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1. 发明申请

WO2005082436A9 INTEGRATED DELIVERY DEVICE FOR CONTINUOUS GLUCOSE SENSOR 审中-公开
标题翻译：用于连续葡萄糖传感器的集成传送装置
公开(公告)号：WO2005082436A9
公开(公告)日：2006-11-16
申请号：PCT/US2005006301
申请日：2005-02-24
申请人： DEXCOM INC , BRAUKER JAMES H , TAPSAK MARK A , SAINT SEAN T , KAMATH APURV U , NEALE PAUL V , SIMPSON PETER C , MENSINGER MICHAEL ROBERT , MARKOVIC DUBRAVKA
发明人： BRAUKER JAMES H , TAPSAK MARK A , SAINT SEAN T , KAMATH APURV U , NEALE PAUL V , SIMPSON PETER C , MENSINGER MICHAEL ROBERT , MARKOVIC DUBRAVKA
IPC分类号： A61M1/00 , A61B5/00 , A61M31/00
CPC分类号： A61M5/31525 , A61B5/0002 , A61B5/14532 , A61B5/1486 , A61B5/14865 , A61B5/4839 , A61B2560/0443 , A61M5/1723 , A61M11/00 , A61M15/0001 , A61M2005/1726 , A61M2205/18 , A61M2205/3303 , A61M2205/502 , A61M2205/52 , A61M2230/201 , G06F19/3468 , G16H40/63
摘要： Systems and methods for integrating a continuous glucose sensor (12), including a receiver (14), a medicament delivery device (16), and optionally a single point glucose monitor 18 are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.
摘要翻译：提供了用于集成包括接收器（14），药物输送装置（16）和任选的单点葡萄糖监测器18的连续葡萄糖传感器（12）的系统和方法。手动集成提供了用户（例如，患者或医生）手动选择数量，类型和/或递送时间的设备之间的物理关联。设备的半自动化集成包括集成，其中集成组件之间的可操作连接有助于用户（例如患者或医生）在选择，输入，计算或验证葡萄糖值的药物递送量，类型或时间例如，通过将数据发送到另一个组件，从而减少所需的用户输入量。设备之间的自动集成包括集成，其中集成组件之间的可操作连接提供对系统的完全控制，而不需要用户交互。

2. 发明申请

WO2007120442A3 DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR 审中-公开
标题翻译：用于连续分析仪传感器的双电极系统
公开(公告)号：WO2007120442A3
公开(公告)日：2008-11-06
申请号：PCT/US2007007612
申请日：2007-03-27
申请人： DEXCOM INC , SIMPSON PETER C , BRAUKER JAMES H , GOODE PAUL V , KAMATH APURV U , PETISCE JAMES R , WOO KUM MING , NICHOLAS MELISSA A , BOOCK ROBERT J , RIXMAN MONICA A , BURD JOHN , RHODES RATHBUN K , TAPSAK MARK A
发明人： SIMPSON PETER C , BRAUKER JAMES H , GOODE PAUL V , KAMATH APURV U , PETISCE JAMES R , WOO KUM MING , NICHOLAS MELISSA A , BOOCK ROBERT J , RIXMAN MONICA A , BURD JOHN , RHODES RATHBUN K , TAPSAK MARK A
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/14865 , B33Y70/00
摘要： Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor (10b). One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain. The sensor (10b) can include a glucose-measuring working electrode (16), an optional auxiliary working electrode (18), and at least one additional electrode (20), which may function as a counter and/or reference electrode.
摘要翻译：本文公开了用于连续分析物传感器的系统和方法，例如连续葡萄糖传感器（10b）。一个这样的系统利用第一和第二工作电极来测量分析物或非分析物相关的信号，这两个电极都包括干扰域。传感器（10b）可以包括葡萄糖测量工作电极（16），可选的辅助工作电极（18）和至少一个可用作计数器和/或参考电极的附加电极（20）。

