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1. 发明授权

US06417224B1 Prophylactic, therapeutic agent for osteoporosis 有权
标题翻译：预防，治疗骨质疏松症的药物
公开(公告)号：US06417224B1
公开(公告)日：2002-07-09
申请号：US09623747
申请日：2000-09-05
申请人： Atsutane Ohta , Masao Hirayama , Takashi Adachi
发明人： Atsutane Ohta , Masao Hirayama , Takashi Adachi
IPC分类号： A61K3135
CPC分类号： A61K36/45 , A61K36/185 , A61K36/48 , A61K36/82 , A61K36/899 , C07H3/04 , C07H3/06 , A61K2300/00
摘要： The prophylactic, therapeutic agent for osteoporosis of the invention is a combination of an indigestible oligosaccharide with phytoestrogen which inhibits bone loss. The action of inhibiting the reduction of bone density can be improved remarkably by combining the indigestible oligosaccharide with phytoestrogen.
摘要翻译：本发明的用于骨质疏松症的预防性治疗剂是不消化的寡糖与植物雌激素的组合，其抑制骨丢失。通过将难消化的寡糖与植物雌激素结合，可以显着改善抑制骨密度降低的作用。

2. 发明授权

US06479657B1 Crystalline 1-kestose and process for preparing the same 有权
标题翻译：结晶1-kestose及其制备方法
公开(公告)号：US06479657B1
公开(公告)日：2002-11-12
申请号：US09091182
申请日：1998-09-29
申请人： Koji Nishizawa , Hitoshi Matsumoto , Hirofumi Nakamura , Takashi Kawakami , Yuko Nakada , Masao Hirayama , Takashi Adachi
发明人： Koji Nishizawa , Hitoshi Matsumoto , Hirofumi Nakamura , Takashi Kawakami , Yuko Nakada , Masao Hirayama , Takashi Adachi
IPC分类号： C07H106
CPC分类号： C07H3/06 , C12P19/18 , C30B7/00
摘要： A process for producing crystal 1-kestose wherein granular crystal 1-kestose in the form of large crystals can be produced at a high yield is disclosed. A highly pure solution of 1-kestose is concentrated to a Brix of 75 or higher; either seed crystals are added, or the solution is vacuum-concentrated to generate microcrystals for use as nuclei; then, a crystal growing step by vacuum-concentration and a microcrystal dissolving step for redissolving microcrystals which have formed in the concentrate are repeated at least twice each. Alternatively, a highly pure solution of 1-kestose is concentrated to a Brix of 80 or higher; either seed crystals are added, or the solution is allowed to initiate crystallization; after crystals are allowed to grow, a cooling step where the temperature is lowered by 5° C. to 20° C. from the previous step and a crystal growing step where the concentrate is maintained at the temperature to allow the crystals to grow are repeated at least twice each. Also, an enzyme for producing 1-kestose efficiently from sucrose is disclosed.
摘要翻译：公开了一种生产晶体1-晶体的方法，其中可以以高产率制备大晶体形式的颗粒状晶体1-晶体。 1-kestose的高纯度溶液浓缩至75或更高的白利糖度; 加入晶种，或者将溶液真空浓缩以产生用作核的微晶; 然后，通过真空浓缩的晶体生长步骤和在浓缩物中形成的再溶解微晶的微晶溶解步骤重复至少两次。或者，将高效纯化的1-kestose溶液浓缩至白利糖度为80或更高; 加入晶种，或使溶液开始结晶; 在使晶体生长之后，重复上述步骤的温度降低5℃至20℃的冷却步骤和将浓缩物保持在允许晶体生长的温度的晶体生长步骤至少两次。另外，公开了一种从蔗糖中有效产生1-kestose的酶。

3. 发明授权

US5308703A Adsorbent having good heat conductivity 失效
标题翻译：吸附剂具有良好的导热性
公开(公告)号：US5308703A
公开(公告)日：1994-05-03
申请号：US797014
申请日：1991-11-25
申请人： Soichiro Tsujimoto , Katsuya Kitaba , Yoshinobu Otake , Masao Hirayama , Habikino , Harushi Okabe
发明人： Soichiro Tsujimoto , Katsuya Kitaba , Yoshinobu Otake , Masao Hirayama , Habikino , Harushi Okabe
IPC分类号： B01J20/28 , F25B35/04 , B32B23/02 , B01D39/14 , B32B5/16
CPC分类号： F25B35/04 , B01J20/28033 , B01J20/28052 , Y10S95/901 , Y10T428/24727 , Y10T428/24777 , Y10T428/30
摘要： An adsorbent having high adsorption characteristics and high heat conductivity, which comprises a heat conductive sheet and at least one adsorbing sheet provided on at least one surface of the heat conductive sheet in contact therewith and which can perform a removal or supply of a heat through the heat conductive sheet to improve the adsorption or desorption efficiency, and an assembly comprising at least two adsorbents arranged in layers so as to form spaces between the adjacent adsorbents.
摘要翻译：具有高吸附特性和高导热性的吸附剂，其包括导热片和设置在与其接触的导热片的至少一个表面上的至少一个吸附片，并且能够通过导热片以提高吸附或解吸效率，以及包括至少两个排列成层的吸附剂以在相邻的吸附剂之间形成空间的组件。

