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1. 发明申请

US20080314749A1 Microelectronic Device with Magnetic Excitation Wires 审中-公开
标题翻译：具有励磁线的微电子器件
公开(公告)号：US20080314749A1
公开(公告)日：2008-12-25
申请号：US12159465
申请日：2006-10-25
申请人： Mark Thomas Johnson , Albert Hendrik Jan Immink , Marc Wilhelmus Gijsbert Ponjee , Mirielle Ann Reijme , Josephus Arnoldus Henricus Maria Kahlman , Jeroen Hans Nieuwenhuis , Bart Michiel De Boer
发明人： Mark Thomas Johnson , Albert Hendrik Jan Immink , Marc Wilhelmus Gijsbert Ponjee , Mirielle Ann Reijme , Josephus Arnoldus Henricus Maria Kahlman , Jeroen Hans Nieuwenhuis , Bart Michiel De Boer
IPC分类号： G01N27/26
CPC分类号： G01N33/54326 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2400/0415 , B01L2400/043 , G01N27/745 , G01N33/5438
摘要： The invention relates to a microelectronic device (200), particularly a magnetic biosensor, comprising B/E-electrodes (21) that can generate a magnetic field (B) in a sample chamber (10). The device further comprises E-electrodes (23, 24) that can generate an electrical field (E) in the sample chamber (10) in cooperation with the B/E-electrodes (21). Thus the B/E-electrodes are used for two purposes. Electrical fields (E) in the sample chamber (10) may particularly be used for pumping and/or mixing of a fluid sample or for a stringency test of particle bindings.
摘要翻译：本发明涉及一种微电子器件（200），特别是包括可在样品室（10）中产生磁场（B））的B / E电极（21）的磁性生物传感器。所述装置还包括可与所述B / E电极（21）配合地在样品室（10）中产生电场（E）的E电极（23,24）。因此，B / E电极用于两个目的。样品室（10）中的电场（E）可特别用于泵送和/或混合流体样品或用于颗粒结合的严格性测试。

2. 发明申请

US20080278156A1 Sensor Device With Generator and Sensor Current Sources 审中-公开
标题翻译：带发生器和传感器电流源的传感器装置
公开(公告)号：US20080278156A1
公开(公告)日：2008-11-13
申请号：US12067316
申请日：2006-09-12
申请人： Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
发明人： Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
IPC分类号： G01R33/00
CPC分类号： G01R33/093 , B82Y25/00 , G01R33/1269
摘要： The invention relates to a magnetic sensor device (10) comprising wires (11, 13) for the generation of a magnetic field and a magnetic sensor element (12), for example a GMR (12), for sensing changes of the generated magnetic field caused by magnetic particles (2). The wires (11, 13) and the magnetic sensor element (12) are supplied with alternating currents (I1, I2) of high frequencies f1 and f2. Said frequencies are chosen such that their difference Δf=æf2−f1æ is low and lies in a range of thermal white noise above the 1/f noise of an amplifier (24) and below the 1/f noise of the GMR (12). In this way it is possible to use a high-frequency magnetic field while only low frequency signals have to be processed.
摘要翻译：本发明涉及一种磁传感器装置（10），其包括用于产生磁场的导线（11,13）和用于感测所产生的磁场的变化的磁传感器元件（12），例如GMR（12）由磁性颗粒（2）引起。电线（11,13）和磁性传感器元件（12）被提供有高频f 1和f 2的交流电流（I 1，I 2）。所述频率被选择为使得它们的差值Deltaf = aef 2 -f 1 ae为低，并且位于高于放大器（24）的1 / f噪声并低于GMR的1 / f噪声的热白噪声范围（ 12）。以这种方式，可以使用高频磁场，而只需要处理低频信号。

