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1. 发明授权

US07362690B2 Laser driver/method for generating a laser drive signal 失效
标题翻译：用于产生激光驱动信号的激光驱动器/方法
公开(公告)号：US07362690B2
公开(公告)日：2008-04-22
申请号：US10560678
申请日：2004-06-16
申请人： Bart Michiel De Boer , Johannes Aldegonda Theodora Maria Van Den Homberg , Albert Hendrik Jan Immink
发明人： Bart Michiel De Boer , Johannes Aldegonda Theodora Maria Van Den Homberg , Albert Hendrik Jan Immink
IPC分类号： G11B7/00
CPC分类号： G11B7/126 , G11B7/00456 , G11B7/0062 , H01S5/0427
摘要： A driver for driving a light generator for generating light, comprising a digitalto-analog converter (DAC) having a data input, a data output for generating an analog signal, a first multiplexer (MUX1) for cyclic selection of a number of data levels corresponding to desired intensity levels of the light and for coupling the data levels to the data input; a de multiplexer (DE-MUX) synchronized with the first multiplexer (MUX1) for de-multiplexing the analog signal into a set of analog signals; memory means for temporarily storing the set of analog signals; and a second multiplexer (MUX2) for selection of the stored set of analog signals and for generating a drive signal (IL) for the light generator. The memory means is preferably implemented by a set of capacitors (C1-C8). Usually, for instance in an optical disc drive, the light generator is implemented by a laser (Ls). In this situation the data input of the digital-to-analog converter comprises a threshold data input part; a delta data input part; a threshold gain reference input associated with the threshold data input part; and a delta gain reference input associated with the delta data input part. So in fact the DAC is split into two parts (DAC1 and DAC2) for separate threshold power and delta power control of the laser (LS).
摘要翻译：一种用于驱动用于产生光的光发生器的驱动器，包括具有数据输入的数模转换器（DAC），用于产生模拟信号的数据输出端，用于循环选择多个数据电平的第一多路复用器（MUX1）对应于光的期望强度水平并且用于将数据电平耦合到数据输入; 与多路复用器（DE-MUX）同步的第一多路复用器（MUX1），用于将模拟信号解复用为一组模拟信号; 用于临时存储该组模拟信号的存储装置; 和用于选择存储的模拟信号组并用于产生用于光发生器的驱动信号（IL）的第二多路复用器（MUX2）。存储装置优选地由一组电容器（C 1 -C 8）实现。通常，例如在光盘驱动器中，光发生器通过激光（L s）实现。在这种情况下，数模转换器的数据输入包括阈值数据输入部分; 增量数据输入部分; 与阈值数据输入部分相关联的阈值增益参考输入; 以及与增量数据输入部分相关联的增量增益参考输入。因此，事实上，DAC分为两部分（DAC 1和DAC 2），用于激光器（LS）的单独阈值功率和Δ功率控制。

2. 发明授权

US07535815B2 Disc drive apparatus 失效
标题翻译：盘驱动装置
公开(公告)号：US07535815B2
公开(公告)日：2009-05-19
申请号：US10539363
申请日：2003-12-02
申请人： Johannes Aldegonda Theodora Maria Van Den Homberg , Albert Hendrik Jan Immink , Bart Michiel De Boer
发明人： Johannes Aldegonda Theodora Maria Van Den Homberg , Albert Hendrik Jan Immink , Bart Michiel De Boer
IPC分类号： G11B7/00
CPC分类号： G11B7/126
摘要： An optical disc drive apparatus includes a laser device for generating a light beam for optically reading data from a disc. The laser device is electrically incorporated in a resonant circuit which includes an inductance coupled to the laser device.
摘要翻译：光盘驱动装置包括用于产生用于从盘读取数据的光束的激光装置。激光器件电连接在包括耦合到激光器件的电感的谐振电路中。