4. 发明授权

US4719231A 3-[N-(mercaptoacyl)]amino-4-arylbutanoic acid derivatives and an analgesic agent comprising the same 失效
标题翻译： 3- [N-（巯基酰基）]氨基-4-芳基丁酸衍生物和包含其的止痛剂
公开(公告)号：US4719231A
公开(公告)日：1988-01-12
申请号：US735643
申请日：1985-05-20
申请人： Hamao Umezawa , Tomio Takeuchi , Takaaki Aoyagi , Mitsugu Hachisu , Masao Hirayama , Shinjiro Murata , Shunzo Fukatsu
发明人： Hamao Umezawa , Tomio Takeuchi , Takaaki Aoyagi , Mitsugu Hachisu , Masao Hirayama , Shinjiro Murata , Shunzo Fukatsu
IPC分类号： A61K31/165 , A61K31/195 , A61K31/215 , A61P25/04 , C07C67/00 , C07C313/00 , C07C323/60 , C07C327/32 , C07C153/017 , C07C149/41 , C07C149/43 , C07C153/023
CPC分类号： C07C323/60
摘要： New 3-[N-(mercaptoacyl)]amino-4-arylbutanoic acid derivatives are now provided, which exhibit analgesic activity and are effective to enhance the analgesia induced by a known analgesic compound, ]D-ala.sup.2,met.sup.5 ]-enkephalin (DAME).
摘要翻译：现在提供新的3- [N-（巯基乙酰基）]氨基-4-芳基丁酸衍生物，其显示镇痛活性并且有效增强已知镇痛化合物[D-ala2，met5] - 脑啡肽（DAME）诱导的镇痛）。

5. 发明授权

US08722126B2 Compositions for food, process for producing the same, and functional foods and drinks containing the same 有权
标题翻译：用于食品的组合物，其制备方法以及含有其的功能性食品和饮料
公开(公告)号：US08722126B2
公开(公告)日：2014-05-13
申请号：US12585783
申请日：2009-09-24
申请人： Hitoshi Matsumoto , Shigeru Tominaga , Mitsuo Kishi , Takashi Kawakami , Takahisa Tokunaga , Masao Hirayama
发明人： Hitoshi Matsumoto , Shigeru Tominaga , Mitsuo Kishi , Takashi Kawakami , Takahisa Tokunaga , Masao Hirayama
IPC分类号： A23L2/06 , A23L1/29 , B01D61/02 , A61K36/45 , A61K36/00 , A23G3/36 , A23G1/42 , A23G4/12
CPC分类号： A23G3/368 , A23G1/30 , A23G1/426 , A23G1/48 , A23G3/36 , A23G3/48 , A23G4/06 , A23G4/068 , A23G4/126 , A23L2/085 , A23L2/52 , A23L33/105 , A23V2002/00 , A23V2250/21 , A23V2250/2104
摘要： Black currant anthocyanin-containing compositions for foods comprising 1 to 25% by weight of black currant anthocyanin on the basis of solid matters; a process for producing a black currant anthocyanin-containing composition for foods characterized by purifying and concentrating black currant juice employed as a starting material by using a charged reverse osmosis membrane; functional foods and drinks characterized by containing the above compositions for foods; and the above-described compositions for foods and the above-described functional foods and drinks having an effect of improving visual function, a function of improving blood fluidity, and/or a function of lowering blood pressure. The conventional black currant anthocyanin compositions have a low black currant anthocyanin content, strong acidity and poor stability, which makes them unsuitable as additives for foods and drinks. However, the production process according to the present invention makes it possible to provide black currant anthocyanin-containing compositions for foods which have a high black currant anthocyanin content, an adequate acidity, and a high stability and can be added to foods and drinks. Moreover, functional foods and drinks containing these compositions, which have an effect of improving visual function, a function of improving blood fluidity, or a function of lowering blood pressure, can be provided.
摘要翻译：含有黑醋栗花青素的食品组合物，其包含基于固体物质的1至25重量％的黑醋栗花青素; 一种用于生产含黑醋栗花青素的食品组合物的方法，其特征在于通过使用带电的反渗透膜来纯化和浓缩用作原料的黑醋栗汁; 特征在于含有上述食品组合物的功能性食品和饮料; 和上述食品用组合物和上述具有改善视觉功能的作用的功能食品和饮料，改善血液流动性的功能和/或降低血压的功能。常规的黑醋栗花青素组合物具有低黑醋栗花青素含量，酸度强，稳定性差，使得它们不适合作为食品和饮料的添加剂。然而，根据本发明的制备方法使得可以提供含黑醋栗花青素的组合物，其具有高黑醋栗花青素含量，足够的酸度和高稳定性的食品，并且可以添加到食品和饮料中。此外，可以提供含有这些组合物的功能性食品和饮料，其具有改善视觉功能的效果，改善血液流动性的功能或降低血压的功能。