3. 发明申请

WO2006073453A2 IMPLANTABLE ANALYTE SENSOR 审中-公开
标题翻译：可植入分析传感器
公开(公告)号：WO2006073453A2
公开(公告)日：2006-07-13
申请号：PCT/US2005014696
申请日：2005-05-02
申请人： DEXCOM INC , GOODE JR PAUL V , HOLMQUIST ARNOLD L , TAPSAK MARK A , SHULTS MARK , CARR-BRENDEL VICTORIA , BRAUKER JAMES H , NEALE PAUL V , MCCLURE JASON D , BRISTER MARK , SIMPSON PETER C , RHODES RATHBUN K
发明人： GOODE JR PAUL V , HOLMQUIST ARNOLD L , TAPSAK MARK A , SHULTS MARK , CARR-BRENDEL VICTORIA , BRAUKER JAMES H , NEALE PAUL V , MCCLURE JASON D , BRISTER MARK , SIMPSON PETER C , RHODES RATHBUN K
IPC分类号： A61B5/07 , A61B5/00 , A61B5/05 , H04B1/03
CPC分类号： A61B5/0031 , A61B5/076 , A61B5/14532 , A61B5/14865 , A61B2560/04 , A61B2560/0462 , H04B1/03 , Y10T29/49117
摘要： An implantable analyte sensor (12) including a sensor body substantially formed from a water vapor permeable material and electrical components encapsulated within the sensor body, wherein the electrical components comprise RF circuitry (38) and an antenna (42) adapted for RF transmission from the sensor (12) in vivo to a receiver (14) ex vivo, wherein the RF circuitry (38) is spaced a fixed distance from the sensor body so as to support a dielectric constant that enables RF transmission between the sensor (12) in vivo to the receiver (14) ex vivo.
摘要翻译：一种可植入分析物传感器（12），其包括基本由水蒸气可渗透材料形成的传感器主体和封装在传感器主体内的电子部件，其中电子部件包括RF电路（38）和适于从传感器（12）在体内与接收器（14）离体接触，其中所述RF电路（38）与所述传感器主体间隔固定距离，以支持介电常数，所述介电常数使所述传感器（12）能够在体内到体外的接收器（14）。

4. 发明申请

WO2007002189A3 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2007002189A3
公开(公告)日：2007-09-07
申请号：PCT/US2006024132
申请日：2006-06-20
申请人： DEXCOM INC , DOBBLES J MICHAEL , BRISTER MARK , BRAUKER JAMES H , KAMATH APURV ULLAS , KLINE DANIEL S , MASTERSON STEVE , MENSINGER MICHAEL ROBERT , SAINT SEAN , SIMPSON PETER C
发明人： DOBBLES J MICHAEL , BRISTER MARK , BRAUKER JAMES H , KAMATH APURV ULLAS , KLINE DANIEL S , MASTERSON STEVE , MENSINGER MICHAEL ROBERT , SAINT SEAN , SIMPSON PETER C
IPC分类号： A61B5/05
CPC分类号： A61B5/1451 , A61B5/0031 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/6832 , A61B5/6833 , A61B5/6848 , A61B5/6849 , A61B5/7264 , A61B5/742 , A61B2560/0223 , A61B2560/0276 , A61B2560/028 , A61L2/12 , A61L2/206 , Y02A90/22 , Y02A90/26 , Y10T29/49004
摘要： The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. The system can include an applicator 12, a mounting unit 14, and an electronics unit 16.
摘要翻译：本发明总体上涉及用于测量宿主中的分析物的系统和方法。更具体地说，本发明涉及用于经皮测量宿主中的葡萄糖的系统和方法。该系统可以包括施加器12，安装单元14和电子单元16。