3. 发明申请

US20080129286A1 Means and Method for Reducing Magnetic Cross-Talk in Biosensors 失效
标题翻译：减少生物传感器中磁交互的手段和方法
公开(公告)号：US20080129286A1
公开(公告)日：2008-06-05
申请号：US11719955
申请日：2005-11-28
申请人： Josephus Arnoldus Henricus Maria Kahlman , Bart Michiel De Boer
发明人： Josephus Arnoldus Henricus Maria Kahlman , Bart Michiel De Boer
IPC分类号： G01N27/72
CPC分类号： G01R33/093 , B82Y25/00 , G01R33/1269
摘要： A magnetic sensor (MS) for sensing a magnetic stray field (SF) generated by magnetizable object (SPB) when magnetized and for generating an electrical object signal (UOB) which depends on the sensed magnetic stray field (SF), comprising a magnetic field generator (WR1, WR2) for generating a magnetic main field (H) for magnetizing the magnetizable object (SPB), and cross-talk reduction means for reducing the effect of a cross talk signal component in the electrical object signal (UOB) caused by magnetic cross-talk between the magnetic main field (H) and the magnetic stray field (SF), wherein the cross-talk reduction means is arranged for distinguishing a signal property between the cross-talk signal component and the remaining part of the electrical object signal (UOB) and for generating an electrical output signal (Uo).
摘要翻译：一种磁传感器（MS），用于感测磁化物体（SPB）产生的磁性杂散场（SF），当被磁化并产生取决于感测的磁性杂散场的电气对象信号（U OB OB）时（SF），包括用于产生用于磁化可磁化物体（SPB）的磁性主场（H）的磁场发生器（WR 1，W 2），并且交叉 - 减小装置，用于降低由磁性主场（H）和磁性杂散场（H）和磁性杂散场（H）之间的磁场串扰引起的电气对象信号（U OB OB）中串扰信号分量的影响 SF），其中所述串扰降低装置被布置用于区分串扰信号分量与电对象信号的剩余部分（U OB OB）之间的信号特性，并用于产生电输出信号（U o）。

4. 发明授权

US08797028B2 Sensor device for target particles in a sample 有权
标题翻译：样品中目标颗粒的传感器装置
公开(公告)号：US08797028B2
公开(公告)日：2014-08-05
申请号：US12738317
申请日：2008-10-21
申请人： Coen Adrianus Johannes Verschuren , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Mischa Megens , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
发明人： Coen Adrianus Johannes Verschuren , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Mischa Megens , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
IPC分类号： G01R33/02 , G01N33/00 , G01N21/55
CPC分类号： G01N15/06 , G01N15/0656 , G01N2015/0693 , G01R33/1269
摘要： A sensor device and a method for the determination of the amount of target particles at a contact surface adjacent to a sample chamber include detecting, by a detector, the target particles in the sample chamber by a sensor element, and providing at least one corresponding sensor signal. An evaluation unit determines the amount of target particles in a first zone at the contracts surface and in a second zone a distance away from the contact surface based on this sensor signal. In an optical measurement approach, frustrated total internal reflection taking place under different operating conditions, such as wavelength and/or angle of incidence, may be used to extract information about the first and second zones. In a magnetic measurement approach, different magnetic excitation fields may be used to excite magnetic target particles differently in the first and second zone.
摘要翻译：用于确定与样品室相邻的接触表面处的目标颗粒的量的传感器装置和方法包括通过检测器通过传感器元件检测样品室中的目标颗粒，并且提供至少一个相应的传感器信号。评估单元基于该传感器信号确定在合同表面处的第一区域中的目标颗粒的量和距接触表面一定距离的第二区域中的目标颗粒的量。在光学测量方法中，可以使用在诸如波长和/或入射角的不同操作条件下发生的沮丧的全内反射来提取关于第一和第二区域的信息。在磁测量方法中，可以使用不同的磁激励场来在第一和第二区域中不同地激励磁性目标颗粒。

