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1. 发明申请

WO2011003039A3 ANALYTE SENSORS AND METHODS OF MANUFACTURING SAME 审中-公开
标题翻译：分析传感器及其制造方法
公开(公告)号：WO2011003039A3
公开(公告)日：2011-04-14
申请号：PCT/US2010040842
申请日：2010-07-01
申请人： DEXCOM INC , SIMPSON PETER C , BOOCK ROBERT , NEALE PAUL V , BOHM SEBASTIAN , WIGHTLIN MATTHEW , PRYOR JACK , MITCHELL JASON , JACKSON JEFF , PATEL KAUSHIK , LLEVARES ANTONIO C
发明人： SIMPSON PETER C , BOOCK ROBERT , NEALE PAUL V , BOHM SEBASTIAN , WIGHTLIN MATTHEW , PRYOR JACK , MITCHELL JASON , JACKSON JEFF , PATEL KAUSHIK , LLEVARES ANTONIO C
IPC分类号： A61B5/145 , A61B5/1468
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system (800) comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system (800) comprises first and second elongated bodies El, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer (810) that separates the conductive layer (820) from the elongated body, a membrane layer deposited on top of the elongated bodies El, E2, and working electrodes (802', 802") formed by removing portions of the conductive layer (820) and the insulating layer (810), thereby exposing electroactive surface of the elongated bodies El, E2.
摘要翻译：提供分析物传感器及其制造方法，包括包含多轴灵活性的分析物传感器。例如，提供了包括两个工作电极和至少一个参考/对电极的多电极传感器系统（800）。传感器系统（800）包括第一和第二细长体E1，E2，每个由导电芯或具有沉积在其上的导电层的芯构成;绝缘层（810），其将导电层（820）与细长体，沉积在细长体E1，E2和通过去除导电层（820）和绝缘层（810）的部分形成的工作电极（802'，802“）之上的膜层，从而暴露电活性表面细长体E1，E2。

2. 发明申请

WO2011041463A3 TRANSCUTANEOUS ANALYTE SENSOR 审中-公开
标题翻译： TRANSCUTANEOUS分析仪传感器
公开(公告)号：WO2011041463A3
公开(公告)日：2011-07-14
申请号：PCT/US2010050788
申请日：2010-09-29
申请人： DEXCOM INC , NEALE PAUL V , BOOCK ROBERT , BOHM SEBASTIAN , SIMPSON PETER C , BRAUKER JAMES
发明人： NEALE PAUL V , BOOCK ROBERT , BOHM SEBASTIAN , SIMPSON PETER C , BRAUKER JAMES
IPC分类号： A61B5/151 , A61B5/157
CPC分类号： A61B5/14865 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/6843 , A61B5/6848 , A61B5/6849 , A61B2560/0443 , A61B2562/0209 , A61B2562/04
摘要： A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor device 100 comprises an in vivo portion 160 configured for insertion under the skin 180 of the host and an ex vivo portion 170 configured to remain above the surface of the skin 180 of the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing element 110 configured for piercing the skin 180 of the host and a sensor body 120 comprising a material or support member 130 that provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portion 170 may be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit 150. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.
摘要翻译：提供了经配置以连续测量宿主中的分析物浓度的经皮传感器装置。在一些实施例中，经皮传感器装置100包括构造成用于插入主体皮肤180下方的体内部分160，以及配置成在传感器插入入口之后保留在主体的皮肤180的表面上方的离体部分170 体内部分。体内部分可以包括构造成用于刺穿主体的皮肤180的组织刺穿元件110和传感器主体120，传感器主体120包括材料或支撑构件130，材料或支撑构件130提供足够的柱强度，以允许传感器主体可在主机组织中推出而不用实质屈曲。离体部分170可以被配置为包括（或可操作地连接）传感器电子单元，并且可以包括安装单元150.此处还描述了传感器主体和组织刺穿元件的各种配置，其可以用于保护传感器体的膜。

