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1. 发明授权

US06675033B1 Magnetic resonance imaging guidewire probe 有权
标题翻译：磁共振成像导丝探针
公开(公告)号：US06675033B1
公开(公告)日：2004-01-06
申请号：US09536090
申请日：2000-03-24
申请人： Albert C. Lardo , Xiaoming Yang , Ergin Atalar , Parag Karmarkar , Elliott R. McVeigh , Henry R. Halperin , Christine Enger McNamara , Paul A. Bottomley
发明人： Albert C. Lardo , Xiaoming Yang , Ergin Atalar , Parag Karmarkar , Elliott R. McVeigh , Henry R. Halperin , Christine Enger McNamara , Paul A. Bottomley
IPC分类号： A61B5055
CPC分类号： G01R33/287 , G01R33/34084
摘要： The invention describes a system, method, and means for an MRI guidewire that can be visible on an MRI, can act as an antenna and receive MRI signals from surrounding subject matter, and can allow the use of multiple interventional tools without removal of the guidewire from a subject.
摘要翻译：本发明描述了可以在MRI上可见的用于MRI导丝的系统，方法和装置，可用作天线并从周围主题接收MRI信号，并且可以允许使用多个介入工具而不去除导丝从一个主题。

2. 发明授权

US07848788B2 Magnetic resonance imaging probe 有权
标题翻译：磁共振成像探头
公开(公告)号：US07848788B2
公开(公告)日：2010-12-07
申请号：US10123065
申请日：2002-04-11
申请人： Steve Tulley , Albert C. Lardo , Parag Karmarkar , Elliot McVeigh , Henry R. Halperin , Christine Enger McNamara , Paul A. Bottomley , Ergin Atalar , Xiaoming Yang
发明人： Steve Tulley , Albert C. Lardo , Parag Karmarkar , Elliot McVeigh , Henry R. Halperin , Christine Enger McNamara , Paul A. Bottomley , Ergin Atalar , Xiaoming Yang
IPC分类号： A61B5/055
CPC分类号： G01R33/34084 , A61M25/09 , G01R33/287 , G01R33/34053 , G01R33/3657 , H01Q1/36 , H01Q1/362 , H01Q1/40 , H01Q1/42 , H01Q1/44 , H01Q11/08
摘要： Herein is disclosed a magnetic resonance imaging probe, having a probe shaft including a magnetic resonance antenna, and a spring tip attached to a distal end of the antenna.
摘要翻译：本文公开了一种磁共振成像探头，其具有包括磁共振天线的探针轴以及连接到天线远端的弹簧尖端。

3. 发明授权

US06628980B2 Apparatus, systems, and methods for in vivo magnetic resonance imaging 有权
公开(公告)号：US06628980B2
公开(公告)日：2003-09-30
申请号：US09817893
申请日：2001-03-26
申请人： Ergin Atalar , Paul A. Bottomley , Parag Karmarkar , Albert C. Lardo , Elias Zerhouni
发明人： Ergin Atalar , Paul A. Bottomley , Parag Karmarkar , Albert C. Lardo , Elias Zerhouni
IPC分类号： A61B5055
CPC分类号： A61B1/00154 , A61B5/055 , A61B34/20 , A61B2034/2051 , A61B2090/374 , A61B2090/3958 , G01R33/285 , G01R33/34007 , G01R33/34084
摘要： The apparatus, systems and methods of the present invention provide for MRI sleeves, probes, and combinations thereof adapted for insertion into a subject, in order to internally image regions of the subject.

4. 发明授权

US06549800B1 Methods for in vivo magnetic resonance imaging 有权
标题翻译：体内磁共振成像方法
公开(公告)号：US06549800B1
公开(公告)日：2003-04-15
申请号：US09549921
申请日：2000-04-14
申请人： Ergin Atalar , Paul A. Bottomley , Elias Zerhouin , Henry Halperin , Elliot McVeigh , Albert C. Lardo
发明人： Ergin Atalar , Paul A. Bottomley , Elias Zerhouin , Henry Halperin , Elliot McVeigh , Albert C. Lardo
IPC分类号： A61B505
CPC分类号： A61B5/415 , A61B1/273 , A61B1/303 , A61B1/307 , A61B1/31 , A61B5/055 , A61B5/418 , A61B5/42 , A61B5/4381 , A61B10/0275 , A61B2090/374 , G01R33/285 , G01R33/34084 , G01R33/3628 , H01Q1/36 , H01Q1/362 , H01Q1/40 , H01Q1/44 , H01Q11/08
摘要： The systems and methods of the present invention provide for MRI probes adapted for insertion into a plurality of body orifices, in order to evaluate the anatomy of proximate anatomic structures, to diagnose abnormalities thereof and to treat the diagnosed abnormalities. MRI probes are described that are suitable for use in the mediastinum, in the pancreaticohepaticobiliary system, in the tracheobronchopulmonary system, in the head and neck, in the genitourinary system, the gastrointestinal system, the vascular system, and in the evaluation, diagnosis and treatment of internal fluid collections.
摘要翻译：本发明的系统和方法提供适于插入多个体孔的MRI探针，以评估近端解剖结构的解剖结构，诊断其异常并治疗诊断异常。描述了适用于纵隔，胰胆管系统，气管支气管系统，头颈部，泌尿生殖系统，胃肠系统，血管系统以及评估，诊断和治疗中的MRI探针的内部流体收集。

