61B5/14865 , C12Q1/001
摘要： The present invention relates generally to systems and methods for improved electrochemical measurement of analytes. The preferred embodiments employ electrode systems including an analyte-measuring electrode (16a) for measuring the analyte or the product of an enzyme reaction with the analyte and an auxiliary electrode (36) configured to generate oxygen and/or reduce electrochemical interferants. Oxygen generation by the auxiliary electrode (36) advantageously improves oxygen availability to the enzyme (38) and/or counter electrode; thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. Interferant modification by the auxiliary electrode (36) advantageously renders them substantially non-reactive at the analyte-measuring electrode, thereby reducing or eliminating inaccuracies in the analyte signal due to electrochemical interferants.
摘要翻译：本发明一般涉及用于改进分析物的电化学测量的系统和方法。优选实施例采用电极系统，包括分析物测量电极（16a），用于测量分析物或与分析物的酶反应产物以及被配置为产生氧和/或减少电化学干扰剂的辅助电极（36）。通过辅助电极（36）产生的氧有利地提高了对酶（38）和/或对电极的氧可用性; 从而使得优选实施例的电化学传感器能够在缺血状况下起作用。辅助电极（36）的干扰修饰有利地使它们在分析物测量电极处基本上不反应，从而减少或消除由于电化学干扰剂引起的分析物信号的不准确性。

4. 发明申请

WO2005011520A3 OXYGEN ENHANCING MEMBRANE SYSTEMS FOR IMPLANTABLE DEVICES 审中-公开
标题翻译：用于可植入设备的氧气增强膜系统
公开(公告)号：WO2005011520A3
公开(公告)日：2005-12-15
申请号：PCT/US2004023454
申请日：2004-07-21
申请人： DEXCOM INC , PETISCE JAMES R , TAPSAK MARK A , SIMPSON PETER C , CARR-BRENDEL VICTORIA
发明人： PETISCE JAMES R , TAPSAK MARK A , SIMPSON PETER C , CARR-BRENDEL VICTORIA
IPC分类号： A61B5/00 , A61B5/05 , A61F20060101 , G01N27/327
CPC分类号： A61B5/1473 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/14735 , A61B5/14865
摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system (18) configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. The membrane system (18) can include a cell disruptive domain (40), a cell impermeable domain (42), a resistance domain (44), an enzyme domain (46), an interference domain (48), and an electrolyte domain (50) adjacent to the electrochemically reactive surfaces. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
摘要翻译：本发明一般涉及用于增加可植入装置的氧气可用性的系统和方法。优选的实施方案提供了一种膜系统（18），其被配置为提供该装置与生物环境的保护和/或用于实现酶反应的催化剂，其中所述膜系统包括由高氧可溶性材料形成的聚合物。高氧可溶性聚合物材料与可植入装置上的氧气源相邻设置，以便在缺氧期间动态地保持氧利用源的高氧可利用性。膜系统（18）可以包括细胞破碎结构域（40），细胞不可渗透结构域（42），电阻结构域（44），酶结构域（46），干扰结构域（48）和电解质结构域邻近电化学反应的表面。优选实施方案的膜系统对于具有氧利用源的可植入装置和/或在低氧环境中起作用，例如基于酶的电化学传感器和细胞移植装置是有用的。

5. 发明申请

WO2006110193A3 CELLULOSIC-BASED INTERFERENCE DOMAIN FOR AN ANALYTE SENSOR 审中-公开
标题翻译：用于分析仪传感器的基于纤维素的干扰域
公开(公告)号：WO2006110193A3
公开(公告)日：2009-05-14
申请号：PCT/US2006001661
申请日：2006-01-18
申请人： DEXCOM INC , PETISCE JAMES R , WOO KUM MING , HA VICTOR , NICOLAS MELISSA , BOOCK ROBERT
发明人： PETISCE JAMES R , WOO KUM MING , HA VICTOR , NICOLAS MELISSA , BOOCK ROBERT
IPC分类号： G01N27/327 , A61B5/05
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/6833 , A61B5/6848 , A61B5/6849 , Y02A90/26
摘要： The present invention relates generally to devices for measuring an analyte in a host. More particularly, the present invention relates to electrochemical glucose sensing systems including a sensor incorporating a cellulosic interference membrane, an applicator (12), a mounting unit (14), an electronics unit (16), and one or more contacts (28) configured to provide secure electrical contact between the sensor and the electronics unit (16).
摘要翻译：本发明一般涉及用于测量宿主中分析物的装置。更具体地说，本发明涉及电化学葡萄糖感测系统，其包括包含纤维素干涉膜的传感器，施加器（12），安装单元（14），电子单元（16）和配置的一个或多个触点（28）以在传感器和电子单元（16）之间提供牢固的电接触。