6. 发明授权

US07658963B1 Compositions for foods, process for producing the same and functional foods and drinks containing the same 有权
标题翻译：食品组合物，生产相同功能的食品和饮料的组合物
公开(公告)号：US07658963B1
公开(公告)日：2010-02-09
申请号：US10019402
申请日：2000-06-30
申请人： Hitoshi Matsumoto , Shigeru Tominaga , Mitsuo Kishi , Takashi Kawakami , Takahisa Tokunaga , Masao Hirayama
发明人： Hitoshi Matsumoto , Shigeru Tominaga , Mitsuo Kishi , Takashi Kawakami , Takahisa Tokunaga , Masao Hirayama
IPC分类号： A23L2/06 , A23L1/29 , B01D61/02 , A61K36/45 , A61K36/00
CPC分类号： A23G3/368 , A23G1/30 , A23G1/426 , A23G1/48 , A23G3/36 , A23G3/48 , A23G4/06 , A23G4/068 , A23G4/126 , A23L2/085 , A23L2/52 , A23L33/105 , A23V2002/00 , A23V2250/21 , A23V2250/2104
摘要： Black currant anthocyanin-containing compositions for foods comprising 1 to 25% by weight of black currant anthocyanin on the basis of solid matters; a process for producing a black currant anthocyanin-containing composition for foods characterized by purifying and concentrating black currant juice employed as a starting material by using a charged reverse osmosis membrane; functional foods and drinks characterized by containing the above compositions for foods; and the above-described compositions for foods and the above-described functional foods and drinks having an effect of improving visual function, a function of improving blood fluidity, and/or a function of lowering blood pressure. The conventional black currant anthocyanin compositions have a low black currant anthocyanin content, strong acidity and poor stability, which makes them unsuitable as additives for foods and drinks. However, the production process according to the present invention makes it possible to provide black currant anthocyanin-containing compositions for foods which have a high black currant anthocyanin content, an adequate acidity, and a high stability and can be added to foods and drinks. Moreover, functional foods and drinks containing these compositions, which have an effect of improving visual function, a function of improving blood fluidity, or a function of lowering blood pressure, can be provided.
摘要翻译：含有黑醋栗花青素的食品组合物，其包含基于固体物质的1至25重量％的黑醋栗花青素; 一种用于生产含黑醋栗花青素的食品组合物的方法，其特征在于通过使用带电的反渗透膜来纯化和浓缩用作原料的黑醋栗汁; 特征在于含有上述食品组合物的功能性食品和饮料; 和上述食品用组合物和上述具有改善视觉功能的作用的功能食品和饮料，改善血液流动性的功能和/或降低血压的功能。常规的黑醋栗花青素组合物具有低黑醋栗花青素含量，酸度强，稳定性差，使得它们不适合作为食品和饮料的添加剂。然而，根据本发明的制备方法使得可以提供含黑醋栗花青素的组合物，其具有高黑醋栗花青素含量，足够的酸度和高稳定性的食品，并且可以添加到食品和饮料中。此外，可以提供含有这些组合物的功能性食品和饮料，其具有改善视觉功能的效果，改善血液流动性的功能或降低血压的功能。