5. 发明授权

US06263229B1 Miniature magnetic resonance catheter coils and related methods 有权
标题翻译：微型磁共振导管线圈及相关方法
公开(公告)号：US06263229B1
公开(公告)日：2001-07-17
申请号：US09191563
申请日：1998-11-13
申请人： Ergin Atalar , Jeffrey C. Lestio , Harry K. Charles, Jr. , Bliss G. Carkhuff , Paul A. Bottomley
发明人： Ergin Atalar , Jeffrey C. Lestio , Harry K. Charles, Jr. , Bliss G. Carkhuff , Paul A. Bottomley
IPC分类号： A61B5055
CPC分类号： G01R33/34084 , G01R33/34007 , G01R33/341 , G01R33/3657 , G01R33/3678
摘要： The present invention provides several embodiments of methods of making magnetic resonance catheter coils which include employing a flexible electrically insulative base member, depositing an electrically conductive material on the base member in a predetermined pattern to create at least one pair of generally parallel electrically conductive coil elements which are electrically connected to each other. A catheter is provided over the coil assembly. In one embodiment, a second pair of generally parallel electrically conductive coil elements are provided in order to create a quadrature coil. In this latter embodiment, the electrically insulative base member may have the first pair of coil elements created on one surface thereof and a second pair on the other with the base member subsequently being deformed to create a tubular coil having one pair of coil elements on the outside and the other pair on the inside. In some embodiments, tuning and matching circuits and decoupling circuits may be provided. The (a) coils, (b) coil assemblies, as well as (c) catheter coils containing coil assemblies produced by these methods are also disclosed. The coils may be miniaturized so as to facilitate ready insertion within a suitable sheath, such as a probe or catheter, into a patient, including into body openings, or into blood vessels or into interior regions of the body.
摘要翻译：本发明提供了制造磁共振导管线圈的方法的几个实施例，其包括采用柔性电绝缘基底部件，以预定图案在基底部件上沉积导电材料，以产生至少一对大致平行的导电线圈元件它们彼此电连接。在线圈组件上提供导管。在一个实施例中，提供第二对大致平行的导电线圈元件以便产生正交线圈。在后一个实施例中，电绝缘基体可以具有在其一个表面上形成的第一对线圈元件，而另一对线圈元件可以具有另一对线圈元件，而第二对线圈元件随后变形，从而形成管状线圈，该管状线圈在其上具有一对线圈元件外面和另一对在里面。在一些实施例中，可以提供调谐和匹配电路和去耦电路。还公开了（a）线圈，（b）线圈组件，以及（c）包含由这些方法制造的线圈组件的导管线圈。线圈可以被小型化，以便于在适当的护套（例如探针或导管）内容易地插入患者体内，包括进入体内开口，或进入血管或进入体内的内部区域。

