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1. 发明授权

US10488408B2 Detection of target molecules in a sample by using a magnetic field 有权
公开(公告)号：US10488408B2
公开(公告)日：2019-11-26
申请号：US12299806
申请日：2007-04-27
申请人： Thea Van Der Wijk , Eduard Gerard Marie Pelssers , Jessica Amadio
发明人： Thea Van Der Wijk , Eduard Gerard Marie Pelssers , Jessica Amadio
IPC分类号： G01N33/543 , G01N27/74
CPC分类号： G01N33/54333 , G01N27/745 , G01N2446/00
摘要： The application relates to a method for detecting a target in a sample suspected of containing the target. The method comprises contacting the sample and a first binding molecule attached to a magnetic particle with a second binding molecule attached to a solid support. The first binding molecule is capable of binding to the second binding molecule, and the target is capable of interfering with this binding. Magnetic force is applied to bring the magnetic particle into close proximity with the solid support. The number of magnetic particles bound to the solid support is detected.

2. 发明授权

US09778254B2 Methods and systems for detecting 有权
公开(公告)号：US09778254B2
公开(公告)日：2017-10-03
申请号：US12669217
申请日：2008-07-18
申请人： Femke Karina De Theije , Thea Van Der Wijk , Albert Hendrik Jan Immink , Eduard Gerard Marie Pelssers , Wilhelmina Maria Hardeman , Sandra Marlin , Gordon Thomas Jowett
发明人： Femke Karina De Theije , Thea Van Der Wijk , Albert Hendrik Jan Immink , Eduard Gerard Marie Pelssers , Wilhelmina Maria Hardeman , Sandra Marlin , Gordon Thomas Jowett
IPC分类号： G01N27/74 , G01N33/543
CPC分类号： G01N33/54366 , G01N27/745 , Y10T29/49885
摘要： A system and method wherein components of a reagent such as labeled antibodies are separated from a biologically active sensor surface by depositing the reagent on a carrier surface distinct from a sensor surface in a detection region. The present device provides a short, well-defined and controlled, pre-incubation time between the particles of interest in the sample fluid and the reagent, thereby increasing the reproducibility by providing all components in one detection region such as a detection chamber.

3. 发明授权

US09658219B2 Microelectronic sensor device for detecting label particles 有权
公开(公告)号：US09658219B2
公开(公告)日：2017-05-23
申请号：US12518164
申请日：2007-12-10
申请人： Coen Adrianus Verschuren , Dominique Maria Bruls , Albert Hendrik Jan Immink , Femke Karina De Theije , Thea Van Der Wijk , Alexander Marc Van Der Lee , Johannes Joseph Hubertina Barbara Schleipen
发明人： Coen Adrianus Verschuren , Dominique Maria Bruls , Albert Hendrik Jan Immink , Femke Karina De Theije , Thea Van Der Wijk , Alexander Marc Van Der Lee , Johannes Joseph Hubertina Barbara Schleipen
IPC分类号： G01N21/552 , G01N21/64 , G01N33/543 , G01N27/74 , G01N21/39
CPC分类号： G01N33/543 , G01N21/552 , G01N21/553 , G01N21/6428 , G01N21/6452 , G01N21/648 , G01N27/745 , G01N33/54306 , G01N33/54386 , Y10S436/00
摘要： A microelectronic sensor device for the detection of target components with label or magnetic particles includes a carrier with a binding surface at which target components can collect and optionally bind to specific capture elements. An input light beam is transmitted into the carrier and totally internally reflected at the binding surface. The amount of light in the output light beam is detected by a light detector. Evanescent light generated during the total internal reflection is affected by target components and/or label particles at the binding surface and will be missing in the output light beam. This is used to determine the amount of target components at the binding surface from the amount of light in the output light beam. A magnetic field generator is optionally used to generate a magnetic field at the binding surface by which magnetic label particles can be manipulated, such as attracted or repelled.