6. 发明申请

WO2007084516A3 MEMBRANES FOR AN ANALYTE SENSOR 审中-公开
标题翻译：分析仪传感器膜
公开(公告)号：WO2007084516A3
公开(公告)日：2007-11-29
申请号：PCT/US2007001158
申请日：2007-01-17
申请人： DEXCOM INC , PETISCE JAMES R , WOO KUM MING , NICHOLAS MELISSA , CAMPBELL REBECCA A , TRAN OLIVIA
发明人： PETISCE JAMES R , WOO KUM MING , NICHOLAS MELISSA , CAMPBELL REBECCA A , TRAN OLIVIA
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： A61B5/14532 , A61B5/1468 , A61B5/1473 , A61B5/14865 , A61B5/6849 , A61B5/686 , C12Q1/002 , C12Q1/003
摘要： The present invention relates generally to devices for measuring an analyte in a host. More particularly, the present invention relates to devices for measurement of glucose in a host that incorporate a hydrophilic electrode domain and/or a cellulosic-based interference domain.
摘要翻译：本发明一般涉及用于测量宿主中分析物的装置。更具体地说，本发明涉及用于测量宿主中含有亲水电极结构域和/或基于纤维素的干扰域的葡萄糖的装置。

7. 发明申请

WO2006121661A3 CELLULOSIC-BASED RESISTANCE DOMAIN FOR AN ANALYTE SENSOR 审中-公开
标题翻译：用于分析仪传感器的基于纤维素的电阻域
公开(公告)号：WO2006121661A3
公开(公告)日：2007-03-08
申请号：PCT/US2006016515
申请日：2006-04-28
申请人： DEXCOM INC , PETISCE JAMES R , WOO KUM MING , HA VICTOR , NICOLAS MELISSA
发明人： PETISCE JAMES R , WOO KUM MING , HA VICTOR , NICOLAS MELISSA
IPC分类号： A61B5/05
CPC分类号： A61B5/14865 , A61B5/076 , A61B5/145 , A61B5/14532 , A61B5/14546 , A61B5/6848 , C12Q1/002 , C12Q1/003
摘要： The present invention relates generally to devices for measuring an analyte in a host. More particularly, the present invention relates to devices for measurement of glucose in a host that incorporate a membrane system (32) comprising a cellulosic-based resistance domain (38), an enzyme domain (36), and an interference domain (34) overlying a working electrode (28).
摘要翻译：本发明一般涉及用于测量宿主中分析物的装置。更具体地说，本发明涉及用于测量宿主中葡萄糖的装置，该装置包括一个膜系统（32），该膜系统包括基于纤维素的电阻结构域（38），酶结构域（36）和上面的干扰域（34）工作电极（28）。

