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1. 发明授权

US06969721B2 Tricyclic-2-pyridone compounds useful as HIV reverse transcriptase inhibitors 有权
标题翻译：可用作HIV逆转录酶抑制剂的三环-2-吡啶酮化合物
公开(公告)号：US06969721B2
公开(公告)日：2005-11-29
申请号：US10457902
申请日：2003-06-10
申请人： James D. Rodgers , Haisheng Wang , Mona Patel , Argyrios Arvanitis , Anthony J. Cocuzza
发明人： James D. Rodgers , Haisheng Wang , Mona Patel , Argyrios Arvanitis , Anthony J. Cocuzza
IPC分类号： A61K20060101 , A61P20060101 , C07D20060101 , C07D471/04 , A61K31/4375
CPC分类号： C07D471/04
摘要： The present invention relates to tricyclic 2-pyridone compounds of formula (I): or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.
摘要翻译：本发明涉及可用作HIV逆转录酶抑制剂的式（I）的三环2-吡啶酮化合物或其立体异构形式，立体异构混合物或其药学上可接受的盐形式，以及包含其的药物组合物和诊断试剂盒，以及使用该药物治疗病毒感染或作为测定标准品或试剂的方法。

2. 发明申请

US20070135461A1 Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors 有权
标题翻译：杂芳基取代的吡咯并[2,3-b]吡啶和吡咯并[2,3-b]
公开(公告)号：US20070135461A1
公开(公告)日：2007-06-14
申请号：US11637545
申请日：2006-12-12
申请人： James Rodgers , Stacey Shepard , Thomas Maduskuie , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios Arvanitis , Louis Storace , Ravi Jalluri , Jordan Fridman , Krishna Vaddi
发明人： James Rodgers , Stacey Shepard , Thomas Maduskuie , Haisheng Wang , Nikoo Falahatpisheh , Maria Rafalski , Argyrios Arvanitis , Louis Storace , Ravi Jalluri , Jordan Fridman , Krishna Vaddi
IPC分类号： A61K31/519 , A61K31/4745 , C07D487/02 , C07D471/02
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0053 , A61K9/20 , A61K31/573 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
摘要翻译：本发明提供调节Janus激酶活性的杂芳基取代的吡咯并[2,3-b]吡啶和杂芳基取代的吡咯并[2,3-b]嘧啶，可用于治疗与Janus激酶活性有关的疾病，例如免疫相关疾病，皮肤病，骨髓增生性疾病，癌症和其它疾病。

3. 发明申请

US20060252756A1 Azolo triazines and pyrimidines 失效
公开(公告)号：US20060252756A1
公开(公告)日：2006-11-09
申请号：US11477680
申请日：2006-06-29
申请人： Liqi He , Paul Gilligan , Robert Chorvat , Argyrios Arvanitis
发明人： Liqi He , Paul Gilligan , Robert Chorvat , Argyrios Arvanitis
IPC分类号： A61K31/53
CPC分类号： A61K31/53 , C07D487/04
摘要： Corticotropin releasing factor (CRF) antagonists of formula I or II: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.

4. 发明申请

US20070155740A1 SUBSTITUTED PYRAZINONES, PYRIDINES AND PYRIMIDINES AS CORTICOTROPIN RELEASING FACTOR LIGANDS 有权
标题翻译：替代吡咯烷酮，吡啶类和吡啶类作为科西乐素释放因子配体
公开(公告)号：US20070155740A1
公开(公告)日：2007-07-05
申请号：US11675012
申请日：2007-02-14
申请人： Argyrios Arvanitis , Paul Gilligan , Richard Hartz
发明人： Argyrios Arvanitis , Paul Gilligan , Richard Hartz
IPC分类号： A61K31/538 , A61K31/497 , C07D403/02 , C07D413/02
CPC分类号： C07D401/04 , C07D403/04 , C07D403/14 , C07D413/04
摘要： Compounds provided herein are novel substituted pyrazinones, pyridines and pyrimidines of Formula (I) and (II): Such compounds are particularly useful as CRF receptor ligands, and hence, in the treatment of various neurologically-related disorders such as affective disorder, anxiety and depression.
摘要翻译：本文提供的化合物是式（I）和（II）的新的取代的吡嗪酮，吡啶和嘧啶：这些化合物特别可用作CRF受体配体，因此在治疗各种神经学相关的疾病如情感障碍，焦虑和萧条。