3. 发明申请

WO2011003035A3 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2011003035A3
公开(公告)日：2011-04-14
申请号：PCT/US2010040838
申请日：2010-07-01
申请人： DEXCOM INC , SIMPSON PETER C , BOOCK ROBERT , KAMATH APURV ULLAS , WIGHTLIN MATTHEW , ESTES MICHAEL J
发明人： SIMPSON PETER C , BOOCK ROBERT , KAMATH APURV ULLAS , WIGHTLIN MATTHEW , ESTES MICHAEL J
IPC分类号： A61B5/145 , A61B5/1468
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system (180) is provided having a first working electrode (150) comprising a first sensor element (102) and a second working electrode (160) comprising a second sensor element (104), and a reference electrode (108) for providing a reference value for measuring the working electrode potential of the sensor elements (102, 104).
摘要翻译：提供了用于连续测量分析物浓度的装置和方法。该装置可以包括具有多个传感器元件的传感器，每个传感器元件具有与装置的其它传感器不同的至少一个特性。在一些实施例中，多个传感器元件各自被调谐以测量分析物浓度的不同范围，从而为器件提供在生理学相关范围内实现基本一致的测量精度水平的能力。在其他实施例中，该装置包括多个传感器元件，每个传感器元件在插入或植入之后的不同时间期间被调整以测量，从而为传感器提供在宽范围的时间段内连续且精确地测量分析物浓度的能力。例如，提供传感器系统（180），其具有包括第一传感器元件（102）的第一工作电极（150）和包括第二传感器元件（104）的第二工作电极（160）和参考电极（108）），用于提供用于测量传感器元件（102,104）的工作电极电位的参考值。

4. 发明申请

WO2011003036A3 CONTINUOUS ANALYTE SENSORS AND METHODS OF MAKING SAME 审中-公开
标题翻译：连续分析仪传感器及其制作方法
公开(公告)号：WO2011003036A3
公开(公告)日：2011-04-14
申请号：PCT/US2010040839
申请日：2010-07-01
申请人： DEXCOM INC , BOOCK ROBERT , JACKSON JEFF , ZHANG HUASHI , MITCHELL JASON
发明人： BOOCK ROBERT , JACKSON JEFF , ZHANG HUASHI , MITCHELL JASON
IPC分类号： A61B5/155 , A61B5/145 , A61B5/157
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Described here are embodiments of processes and systems for the continuous manufacturing of implantable continuous analyte sensors. In some embodiments, a method is provided for sequentially advancing an elongated conductive body through a plurality of stations, each configured to treat the elongated conductive body. In some of these embodiments, one or more of the stations is configured to coat the elongated conductive body using a meniscus coating process, whereby a solution formed of a polymer and a solvent is prepared, the solution is continuously circulated to provide a meniscus on a top portion of a vessel holding the solution, and the elongated conductive body is advanced through the meniscus. The method may also comprise the step of removing excess coating material from the elongated conductive body by advancing the elongated conductive body through a die orifice. For example, a provided elongated conductive body (510) is advanced through a pre-coating treatment station (520), through a coating station 530, through a thickness control station (540), through a drying or curing station (550), through a thickness measurement station (560), and through a post-coating treatment station (570).
摘要翻译：这里描述了用于连续制造可植入的连续分析物传感器的方法和系统的实施方案。在一些实施例中，提供了一种方法，用于顺序地将细长导电体穿过多个工位，每个工位都构造成处理细长导电体。在这些实施例中的一些实施例中，一个或多个工位被配置为使用弯液面涂覆工艺涂覆细长导电体，由此制备由聚合物和溶剂形成的溶液，所述溶液被连续循环以在保持溶液的容器的顶部，并且细长导电体前进通过弯液面。该方法还可以包括通过使细长导电体通过模头孔从细长导电体去除多余涂层材料的步骤。例如，所提供的细长导电体（510）穿过预涂处理站（520），穿过涂覆站530穿过厚度控制站（540），通过干燥或固化站（550），通过厚度测量站（560），并通过后涂层处理站（570）。