5. 发明授权

US08774906B2 Apparatus, method and computer program for determining a property of a heart 有权
标题翻译：用于确定心脏特性的装置，方法和计算机程序
公开(公告)号：US08774906B2
公开(公告)日：2014-07-08
申请号：US13319849
申请日：2010-05-10
申请人： Godefridus Antonius Harks , Szabolcs Deladi , Bart Michiel De Boer , Maya Ella Barley , Jan Frederik Suijver
发明人： Godefridus Antonius Harks , Szabolcs Deladi , Bart Michiel De Boer , Maya Ella Barley , Jan Frederik Suijver
IPC分类号： A61B5/0452
CPC分类号： A61B5/1107 , A61B5/0073 , A61B5/0084 , A61B5/0507 , A61B5/053 , A61B5/061 , A61B5/062 , A61B5/6852 , A61B8/12 , A61B8/445 , A61B18/02 , A61B18/1492 , A61B18/18 , A61B90/39 , A61B2017/00106 , A61B2218/002 , A61B2562/0209
摘要： The present invention relates to an apparatus for determining a property of a heart. The apparatus comprises a catheter (5), which comprises a first property sensing unit for sensing a contraction signal indicative of a reoccurring local contraction of the heart (2) at a sensing site of the heart (2). The apparatus further comprises a first property determining unit (8) for determining the reoccurring local contraction of the heart (2) at the sensing site from the sensed contraction signal as a first property of the heart (2). The reoccurring local contraction provides information about the heart (2), which can be used for a better and/or more reliable characterization of the heart (2).
摘要翻译：本发明涉及一种用于确定心脏特性的装置。该装置包括导管（5），其包括第一特性感测单元，用于感测指示在心脏（2）的感测位置处心脏（2）的再次出现的局部收缩的收缩信号。该装置还包括第一属性确定单元（8），用于根据感测到的收缩信号确定心脏（2）在感测位置处的再次出现的局部收缩，作为心脏（2）的第一属性。复发的局部收缩提供了关于心脏（2）的信息，其可以用于更好和/或更可靠地表征心脏（2）。

6. 发明申请

US20110204902A1 DEVICE FOR MEASURING A FLUID MENISCUS 有权
标题翻译：用于测量流体肉汁的装置
公开(公告)号：US20110204902A1
公开(公告)日：2011-08-25
申请号：US13126035
申请日：2009-10-27
申请人： Bart Michiel De Boer , Thomas Jan De Hoog , Theodorus Petrus Henricus Gerardus Jansen
发明人： Bart Michiel De Boer , Thomas Jan De Hoog , Theodorus Petrus Henricus Gerardus Jansen
IPC分类号： G01R27/26
CPC分类号： G01B7/28 , G01R27/2605 , G02B26/005
摘要： The invention relates to a device (102) arranged for measuring a geometry of a fluid meniscus (132). The device comprises a fluid chamber (104) storing a first electrically conductive fluid (128) and a second electrically insulating fluid (324). The fluids are mutually immiscible and define a fluid meniscus (132) in between them. Furthermore a main electrowetting electrode (118) and auxiliary electrowetting electrodes (120, 122, 124, 126) are provided for controlling the geometry of the fluid meniscus. Hereto a voltage source (134) for providing a voltage between the main electrowetting electrode and the auxiliary electrowetting electrodes is comprised, as well as a measurement circuit (144) for separately measuring capacitances between the main electrowetting electrode and at least two of the auxiliary electrowetting electrodes. For this purpose the measurement circuit comprises a multiplexer for demodulating a signal indicative for said capacitances. The invention further relates to a method for measuring a fluid meniscus.
摘要翻译：本发明涉及一种被设置用于测量流体弯液面（132）的几何形状的装置（102）。该装置包括存储第一导电流体（128）和第二电绝缘流体（324）的流体室（104）。流体是相互不混溶的并且在它们之间限定流体弯液面（132）。此外，提供主电润湿电极（118）和辅助电润湿电极（120,122,124,126）以控制流体弯液面的几何形状。包括用于在主电润湿电极和辅助电润湿电极之间提供电压的电压源（134），以及用于分别测量主电润湿电极与至少两个辅助电润湿之间的电容的测量电路（144）电极。为此，测量电路包括用于解调指示所述电容的信号的多路复用器。本发明还涉及一种用于测量流体弯液面的方法。

