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1. 发明申请

US20050272778A1 Inhibitors of proteins that bind phosphorylated molecules 失效
标题翻译：结合磷酸化分子的蛋白质的抑制剂
公开(公告)号：US20050272778A1
公开(公告)日：2005-12-08
申请号：US10960344
申请日：2004-10-07
申请人： Andrew Combs , Eddy Yue , Michael Bower , Wenyu Zhu , Matthew Crawley , Richard Sparks , James Pruitt , Amy Takvorian
发明人： Andrew Combs , Eddy Yue , Michael Bower , Wenyu Zhu , Matthew Crawley , Richard Sparks , James Pruitt , Amy Takvorian
IPC分类号： A61K31/425 , C07D275/02 , C07D275/03 , C07D417/04 , C07D417/10 , C07K20060101
CPC分类号： C07D275/03 , C07D417/10 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07F9/6539
摘要： The present invention provides compounds that can modulate the activity of a target protein, such as a phosphatase, that selectively binds phosphorylated peptides or proteins. The present compounds can be useful in treating diseases or disorders, including, for example, diabetes and obesity, that are connected directly or indirectly to the activity of the target protein.
摘要翻译：本发明提供可以调节选择性结合磷酸化肽或蛋白质的靶蛋白（例如磷酸酶）的活性的化合物。本发明化合物可用于治疗与靶蛋白的活性直接或间接连接的疾病或病症，包括例如糖尿病和肥胖症。

2. 发明申请

US20070194792A1 NON-METALLIC FLOW-THROUGH ELECTRODELESS CONDUCTIVITY SENSOR WITH LEAK AND TEMPERATURE DETECTION 有权
标题翻译：具有漏电和温度检测的非金属流通电导率传感器
公开(公告)号：US20070194792A1
公开(公告)日：2007-08-23
申请号：US11650154
申请日：2007-01-05
申请人： John Quackenbush , Michael Bower , Stephen Talutis , Donald McKinlay , Daniel Tower
发明人： John Quackenbush , Michael Bower , Stephen Talutis , Donald McKinlay , Daniel Tower
IPC分类号： G01N27/02
CPC分类号： G01N27/023
摘要： A non metallic flow through electrodeless conductivity sensor is provided with a conduit having primary and secondary process fluid flow paths to form a fluid loop. At least one drive and one sense toroid surround the conduit on the fluid loop. Voltage supplied to the drive toroid induces a current in the sense toroid via the fluid loop to eliminate any need for metallic electrodes in contact with the process fluid. At least one additional drive and/or sense toroid is disposed on the fluid loop to enhance induction. Optionally one or more sense coils are disposed about the conduit outside of the fluid loop to cancel out stray electrical noise. An optional conductor disposed along the conduit detects any fluid leakage through changes in resistance thereof. A temperature detector is supported within an electrically non-conductive holder extending into the fluid flow path, so that the detector is free from physical contact with the fluid. An optional enclosure is provided with ports to enable a user to purge any gas permeating the conduit walls.
摘要翻译：通过无电极电导率传感器的非金属流提供有具有初级和次级过程流体流动路径以形成流体回路的导管。至少一个驱动器和一个感测环绕环绕流体回路上的导管。提供给驱动环形电极的电压通过流体回路在一定程度上引起电流，以消除与工艺流体接触的金属电极的任何需要。至少一个额外的驱动和/或感测环形线圈设置在流体回路上以增强感应。可选地，一个或多个感测线圈布置在流体回路外部的导管周围以消除杂散的电噪声。沿着管道设置的可选导体通过其电阻的变化来检测任何流体泄漏。温度检测器被支撑在延伸到流体流动路径内的非导电保持器内，使得检测器没有与流体的物理接触。可选的外壳提供有端口，以使用户能够清除渗透导管壁的任何气体。

3. 发明申请

US20060249386A1 Use of an osmotic pump to create a flowing reference junction for ionic-activity sensors 审中-公开
标题翻译：使用渗透泵为离子活性传感器创建流动参考接头
公开(公告)号：US20060249386A1
公开(公告)日：2006-11-09
申请号：US11122469
申请日：2005-05-05
申请人： Michael Bower , Lauren Catalano , John Connelly , Stephen Talutis , Daniel Tower , Brian Bischoff
发明人： Michael Bower , Lauren Catalano , John Connelly , Stephen Talutis , Daniel Tower , Brian Bischoff
IPC分类号： G01N27/26
CPC分类号： G01N27/4035
摘要： In an ionic-activity sensor, an osmotic pump drives a reference-cell electrolyte to flow through an interface with the solution to be measured. This minimizes contamination of the reference cell by that solution. The driving force results from expansion of an electrolytic-agent reservoir into which solvent from a solvent reservoir diffuses through a semi-permeable membrane. The electrolytic-agent reservoir contains an electrolytic-agent solution in which a quantity of undissolved is disposed to keep the electrolytic-agent solution saturated as solvent diffuses into it.
摘要翻译：在离子活性传感器中，渗透泵驱动参比细胞电解质流过与要测量的溶液的界面。这最小化了该溶液对参比细胞的污染。驱动力来自电解质储库的膨胀，其中来自溶剂储存器的溶剂通过半透膜扩散。电解质储存器包含电解质溶液，其中设置一定量的未溶解剂以使溶解剂溶解在其中饱和。