5. 发明申请

WO2009105337A3 CONTINUOUS MEDICAMENT SENSOR SYSTEM FOR IN VIVO USE 审中-公开
标题翻译：连续使用医疗传感器系统
公开(公告)号：WO2009105337A3
公开(公告)日：2010-12-16
申请号：PCT/US2009033096
申请日：2009-02-04
申请人： DEXCOM INC , SIMPSON PETER C , YANG RICHARD C , MATSUBARA BRADLEY SHIGETO , BOOCK ROBERT , MCCARTHY ELEANOR , BRISTER MARK
发明人： SIMPSON PETER C , YANG RICHARD C , MATSUBARA BRADLEY SHIGETO , BOOCK ROBERT , MCCARTHY ELEANOR , BRISTER MARK
IPC分类号： A61M31/00
CPC分类号： A61B5/14546 , A61B5/0002 , A61B5/064 , A61B5/14532 , A61B5/4094 , A61B5/411 , A61B5/4839 , A61B5/4848 , A61M5/1723 , A61M2005/14296 , A61M2230/201
摘要： Systems and methods for continuous measurement of a medicament In vivo are provided. In some embodiments, the system 10 is configured to provide information associated with medicament titration using continuous analyte sensor 100 and communication device 110. In some embodiments, the system Is configured for continuous ambulatory drug testing in a host ß, including a host monitor having a continuous sensor, location module, processor module and transmitter. In some embodiments, the system Is configured for continuously monitoring hormone levels and Includes a continuous hormone sensor and a communication device configured to output hormone information in real time. Another embodiment provides an analyte sensor for continuous monitoring of a host's nutritional status, and Is configured for both continuous glucose and albumin detection. The sensor system 10 is configured to interact with one or more secondary devices 120, which can be non-medical or medical devices, e.g., an infusion pump.
摘要翻译：用于连续测量药物的系统和方法提供体内。在一些实施例中，系统10被配置为使用连续分析物传感器100和通信设备110来提供与药物滴定相关联的信息。在一些实施例中，该系统被配置为用于主机ß中的连续动态药物测试，包括具有连续传感器，位置模块，处理器模块和变送器。在一些实施例中，系统被配置为连续监测激素水平，并且包括连续激素传感器和被配置为实时输出激素信息的通信装置。另一个实施方案提供了用于连续监测宿主营养状态的分析物传感器，并且被配置用于连续葡萄糖和白蛋白检测。传感器系统10被配置为与一个或多个辅助设备120相互作用，其可以是非医疗或医疗设备，例如输液泵。

6. 发明申请

WO2007120381A3 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2007120381A3
公开(公告)日：2008-03-27
申请号：PCT/US2007003881
申请日：2007-02-14
申请人： DEXCOM INC , BOOCK ROBERT , RIXMAN MONICA , BRAUKER JAMES H , PETISCE JAMES R , SIMPSON PETER , BRISTER MARK , TAPSAK MARK A , CARR-BRENDEL VICTORIA
发明人： BOOCK ROBERT , RIXMAN MONICA , BRAUKER JAMES H , PETISCE JAMES R , SIMPSON PETER , BRISTER MARK , TAPSAK MARK A , CARR-BRENDEL VICTORIA
IPC分类号： A61B5/05
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532 , A61B5/418 , B33Y70/00
摘要： The present invention relates generally to membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel silicone-hydrophilic polymer blend membranes, and to devices and implantable devices including these membranes, for example, a continuous analyte needle-type sensor (34) including a reference electrode (30) helically wound around the working electrode (38), and covered by a membrane system (32) including a silicone-hydrophilic polymer blend membrane.
摘要翻译：本发明一般涉及与可植入装置一起使用的膜，例如用于检测生物样品中分析物浓度的装置。更具体地说，本发明涉及新颖的硅氧烷亲水性聚合物共混膜，以及包括这些膜的装置和可植入装置，例如连续的分析物针型传感器（34），其包括在工作中螺旋缠绕的参比电极（30）电极（38），并被包括硅氧烷亲水聚合物共混膜的膜系统（32）覆盖。

7. 发明申请

WO2006110193A3 CELLULOSIC-BASED INTERFERENCE DOMAIN FOR AN ANALYTE SENSOR 审中-公开
标题翻译：用于分析仪传感器的基于纤维素的干扰域
公开(公告)号：WO2006110193A3
公开(公告)日：2009-05-14
申请号：PCT/US2006001661
申请日：2006-01-18
申请人： DEXCOM INC , PETISCE JAMES R , WOO KUM MING , HA VICTOR , NICOLAS MELISSA , BOOCK ROBERT
发明人： PETISCE JAMES R , WOO KUM MING , HA VICTOR , NICOLAS MELISSA , BOOCK ROBERT
IPC分类号： G01N27/327 , A61B5/05
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/6833 , A61B5/6848 , A61B5/6849 , Y02A90/26
摘要： The present invention relates generally to devices for measuring an analyte in a host. More particularly, the present invention relates to electrochemical glucose sensing systems including a sensor incorporating a cellulosic interference membrane, an applicator (12), a mounting unit (14), an electronics unit (16), and one or more contacts (28) configured to provide secure electrical contact between the sensor and the electronics unit (16).
摘要翻译：本发明一般涉及用于测量宿主中分析物的装置。更具体地说，本发明涉及电化学葡萄糖感测系统，其包括包含纤维素干涉膜的传感器，施加器（12），安装单元（14），电子单元（16）和配置的一个或多个触点（28）以在传感器和电子单元（16）之间提供牢固的电接触。