6. 发明授权

US5699801A Method of internal magnetic resonance imaging and spectroscopic analysis and associated apparatus 失效
标题翻译：内部磁共振成像和光谱分析方法及相关设备
公开(公告)号：US5699801A
公开(公告)日：1997-12-23
申请号：US457833
申请日：1995-06-01
申请人： Ergin Atalar , Paul A. Bottomley , Elias A. Zerhouni
发明人： Ergin Atalar , Paul A. Bottomley , Elias A. Zerhouni
IPC分类号： A61B10/00 , A61B5/055 , A61B10/02 , A61B19/00 , G01R33/34
CPC分类号： G01R33/34084 , A61B5/055 , G01R33/341 , G01R33/3657 , G01R33/3678 , G01R33/34007
摘要： The invention provides a method for magnetic resonance imaging and spectroscopic analysis of the interior of a specimen which includes positioning the specimen within a main magnetic field, introducing an invasive probe having an elongated receiver coil into or adjacent to the specimen with the coil having at least one pair of elongated electrical conductors, preferably, generally parallel to each other disposed within a dielectric material and having a pair of ends electrically connected to each other. RF pulses are provided to the region of interest to excite magnetic resonance signals, gradient magnetic pulses are applied to the region of interest with the receiver coil receiving magnetic resonance signals and emitting responsive output signals which may be processed by a computer to provide image information for display in a desired manner. The method in a preferred form involves employing a flexible receiver coil which has uniform sensitivity along the coil and may be operated even when the magnetic resonance signal is in an oblique position. Tuning capacitance may be distributed along the length of the coil and/or a Faraday screen provided to minimize dielectric losses between the coil and the surrounding material of the specimen. The method may be used on a wide variety of specimens and in a preferred use is introduced into small blood vessels of a patient to facilitate determination of atherosclerotic plaque. Medical intervention procedures, such as plaque removal, may be employed generally simultaneously with the imaging of the present invention. Corresponding apparatus is provided.
摘要翻译：本发明提供了一种用于磁共振成像和样品内部光谱分析的方法，其包括将样品定位在主磁场内，将具有细长的接收器线圈的侵入性探针引入到试样中或与样品相邻，线圈至少具有一对细长的电导体，优选地大致彼此平行地设置在电介质材料内并且具有彼此电连接的一对端部。将RF脉冲提供给感兴趣的区域以激励磁共振信号，梯度磁脉冲被施加到感兴趣的区域，接收器线圈接收磁共振信号并且发出可由计算机处理的响应输出信号，以提供图像信息以期望的方式显示。优选形式的方法涉及使用具有沿线圈的均匀灵敏度的柔性接收器线圈，并且即使当磁共振信号处于倾斜位置时也可以进行操作。调谐电容可以沿着线圈的长度和/或法拉第屏幕分布，以最小化线圈和样品的周围材料之间的介电损耗。该方法可以用于各种各样的样品，并且优选的用途被引入到患者的小血管中以便于确定动脉粥样硬化斑块。医疗干预程序，例如除斑，可以与本发明的成像通常同时使用。提供相应的设备。

7. 发明授权

US09791489B2 High dynamic range RF power monitor 有权
公开(公告)号：US09791489B2
公开(公告)日：2017-10-17
申请号：US14005804
申请日：2012-03-22
申请人： Paul A. Bottomley , William Edelstein , Abdel-Monem M. El-Sharkawy , Di Qian
发明人： Paul A. Bottomley , William Edelstein , Abdel-Monem M. El-Sharkawy , Di Qian
IPC分类号： G01R27/32 , G01R21/00 , G01R33/36 , A61N1/00 , G06F1/00 , G01R1/00 , G01R21/10 , G01R33/28
CPC分类号： G01R27/32 , A61N1/00 , G01R1/00 , G01R21/00 , G01R21/10 , G01R33/288 , G01R33/3614 , G06F1/00 , G06F2101/00
摘要： A device with at least one channel for measuring high dynamic range, radio frequency (RF) power levels over broad-ranging duty cycles includes a power sensor circuit comprising at least one logarithmic amplifier; at least one directional RF coupler electrically connected to the at least one power sensor; at least one RF attenuator electrically connected to the at least one RF coupler; and at least one sampling circuit electrically connected to the at least one RF attenuator and the at least one RF coupler. The at least one sampling circuit performs analog-to-digital conversion of electrical signals received to provide digitals signals for measuring the RF power level in the at least one channel.

8. 发明授权

US08717021B2 SAR dosimeter for RF power deposition in MRI and methods and systems related thereto 有权
标题翻译：用于MRI中RF功率沉积的SAR剂量计及与其相关的方法和系统
公开(公告)号：US08717021B2
公开(公告)日：2014-05-06
申请号：US12677097
申请日：2008-09-08
申请人： Paul A. Bottomley , John P. Stralka
发明人： Paul A. Bottomley , John P. Stralka
IPC分类号： G01V3/00
CPC分类号： G01R33/288 , G01R33/58
摘要： Featured is a dosimeter device that measures SAR deposited by RF power deposition during MRI of a specimen. Such a dosimeter device includes a transducer that is configured to present a load to the MRI scanner in which the transducer is located and to provide an output representative of signals induced in the transducer. The transducer also is configured so that the presented load is substantially equivalent to another load which would be presented by the specimen during MRI of the specimen. Such a transducer also is configured so as to generate an MRI signal that is sufficient to allow the MRI scanner to adjust the RF power to a value substantially equal to that of the specimen. Also featured are methods for measuring SAR deposited by RF power deposition and apparatuses or system embodying such a dosimeter device.
摘要翻译：特色是一种剂量计装置，可以在样品的MRI期间测量通过RF功率沉积沉积的SAR。这样一种剂量计装置包括一个换能器，该换能器被配置为向换能器所在的MRI扫描器提供负载，并提供代表在换能器中感应的信号的输出。传感器还被配置成使得所呈现的负载基本上等于在样本的MRI期间由样本呈现的另一负载。这样的换能器也被配置为产生足以使MRI扫描器将RF功率调整到基本上等于样本的值的MRI信号。还有一些用于测量通过RF功率沉积沉积的SAR的方法以及体现这种剂量计装置的装置或系统。

