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    • 6. 发明申请
    • MAGNETIC WASHING FOR BIOSENSOR
    • 生物传感器的磁性清洗
    • US20100253323A1
    • 2010-10-07
    • US12746182
    • 2008-12-04
    • Femke Karina De TheijeDominique Maria BrulsThea Van Der WijkCoen Adrianus VerschurenAlbert Hendrik Jan Immink
    • Femke Karina De TheijeDominique Maria BrulsThea Van Der WijkCoen Adrianus VerschurenAlbert Hendrik Jan Immink
    • G01N27/74
    • G01N33/54326G01N21/552G01N21/648G01N27/745
    • Detecting magnetized or magnetizable target components in a fluid containing the magnetized or magnetizable target components amongst other magnetized or magnetizable components, uses a magnetic field generator (M1, 28) to attract the magnetized or magnetizable components towards a binding surface. A magnetic field controller (C1) applies the magnetic field to concentrate the magnetized or magnetizable components in columns on the binding surface, subsequently reduces the magnetic field to enable the columns to collapse, to allow more components to reach the binding surface, and reapplies the magnetic field so as to cause other components to be pulled off the binding surface to reform columns based on the bound target components. A surface sensitive sensor (S1, 26, 29) detects the bound magnetized or magnetizable target components. The reapplication of the magnetic field acts as a magnetic washing step to release unwanted aspecific adsorption binding, leaving the targets, to improve sensitivity with simplified hardware and a reduction in cost and size.
    • 检测包含磁化或可磁化的目标部件的流体中的磁化或可磁化的目标部件在其他磁化或可磁化部件之间,使用磁场发生器(M1,28)将磁化或可磁化的部件吸引到装订表面。 磁场控制器(C1)施加磁场以将磁化的或可磁化的组件在列中集中在结合表面上,随后减小磁场以使柱能够塌陷,以允许更多的部件到达结合表面,并重新应用 磁场,以便使其他组分从结合表面上拉出,以便根据结合的目标组分重新制备柱。 表面敏感传感器(S1,26,29)检测结合的磁化或可磁化的目标部件。 磁场的重新应用充当磁性洗涤步骤以释放不期望的特异性吸附结合,留下目标,以通过简化的硬件提高灵敏度并降低成本和尺寸。