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1. 发明授权

US08797028B2 Sensor device for target particles in a sample 有权
标题翻译：样品中目标颗粒的传感器装置
公开(公告)号：US08797028B2
公开(公告)日：2014-08-05
申请号：US12738317
申请日：2008-10-21
申请人： Coen Adrianus Johannes Verschuren , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Mischa Megens , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
发明人： Coen Adrianus Johannes Verschuren , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Mischa Megens , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
IPC分类号： G01R33/02 , G01N33/00 , G01N21/55
CPC分类号： G01N15/06 , G01N15/0656 , G01N2015/0693 , G01R33/1269
摘要： A sensor device and a method for the determination of the amount of target particles at a contact surface adjacent to a sample chamber include detecting, by a detector, the target particles in the sample chamber by a sensor element, and providing at least one corresponding sensor signal. An evaluation unit determines the amount of target particles in a first zone at the contracts surface and in a second zone a distance away from the contact surface based on this sensor signal. In an optical measurement approach, frustrated total internal reflection taking place under different operating conditions, such as wavelength and/or angle of incidence, may be used to extract information about the first and second zones. In a magnetic measurement approach, different magnetic excitation fields may be used to excite magnetic target particles differently in the first and second zone.
摘要翻译：用于确定与样品室相邻的接触表面处的目标颗粒的量的传感器装置和方法包括通过检测器通过传感器元件检测样品室中的目标颗粒，并且提供至少一个相应的传感器信号。评估单元基于该传感器信号确定在合同表面处的第一区域中的目标颗粒的量和距接触表面一定距离的第二区域中的目标颗粒的量。在光学测量方法中，可以使用在诸如波长和/或入射角的不同操作条件下发生的沮丧的全内反射来提取关于第一和第二区域的信息。在磁测量方法中，可以使用不同的磁激励场来在第一和第二区域中不同地激励磁性目标颗粒。

2. 发明申请

US20100259254A1 SENSOR DEVICE FOR TARGET PARTICLES IN A SAMPLE 有权
标题翻译：传感器装置在样品中的目标颗粒
公开(公告)号：US20100259254A1
公开(公告)日：2010-10-14
申请号：US12738317
申请日：2008-10-21
申请人： Coen Adrianus Johannes Verschuren , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Mischa Megens , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
发明人： Coen Adrianus Johannes Verschuren , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Mischa Megens , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
IPC分类号： G01R33/02 , G01N33/00 , G01N21/55
CPC分类号： G01N15/06 , G01N15/0656 , G01N2015/0693 , G01R33/1269
摘要： The invention relates to a sensor device (100) and a method for the determination of the amount of target particles (1) at a contact surface (112) adjacent to a sample chamber (2). Target particles (1) in the sample chamber are detected by a sensor element (SE) and at least one corresponding sensor-signal (s, s′) is provided. An evaluation unit (EU) then determines the amount of target particles (1) in a first zone (Z1) immediately at the contracts surface (112) and a second zone (Z2) a distance (z) away from the contact surface based on this sensor-signal. In an optical measurement approach, frustrated total internal reflection taking place under different operating conditions (e.g. wavelength, angle of incidence) may be used to extract information about the first and second zones (Z1, Z2). In a magnetic measurement approach, different magnetic excitation fields may be used to excite magnetic target particles differently in the first and second zone (Z2). Moreover, the temporal course of a sensor-signal (s, s′) can be evaluated, particularly with respect to stochastic movements of the target particles (1).
摘要翻译：本发明涉及一种传感器装置（100）和用于确定在与样品室（2）相邻的接触表面（112）处的目标颗粒（1）的量的方法。通过传感器元件（SE）检测样品室中的目标颗粒（1），并提供至少一个对应的传感器信号（s，s'）。然后，评估单元（EU）基于紧接表面（112）立即确定第一区域（Z1）中的目标颗粒（1）的数量和远离接触表面的距离（z）的第二区域（Z2），基于这个传感器信号。在光学测量方法中，可以使用在不同操作条件（例如波长，入射角）下发生的沮丧的全内反射来提取关于第一和第二区（Z1，Z2）的信息。在磁测量方法中，可以使用不同的磁激励场来在第一和第二区（Z2）中不同地激励磁目标颗粒。此外，可以评估传感器信号（s，s'）的时间过程，特别是关于目标颗粒（1）的随机运动。

