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1. 发明申请

US20050272778A1 Inhibitors of proteins that bind phosphorylated molecules 失效
标题翻译：结合磷酸化分子的蛋白质的抑制剂
公开(公告)号：US20050272778A1
公开(公告)日：2005-12-08
申请号：US10960344
申请日：2004-10-07
申请人： Andrew Combs , Eddy Yue , Michael Bower , Wenyu Zhu , Matthew Crawley , Richard Sparks , James Pruitt , Amy Takvorian
发明人： Andrew Combs , Eddy Yue , Michael Bower , Wenyu Zhu , Matthew Crawley , Richard Sparks , James Pruitt , Amy Takvorian
IPC分类号： A61K31/425 , C07D275/02 , C07D275/03 , C07D417/04 , C07D417/10 , C07K20060101
CPC分类号： C07D275/03 , C07D417/10 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07F9/6539
摘要： The present invention provides compounds that can modulate the activity of a target protein, such as a phosphatase, that selectively binds phosphorylated peptides or proteins. The present compounds can be useful in treating diseases or disorders, including, for example, diabetes and obesity, that are connected directly or indirectly to the activity of the target protein.
摘要翻译：本发明提供可以调节选择性结合磷酸化肽或蛋白质的靶蛋白（例如磷酸酶）的活性的化合物。本发明化合物可用于治疗与靶蛋白的活性直接或间接连接的疾病或病症，包括例如糖尿病和肥胖症。

2. 发明申请

US20070185165A1 N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase 有权
标题翻译： N-羟基脒基杂环作为吲哚胺2,3-双加氧酶的调节剂
公开(公告)号：US20070185165A1
公开(公告)日：2007-08-09
申请号：US11641284
申请日：2006-12-19
申请人： Andrew Combs , Amy Takvorian , Wenyu Zhu , Richard Sparks
发明人： Andrew Combs , Amy Takvorian , Wenyu Zhu , Richard Sparks
IPC分类号： A61K31/454 , A61K31/433 , A61K31/4245 , C07D417/02 , C07D413/02
CPC分类号： A61K31/541 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D271/08 , C07D285/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12
摘要： The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as pharmaceutical compositions thereof and methods of use thereof relating to the treatment of cancer and other diseases.
摘要翻译：本发明涉及作为吲哚胺2,3-双加氧酶（IDO）的调节剂的N-羟基脒基化合物及其药物组合物及其与治疗癌症和其它疾病有关的使用方法。

3. 发明申请

US20070149506A1 Azepine inhibitors of Janus kinases 审中-公开
标题翻译：阿诺地抑制剂Janus激酶
公开(公告)号：US20070149506A1
公开(公告)日：2007-06-28
申请号：US11524641
申请日：2006-09-21
申请人： Argyrios Arvanitis , James Rodgers , Andrew Combs , Richard Sparks , Darius Robinson
发明人： Argyrios Arvanitis , James Rodgers , Andrew Combs , Richard Sparks , Darius Robinson
IPC分类号： A61K31/55 , C07D487/22
CPC分类号： C07D471/14 , C07D471/22 , C07D487/14 , C07D487/22
摘要： The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
摘要翻译：本发明提供调节Janus激酶活性的化合物，并且可用于治疗与Janus激酶活性相关的疾病，包括例如免疫相关疾病，皮肤病，骨髓增生性疾病，癌症和其它疾病。

4. 发明申请

US20060183906A1 Pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2,3-b]pyrimidin-4-yl-amines as janus kinase inhibitors 有权
标题翻译：吡咯并[2,3-b]吡啶-4-基 - 胺和吡咯并[2,3-b]嘧啶-4-基胺
公开(公告)号：US20060183906A1
公开(公告)日：2006-08-17
申请号：US11313394
申请日：2005-12-21
申请人： James Rodgers , Haisheng Wang , Andrew Combs , Richard Sparks
发明人： James Rodgers , Haisheng Wang , Andrew Combs , Richard Sparks
IPC分类号： C07D471/02 , A61K31/44 , C07D491/02
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention provides pyrrolo[2,3-b]pyridine-4-yl amines pyrrolo[2,3-b]pyrimidin-4-yl amines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.
摘要翻译：本发明提供调节Janus激酶活性的吡咯并[2,3-b]吡啶-4-基胺吡咯并[2,3-b]嘧啶-4-基胺，可用于治疗与活性有关的疾病的Janus激酶，包括例如免疫相关疾病和癌症。

5. 发明申请

US20120100764A1 POD DRIVE INSTALLATION AND HULL CONFIGURATION FOR A MARINE VESSEL 有权
标题翻译：海上船只的POD驾驶安装和船体配置
公开(公告)号：US20120100764A1
公开(公告)日：2012-04-26
申请号：US13378486
申请日：2010-06-24
申请人： Wayne Wingate , Richard Sparks
发明人： Wayne Wingate , Richard Sparks
IPC分类号： B63H5/125 , B63H20/14
CPC分类号： B63H5/16 , B63B39/06 , B63H5/10 , B63H5/125 , B63H2005/1254
摘要： A pod drive installation and hull configurations for mounting a pod drive unit to a hull which includes a horizontally disposed pod drive platform for supporting a rotational pod drive mount for mounting the pod drive unit with a vertically oriented steering axis. The pod drive platform is mounted to the hull, outward of the keel of the vessel, such that the pod drive platform intersects a plane defined by a bottom hull surface tilted from the horizontal along a contour of intersection, between an outboard boundary of the pod drive platform and an inboard boundary of the pod drive platform, and is connected to the bottom hull surface by at least one of an outboard sidewall and an inboard sidewall.
摘要翻译：荚驱动器安装和船体配置，用于将吊舱驱动单元安装到船体，其包括水平布置的吊舱驱动平台，用于支撑用于通过垂直取向的转向轴安装吊舱驱动单元的旋转舱驱动座。荚驱动平台安装在船体的外面，在船的龙骨外面，使得荚驱动平台与由水平面倾斜的底部船体表面沿着轮廓线相交的平面相交，在舷外外侧边界之间驱动平台和舱驱动平台的内侧边界，并且通过外侧侧壁和内侧壁中的至少一个连接到底壳表面。