4. 发明申请

US20060243050A1 Non-metallic flow-through electrodeless conductivity sensor and leak detector 有权
标题翻译：非金属流通无电极传感器和检漏仪
公开(公告)号：US20060243050A1
公开(公告)日：2006-11-02
申请号：US11351856
申请日：2006-02-09
申请人： John Quackenbush , Michael Bower , Stephen Talutis , Donald McKinlay
发明人： John Quackenbush , Michael Bower , Stephen Talutis , Donald McKinlay
IPC分类号： G01N7/00
CPC分类号： G01N27/023 , Y10T29/49002
摘要： A non metallic flow through electrodeless conductivity sensor is provided with a conduit having primary and secondary process fluid flowpaths to form a fluid loop. At least one drive and one sense toroid surround the conduit on the fluid loop. Voltage supplied to the drive toroid induces a current in the sense toroid via the fluid loop to eliminate any need for metallic electrodes in contact with the process fluid. At least one additional drive and/or sense toroid is disposed on the fluid loop to enhance induction. Optionally one or more sense coils are disposed about the conduit outside of the fluid loop to cancel out stray electrical noise. An optional conductor disposed along the conduit detects any fluid leakage through changes in resistance thereof.
摘要翻译：通过无电极电导率传感器的非金属流动提供有具有初级和次级过程流体流路以形成流体回路的导管。至少一个驱动器和一个感测环绕环绕流体回路上的导管。提供给驱动环形电极的电压通过流体回路在一定程度上引起电流，以消除与工艺流体接触的金属电极的任何需要。至少一个额外的驱动和/或感测环形线圈设置在流体回路上以增强感应。可选地，一个或多个感测线圈布置在流体回路外部的导管周围以消除杂散的电噪声。沿着管道设置的可选导体通过其电阻的变化来检测任何流体泄漏。

5. 发明申请

US20050075352A1 3,4-Dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors 审中-公开
标题翻译： 3,4-二氢 - （1H） - 喹唑啉-2-酮及其作为CSBP / p38激酶抑制剂的用途
公开(公告)号：US20050075352A1
公开(公告)日：2005-04-07
申请号：US10884788
申请日：2004-07-02
申请人： Jerry Adams , Michael Bower , Ralph Hall , Don Griswold , David Underwood
发明人： Jerry Adams , Michael Bower , Ralph Hall , Don Griswold , David Underwood
IPC分类号： C07D239/80 , C07D401/06 , A61K31/517 , C07D43/02
CPC分类号： C07D401/06 , C07D239/80
摘要： Novel substituted quinazoline compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
摘要翻译：新型取代喹唑啉化合物和用作CSBP / p38激酶抑制剂治疗的组合物。

6. 发明授权

US06855778B2 Blended thermoformable RF sealable plastic 失效
公开(公告)号：US06855778B2
公开(公告)日：2005-02-15
申请号：US10230607
申请日：2002-08-29
申请人： Keith Yanuzzi , Donald R. Hacker , Michael Bower
发明人： Keith Yanuzzi , Donald R. Hacker , Michael Bower
IPC分类号： B29C47/00 , B29C65/00 , B29C65/04 , C08J5/12 , C08L67/02 , C08F20/00
CPC分类号： C08J5/121 , B29C47/0004 , B29C47/0021 , B29C65/04 , B29C65/08 , B29C65/14 , B29C66/71 , B29K2027/06 , B29K2067/00 , B29K2105/0032 , C08J2367/00 , C08L67/02 , C08L2666/18 , B29C65/00 , B29K2067/043 , B29K2067/003
摘要： A thermoformable, RF-sealable material for use in packaging. The material is produced from a blend including between approximately 5% and 50% by weight of PETG, and between approximately 50% and 95% by weight of PET. A small amount of color concentrate may be added to the blend. The blend may be extruded into sheets and thermoformed to produce packaging material.