7. 发明申请

US20100259254A1 SENSOR DEVICE FOR TARGET PARTICLES IN A SAMPLE 有权
标题翻译：传感器装置在样品中的目标颗粒
公开(公告)号：US20100259254A1
公开(公告)日：2010-10-14
申请号：US12738317
申请日：2008-10-21
申请人： Coen Adrianus Johannes Verschuren , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Mischa Megens , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
发明人： Coen Adrianus Johannes Verschuren , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Mischa Megens , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
IPC分类号： G01R33/02 , G01N33/00 , G01N21/55
CPC分类号： G01N15/06 , G01N15/0656 , G01N2015/0693 , G01R33/1269
摘要： The invention relates to a sensor device (100) and a method for the determination of the amount of target particles (1) at a contact surface (112) adjacent to a sample chamber (2). Target particles (1) in the sample chamber are detected by a sensor element (SE) and at least one corresponding sensor-signal (s, s′) is provided. An evaluation unit (EU) then determines the amount of target particles (1) in a first zone (Z1) immediately at the contracts surface (112) and a second zone (Z2) a distance (z) away from the contact surface based on this sensor-signal. In an optical measurement approach, frustrated total internal reflection taking place under different operating conditions (e.g. wavelength, angle of incidence) may be used to extract information about the first and second zones (Z1, Z2). In a magnetic measurement approach, different magnetic excitation fields may be used to excite magnetic target particles differently in the first and second zone (Z2). Moreover, the temporal course of a sensor-signal (s, s′) can be evaluated, particularly with respect to stochastic movements of the target particles (1).
摘要翻译：本发明涉及一种传感器装置（100）和用于确定在与样品室（2）相邻的接触表面（112）处的目标颗粒（1）的量的方法。通过传感器元件（SE）检测样品室中的目标颗粒（1），并提供至少一个对应的传感器信号（s，s'）。然后，评估单元（EU）基于紧接表面（112）立即确定第一区域（Z1）中的目标颗粒（1）的数量和远离接触表面的距离（z）的第二区域（Z2），基于这个传感器信号。在光学测量方法中，可以使用在不同操作条件（例如波长，入射角）下发生的沮丧的全内反射来提取关于第一和第二区（Z1，Z2）的信息。在磁测量方法中，可以使用不同的磁激励场来在第一和第二区（Z2）中不同地激励磁目标颗粒。此外，可以评估传感器信号（s，s'）的时间过程，特别是关于目标颗粒（1）的随机运动。

8. 发明申请

US20090224755A1 MEANS AND METHOD FOR SENSING A MAGNETIC STRAY FIELD IN BIOSENSORS 审中-公开
标题翻译：用于感应生物传感器中磁场的方法和方法
公开(公告)号：US20090224755A1
公开(公告)日：2009-09-10
申请号：US11719953
申请日：2005-11-28
申请人： Josephus Arnoldus Henricus Maria Kahlman , Bart Michiel De Boer
发明人： Josephus Arnoldus Henricus Maria Kahlman , Bart Michiel De Boer
IPC分类号： G01R33/09
CPC分类号： G01R33/093 , B82Y25/00 , G01R33/1269
摘要： A magnetic sensor (MS) comprising a magneto-resistive element (GMR) for sensing a magnetic stray field (SF) generated by a magnetizable object (SPB) when magnetized and for generating an electrical object signal (UOB) which depends on the sensed magnetic stray field (SF), the sensor (MS) comprising a magnetic field generator (WR1, WR2) for generating a magnetic field (H, Hext) having a first frequency (ω1) for magnetizing the magnetizable object (SPB), a current source (AC2) for at least generating an AC-current (I2 sin ω2t) having a second frequency (ω2t) through the magneto-resistive element (GMR), and electronic means for generating an electrical output signal (U0) derived from the electrical object signal (UOB), the electronic means comprising stabilization means for stabilizing the amplitude of the electrical output signal (U0), the stabilization means deriving its information which is needed for said stabilization from the amplitude of a signal component, which is present in the object signal (UOB) during operation, which is linearly dependent on the steepness of the magneto-resistive element (GMR), the steepness being defined as the derivative of the resistance of the magneto-resistive element (GMR) as a function of the magnetic field through the magneto-resistive element in a magnetically sensitive direction of the magneto-resistive element (GMR).
摘要翻译：一种磁传感器（MS），包括用于感测由磁化物体（SPB）产生的磁性杂散场（SFB）的磁阻元件（GMR），并且用于产生取决于感测的磁性的电物体信号（UOB）杂散场（SF），包括用于产生具有用于磁化可磁化物体（SPB）的第一频率（ω））的磁场（H，Hext）的磁场发生器（WR1，WR2）的传感器（MS），电流源（AC2），用于至少通过磁阻元件（GMR）产生具有第二频率（ω）的AC电流（I2sinω2t），以及用于产生从电气对象导出的电输出信号（U0）的电子装置信号（UOB），所述电子装置包括用于稳定电输出信号（U0）的振幅的稳定装置，稳定装置从信号分量的幅度导出所述稳定所需的信息，该信号是预先在操作期间发送在对象信号（UOB）中，其与磁阻元件（GMR）的陡度线性相关，陡度被定义为作为功能的磁阻元件（GMR）的电阻的导数通过磁阻元件在磁阻元件（GMR）的磁敏感方向上的磁场。