3. 发明授权

US07046177B2 Servo system, apparatus comprising a servo system, sigma delta modulator, and integrated circuit comprising a sigma delta modulator 失效
标题翻译：伺服系统，包括伺服系统，Σ-Δ调制器和包括Σ-Δ调制器的集成电路的装置
公开(公告)号：US07046177B2
公开(公告)日：2006-05-16
申请号：US10544199
申请日：2004-02-06
申请人： Albert Hendrik Jan Immink , Johannes Aldegonda Theodora Maria Van Den Homberg , Aalbert Stek
发明人： Albert Hendrik Jan Immink , Johannes Aldegonda Theodora Maria Van Den Homberg , Aalbert Stek
IPC分类号： H03M1/48
CPC分类号： G11B7/0941 , G11B7/094
摘要： A servo system comprising an analog sigma delta modulator for generating a normalized digital error correction signal from first and second analog control signals. The sigma delta modulator comprises an analog low-pass filter, a quantizer delivering the digital error correction signal and a multiplying DA-converter in feedback arrangement between the output of the quantizer and the input of the low-pass filter for multiplying the feedback signals with the sum of the analog control signals.
摘要翻译：一种伺服系统，包括用于从第一和第二模拟控制信号产生归一化数字纠错信号的模拟Σ-Δ调制器。 Σ-Δ调制器包括模拟低通滤波器，传送数字纠错信号的量化器和在量化器的输出与低通滤波器的输入之间的反馈布置中的乘法DA转换器，用于将反馈信号与模拟控制信号的总和。

4. 发明申请

US20080314749A1 Microelectronic Device with Magnetic Excitation Wires 审中-公开
标题翻译：具有励磁线的微电子器件
公开(公告)号：US20080314749A1
公开(公告)日：2008-12-25
申请号：US12159465
申请日：2006-10-25
申请人： Mark Thomas Johnson , Albert Hendrik Jan Immink , Marc Wilhelmus Gijsbert Ponjee , Mirielle Ann Reijme , Josephus Arnoldus Henricus Maria Kahlman , Jeroen Hans Nieuwenhuis , Bart Michiel De Boer
发明人： Mark Thomas Johnson , Albert Hendrik Jan Immink , Marc Wilhelmus Gijsbert Ponjee , Mirielle Ann Reijme , Josephus Arnoldus Henricus Maria Kahlman , Jeroen Hans Nieuwenhuis , Bart Michiel De Boer
IPC分类号： G01N27/26
CPC分类号： G01N33/54326 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2400/0415 , B01L2400/043 , G01N27/745 , G01N33/5438
摘要： The invention relates to a microelectronic device (200), particularly a magnetic biosensor, comprising B/E-electrodes (21) that can generate a magnetic field (B) in a sample chamber (10). The device further comprises E-electrodes (23, 24) that can generate an electrical field (E) in the sample chamber (10) in cooperation with the B/E-electrodes (21). Thus the B/E-electrodes are used for two purposes. Electrical fields (E) in the sample chamber (10) may particularly be used for pumping and/or mixing of a fluid sample or for a stringency test of particle bindings.
摘要翻译：本发明涉及一种微电子器件（200），特别是包括可在样品室（10）中产生磁场（B））的B / E电极（21）的磁性生物传感器。所述装置还包括可与所述B / E电极（21）配合地在样品室（10）中产生电场（E）的E电极（23,24）。因此，B / E电极用于两个目的。样品室（10）中的电场（E）可特别用于泵送和/或混合流体样品或用于颗粒结合的严格性测试。