7. 发明授权

US5591478A Desiccant, method for producing the same and method for using the same 失效
标题翻译：干燥剂，其制造方法及其使用方法
公开(公告)号：US5591478A
公开(公告)日：1997-01-07
申请号：US487585
申请日：1995-06-07
申请人： Takahisa Tokunaga , Junko Kajihara , Masao Hirayama , Hidemasa Hidaka , Hayami Itoh , Masao Hayashitani , Yoshihiro Kajibata , Tatsuya Imura
发明人： Takahisa Tokunaga , Junko Kajihara , Masao Hirayama , Hidemasa Hidaka , Hayami Itoh , Masao Hayashitani , Yoshihiro Kajibata , Tatsuya Imura
IPC分类号： A23L3/42 , A23G1/00 , A23G1/56 , A23G3/34 , B01J20/22 , A23G3/00
CPC分类号： A23G1/56 , A23G3/346 , A23L3/42 , A23G2200/06 , Y10S426/804
摘要： A desiccant comprising crystalline, anhydrated nystose, which contains 70% or more of nystose and 2% or less of moisture and is in the form of a crystalline powder, is capable of maintaining water activity of a food at an extremely low level without heat drying the food or drying the food with silica gel or the like and can safely prevent deteriorations of foods and maintain the qualities at a low cost. The desiccant can be produced by anhydrating crystalline nystose hydrate under reduced pressure or in the presence of a dehydrating agent. The desiccant is used for lowering water activity of a food and maintaining the same, by directly contacting the desiccant with the food or mixing the same with the food.
摘要翻译：含有70％以上的含水分和2％以下的水分并且呈结晶性粉末状的结晶性，水合性的干燥剂能够将食品的水分活度维持在极低的水平而不加热干燥食品或用硅胶等干燥食物，能够安全地防止食品的劣化，并以低成本维持品质。干燥剂可以通过在减压下或在脱水剂的存在下通过水合水合半胱氨酸水合物来制备。干燥剂用于降低食物的水分活性并保持其状态，通过将干燥剂与食物直接接触或将其与食物混合。

8. 发明授权

US4350548A Method and apparatus for providing the inner surface of a pipe line with a lining 失效
标题翻译：用于为管线的内表面提供衬里的方法和装置
公开(公告)号：US4350548A
公开(公告)日：1982-09-21
申请号：US234861
申请日：1981-02-13
申请人： Katsuaki Zenbayashi , Akio Morinaga , Masao Hirayama , Akira Morita
发明人： Katsuaki Zenbayashi , Akio Morinaga , Masao Hirayama , Akira Morita
IPC分类号： F16L9/00 , B29B13/02 , B29C51/00 , B29C63/00 , B29C63/36 , B32B31/20
CPC分类号： B29B13/024 , B29C63/0069 , B29L2023/22
摘要： A method and apparatus for causing a flexible tubular lining material to be fixed to the inner surface of a pipe line wherein the tubular lining material is initially attached to the inner surface of the pipe line by a binder provided on the surface of the tubular lining material which comprises providing a flexible hose material having a porous structure inside the pipe line which has been lined with the tubular lining material and introducing a heated gaseous fluid stream into the interior of the flexible hose whereby the heated gaseous fluid stream is introduced through the pores of the flexible hose along the inner surface of the lined pipe line, the flexible tubular lining material being warmed to accelerate the curing of the binder interposed between the inner surface of the pipe line and the flexible lining material.
摘要翻译：一种用于使柔性管状衬里材料固定到管线的内表面的方法和装置，其中管状衬里材料最初通过设置在管状衬里材料的表面上的粘合剂附接到管线的内表面其包括提供在管线内具有多孔结构的柔性软管材料，其已经衬有管状衬里材料并将加热的气态流体流引入柔性软管的内部，由此将加热的气态流体流通过柔性软管沿着衬里管线的内表面，柔性管状衬里材料被加热以加速夹在管线内表面和柔性衬里材料之间的粘合剂的固化。