5. 发明申请

WO2005019795A3 ELECTROCHEMICAL SENSORS INCLUDING ELECTRODE SYSTEMS WITH INCREASED OXYGEN GENERATION 审中-公开
标题翻译：包括电极系统在内的电化学传感器与增加的氧气发生
公开(公告)号：WO2005019795A3
公开(公告)日：2006-03-16
申请号：PCT/US2004023650
申请日：2004-07-21
申请人： DEXCOM INC , SIMPSON PETER C , GOODE PAUL , TAPSAK MARK A , CARR-BRENDEL VICTORIA
发明人： SIMPSON PETER C , GOODE PAUL , TAPSAK MARK A , CARR-BRENDEL VICTORIA
IPC分类号： A61B5/00 , C12Q1/00 , G01N33/487 , G01N27/327
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14546 , C12Q1/003 , G01N27/3272
摘要： The present invention relates generally to systems and methods for increasing oxygen generation in electrochemical sensors (10) in order to overcome the oxygen limitations. The preferred embodiments employ electrode systems (16b) with at least two electrodes in relatively close proximity to each other; wherein at least one electrode is configured to generate oxygen and at least one other electrode is configured to sense an analyte or a product of a reaction indicative of the concentration of analyte. The oxygen generated by the oxygen-generating electrode is available to the catalyst within a membrane system and/or the counter electrode, thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. The electrochemical sensor (10) can include a body with a sensing region (14), and a membrane system (18) disposed over the electroactive surfaces of the electrode system (16b).
摘要翻译：本发明一般涉及用于增加电化学传感器（10）中的氧气产生的系统和方法，以克服氧的限制。优选实施例采用电极系统（16b），其中至少两个电极彼此相对靠近; 其中至少一个电极被配置为产生氧，并且至少一个其它电极被配置为感测分析物或指示分析物浓度的反应的产物。由氧发生电极产生的氧气可用于膜系统和/或对电极中的催化剂，从而使得优选实施方案的电化学传感器能够在缺血条件下起作用。电化学传感器（10）可以包括具有感测区域（14）的主体和设置在电极系统（16b）的电活性表面之上的膜系统（18）。

6. 发明申请

WO2005057168A3 CALIBRATION TECHNIQUES FOR A CONTINUOUS ANALYTE SENSOR 审中-公开
标题翻译：连续分析仪传感器的校准技术
公开(公告)号：WO2005057168A3
公开(公告)日：2007-03-22
申请号：PCT/US2004040476
申请日：2004-12-03
申请人： DEXCOM INC , KAMATH APURV ULLAS , SIMPSON PETER C , BRAUKER JAMES H , GOODE JR PAUL V
发明人： KAMATH APURV ULLAS , SIMPSON PETER C , BRAUKER JAMES H , GOODE JR PAUL V
IPC分类号： A61B5/05 , A61B5/00 , G01N20060101
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1495 , A61B5/7203 , A61B5/742 , A61B2560/0223 , B33Y70/00 , B33Y80/00
摘要： Disclosed herein are systems and methods for calibrating a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes one or more electrodes to measure an additional analyte. Such measurements may provide a baseline or sensitivity measurement for use in calibrating the sensor. Furthermore, baseline and/or sensitivity measurements may be used to trigger events such as digital filtering of data or suspending display of data.
摘要翻译：本文公开了用于校准连续分析物传感器（例如连续葡萄糖传感器）的系统和方法。一个这样的系统利用一个或多个电极来测量另外的分析物。这样的测量可以提供用于校准传感器的基线或灵敏度测量。此外，可以使用基线和/或灵敏度测量来触发诸如数字数字滤波或暂停显示数据的事件。