4. 发明授权

US09128084B2 Fast biosensor with reagent layer 有权
标题翻译：快速生物传感器与试剂层
公开(公告)号：US09128084B2
公开(公告)日：2015-09-08
申请号：US12444696
申请日：2007-10-10
申请人： Menno Willem Jose Prins , Thea Van Der Wijk
发明人： Menno Willem Jose Prins , Thea Van Der Wijk
IPC分类号： G01N21/00 , G01N33/558 , G01N21/64 , G01N21/65
CPC分类号： G01N33/558 , G01N21/6428 , G01N21/658
摘要： A detection system (100) and a sensor chip (1) for detecting target molecules, and thus corresponding analytes in a sample is described. Typically the detection system (100) includes a sensor chip (1). The sensor chip (1) comprises on its detection surface (33) a dissolvable reagent layer (5). When the dissolvable reagent layer (5) is in contact with sample fluid, free reagent is generated, assisting in the interaction between a label and target molecules, thus allowing for label based detection. The sample thereby is exposed to mobile reagents in a burst. The reagent layer may contain an enzyme allowing enzymatic assays.
摘要翻译：描述了用于检测目标分子的检测系统（100）和传感器芯片（1），并因此检测样品中相应的分析物。通常，检测系统（100）包括传感器芯片（1）。传感器芯片（1）在其检测表面（33）上包含可溶解的试剂层（5）。当可溶解试剂层（5）与样品流体接触时，产生游离试剂，有助于标记物与目标分子之间的相互作用，从而允许基于标签的检测。由此将样品暴露于移动试剂中。试剂层可以含有允许酶分析的酶。

5. 发明申请

US20100273142A1 MULTI-COMPARTMENT DEVICE WITH MAGNETIC PARTICLES 审中-公开
标题翻译：具有磁性颗粒的多间隔装置
公开(公告)号：US20100273142A1
公开(公告)日：2010-10-28
申请号：US12809208
申请日：2008-12-16
申请人： Menno Willem Jose Prins , Joost Hubert Maas , Albert Hendrik Jan Immink , Dirkjan Bernhard Van Dam , Maatje Koets , Michel J.M. Bruyninckx , Thea Van Der Wijk , Marius losif Boamfa , Remco Den Dulk
发明人： Menno Willem Jose Prins , Joost Hubert Maas , Albert Hendrik Jan Immink , Dirkjan Bernhard Van Dam , Maatje Koets , Michel J.M. Bruyninckx , Thea Van Der Wijk , Marius losif Boamfa , Remco Den Dulk
IPC分类号： C12Q1/00 , G01N33/553 , G01N33/53
CPC分类号： B01L3/502738 , B01L2200/0647 , B01L2300/089 , B01L2300/161 , B01L2400/043 , B01L2400/0688 , B01L2400/088
摘要： The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles.
摘要翻译：本发明公开了具有阀状结构（3）的微流体装置，通过该微流体装置可以以最少的流体输送运输磁性颗粒。这允许顺序处理磁性颗粒。

6. 发明申请

US20100253323A1 MAGNETIC WASHING FOR BIOSENSOR 审中-公开
标题翻译：生物传感器的磁性清洗
公开(公告)号：US20100253323A1
公开(公告)日：2010-10-07
申请号：US12746182
申请日：2008-12-04
申请人： Femke Karina De Theije , Dominique Maria Bruls , Thea Van Der Wijk , Coen Adrianus Verschuren , Albert Hendrik Jan Immink
发明人： Femke Karina De Theije , Dominique Maria Bruls , Thea Van Der Wijk , Coen Adrianus Verschuren , Albert Hendrik Jan Immink
IPC分类号： G01N27/74
CPC分类号： G01N33/54326 , G01N21/552 , G01N21/648 , G01N27/745
摘要： Detecting magnetized or magnetizable target components in a fluid containing the magnetized or magnetizable target components amongst other magnetized or magnetizable components, uses a magnetic field generator (M1, 28) to attract the magnetized or magnetizable components towards a binding surface. A magnetic field controller (C1) applies the magnetic field to concentrate the magnetized or magnetizable components in columns on the binding surface, subsequently reduces the magnetic field to enable the columns to collapse, to allow more components to reach the binding surface, and reapplies the magnetic field so as to cause other components to be pulled off the binding surface to reform columns based on the bound target components. A surface sensitive sensor (S1, 26, 29) detects the bound magnetized or magnetizable target components. The reapplication of the magnetic field acts as a magnetic washing step to release unwanted aspecific adsorption binding, leaving the targets, to improve sensitivity with simplified hardware and a reduction in cost and size.
摘要翻译：检测包含磁化或可磁化的目标部件的流体中的磁化或可磁化的目标部件在其他磁化或可磁化部件之间，使用磁场发生器（M1,28）将磁化或可磁化的部件吸引到装订表面。磁场控制器（C1）施加磁场以将磁化的或可磁化的组件在列中集中在结合表面上，随后减小磁场以使柱能够塌陷，以允许更多的部件到达结合表面，并重新应用磁场，以便使其他组分从结合表面上拉出，以便根据结合的目标组分重新制备柱。表面敏感传感器（S1,26,29）检测结合的磁化或可磁化的目标部件。磁场的重新应用充当磁性洗涤步骤以释放不期望的特异性吸附结合，留下目标，以通过简化的硬件提高灵敏度并降低成本和尺寸。