9. 发明申请

US20100015672A1 Gene Expression Cassette and a Transformant, and a Method for Manufacturing 2-Deoxy-Scyllo-Inosose and a Method for Purifying 2-Deoxy-Scyllo-Inosose Using Said Transformant 有权
标题翻译：基因表达盒和转化体及其制备方法，以及使用所述转化体纯化2-脱氧肌氨酸的方法
公开(公告)号：US20100015672A1
公开(公告)日：2010-01-21
申请号：US11887445
申请日：2006-03-23
申请人： Masamichi Takagi , Takahisa Kogure , Naoki Wakisaka , Hiroaki Takaku , Katsumi Ajisaka , Tatsuo Miyazaki , Masao Hirayama
发明人： Masamichi Takagi , Takahisa Kogure , Naoki Wakisaka , Hiroaki Takaku , Katsumi Ajisaka , Tatsuo Miyazaki , Masao Hirayama
IPC分类号： C12P19/02 , C12N15/00 , C12N1/21 , C07H3/02
CPC分类号： C12P17/06 , C07D309/30 , C12N9/88 , C12N9/90 , C12N9/92 , C12P7/26 , C12Y503/01009
摘要： A transformant is prepared to insert at least a gene expression cassette comprising a gene involved in the synthesis of 2-deoxy-scyllo-inosose into E. coli as host cells. A 2-deoxy-scyllo-inosose is synthesized from D-glucose, oligosaccharide, polysaccharide, starch and rice bran, using the transformant. A culture solution containing the 2-deoxy-scyllo-inosose is treated with a mixed bed or double bed type column comprising a hydrogen form of strong acidic cation exchange resin and an organic ion form of basic anion exchange resin. The 2-deoxy-scyllo-inosose as purified is reacted with trimethoxymethane to convert into 2-deoxy-scyllo-inosose dimethylketal, and the dimethylketal is crystallized and purified. Then, DOI is highly purified through hydrolyzing the dimethylketal in the presence of acid.
摘要翻译：制备转化体至少将含有参与合成2-脱氧 - 青蟹肌糖的基因的基因表达盒插入大肠杆菌作为宿主细胞。使用转化体从D-葡萄糖，寡糖，多糖，淀粉和米糠合成2-脱氧 - 青蟹肌糖。含有2-脱氧 - 青蟹肌糖的培养液用含氢形式的强酸性阳离子交换树脂和有机离子形式的碱性阴离子交换树脂的混合床或双床型柱处理。将纯化的2-脱氧 - 青蟹肌糖与三甲氧基甲烷反应以转化成2-脱氧 - 鲨糖醛糖二甲基缩酮，并将二甲基缩酮结晶并纯化。然后，DOI通过在酸存在下水解二甲基缩酮而高度纯化。

10. 发明申请

US20100015065A1 Compositions for food, process for producing the same, and functional foods and drinks containing the same 有权
标题翻译：用于食品的组合物，其制备方法以及含有其的功能性食品和饮料
公开(公告)号：US20100015065A1
公开(公告)日：2010-01-21
申请号：US12585783
申请日：2009-09-24
申请人： Hitoshi Matsumoto , Shigeru Tominaga , Mitsuo Kishi , Takashi Kawakami , Takahisa Tokunaga , Masao Hirayama
发明人： Hitoshi Matsumoto , Shigeru Tominaga , Mitsuo Kishi , Takashi Kawakami , Takahisa Tokunaga , Masao Hirayama
IPC分类号： A61K9/68 , A61K31/35 , A61P27/02 , A61P7/00
CPC分类号： A23G3/368 , A23G1/30 , A23G1/426 , A23G1/48 , A23G3/36 , A23G3/48 , A23G4/06 , A23G4/068 , A23G4/126 , A23L2/085 , A23L2/52 , A23L33/105 , A23V2002/00 , A23V2250/21 , A23V2250/2104
摘要： Black currant anthocyanin-containing compositions for foods comprising 1 to 25% by weight of black currant anthocyanin on the basis of solid matters; a process for producing a black currant anthocyanin-containing composition for foods characterized by purifying and concentrating black currant juice employed as a starting material by using a charged reverse osmosis membrane; functional foods and drinks characterized by containing the above compositions for foods; and the above-described compositions for foods and the above-described functional foods and drinks having an effect of improving visual function, a function of improving blood fluidity, and/or a function of lowering blood pressure. The conventional black currant anthocyanin compositions have a low black currant anthocyanin content, strong acidity and poor stability, which makes them unsuitable as additives for foods and drinks. However, the production process according to the present invention makes it possible to provide black currant anthocyanin-containing compositions for foods which have a high black currant anthocyanin content, an adequate acidity, and a high stability and can be added to foods and drinks. Moreover, functional foods and drinks containing these compositions, which have an effect of improving visual function, a function of improving blood fluidity, or a function of lowering blood pressure, can be provided.
摘要翻译：含有黑醋栗花青素的食品组合物，其包含基于固体物质的1至25重量％的黑醋栗花青素; 一种用于生产含黑醋栗花青素的食品组合物的方法，其特征在于通过使用带电的反渗透膜来纯化和浓缩用作原料的黑醋栗汁; 特征在于含有上述食品组合物的功能性食品和饮料; 和上述食品用组合物和上述具有改善视觉功能的作用的功能食品和饮料，改善血液流动性的功能和/或降低血压的功能。常规的黑醋栗花青素组合物具有低黑醋栗花青素含量，酸度强，稳定性差，使得它们不适合作为食品和饮料的添加剂。然而，根据本发明的制备方法使得可以提供含黑醋栗花青素的组合物，其具有高黑醋栗花青素含量，足够的酸度和高稳定性的食品，并且可以添加到食品和饮料中。此外，可以提供含有这些组合物的功能性食品和饮料，其具有改善视觉功能的效果，改善血液流动性的功能或降低血压的功能。

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