9. 发明授权

US07535815B2 Disc drive apparatus 失效
标题翻译：盘驱动装置
公开(公告)号：US07535815B2
公开(公告)日：2009-05-19
申请号：US10539363
申请日：2003-12-02
申请人： Johannes Aldegonda Theodora Maria Van Den Homberg , Albert Hendrik Jan Immink , Bart Michiel De Boer
发明人： Johannes Aldegonda Theodora Maria Van Den Homberg , Albert Hendrik Jan Immink , Bart Michiel De Boer
IPC分类号： G11B7/00
CPC分类号： G11B7/126
摘要： An optical disc drive apparatus includes a laser device for generating a light beam for optically reading data from a disc. The laser device is electrically incorporated in a resonant circuit which includes an inductance coupled to the laser device.
摘要翻译：光盘驱动装置包括用于产生用于从盘读取数据的光束的激光装置。激光器件电连接在包括耦合到激光器件的电感的谐振电路中。

10. 发明授权

US07508200B2 Means and method for reducing magnetic cross-talk in biosensors 失效
标题翻译：用于减少生物传感器中磁串扰的方法和方法
公开(公告)号：US07508200B2
公开(公告)日：2009-03-24
申请号：US11719955
申请日：2005-11-28
申请人： Josephus Arnoldus Henricus Maria Kahlman , Bart Michiel De Boer
发明人： Josephus Arnoldus Henricus Maria Kahlman , Bart Michiel De Boer
IPC分类号： G01N27/72 , G01R33/12 , G01R33/02 , C12M1/34
CPC分类号： G01R33/093 , B82Y25/00 , G01R33/1269
摘要： A magnetic sensor (MS) for sensing a magnetic stray field (SF) generated by magnetizable object (SPB) when magnetized and for generating an electrical object signal (UOB) which depends on the sensed magnetic stray field (SF), comprising a magnetic field generator (WR1, WR2) for generating a magnetic main field (H) for magnetizing the magnetizable object (SPB), and cross-talk reduction means for reducing the effect of a cross talk signal component in the electrical object signal (UOB) caused by magnetic cross-talk between the magnetic main field (H) and the magnetic stray field (SF), wherein the cross-talk reduction means is arranged for distinguishing a signal property between the cross-talk signal component and the remaining part of the electrical object signal (UOB) and for generating an electrical output signal (Uo).
摘要翻译：一种磁传感器（MS），用于感测由磁化物体（SPB）产生的磁性杂散场（SF），并且用于产生取决于感测的磁性杂散场（SF）的电对象信号（UOB），该电对象信号包括磁场用于产生用于磁化可磁化物体（SPB）的磁性主场（H）的发生器（WR1，WR2）以及用于降低由电子对象信号（UOB）引起的串扰信号分量对其的影响的串扰降低装置在磁主场（H）和磁杂散场（SF）之间的磁串扰，其中串扰减少装置被设置用于区分串扰信号分量和电气对象的剩余部分之间的信号特性信号（UOB）和用于产生电输出信号（Uo）。

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