5. 发明申请

US20070149506A1 Azepine inhibitors of Janus kinases 审中-公开
标题翻译：阿诺地抑制剂Janus激酶
公开(公告)号：US20070149506A1
公开(公告)日：2007-06-28
申请号：US11524641
申请日：2006-09-21
申请人： Argyrios Arvanitis , James Rodgers , Andrew Combs , Richard Sparks , Darius Robinson
发明人： Argyrios Arvanitis , James Rodgers , Andrew Combs , Richard Sparks , Darius Robinson
IPC分类号： A61K31/55 , C07D487/22
CPC分类号： C07D471/14 , C07D471/22 , C07D487/14 , C07D487/22
摘要： The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
摘要翻译：本发明提供调节Janus激酶活性的化合物，并且可用于治疗与Janus激酶活性相关的疾病，包括例如免疫相关疾病，皮肤病，骨髓增生性疾病，癌症和其它疾病。

6. 发明授权

US07045529B2 Imidazopyrimidinyl and imidazopyri dinyl derivatives 有权
标题翻译：咪唑并嘧啶基和咪唑并二烯基衍生物
公开(公告)号：US07045529B2
公开(公告)日：2006-05-16
申请号：US09738666
申请日：2000-12-15
申请人： Richard G. Wilde , Rajagopal Bakthavatchalam , James P. Beck , Argyrios Arvanitis
发明人： Richard G. Wilde , Rajagopal Bakthavatchalam , James P. Beck , Argyrios Arvanitis
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D471/04 , C07D473/00
摘要： Provided herein are compounds of the formula (I): as well as stereoisomers and pharmaceutically acceptable salts thereof. Such compounds are, because of their ability to antagonize CRF, useful in the treatment of a variety of disorders characterized by execssive CRF expression. These include, for example: affective disorder, anxiety, depression, headache, irritable bowel syndrome, post-traumatic stress disorder, supranuclear palsy, immune suppression, Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, gastrointestinal diseases, anorexia nervosa or other feeding disorder, drug addiction, drug or alcohol withdrawal symptoms, inflammatory diseases, cardiovascular or heart-related diseases, fertility problems, human immunodeficiency virus infections, hemorrhagic stress, obesity, infertility, head and spinal cord traumas, epilepsy, stroke, ulcers, amyotrophic lateral sclerosis and hypoglycemia.
摘要翻译：本文提供了式（I）的化合物：及其立体异构体及其药学上可接受的盐。因为这些化合物具有拮抗CRF的能力，其可用于治疗以执行性CRF表达为特征的多种疾病。这些包括例如：情感障碍，焦虑症，抑郁症，头痛，肠易激综合征，创伤后应激障碍，核核性麻痹，免疫抑制，阿尔茨海默病，亨廷顿氏病，帕金森病，肌萎缩性侧索硬化，胃肠道疾病，神经性厌食症或其他喂养障碍，药物成瘾，药物或酒精戒断症状，炎症性疾病，心血管疾病或心脏病，肥胖问题，人体免疫缺陷病毒感染，出血性压力，肥胖症，不育症，头部和脊髓创伤，癫痫，中风，溃疡，肌萎缩性侧索硬化和低血糖。

7. 发明授权

US06596729B2 Tricyclic-2-pyridone compounds useful as HIV reverse transcriptase inhibitors 有权
标题翻译：可用作HIV逆转录酶抑制剂的三环-2-吡啶酮化合物
公开(公告)号：US06596729B2
公开(公告)日：2003-07-22
申请号：US09908995
申请日：2001-07-19
申请人： James D. Rodgers , Haisheng Wang , Mona Patel , Argyrios Arvanitis , Anthony J. Cocuzza
发明人： James D. Rodgers , Haisheng Wang , Mona Patel , Argyrios Arvanitis , Anthony J. Cocuzza
IPC分类号： A61K314375
CPC分类号： C07D471/04 , A61K31/496 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： The present invention relates to tricyclic 2-pyridone compounds of formula (I): or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.
摘要翻译：本发明涉及可用作HIV逆转录酶抑制剂的式（I）的三环2-吡啶酮化合物或其立体异构形式，立体异构混合物或其药学上可接受的盐形式，以及包含其的药物组合物和诊断试剂盒，以及使用该药物治疗病毒感染或作为测定标准品或试剂的方法。

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