5. 发明授权

US08797028B2 Sensor device for target particles in a sample 有权
标题翻译：样品中目标颗粒的传感器装置
公开(公告)号：US08797028B2
公开(公告)日：2014-08-05
申请号：US12738317
申请日：2008-10-21
申请人： Coen Adrianus Johannes Verschuren , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Mischa Megens , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
发明人： Coen Adrianus Johannes Verschuren , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Mischa Megens , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
IPC分类号： G01R33/02 , G01N33/00 , G01N21/55
CPC分类号： G01N15/06 , G01N15/0656 , G01N2015/0693 , G01R33/1269
摘要： A sensor device and a method for the determination of the amount of target particles at a contact surface adjacent to a sample chamber include detecting, by a detector, the target particles in the sample chamber by a sensor element, and providing at least one corresponding sensor signal. An evaluation unit determines the amount of target particles in a first zone at the contracts surface and in a second zone a distance away from the contact surface based on this sensor signal. In an optical measurement approach, frustrated total internal reflection taking place under different operating conditions, such as wavelength and/or angle of incidence, may be used to extract information about the first and second zones. In a magnetic measurement approach, different magnetic excitation fields may be used to excite magnetic target particles differently in the first and second zone.
摘要翻译：用于确定与样品室相邻的接触表面处的目标颗粒的量的传感器装置和方法包括通过检测器通过传感器元件检测样品室中的目标颗粒，并且提供至少一个相应的传感器信号。评估单元基于该传感器信号确定在合同表面处的第一区域中的目标颗粒的量和距接触表面一定距离的第二区域中的目标颗粒的量。在光学测量方法中，可以使用在诸如波长和/或入射角的不同操作条件下发生的沮丧的全内反射来提取关于第一和第二区域的信息。在磁测量方法中，可以使用不同的磁激励场来在第一和第二区域中不同地激励磁性目标颗粒。

6. 发明申请

US20100259254A1 SENSOR DEVICE FOR TARGET PARTICLES IN A SAMPLE 有权
标题翻译：传感器装置在样品中的目标颗粒
公开(公告)号：US20100259254A1
公开(公告)日：2010-10-14
申请号：US12738317
申请日：2008-10-21
申请人： Coen Adrianus Johannes Verschuren , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Mischa Megens , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
发明人： Coen Adrianus Johannes Verschuren , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink , Mischa Megens , Jeroen Veen , Bart Michiel De Boer , Theodorus Petrus Henricus Gerardus Jansen
IPC分类号： G01R33/02 , G01N33/00 , G01N21/55
CPC分类号： G01N15/06 , G01N15/0656 , G01N2015/0693 , G01R33/1269
摘要： The invention relates to a sensor device (100) and a method for the determination of the amount of target particles (1) at a contact surface (112) adjacent to a sample chamber (2). Target particles (1) in the sample chamber are detected by a sensor element (SE) and at least one corresponding sensor-signal (s, s′) is provided. An evaluation unit (EU) then determines the amount of target particles (1) in a first zone (Z1) immediately at the contracts surface (112) and a second zone (Z2) a distance (z) away from the contact surface based on this sensor-signal. In an optical measurement approach, frustrated total internal reflection taking place under different operating conditions (e.g. wavelength, angle of incidence) may be used to extract information about the first and second zones (Z1, Z2). In a magnetic measurement approach, different magnetic excitation fields may be used to excite magnetic target particles differently in the first and second zone (Z2). Moreover, the temporal course of a sensor-signal (s, s′) can be evaluated, particularly with respect to stochastic movements of the target particles (1).
摘要翻译：本发明涉及一种传感器装置（100）和用于确定在与样品室（2）相邻的接触表面（112）处的目标颗粒（1）的量的方法。通过传感器元件（SE）检测样品室中的目标颗粒（1），并提供至少一个对应的传感器信号（s，s'）。然后，评估单元（EU）基于紧接表面（112）立即确定第一区域（Z1）中的目标颗粒（1）的数量和远离接触表面的距离（z）的第二区域（Z2），基于这个传感器信号。在光学测量方法中，可以使用在不同操作条件（例如波长，入射角）下发生的沮丧的全内反射来提取关于第一和第二区（Z1，Z2）的信息。在磁测量方法中，可以使用不同的磁激励场来在第一和第二区（Z2）中不同地激励磁目标颗粒。此外，可以评估传感器信号（s，s'）的时间过程，特别是关于目标颗粒（1）的随机运动。

