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1. 发明申请

US20060106020A1 Tetracyclic inhibitors of Janus kinases 审中-公开
标题翻译： Janus激酶的四环抑制剂
公开(公告)号：US20060106020A1
公开(公告)日：2006-05-18
申请号：US11115702
申请日：2005-04-27
申请人： James Rodgers , Darius Robinson , Argrios Arvanitis , Thomas Maduskuie , Stacey Shepard , Louis Storace , Haisheng Wang , Maria Rafalski , Ravi Jalluri , Andrew Combs , Matthew Crawley
发明人： James Rodgers , Darius Robinson , Argrios Arvanitis , Thomas Maduskuie , Stacey Shepard , Louis Storace , Haisheng Wang , Maria Rafalski , Ravi Jalluri , Andrew Combs , Matthew Crawley
IPC分类号： A61K31/503 , A61K31/519 , C07D487/14
CPC分类号： C07D471/22 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D498/04 , C07D498/14 , C07D513/04 , C07D513/14
摘要： The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.
摘要翻译：本发明提供调节Janus激酶活性的化合物，并且可用于治疗与Janus激酶（例如免疫相关疾病和癌症）的活性相关的疾病。

2. 发明申请

US20050216287A1 Method for integrating an entrepreneur's web site and a store front web site 审中-公开
标题翻译：整合企业家网站和商店前台网站的方法
公开(公告)号：US20050216287A1
公开(公告)日：2005-09-29
申请号：US10811615
申请日：2004-03-29
申请人： Michael Crosby , Jeff Carradus , Darius Robinson
发明人： Michael Crosby , Jeff Carradus , Darius Robinson
IPC分类号： G06Q10/00 , G06F17/60
CPC分类号： G06Q30/02 , G06Q10/00 , G06Q10/0637 , G06Q30/0601
摘要： The present invention provides a method for an Entrepreneur to design and integrate an Entrepreneur's web site and a store front web site using tools provided at a Facilitator's web site. The method allows the Entrepreneur to design an Entrepreneur's web site and a store front web site using substantially similar, and preferably identical, templates available on the Facilitator's web site. This process allows an Entrepreneur to quickly design a professional looking virtual web site that seamlessly integrates their Entrepreneur's web site with a store front web site designed for handling electrical commerce. Tremendous synergizes, such as the elimination of multiple entries of data, may be achieved and serious pitfalls avoided by receiving overall guidance and assistance from one web site, i.e. a Facilitator's web site, in performing these processes.
摘要翻译：本发明提供了一种企业家使用协调人网站提供的工具来设计和整合企业家网站和商店前端网站的方法。该方法允许企业家设计一个企业家网站和一个商店前台网站，使用协调人网站上可用的基本相似的，最好是相同的模板。这个过程允许企业家快速设计一个专业的虚拟网站，将企业家的网站与专门用于处理电子商务的商店前台网站无缝集成。通过从一个网站（即协调人的网站）接收总体指导和帮助，可以实现巨大的协同作用，例如消除多个数据条目，并避免严重的陷阱。