3. 发明申请

US20100231213A1 MAGNETORESISTIVE SENSOR AS TEMPERATURE SENSOR 审中-公开
标题翻译：磁传感器作为温度传感器
公开(公告)号：US20100231213A1
公开(公告)日：2010-09-16
申请号：US12294479
申请日：2007-03-23
申请人： Jeroen Hans Nieuwenhuis , Theodorus Petrus Henricus Gerardus Jansen , Jeroen Veen , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink
发明人： Jeroen Hans Nieuwenhuis , Theodorus Petrus Henricus Gerardus Jansen , Jeroen Veen , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink
IPC分类号： G01R33/02
CPC分类号： G01R33/09 , B82Y25/00 , G01R33/007 , G01R33/093 , G01R33/12 , G01R33/1269
摘要： A detection system (100, 150) for qualitative or quantitative detection of a magnetic field property of a modulated magnetic field is described. The modulated magnetic field may e.g. stem from an adjacent electrical current (Iadj) or magnetic particles. The detection system (100, 150) comprises at least one magneto resistive sensor element (102), a current controller (104) for providing a sensing current (Isense) flowing through the magnetic sensor element (102) and a controlling means (108). The controlling means (108) is adapted for deriving at a first frequency f1 a temperature-related parameter of the at least one magneto resistive sensor. The controlling means (108) furthermore is adapted for deriving a qualitative or quantitative characteristic of the adjacent electrical current (Iadj) or magnetic particles, taking into account the derived temperature-related parameter. This second frequency (f1) is different from the first frequency (f1}). The invention also relates to a corresponding method.
摘要翻译：描述了用于定性或定量检测调制磁场的磁场特性的检测系统（100,150）。调制磁场可以例如。来自相邻的电流（Iadj）或磁性颗粒。检测系统（100,150）包括至少一个磁阻传感器元件（102），用于提供流过磁传感器元件（102）的感测电流（Isense）的电流控制器（104）和控制装置（108）。控制装置（108）适于以第一频率f1导出至少一个磁阻传感器的温度相关参数。此外，控制装置（108）还适于导出相邻电流（Iadj）或磁性颗粒的定性或定量特性，同时考虑导出的温度相关参数。该第二频率（f1）与第一频率（f1）不同。本发明还涉及相应的方法。

4. 发明申请

US20080314749A1 Microelectronic Device with Magnetic Excitation Wires 审中-公开
标题翻译：具有励磁线的微电子器件
公开(公告)号：US20080314749A1
公开(公告)日：2008-12-25
申请号：US12159465
申请日：2006-10-25
申请人： Mark Thomas Johnson , Albert Hendrik Jan Immink , Marc Wilhelmus Gijsbert Ponjee , Mirielle Ann Reijme , Josephus Arnoldus Henricus Maria Kahlman , Jeroen Hans Nieuwenhuis , Bart Michiel De Boer
发明人： Mark Thomas Johnson , Albert Hendrik Jan Immink , Marc Wilhelmus Gijsbert Ponjee , Mirielle Ann Reijme , Josephus Arnoldus Henricus Maria Kahlman , Jeroen Hans Nieuwenhuis , Bart Michiel De Boer
IPC分类号： G01N27/26
CPC分类号： G01N33/54326 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2400/0415 , B01L2400/043 , G01N27/745 , G01N33/5438
摘要： The invention relates to a microelectronic device (200), particularly a magnetic biosensor, comprising B/E-electrodes (21) that can generate a magnetic field (B) in a sample chamber (10). The device further comprises E-electrodes (23, 24) that can generate an electrical field (E) in the sample chamber (10) in cooperation with the B/E-electrodes (21). Thus the B/E-electrodes are used for two purposes. Electrical fields (E) in the sample chamber (10) may particularly be used for pumping and/or mixing of a fluid sample or for a stringency test of particle bindings.
摘要翻译：本发明涉及一种微电子器件（200），特别是包括可在样品室（10）中产生磁场（B））的B / E电极（21）的磁性生物传感器。所述装置还包括可与所述B / E电极（21）配合地在样品室（10）中产生电场（E）的E电极（23,24）。因此，B / E电极用于两个目的。样品室（10）中的电场（E）可特别用于泵送和/或混合流体样品或用于颗粒结合的严格性测试。