7. 发明申请

US20080218165A1 Microsensor Device 审中-公开
标题翻译：微传感器装置
公开(公告)号：US20080218165A1
公开(公告)日：2008-09-11
申请号：US12065612
申请日：2006-09-07
申请人： Josephus Arnoldus Henricus Maria Kahlman , Bart Michiel De Boer , Albert Hendrik Jan Immink , Jeroen Hans Nieuwenhuis
发明人： Josephus Arnoldus Henricus Maria Kahlman , Bart Michiel De Boer , Albert Hendrik Jan Immink , Jeroen Hans Nieuwenhuis
IPC分类号： G01N27/72
CPC分类号： G01N33/54326 , G01N27/745
摘要： The invention relates to a microsensor device like a magnetic biosensor (100). The microsensor device comprises an array of probe-sensors (10.1, 10.2, 10.3) for the measurement of a physical quantity, for example the concentration of molecules labeled with magnetic beads in a sample chamber. The array further comprises a reference-sensor (10.4) that is disposed close to the probe-sensors (10.1, 10.2, 10.3) but shielded from the physical quantity to be measured. The measuring signal of the reference-sensor (10.4) reflects the influence of environmental conditions like temperature and can therefore be used to correct the measuring signals of the probe-sensors (10.1, 10.2, 10.3). The sensors (10.1, 10.2, 10.3, 10.4) are connected via a multiplexer to the same detector unit for further processing in order to minimize variations and to reduce hardware complexity.
摘要翻译：本发明涉及一种诸如磁性生物传感器（100）的微传感器装置。微传感器装置包括用于测量物理量的探针传感器阵列（10.1,10.2,10.3），例如在样品室中用磁珠标记的分子的浓度。该阵列还包括靠近探头传感器（10.1,10.2,10.3）设置但与被测量的物理量屏蔽的参考传感器（10.4）。参考传感器（10.4）的测量信号反映了诸如温度等环境条件的影响，因此可用于校正探头传感器（10.1,10.2,10.3）的测量信号。传感器（10.1,10.2,10.3,10.4）通过多路复用器连接到相同的检测器单元以进行进一步处理，以便最小化变化并降低硬件复杂度。

8. 发明授权

US10092903B2 Multi-compartment device with magnetic particles 有权
公开(公告)号：US10092903B2
公开(公告)日：2018-10-09
申请号：US12809208
申请日：2008-12-16
申请人： Menno Willem Jose Prins , Joost Hubert Maas , Albert Hendrik Jan Immink , Dirkjan Bernhard Van Dam , Maatje Koets , Michel J. M. Bruyninckx , Thea Van Der Wijk , Marius Iosif Boamfa , Remco Den Dulk
发明人： Menno Willem Jose Prins , Joost Hubert Maas , Albert Hendrik Jan Immink , Dirkjan Bernhard Van Dam , Maatje Koets , Michel J. M. Bruyninckx , Thea Van Der Wijk , Marius Iosif Boamfa , Remco Den Dulk
IPC分类号： B01L3/00
摘要： The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles.