3. 发明申请

US20060252751A1 3-Aminopyrrolidine derivaties as modulators of chemokine receptors 有权
标题翻译： 3-氨基吡咯烷衍生物作为趋化因子受体的调节剂
公开(公告)号：US20060252751A1
公开(公告)日：2006-11-09
申请号：US10535795
申请日：2003-11-26
申请人： Chu-Biao Xue , Brian Metcalf , Hao Feng , Ganfeng Cao , Taisheng Huang , Changsheng Zheng , Darius Robinson
发明人： Chu-Biao Xue , Brian Metcalf , Hao Feng , Ganfeng Cao , Taisheng Huang , Changsheng Zheng , Darius Robinson
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/506 , A61K31/444 , A61K31/4439 , A61K31/427 , A61K31/425 , A61K31/401 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D491/107 , C07D207/14 , C07D401/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/08 , C07D403/10 , C07D405/04 , C07D405/08 , C07D405/10 , C07D405/14 , C07D409/08 , C07D413/08 , C07D413/10 , C07D413/14 , C07D417/08 , C07D417/10 , C07D417/14 , C07D491/10 , C07D495/10
摘要： The present invention relates to 3-aminopyrrolidine derivatives of the formula I: (wherein R1, R2, R3, R4, R5, R6, R7, R8, X, Y and X are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as a modulator of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.
摘要翻译：本发明涉及式I的3-氨基吡咯烷衍生物：其中R 1，R 2，R 3，R 3， R 5，R 5，R 6，R 7，R 8，X，Y和 X如本文所定义），其可用作趋化因子受体活性的调节剂。特别地，这些化合物可用作趋化因子受体的调节剂，更具体地可用作CCR2和/或CCR5受体的调节剂。本发明的化合物和组合物可以结合趋化因子受体，例如CCR2和/或CCR5趋化因子受体，并且可用于治疗与趋化因子（例如CCR2和/或CCR5）相关的疾病，例如动脉粥样硬化，再狭窄，狼疮，器官移植排斥和类风湿关节炎。

4. 发明申请

US20070149506A1 Azepine inhibitors of Janus kinases 审中-公开
标题翻译：阿诺地抑制剂Janus激酶
公开(公告)号：US20070149506A1
公开(公告)日：2007-06-28
申请号：US11524641
申请日：2006-09-21
申请人： Argyrios Arvanitis , James Rodgers , Andrew Combs , Richard Sparks , Darius Robinson
发明人： Argyrios Arvanitis , James Rodgers , Andrew Combs , Richard Sparks , Darius Robinson
IPC分类号： A61K31/55 , C07D487/22
CPC分类号： C07D471/14 , C07D471/22 , C07D487/14 , C07D487/22
摘要： The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
摘要翻译：本发明提供调节Janus激酶活性的化合物，并且可用于治疗与Janus激酶活性相关的疾病，包括例如免疫相关疾病，皮肤病，骨髓增生性疾病，癌症和其它疾病。

5. 发明申请

US20050192302A1 3-Cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors 有权
标题翻译： 3-环烷基氨基吡咯烷衍生物作为趋化因子受体的调节剂
公开(公告)号：US20050192302A1
公开(公告)日：2005-09-01
申请号：US11014322
申请日：2004-12-16
申请人： Chu-Biao Xue , Brian Metcalf , Amy Han , Darius Robinson , Changsheng Zheng , Anlai Wang , Yingxin Zhang
发明人： Chu-Biao Xue , Brian Metcalf , Amy Han , Darius Robinson , Changsheng Zheng , Anlai Wang , Yingxin Zhang
IPC分类号： A61K31/4025 , A61K31/427 , A61K31/44 , A61K31/4439 , A61K31/506 , C07D401/12 , C07D401/14 , C07D417/02 , C07D43/02
CPC分类号： C07D277/24 , A61K31/4025 , A61K31/454 , C07D207/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to 3-cycloalkylaminopyrrolidine derivatives of the formula I: (wherein R1, R2, R3, R4, R5, R6, R7, X, Y and Z are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as modulators of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.
摘要翻译：本发明涉及式I的3-环烷基氨基吡咯烷衍生物：其中R 1，R 2，R 3，R 3， 4，R 5，R 6，R 7，X，Y和Z如本文所定义），其可用作趋化因子受体活性的调节剂。特别地，这些化合物可用作趋化因子受体的调节剂，更具体地可用作CCR2和/或CCR5受体的调节剂。本发明的化合物和组合物可以结合趋化因子受体，例如CCR2和/或CCR5趋化因子受体，并且可用于治疗与趋化因子（例如CCR2和/或CCR5）相关的疾病，例如动脉粥样硬化，再狭窄，狼疮，器官移植排斥和类风湿关节炎。

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