5. 发明申请

US20080218165A1 Microsensor Device 审中-公开
标题翻译：微传感器装置
公开(公告)号：US20080218165A1
公开(公告)日：2008-09-11
申请号：US12065612
申请日：2006-09-07
申请人： Josephus Arnoldus Henricus Maria Kahlman , Bart Michiel De Boer , Albert Hendrik Jan Immink , Jeroen Hans Nieuwenhuis
发明人： Josephus Arnoldus Henricus Maria Kahlman , Bart Michiel De Boer , Albert Hendrik Jan Immink , Jeroen Hans Nieuwenhuis
IPC分类号： G01N27/72
CPC分类号： G01N33/54326 , G01N27/745
摘要： The invention relates to a microsensor device like a magnetic biosensor (100). The microsensor device comprises an array of probe-sensors (10.1, 10.2, 10.3) for the measurement of a physical quantity, for example the concentration of molecules labeled with magnetic beads in a sample chamber. The array further comprises a reference-sensor (10.4) that is disposed close to the probe-sensors (10.1, 10.2, 10.3) but shielded from the physical quantity to be measured. The measuring signal of the reference-sensor (10.4) reflects the influence of environmental conditions like temperature and can therefore be used to correct the measuring signals of the probe-sensors (10.1, 10.2, 10.3). The sensors (10.1, 10.2, 10.3, 10.4) are connected via a multiplexer to the same detector unit for further processing in order to minimize variations and to reduce hardware complexity.
摘要翻译：本发明涉及一种诸如磁性生物传感器（100）的微传感器装置。微传感器装置包括用于测量物理量的探针传感器阵列（10.1,10.2,10.3），例如在样品室中用磁珠标记的分子的浓度。该阵列还包括靠近探头传感器（10.1,10.2,10.3）设置但与被测量的物理量屏蔽的参考传感器（10.4）。参考传感器（10.4）的测量信号反映了诸如温度等环境条件的影响，因此可用于校正探头传感器（10.1,10.2,10.3）的测量信号。传感器（10.1,10.2,10.3,10.4）通过多路复用器连接到相同的检测器单元以进行进一步处理，以便最小化变化并降低硬件复杂度。