7. 发明申请

WO2011003039A3 ANALYTE SENSORS AND METHODS OF MANUFACTURING SAME 审中-公开
标题翻译：分析传感器及其制造方法
公开(公告)号：WO2011003039A3
公开(公告)日：2011-04-14
申请号：PCT/US2010040842
申请日：2010-07-01
申请人： DEXCOM INC , SIMPSON PETER C , BOOCK ROBERT , NEALE PAUL V , BOHM SEBASTIAN , WIGHTLIN MATTHEW , PRYOR JACK , MITCHELL JASON , JACKSON JEFF , PATEL KAUSHIK , LLEVARES ANTONIO C
发明人： SIMPSON PETER C , BOOCK ROBERT , NEALE PAUL V , BOHM SEBASTIAN , WIGHTLIN MATTHEW , PRYOR JACK , MITCHELL JASON , JACKSON JEFF , PATEL KAUSHIK , LLEVARES ANTONIO C
IPC分类号： A61B5/145 , A61B5/1468
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system (800) comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system (800) comprises first and second elongated bodies El, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer (810) that separates the conductive layer (820) from the elongated body, a membrane layer deposited on top of the elongated bodies El, E2, and working electrodes (802', 802") formed by removing portions of the conductive layer (820) and the insulating layer (810), thereby exposing electroactive surface of the elongated bodies El, E2.
摘要翻译：提供分析物传感器及其制造方法，包括包含多轴灵活性的分析物传感器。例如，提供了包括两个工作电极和至少一个参考/对电极的多电极传感器系统（800）。传感器系统（800）包括第一和第二细长体E1，E2，每个由导电芯或具有沉积在其上的导电层的芯构成;绝缘层（810），其将导电层（820）与细长体，沉积在细长体E1，E2和通过去除导电层（820）和绝缘层（810）的部分形成的工作电极（802'，802“）之上的膜层，从而暴露电活性表面细长体E1，E2。

8. 发明申请

WO2005012873A3 ELECTRODE SYSTEMS FOR ELECTROCHEMICAL SENSORS 审中-公开
标题翻译：电化学传感器电极系统
公开(公告)号：WO2005012873A3
公开(公告)日：2006-04-13
申请号：PCT/US2004024178
申请日：2004-07-21
申请人： DEXCOM INC , SIMPSON PETER C , PETISCE JAMES R , CARR-BRENDEL VICTORIA , BRAUKER JAMES H
发明人： SIMPSON PETER C , PETISCE JAMES R , CARR-BRENDEL VICTORIA , BRAUKER JAMES H
IPC分类号： G01N20060101 , G01N27/26 , G01N27/416 , G01N27/327
CPC分类号： G01N27/3274 , A61B5/14532 , A61B5/14865 , C12Q1/001
摘要： The present invention relates generally to systems and methods for improved electrochemical measurement of analytes. The preferred embodiments employ electrode systems including an analyte-measuring electrode (16a) for measuring the analyte or the product of an enzyme reaction with the analyte and an auxiliary electrode (36) configured to generate oxygen and/or reduce electrochemical interferants. Oxygen generation by the auxiliary electrode (36) advantageously improves oxygen availability to the enzyme (38) and/or counter electrode; thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. Interferant modification by the auxiliary electrode (36) advantageously renders them substantially non-reactive at the analyte-measuring electrode, thereby reducing or eliminating inaccuracies in the analyte signal due to electrochemical interferants.
摘要翻译：本发明一般涉及用于改进分析物的电化学测量的系统和方法。优选实施例采用电极系统，包括分析物测量电极（16a），用于测量分析物或与分析物的酶反应产物以及被配置为产生氧和/或减少电化学干扰剂的辅助电极（36）。通过辅助电极（36）产生的氧有利地提高了对酶（38）和/或对电极的氧可用性; 从而使得优选实施例的电化学传感器能够在缺血状况下起作用。辅助电极（36）的干扰修饰有利地使它们在分析物测量电极处基本上不反应，从而减少或消除由于电化学干扰剂引起的分析物信号的不准确性。

