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    • 10. 发明授权
    • Isocoumarin derivatives inhibiting angiogenesis
    • 抑制血管生成的异香豆素衍生物
    • US06451846B1
    • 2002-09-17
    • US09980904
    • 2002-02-26
    • Jung Joon LeeHang-Sub KimJeong-Hyung LeeYoung-Soo HongYun Joo Park
    • Jung Joon LeeHang-Sub KimJeong-Hyung LeeYoung-Soo HongYun Joo Park
    • A61K3135
    • C07D311/76
    • The present invention relates to novel isocoumarin derivatves inhibiting angiogenesis, a method for preparation thereof and pharmaceutical compositions comprising the said derivatives as pharmaceutically active ingredients. More particularly, the present invention relates to novel isocoumarin derivatves represented by formula (1), especially 6,8-dihydroxy-4-acetyl-isocoumarin, a method for preparing 6,8-dihydroxy-4-acetyl-isocoumarin from fungi, and pharmaceutical compositions comprising the compounds and/or 6,8-dihydroxy-4-acetyl-isocoumarin as pharmaceutically active ingredients, which would be effective for the treatment of angiogenic diseases such as cancers, rheumatoid arthritis and diabetic retinopathy.
    • 本发明涉及抑制血管生成的新型异香豆素衍生物,其制备方法和包含所述衍生物作为药物活性成分的药物组合物。 更具体地说,本发明涉及由式(1)表示的新型异香豆素衍生物,特别是6,8-二羟基-4-乙酰基异香豆素,一种从真菌中制备6,8-二羟基-4-乙酰基异香豆素的方法,以及 包含化合物和/或6,8-二羟基-4-乙酰基异香豆素作为药物活性成分的药物组合物,其对于治疗血管生成疾病如癌症,类风湿性关节炎和糖尿病性视网膜病变是有效的。