9. 发明申请

US20110037468A1 OPTIMIZED MRI STRIP ARRAY DETECTORS AND APPARATUS, SYSTEMS AND METHODS RELATED THERETO 有权
标题翻译：优化的MRI条带阵列检测器及其相关的设备，系统和方法
公开(公告)号：US20110037468A1
公开(公告)日：2011-02-17
申请号：US12879430
申请日：2010-09-10
申请人： Paul A. Bottomley , Ananda Kumar
发明人： Paul A. Bottomley , Ananda Kumar
IPC分类号： G01R33/44
CPC分类号： G01R33/3415 , G01R33/3678
摘要： Featured is a device for NMR or MRI signals from excited nuclei as well as related apparatus, systems and methods. The device includes a strip array antenna including one or more conductor and N reactive tuning components, where N is an integer≧1 at least one of the N reactive components is electrically coupled to each of the one or more conductors as well as to ground/virtual ground. The apparent electrical length of the conductors is tuned with the reactive tuning components so it is equal to be about nλ/4, where n is an integer≧1 and λ is the wavelength of the signal to be detected. The length of the strip also is such as to be substantially in the approximate range of 1.3 times the depth of interest. The strip conductors are also combined with loop coils to form quadrature detectors.
摘要翻译：特色是用于激发核的NMR或MRI信号以及相关设备，系统和方法的设备。该装置包括带状阵列天线，其包括一个或多个导体和N个非反应调谐组件，其中N是整数≥1，N个无功分量中的至少一个电耦合到一个或多个导体中的每一个以及接地/ 虚拟地面。导体的表观电长度用无功调谐分量进行调谐，因此等于大约nλ/ 4，其中n是整数≧1，λ是待检测信号的波长。条的长度也基本上在感兴趣深度的1.3倍的近似范围内。带状导体也与环形线圈组合以形成正交检测器。

10. 发明申请

US20100274252A1 VERTEBRAL BODY REDUCTION INSTRUMENT AND METHODS RELATED THERETO 有权
标题翻译： VERTEBRAL身体减少仪器及其相关方法
公开(公告)号：US20100274252A1
公开(公告)日：2010-10-28
申请号：US12766481
申请日：2010-04-23
申请人： Paul A. Bottomley , Shashank Sathyanarayana
发明人： Paul A. Bottomley , Shashank Sathyanarayana
IPC分类号： A61B17/60
CPC分类号： A61B17/708
摘要： Featured is a reduction instrument being configured and arranged to allow correction of vertebral translation and applying distraction across a segment in an independent fashion. Such a reduction instrument embodies one or more identical modules that are configured as needed for correcting the deformity. In more particular embodiments, each of the one or more modules has two degrees of freedom (DOF) with uncoupled orthogonal translations. Such a reduction instrument allows the reorientation of the vertebral segment as needed via uncoupled orthogonal translations. Such a reduction instrument also is usable in combination with a plurality of vertebral anchors, such vertebral anchors being any such vertebral anchors as are know to those skilled in the art (e.g., conventional spinal pedicle screw instrumentation) or hereinafter developed so as to form a spinal implant system. Also featured are treatment methods utilizing such a reduction instrument.
摘要翻译：特色是一种减少仪器，其被配置和布置成允许校正脊椎翻译并以独立方式跨越段进行牵引。这种还原器具体现了一个或多个相同的模块，其被配置为需要校正畸形。在更具体的实施例中，一个或多个模块中的每一个具有具有未耦合正交平移的两个自由度（DOF）。这种减少器械允许根据需要通过非耦合的正交平移重新定向椎骨段。这种减速器还可以与多个椎骨锚固件组合使用，这些椎骨锚固件是本领域技术人员已知的任何这样的椎骨锚固件（例如，常规的椎弓根螺钉装置）或下文开发以形成脊柱植入系统。还特征在于使用这种还原装置的处理方法。

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