9. 发明申请

WO2005079257A2 BIOINTERFACE WITH MACRO- AND MICRO- ARCHITECTURE 审中-公开
标题翻译：具有宏观和微观结构的生物界
公开(公告)号：WO2005079257A2
公开(公告)日：2005-09-01
申请号：PCT/US2005004058
申请日：2005-02-09
申请人： DEXCOM INC , CARR-BRENDEL VICTORIA , SIMPSON PETER C , BRAUKER JAMES H
发明人： CARR-BRENDEL VICTORIA , SIMPSON PETER C , BRAUKER JAMES H
IPC分类号： A61F13/00 , A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/10 , B33Y80/00
摘要： Disclosed herein are biointerface membranes including a macro-architecture and a micro-architecture co-continuous with and bonded to and/or located within at least a portion of the macro-architecture.The macro- and micro-architectures work together to manage and manipulate the high-level tissue organization and the low-level cellular organization of the foreign body response in vivo, thereby increasing neovascularization close to a device-tissue interface, interfering with barrier cell layer formation, and providing good tissue anchoring, while reducing the effects of motion artifact, and disrupting the organization and/or contracture of the foreign body capsule. The biointerface membranes of the preferred embodiments can be utilized with implantable devices such as devices for the detection of analyte concentrations in a biological sample (for example, from a body), cell transplantation devices, drug delivery devices, electrical signal delivering or measuring devices, and/or combinations thereof.
摘要翻译：这里公开的是生物界面膜，其包括宏观架构和与宏结构共同连接并结合到宏结构和/或位于宏观架构的至少一部分内的微架构。宏观和微观架构一起工作以管理和操纵高水平组织组织和体内异物反应的低水平细胞组织，从而增加靠近器官组织界面的新生血管形成，干扰屏障细胞层形成，并提供良好的组织锚定，同时降低运动神器，并扰乱异物胶囊的组织和/或挛缩。优选实施方案的生物界面膜可以与可植入装置一起使用，例如用于检测生物样品（例如，来自身体），细胞移植装置，药物递送装置，电信号传递或测量装置中的分析物浓度的装置，和/或其组合。

10. 发明申请

WO2011041463A3 TRANSCUTANEOUS ANALYTE SENSOR 审中-公开
标题翻译： TRANSCUTANEOUS分析仪传感器
公开(公告)号：WO2011041463A3
公开(公告)日：2011-07-14
申请号：PCT/US2010050788
申请日：2010-09-29
申请人： DEXCOM INC , NEALE PAUL V , BOOCK ROBERT , BOHM SEBASTIAN , SIMPSON PETER C , BRAUKER JAMES
发明人： NEALE PAUL V , BOOCK ROBERT , BOHM SEBASTIAN , SIMPSON PETER C , BRAUKER JAMES
IPC分类号： A61B5/151 , A61B5/157
CPC分类号： A61B5/14865 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/6843 , A61B5/6848 , A61B5/6849 , A61B2560/0443 , A61B2562/0209 , A61B2562/04
摘要： A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor device 100 comprises an in vivo portion 160 configured for insertion under the skin 180 of the host and an ex vivo portion 170 configured to remain above the surface of the skin 180 of the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing element 110 configured for piercing the skin 180 of the host and a sensor body 120 comprising a material or support member 130 that provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portion 170 may be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit 150. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.
摘要翻译：提供了经配置以连续测量宿主中的分析物浓度的经皮传感器装置。在一些实施例中，经皮传感器装置100包括构造成用于插入主体皮肤180下方的体内部分160，以及配置成在传感器插入入口之后保留在主体的皮肤180的表面上方的离体部分170 体内部分。体内部分可以包括构造成用于刺穿主体的皮肤180的组织刺穿元件110和传感器主体120，传感器主体120包括材料或支撑构件130，材料或支撑构件130提供足够的柱强度，以允许传感器主体可在主机组织中推出而不用实质屈曲。离体部分170可以被配置为包括（或可操作地连接）传感器电子单元，并且可以包括安装单元150.此处还描述了传感器主体和组织刺穿元件的各种配置，其可以用于保护传感器体的膜。

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