7. 发明申请

US20080041843A1 SURFACE MOUNT HEATER 审中-公开
标题翻译：表面加热器
公开(公告)号：US20080041843A1
公开(公告)日：2008-02-21
申请号：US11925287
申请日：2007-10-26
申请人： Michael Bower , Roger Chase
发明人： Michael Bower , Roger Chase
IPC分类号： H05B3/44
CPC分类号： H05B3/22 , F16K27/003 , F16K49/002 , H05B3/286 , H05B3/36 , H05B2203/003 , H05B2203/021 , H05B2203/022 , H05B2203/037
摘要： A heater that includes a substantially flat layer of electrical resistance material having a first end and a second end, a first electrical conductor electrically connected to the first end of the substantially flat layer of electrical resistance material, a second electrical conductor electrically connected to the second end of the substantially flat layer of electrical resistance material, and an electrically insulating material surrounding the substantially flat layer of electrical resistance material and electrically insulating the first end of the substantially flat layer of electrical resistance material from the second end of the substantially flat layer of electrical resistance material. The heater may be mounted to a surface of a fluid component and used to heat the fluid component, and where the heater includes an aperture that extends through the electrically insulating material, the heater may be placed between a fluid component and a fluid substrate and used to heat both.
摘要翻译：一种加热器，包括具有第一端和第二端的基本上平坦的电阻材料层，电连接到所述基本上平坦的电阻材料层的第一端的第一电导体，电连接到第二端的第二电导体基本上平坦的电阻材料层的端部，以及围绕基本平坦的电阻材料层的电绝缘材料，并将基本上平坦的电阻材料层的第一端与基本上平坦的电阻材料层的第二端电绝缘电阻材料。加热器可以安装到流体部件的表面并且用于加热流体部件，并且其中加热器包括延伸穿过电绝缘材料的孔，加热器可以放置在流体部件和流体基板之间并且被使用加热两者。

8. 发明申请

US20060027453A1 Low resistance reference junction 审中-公开
标题翻译：低电阻参考点
公开(公告)号：US20060027453A1
公开(公告)日：2006-02-09
申请号：US11198085
申请日：2005-08-05
申请人： Lauren Catalano , Michael Bower
发明人： Lauren Catalano , Michael Bower
IPC分类号： G01N27/26
CPC分类号： G01N27/401
摘要： A reference half-cell and method includes a reference electrode and a reference electrolyte disposed in mutual electrolytic contact, and a reference junction including a porous member configured to provide controlled flow of the reference electrolyte therein to form a primary electrical pathway extending through the member. A secondary electrical pathway is disposed electrically in parallel with the primary electrical pathway.
摘要翻译：参考半电池和方法包括参考电极和相互电解接触设置的参考电解质，以及包括多孔构件的参考接合件，其构造成在其中提供参考电解质的受控流动，以形成延伸穿过该构件的主电路。电气路径与主电路并联设置。

9. 发明申请

US20070047933A1 Surface mount heater 失效
标题翻译：表面贴装加热器
公开(公告)号：US20070047933A1
公开(公告)日：2007-03-01
申请号：US11580814
申请日：2006-10-13
申请人： Michael Bower , Roger Chase
发明人： Michael Bower , Roger Chase
IPC分类号： F24H1/18 , A47J27/00 , A47J31/54
CPC分类号： H05B3/22 , F16K27/003 , F16K49/002 , H05B3/286 , H05B3/36 , H05B2203/003 , H05B2203/021 , H05B2203/022 , H05B2203/037
摘要： A heater that includes a substantially flat layer of electrical resistance material having a first end and a second end, a first electrical conductor electrically connected to the first end of the substantially flat layer of electrical resistance material, a second electrical conductor electrically connected to the second end of the substantially flat layer of electrical resistance material, and an electrically insulating material surrounding the substantially flat layer of electrical resistance material and electrically insulating the first end of the substantially flat layer of electrical resistance material from the second end of the substantially flat layer of electrical resistance material. The heater may be mounted to a surface of a fluid component and used to heat the fluid component, and where the heater includes an aperture that extends through the electrically insulating material, the heater may be placed between a fluid component and a fluid substrate and used to heat both.
摘要翻译：一种加热器，包括具有第一端和第二端的基本上平坦的电阻材料层，电连接到所述基本上平坦的电阻材料层的第一端的第一电导体，电连接到第二端的第二电导体基本上平坦的电阻材料层的端部，以及围绕基本平坦的电阻材料层的电绝缘材料，并将基本上平坦的电阻材料层的第一端与基本上平坦的电阻材料层的第二端电绝缘电阻材料。加热器可以安装到流体部件的表面并且用于加热流体部件，并且其中加热器包括延伸穿过电绝缘材料的孔，加热器可以放置在流体部件和流体基板之间并且被使用加热两者。

10. 发明授权

US07003930B2 Blended thermoformable RF sealable plastic 失效
公开(公告)号：US07003930B2
公开(公告)日：2006-02-28
申请号：US11020890
申请日：2004-12-22
申请人： Keith Yanuzzi , Donald R. Hacker , Michael Bower
发明人： Keith Yanuzzi , Donald R. Hacker , Michael Bower
IPC分类号： B65B47/00
CPC分类号： C08J5/121 , B29C47/0004 , B29C47/0021 , B29C65/04 , B29C65/08 , B29C65/14 , B29C66/71 , B29K2027/06 , B29K2067/00 , B29K2105/0032 , C08J2367/00 , C08L67/02 , C08L2666/18 , B29C65/00 , B29K2067/043 , B29K2067/003
摘要： A thermoformable, RF-sealable material for use in packaging. The material is produced from a blend including between approximately 5% and 50% by weight of PETG, and between approximately 50% and 95% by weight of PET. A small amount of color concentrate may be added to the blend. The blend may be extruded into sheets and thermoformed to produce packaging material.

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