7. 发明申请

US20110050215A1 SYSTEM FOR APPLYING MAGNETIC FORCES TO A BIOSENSOR SURFACE BY MECHANICALLY MOVING AT LEAST ONE MAGNET 审中-公开
标题翻译：通过机械移动至少一个磁体将磁力施加到生物传感器表面的系统
公开(公告)号：US20110050215A1
公开(公告)日：2011-03-03
申请号：US12517863
申请日：2007-12-07
申请人： Josephus Arnoldus Henricus Maria Kahlmann , Albert Hendrik Jan Immink , Jeroen Hans Jeroen , Thea Van Der Wijk , Femke Karina De Theije
发明人： Josephus Arnoldus Henricus Maria Kahlmann , Albert Hendrik Jan Immink , Jeroen Hans Jeroen , Thea Van Der Wijk , Femke Karina De Theije
IPC分类号： G01R33/02
CPC分类号： G01N27/745 , G01N33/54333 , G01N35/0098 , H01F7/0273
摘要： A magnetic system for biosensors or a biosystem, wherein magnetic particles that interact with molecules are brought into a magnetic field, in order to be influenced via magnetic attraction or repulsion forces. The external magnetic field is varied by mechanically moving the magnetic poles of at least one magnetic relative to the sensor or at least its surface to allow the magnetic force to be switched between effective attraction towards the sensor surface and effective repulsion away from the sensor surface.
摘要翻译：用于生物传感器或生物系统的磁系统，其中与分子相互作用的磁性颗粒进入磁场，以便通过磁吸引力或排斥力影响。外部磁场通过相对于传感器或至少其表面机械地移动至少一个磁体的磁极来改变，以允许在对传感器表面的有效吸引力和远离传感器表面的有效排斥之间切换磁力。

8. 发明申请

US20100297780A1 METHODS AND SYSTEMS FOR DETECTING 有权
标题翻译：检测方法和系统
公开(公告)号：US20100297780A1
公开(公告)日：2010-11-25
申请号：US12669217
申请日：2008-07-18
申请人： Femke Karina De Theije , Thea Van Der Wijk , Albert Hendrik Jan Immink , Eduard Gerard Marie Pelssers , Wilhelmina Maria Hardeman , Sandra Marlin , Gordon Thomas Jowett
发明人： Femke Karina De Theije , Thea Van Der Wijk , Albert Hendrik Jan Immink , Eduard Gerard Marie Pelssers , Wilhelmina Maria Hardeman , Sandra Marlin , Gordon Thomas Jowett
IPC分类号： G01N33/553 , G01N30/96 , B23P25/00
CPC分类号： G01N33/54366 , G01N27/745 , Y10T29/49885
摘要： A system and method is described wherein components of the reagent (4), e.g. labelled antibodies, are separated from the biologically active sensor surface (5) by depositing the reagent (4) on a carrier surface (3) distinct from the sensor surface (5) in the detection region (2), e.g. detection chamber. In this way, a high assay reproducibility is obtained. By allowing a short, well-defined and controlled, pre-incubation time between the particles of interest, e.g. drugs, in the sample fluid (20) and the reagent (4), the reproducibility will be increased, whereas the speed of the assay is guaranteed by having all components in one detection region (2), e.g. detection chamber.
摘要翻译：描述了一种系统和方法，其中试剂（4）的组分例如。通过将试剂（4）沉积在与检测区域（2）中的传感器表面（5）不同的载体表面（3）上，例如从生物活性传感器表面（5）分离。检测室。以这种方式，获得高的测定重现性。通过在感兴趣的颗粒之间允许短的，明确的和受控的预孵育时间，例如。药物在样品液体（20）和试剂（4）中的重现性将会增加，而测定的速度则通过在一个检测区域（2）中具有所有成分来保证。检测室。