6. 发明授权

US07248194B2 Bit-detection arrangement and apparatus for reproducing information 失效
公开(公告)号：US07248194B2
公开(公告)日：2007-07-24
申请号：US10558712
申请日：2004-05-25
申请人： Albertus Johannes Antonius Rutten , Nicolaas Johannes Hendricus Maria Van Beurden , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink
发明人： Albertus Johannes Antonius Rutten , Nicolaas Johannes Hendricus Maria Van Beurden , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink
IPC分类号： H03M1/00
CPC分类号： G11B20/10037 , G11B20/10009 , G11B20/1403 , H03L7/07 , H03L7/0994 , H04L7/0029 , H04L7/0334
摘要： Disclosed is a bit-detection arrangement able to convert an analog signal (AS) having an amplitude into a digital signal (DS) representing a bit sequence from which the analog signal (AS) is derived. The bit-detection arrangement has a phase detector which detect the phase difference between a quantized analog signal and a clock signal C2. The phase difference is sampled by an AD converter. The AD converter can sample at a relatively slow rate as the phase difference is a low frequency signal. The sampled phase difference is fed to a digital PLL which outputs a phase signal PHI. The phase signal and the quantized analog signal are used to recreate the digital signal (DS). The current invention is characterized in that the bit decision unit further comprises—at least one additional sample and hold unit SH2 able to sample the output signal S1, using a clock signal CSH2 and wherein the frequency of the clock signal CSH2 is equal to the frequency of clock signal CSH1 and the phase of clock signal CSH2 is substantially different from the phase of clock signal CSH1, and an output unit for outputting samples of either the sample and hold units SH1 or SH2, wherein the samples of the sample and hold unit SH1 are outputted when the phase signal PH1 indicates that the phase difference ΔP1 is in a first region and the samples of the additional sample and hold unit SH2 are outputted when the phase signal PH1 indicates that the phase difference ΔP1 is in a second region. This has the advantage that the change of bit errors occurring in the presence of phase jitter is reduced.

7. 发明申请

US20090066318A1 SENSOR DEVICE WITH ALTERNATING EXCITATION FIELDS 审中-公开
标题翻译：带传动装置的传感器装置
公开(公告)号：US20090066318A1
公开(公告)日：2009-03-12
申请号：US12282889
申请日：2007-03-06
申请人： Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Haris Duric , Adrianus Johannes Maria Van Tuijl , Eugenio Cantatore , Hendrik Johannes Bergveld
发明人： Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Haris Duric , Adrianus Johannes Maria Van Tuijl , Eugenio Cantatore , Hendrik Johannes Bergveld
IPC分类号： G01N27/74
CPC分类号： G01N33/54333 , B82Y25/00 , G01N27/745 , G01N2446/00 , G01R33/09 , G01R33/093 , G01R33/12 , G01R33/1269
摘要： The invention relates to a magnetic sensor device comprising excitation wires (11, 13) for generating a magnetic excitation field and a magnetic sensor element, particularly a GMR sensor (12), for sensing magnetic fields generated by labeling particles in reaction to the excitation field. The magnetic excitation fields are generated with non-sinusoidal forms, particularly as square-waves, such that their spectral range comprises a plurality of frequency components. Magnetic particles with different magnetic response characteristics can then be differentiated according to their reactions to the different frequency components of the excitation fields. The magnetic excitation field and the sensing current driving the GMR sensor (12) are preferably generated with the help of ring modulators (22, 24). Moreover, ring modulators (27, 29) may be used for the demodulation of the sensor signal.
摘要翻译：本发明涉及一种包括用于产生磁场的激励线（11,13）和磁传感器元件（特别是GMR传感器）的磁传感器装置，用于感测通过与激发场反应来标记颗粒而产生的磁场。磁激励场以非正弦形式产生，特别是作为方波产生，使得它们的光谱范围包括多个频率分量。然后可以根据其对激发场的不同频率分量的反应来区分具有不同磁响应特性的磁性颗粒。驱动GMR传感器（12）的磁激励场和感测电流优选地通过环形调制器（22,24）的产生。此外，环形调制器（27,29）可以用于解调传感器信号。

8. 发明授权

US07535815B2 Disc drive apparatus 失效
标题翻译：盘驱动装置
公开(公告)号：US07535815B2
公开(公告)日：2009-05-19
申请号：US10539363
申请日：2003-12-02
申请人： Johannes Aldegonda Theodora Maria Van Den Homberg , Albert Hendrik Jan Immink , Bart Michiel De Boer
发明人： Johannes Aldegonda Theodora Maria Van Den Homberg , Albert Hendrik Jan Immink , Bart Michiel De Boer
IPC分类号： G11B7/00
CPC分类号： G11B7/126
摘要： An optical disc drive apparatus includes a laser device for generating a light beam for optically reading data from a disc. The laser device is electrically incorporated in a resonant circuit which includes an inductance coupled to the laser device.
摘要翻译：光盘驱动装置包括用于产生用于从盘读取数据的光束的激光装置。激光器件电连接在包括耦合到激光器件的电感的谐振电路中。