8. 发明申请

WO2010107941A3 MEMBRANE SYSTEM WITH SUFFICIENT BUFFERING CAPACITY 审中-公开
标题翻译：具有足够的缓冲能力的膜系统
公开(公告)号：WO2010107941A3
公开(公告)日：2011-01-13
申请号：PCT/US2010027697
申请日：2010-03-17
申请人： EDWARDS LIFESCIENCES CORP , OVIATT HENRY JR , PETISCE JAMES R , MOONEY CHARLES
发明人： OVIATT HENRY JR , PETISCE JAMES R , MOONEY CHARLES
IPC分类号： G01N27/26 , G01N27/416
CPC分类号： G01N27/3271 , A61B5/14532 , A61B5/14865 , A61B5/1495 , A61B5/415 , C12Q1/001 , C12Q1/002
摘要： Electrochemical sensors for measurement of an analyte comprising an analyte sensing membrane comprising at least one salt of acetate ion, carbonate ion, bicarbonate ion, or mixtures thereof. Sensor testing methods comprising contacting an electrochemical sensor with an aqueous solution comprising at least one salt of acetate ion, carbonate ion, bicarbonate ion, or mixtures thereof and contacting the electrochemical sensor with one or more concentrations of analyte, the one or more concentrations of analyte being in the clinical concentration range of the analyte.
摘要翻译：用于测量包括分析物感测膜的分析物传感膜的电化学传感器，其包含至少一种乙酸根离子，碳酸根离子，碳酸氢根离子或其混合物的盐。传感器测试方法，包括使电化学传感器与包含至少一种乙酸根离子，碳酸根离子，碳酸氢根离子或其混合物的盐的水溶液接触，并使电化学传感器与一种或多种浓度的分析物接触，所述一种或多种分析物浓度处于分析物的临床浓度范围。

9. 发明申请

WO2010051421A3 ANALYTE SENSOR WITH NON-WORKING ELECTRODE LAYER 审中-公开
标题翻译：具有非工作电极层的分析传感器
公开(公告)号：WO2010051421A3
公开(公告)日：2010-07-22
申请号：PCT/US2009062713
申请日：2009-10-30
申请人： EDWARDS LIFESCIENCES CORP , CURRY KENNETH , PETISCE JAMES R
发明人： CURRY KENNETH , PETISCE JAMES R
IPC分类号： A61B5/145 , A61B5/157
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/415 , A61M25/00 , A61M25/003 , A61M25/007 , C12Q1/002
摘要： Disclosed is an electrochemical sensors for measuring an analyte in a subject. More particularly, the sensor comprises a non-working electrode, the non-working electrode comprising a non-working electroactive surface, and a layer covering at least a portion of the non-working electroactive surface, the layer configured to prevent or reduce endogenous or exogenous components from contacting the non-working electrode surface.
摘要翻译：公开了用于测量受试者中的分析物的电化学传感器。更具体地，传感器包括非工作电极，非工作电极包括非工作电活性表面，以及覆盖至少一部分非工作电活性表面的层，该层被配置为防止或减少内源或外部成分与非工作电极表面接触。

10. 发明申请

WO2011025891A3 ANTI-COAGULANT CALIBRANT INFUSION FLUID SOURCE 审中-公开
标题翻译：抗凝血标本输注液体源
公开(公告)号：WO2011025891A3
公开(公告)日：2011-06-03
申请号：PCT/US2010046843
申请日：2010-08-26
申请人： EDWARDS LIFESCIENCES CORP , OVIATT HENRY W , PETISCE JAMES R
发明人： OVIATT HENRY W , PETISCE JAMES R
IPC分类号： G01N33/15 , A61M5/172 , A61M37/00 , G01N27/26 , G01N33/66
CPC分类号： A61B5/14532 , A61B5/1473 , A61B5/1495 , A61B5/6852
摘要： Methods and systems for preventing or eliminating thrombus during use of a sensor are disclosed. The method comprises providing a calibrant infusion fluid source comprising a predetermined amount of a calibrant and adding a predetermined amount of a non-heparin anti-thrombotic agent into the calibrant infusion fluid source. A system and method is disclosed that includes an infusion calibrant source comprising a predetermined amount of a calibrant and a predetermined amount of a non-heparin anti-thrombotic agent with a glucose sensor.
摘要翻译：公开了在使用传感器期间预防或消除血栓的方法和系统。该方法包括提供包含预定量的校准物并将预定量的非肝素抗血栓形成剂加入到校准液输注液源中的校准液输注流体源。公开了一种包括含有预定量的校准物和预定量的具有葡萄糖传感器的非肝素抗血栓形成剂的输注校正物源的系统和方法。

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