6. 发明授权

US4044318A Ganged radio frequency filter 失效
标题翻译：联动射频滤波器
公开(公告)号：US4044318A
公开(公告)日：1977-08-23
申请号：US579165
申请日：1975-05-20
申请人： Edward J. Daly , Richard Sparks , George R. Spencer
发明人： Edward J. Daly , Richard Sparks , George R. Spencer
IPC分类号： G01S13/44 , G01S9/02 , H01P1/20
CPC分类号： G01S13/4436
摘要： A three channel electronically tunable filter arrangement for selecting radio frequency signals to be processed in a monopulse receiver is disclosed. Each channel of the disclosed filter arrangement includes an yttrium-iron-garnet (YIG) filter disposed in a common structure so that the resonant frequency of each channel may be controlled by the magnetic field of a single electromagnet. Also disclosed is an alignment method whereby the response of the YIG filter in each channel may be independently adjusted to eliminate any substantial imbalance between channels as the strength of the magnetic field is changed to change the resonant frequencies of such filters.
摘要翻译：公开了一种用于选择在单脉冲接收机中处理的射频信号的三通道电子可调谐滤波器装置。所公开的滤波器装置的每个通道包括以共同结构设置的钇 - 铁 - 石榴石（YIG）滤波器，使得每个通道的谐振频率可以由单个电磁体的磁场控制。还公开了一种对准方法，其中可以独立地调整每个通道中的YIG滤波器的响应，以消除磁场的强度改变这些滤波器的谐振频率之间的通道之间的任何实质的不平衡。

7. 发明授权

US08740660B2 Pod drive installation and hull configuration for a marine vessel 有权
标题翻译：船舶驱动装置和船体配置
公开(公告)号：US08740660B2
公开(公告)日：2014-06-03
申请号：US13378486
申请日：2010-06-24
申请人： Wayne Wingate , Richard Sparks
发明人： Wayne Wingate , Richard Sparks
IPC分类号： B63H5/20 , B63H5/125 , B63H20/08 , B63B1/00
CPC分类号： B63H5/16 , B63B39/06 , B63H5/10 , B63H5/125 , B63H2005/1254
摘要： A pod drive installation and hull configurations for mounting a pod drive unit to a hull which includes a horizontally disposed pod drive platform for supporting a rotational pod drive mount for mounting the pod drive unit with a vertically oriented steering axis. The pod drive platform is mounted to the hull, outward of the keel of the vessel, such that the pod drive platform intersects a plane defined by a bottom hull surface tilted from the horizontal along a contour of intersection, between an outboard boundary of the pod drive platform and an inboard boundary of the pod drive platform, and is connected to the bottom hull surface by at least one of an outboard sidewall and an inboard sidewall.
摘要翻译：荚驱动器安装和船体配置，用于将吊舱驱动单元安装到船体，其包括水平布置的吊舱驱动平台，用于支撑用于通过垂直取向的转向轴安装吊舱驱动单元的旋转舱驱动座。荚驱动平台安装在船体的外面，在船的龙骨外面，使得荚驱动平台与由水平面倾斜的底部船体表面沿着轮廓线相交的平面相交，在舷外外侧边界之间驱动平台和舱驱动平台的内侧边界，并且通过外侧侧壁和内侧壁中的至少一个连接到底壳表面。

8. 发明授权

US6105487A Cooking appliance 失效
标题翻译：烹饪用具
公开(公告)号：US6105487A
公开(公告)日：2000-08-22
申请号：US104026
申请日：1998-06-24
申请人： Simon Nash , Richard Sparks , Peter Labuschagne , Edward Parrett
发明人： Simon Nash , Richard Sparks , Peter Labuschagne , Edward Parrett
IPC分类号： A47J36/26 , A47J37/07 , A47J37/08
CPC分类号： A47J37/0713 , A47J36/26
摘要： THE INVENTION provides a cooking appliance comprising a concave burner pan having a base and a peripheral side wall which together form a windshield and a gas burner disposed within the concavity of the pan, and an engagement formation adapted to mate with a corresponding engagement formation on a cooking surface, whereby such surface is releasably secured to the burner pan. A number of inter-changeable cooking surfaces are disclosed which may be utilized in conjunction with the burner pan.
摘要翻译：本发明提供了一种烹饪器具，其包括具有基部和周边侧壁的凹形燃烧器盘，所述底部和周边侧壁一起形成挡风玻璃，并且设置在所述锅的凹部内的气体燃烧器，以及适于与相应的接合结构配合的接合构件烹饪表面，由此这种表面可释放地固定到燃烧器盘。公开了可与燃烧器锅一起使用的多个可互换的烹饪表面。

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