9. 发明申请

US20110301047A1 SENSING DEVICE FOR SENSING A FLUID 有权
标题翻译：用于感应流体的感测装置
公开(公告)号：US20110301047A1
公开(公告)日：2011-12-08
申请号：US13140175
申请日：2009-12-07
申请人： Albert Hendrik Jan Immink , Albert F. Gootzen , Dirk Jan Nelly Vananderoye , Petrus Johannes Wilhelmu Van Lankvelt
发明人： Albert Hendrik Jan Immink , Albert F. Gootzen , Dirk Jan Nelly Vananderoye , Petrus Johannes Wilhelmu Van Lankvelt
IPC分类号： C40B30/00 , C12Q1/70 , C40B60/12 , C12Q1/02 , C12M1/34 , G01N33/566 , C12Q1/00 , G01N33/53
CPC分类号： G01N33/54373 , B01L2200/027 , B01L2200/04 , B01L2300/048 , B01L2300/0627 , B01L2300/0816 , B01L2300/087 , B01L2300/14 , B01L2400/0481 , G01N21/03 , G01N21/11 , G01N21/552 , G01N2021/0346
摘要： The invention relates to a sensing device for sensing a fluid. The sensing device comprises an inlet port (20) for receiving the fluid (100) and a measurement chamber (25) for sensing the fluid (100). The sensing device further comprises a fluid channel (30) coupling the inlet port (20) and the measurement chamber (25) for transporting the fluid (100) from the inlet port (20) to the measurement chamber (25) and a fluid stop unit (50) for stopping and controllably releasing the flow of fluid between the inlet port (20) and the measurement chamber (25). This allows stopping the fluid before reaching the measurement chamber (25) and controllably releasing the fluid for allowing the fluid to flow into the measurement chamber (25), if the sensing device is ready for analyzing the fluid.
摘要翻译：本发明涉及一种感测流体的感测装置。感测装置包括用于接收流体（100）的入口（20）和用于感测流体（100）的测量室（25）。感测装置还包括连接入口（20）和测量室（25）的流体通道（30），用于将流体（100）从入口（20）输送到测量室（25）和流体停止单元（50），用于停止和可控地释放入口（20）和测量室（25）之间的流体流。这允许在到达测量室（25）之前停止流体，并且如果感测装置准备好用于分析流体，则可控地释放流体以允许流体流入测量室（25）。

10. 发明申请

US20100289483A1 SENSOR CARTRIDGE 审中-公开
标题翻译：传感器盒
公开(公告)号：US20100289483A1
公开(公告)日：2010-11-18
申请号：US12669218
申请日：2008-07-16
申请人： Albert Hendrik Jan Immink , Femke Karina De Theije , Menno Willem Jose Prins , Wendy Uyen Dittmer , Jeroen Hans Nieuwenhuis
发明人： Albert Hendrik Jan Immink , Femke Karina De Theije , Menno Willem Jose Prins , Wendy Uyen Dittmer , Jeroen Hans Nieuwenhuis
IPC分类号： G01N27/74
CPC分类号： G01R33/1269
摘要： The present invention provides a sensor cartridge (10) for distinctively determining at least two different target moieties in a fluid sample. The sensor cartridge (10) comprises a reaction chamber (1) and at least a first and second region (2, 3) distinct from each other. The first region (2) comprises magnetic or magnetizable objects (4a) labelled with a first type of probes for specifically binding a first type of target moieties and the second region (3) comprises magnetic or magnetizable objects (4b) labelled with a second type of probes for specifically binding a second type of target moieties, the magnetic or magnetizable objects (4a, 4b) in the first and second region (2, 3) being directly contactable by the sample fluid. The present invention also provides a method for the manufacturing of such sensor devices (10) and a method for determining the presence and/or amount of at least two different target moieties in a sample fluid using such sensor cartridge (10).
摘要翻译：本发明提供一种用于区别地确定流体样品中至少两个不同靶部分的传感器盒（10）。传感器盒（10）包括反应室（1）和至少彼此不同的第一和第二区域（2,3）。第一区域（2）包括用第一类型的探针标记的磁性或可磁化物体（4a），用于特异性地结合第一类型的靶部分，并且第二区域（3）包括用第二类型标记的磁性或可磁化物体（4b）的用于特异性结合第二类型的靶部分的探针，第一和第二区域（2,3）中的磁性或可磁化物体（4a，4b）可由样品流体直接接触。本发明还提供了用于制造这种传感器装置（10）的方法以及使用这种传感器盒（10）确定样品流体中至少两种不同靶部分的存在和/或量的方法。

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