9. 发明授权

US07362690B2 Laser driver/method for generating a laser drive signal 失效
标题翻译：用于产生激光驱动信号的激光驱动器/方法
公开(公告)号：US07362690B2
公开(公告)日：2008-04-22
申请号：US10560678
申请日：2004-06-16
申请人： Bart Michiel De Boer , Johannes Aldegonda Theodora Maria Van Den Homberg , Albert Hendrik Jan Immink
发明人： Bart Michiel De Boer , Johannes Aldegonda Theodora Maria Van Den Homberg , Albert Hendrik Jan Immink
IPC分类号： G11B7/00
CPC分类号： G11B7/126 , G11B7/00456 , G11B7/0062 , H01S5/0427
摘要： A driver for driving a light generator for generating light, comprising a digitalto-analog converter (DAC) having a data input, a data output for generating an analog signal, a first multiplexer (MUX1) for cyclic selection of a number of data levels corresponding to desired intensity levels of the light and for coupling the data levels to the data input; a de multiplexer (DE-MUX) synchronized with the first multiplexer (MUX1) for de-multiplexing the analog signal into a set of analog signals; memory means for temporarily storing the set of analog signals; and a second multiplexer (MUX2) for selection of the stored set of analog signals and for generating a drive signal (IL) for the light generator. The memory means is preferably implemented by a set of capacitors (C1-C8). Usually, for instance in an optical disc drive, the light generator is implemented by a laser (Ls). In this situation the data input of the digital-to-analog converter comprises a threshold data input part; a delta data input part; a threshold gain reference input associated with the threshold data input part; and a delta gain reference input associated with the delta data input part. So in fact the DAC is split into two parts (DAC1 and DAC2) for separate threshold power and delta power control of the laser (LS).
摘要翻译：一种用于驱动用于产生光的光发生器的驱动器，包括具有数据输入的数模转换器（DAC），用于产生模拟信号的数据输出端，用于循环选择多个数据电平的第一多路复用器（MUX1）对应于光的期望强度水平并且用于将数据电平耦合到数据输入; 与多路复用器（DE-MUX）同步的第一多路复用器（MUX1），用于将模拟信号解复用为一组模拟信号; 用于临时存储该组模拟信号的存储装置; 和用于选择存储的模拟信号组并用于产生用于光发生器的驱动信号（IL）的第二多路复用器（MUX2）。存储装置优选地由一组电容器（C 1 -C 8）实现。通常，例如在光盘驱动器中，光发生器通过激光（L s）实现。在这种情况下，数模转换器的数据输入包括阈值数据输入部分; 增量数据输入部分; 与阈值数据输入部分相关联的阈值增益参考输入; 以及与增量数据输入部分相关联的增量增益参考输入。因此，事实上，DAC分为两部分（DAC 1和DAC 2），用于激光器（LS）的单独阈值功率和Δ功率控制。

10. 发明授权

US10092903B2 Multi-compartment device with magnetic particles 有权
公开(公告)号：US10092903B2
公开(公告)日：2018-10-09
申请号：US12809208
申请日：2008-12-16
申请人： Menno Willem Jose Prins , Joost Hubert Maas , Albert Hendrik Jan Immink , Dirkjan Bernhard Van Dam , Maatje Koets , Michel J. M. Bruyninckx , Thea Van Der Wijk , Marius Iosif Boamfa , Remco Den Dulk
发明人： Menno Willem Jose Prins , Joost Hubert Maas , Albert Hendrik Jan Immink , Dirkjan Bernhard Van Dam , Maatje Koets , Michel J. M. Bruyninckx , Thea Van Der Wijk , Marius Iosif Boamfa , Remco Den Dulk
IPC分类号： B01L3/00
摘要： The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles.

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