9. 发明申请

US20100092996A1 MICROELECTRONIC SENSOR DEVICE FOR DETECTING LABEL PARTICLES 有权
标题翻译：用于检测标签颗粒的微电子传感器装置
公开(公告)号：US20100092996A1
公开(公告)日：2010-04-15
申请号：US12518164
申请日：2007-12-10
申请人： Coen Adrianus Verschuren , Dominique Maria Bruls , Albert Hendrik Jan Immink , Femke Karina De Theije , Thea Van Der Wijk , Alexander Marc Van Der Lee , Johannes Joseph Hubertina Barbara Schleipen
发明人： Coen Adrianus Verschuren , Dominique Maria Bruls , Albert Hendrik Jan Immink , Femke Karina De Theije , Thea Van Der Wijk , Alexander Marc Van Der Lee , Johannes Joseph Hubertina Barbara Schleipen
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： G01N33/543 , G01N21/552 , G01N21/553 , G01N21/6428 , G01N21/6452 , G01N21/648 , G01N27/745 , G01N33/54306 , G01N33/54386 , Y10S436/00
摘要： The invention relates to a microelectronic sensor device for the detection of target components that comprise label particles, for example magnetic particles (1). The sensor device comprises a carrier (11) with a binding surface (12) at which target components can collect and optionally bind to specific capture elements. An input light beam (L1) is transmitted into the carrier and totally internally reflected at the binding surface (12). The amount of light in the output light beam (L2) and optionally also of fluorescence light emitted by target components at the binding surface is then detected by a light detector (31). Evanescent light generated during the total internal reflection is affected (absorbed, scattered) by target components and/or label particles (1) at the binding surface (12) and will therefore be missing in the output light beam (L2). This can be used to determine the amount of target components at the binding surface (12) from the amount of light in the output light beam (L2, L2a, L2b). A magnetic field generator (41) is optionally used to generate a magnetic field (B) at the binding surface (12) by which magnetic label particles (1) can be manipulated, for example 15 attracted or repelled.
摘要翻译：本发明涉及用于检测包含标签颗粒（例如磁性颗粒（1））的目标组分的微电子传感器装置。传感器装置包括具有结合表面（12）的载体（11），靶组分可以收集并任选地结合到特定的捕获元件。输入光束（L1）被传输到载体中并在结合表面（12）处全反射。由光检测器（31）检测输出光束（L2）中的光量以及可选地由结合表面上的目标成分发出的荧光。在全内反射期间产生的渐消光在目标部件和/或粘合表面（12）处的标签颗粒（1）受到影响（吸收，散射），因此在输出光束（L2）中将被丢失。这可以用于根据输出光束（L2，L2a，L2b）中的光量来确定结合表面（12）处的目标成分的量。可选地使用磁场发生器（41）来在绑定表面（12）处产生磁场（B），通过该磁场可以操纵磁性标签颗粒（1），例如15被吸引或排斥。

10. 发明授权

US10092903B2 Multi-compartment device with magnetic particles 有权
公开(公告)号：US10092903B2
公开(公告)日：2018-10-09
申请号：US12809208
申请日：2008-12-16
申请人： Menno Willem Jose Prins , Joost Hubert Maas , Albert Hendrik Jan Immink , Dirkjan Bernhard Van Dam , Maatje Koets , Michel J. M. Bruyninckx , Thea Van Der Wijk , Marius Iosif Boamfa , Remco Den Dulk
发明人： Menno Willem Jose Prins , Joost Hubert Maas , Albert Hendrik Jan Immink , Dirkjan Bernhard Van Dam , Maatje Koets , Michel J. M. Bruyninckx , Thea Van Der Wijk , Marius Iosif Boamfa , Remco Den Dulk
IPC分类号： B01L3/00
摘要： The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles.

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