8. 发明申请

WO2006127694A3 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2006127694A3
公开(公告)日：2007-04-12
申请号：PCT/US2006019889
申请日：2006-05-23
申请人： DEXCOM INC , BRAUKER JAMES H , SIMPSON PETER , BOOCK ROBERT , RIXMAN MONICA
发明人： BRAUKER JAMES H , SIMPSON PETER , BOOCK ROBERT , RIXMAN MONICA
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/411 , A61B5/418 , A61B5/6848 , A61B2562/08 , C12Q1/006 , G01N33/54366 , G01N33/66
摘要： The present invention relates generally to biointerface membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel biointerface membranes, to devices and implantable devices including these membranes, methods for forming the biointerface membranes on or around the implantable devices, and to methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device. The sensor (34) can incorporate a working electrode (38) and at least one additional electrode (30), and can further incorporate a sensing mechanism (36) comprising a small structure as adapted for insertion under the host's skin.
摘要翻译：本发明一般涉及与可植入装置一起使用的生物界面膜，例如用于检测生物样品中分析物浓度的装置。更具体地，本发明涉及新颖的生物接触膜，包括这些膜的装置和可植入装置，在可植入装置上或周围形成生物接触膜的方法，以及使用可植入分析物检测来监测生物流体样品中的葡萄糖水平的方法设备。传感器（34）可以包括工作电极（38）和至少一个附加电极（30），并且还可以包括感测机构（36），该感测机构包括适于插入主机皮肤下方的小结构。

9. 发明申请

WO2005060606A3 ANEURYSM EMBOLIZATION MATERIAL AND DEVICE 审中-公开
标题翻译： ANEURYSM嵌入材料和器件
公开(公告)号：WO2005060606A3
公开(公告)日：2005-12-29
申请号：PCT/US2004041090
申请日：2004-12-08
申请人： NEUROVASX INC , LEE JEFFREY A , CALABRIA MARIE F , BERTELSON AURTHUR J , BOOCK ROBERT
发明人： LEE JEFFREY A , CALABRIA MARIE F , BERTELSON AURTHUR J , BOOCK ROBERT
IPC分类号： A61B17/00 , A61B17/12 , A61F2/06 , A61F11/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/1219 , A61B2017/00022 , A61B2017/0003 , A61B2017/00477 , A61B2017/12054 , A61B2017/12068 , A61B2017/12072 , A61M2205/36
摘要： The present invention includes a method for treating an aneurysm. The method includes providing a biocompatible polymeric string or hollow tube and transporting the string or hollow tube to the aneurysm. The aneurysm is filled with the string. The string is cut when the aneurysm is substantially filled.
摘要翻译：本发明包括治疗动脉瘤的方法。该方法包括提供生物相容的聚合物线或中空管，并将线或中空管输送到动脉瘤。动脉瘤充满了字符串。当动脉瘤基本上被填充时，切割该绳。

10. 发明申请

WO0106950A3 ANEURYSM EMBOLIZATION MATERIAL AND DEVICE 审中-公开
标题翻译： ANEURYSM嵌入材料和器件
公开(公告)号：WO0106950A3
公开(公告)日：2008-03-27
申请号：PCT/US0019854
申请日：2000-07-21
申请人： NEUROVASX INC , BOOCK ROBERT
发明人： BOOCK ROBERT
IPC分类号： A61M31/00 , A61B17/12
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1215 , A61B17/12168 , A61B17/1219 , A61B2017/1205 , A61B2017/12068 , A61B2017/12072
摘要： The present invention includes a kit for treating an aneurysm and a method of using the kit. The kit and method includes a biocompatible polymeric string (26) that is transported to the site of an aneurysm. After filling the aneurysm with the string (26), the string (26) is cut.
摘要翻译：本发明包括用于治疗动脉瘤的试剂盒和使用试剂盒的方法。试剂盒和方法包括被输送到动脉瘤部位的生物相容性聚合物串（26）。在用串（26）填充动脉瘤之后，切割线（26）。

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