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1. 发明授权

US06832111B2 Device for tumor diagnosis and methods thereof 失效
标题翻译：肿瘤诊断装置及其方法
公开(公告)号：US06832111B2
公开(公告)日：2004-12-14
申请号：US10011062
申请日：2001-11-05
申请人： Hosheng Tu , Rodolfo C. Quijano
发明人： Hosheng Tu , Rodolfo C. Quijano
IPC分类号： A61B505
CPC分类号： A61B5/053 , A61B5/0538 , A61B5/4381
摘要： A method and devices for differentiating in a given area of tissue a tumorous tissue from a normal tissue, the method comprising measuring a plurality of tissue impedance over a range of tissue temperatures and comparing the measured tissue impedance with reference tissue impedance of the normal tissue adapted for tissue differentiation. The management of tissue temperatures may be accomplished with a probe arrangement comprising two elements of different electromotive potential conductively connected at a probe junction, and passing an electrical current through the elements to reduce or raise a temperature of the probe junction in accordance with the Peltier effect.
摘要翻译：一种用于在组织的给定区域中区分来自正常组织的肿瘤组织的方法和装置，所述方法包括在组织温度范围内测量多个组织阻抗，并将所测量的组织阻抗与正常组织的参考组织阻抗进行比较用于组织分化。组织温度的管理可以用包括在探针结上导电连接的两个不同电动势元件的探针装置来实现，并且使电流通过元件以根据珀耳帖效应来降低或升高探针结的温度。

2. 发明授权

US06807439B2 System and method for detecting dislodgement of an implantable medical device 有权
标题翻译：用于检测植入式医疗装置的移动的系统和方法
公开(公告)号：US06807439B2
公开(公告)日：2004-10-19
申请号：US09824953
申请日：2001-04-03
申请人： Jerome Edwards , William J. Flickinger , Bradley A. Jascob
发明人： Jerome Edwards , William J. Flickinger , Bradley A. Jascob
IPC分类号： A61B505
CPC分类号： A61N1/08 , A61N2001/083
摘要： An improved system and method for detecting dislodgement of an implantable medical device (IMD) such as a catheter or lead is disclosed. The system includes means for generating multiple, orthogonally-related signals within a body. For example, three current signals having a current path substantially oriented in the X, Y, and Z directions may be generated within the body. The invention further includes an IMD having an affixation device such as a helix at a distal tip for attachment to body tissue, and at least two sensing devices to sense the signals generated within the body. The difference in signal levels between two of the sensing devices may be measured. For example, a voltage potential difference created by the currents within the body may be measured between two electrodes. This measured signal level has components in the X, Y, and Z directions, and may therefore be used to define a directional vector in three-dimensional space. This vector is indicative of the orientation of the IMD. By comparing a directional vector indicative of a current IMD position with a vector indicative of a reference orientation, dislodgement of the IMD may be detected. In one embodiment, the reference orientation may be associated with a position wherein the IMD distal end is substantially perpendicular to the tissue. The comparison between the reference orientation and a subsequent IMD orientation may be performed by calculating the angle between the two associated vectors. If the angle exceeds a predetermined maximum angle, dislodgement is indicated.
摘要翻译：公开了用于检测诸如导管或引线的可植入医疗装置（IMD）的移位的改进的系统和方法。该系统包括用于在身体内产生多个正交相关信号的装置。例如，可以在体内产生具有基本上在X，Y和Z方向定向的电流路径的三个电流信号。本发明还包括具有固定装置的IMD，所述附着装置例如在远侧末端处用于附接到身体组织的螺旋，以及用于感测在体内产生的信号的至少两个感测装置。可以测量两个感测装置之间的信号电平差。例如，可以在两个电极之间测量由主体内的电流产生的电压电位差。该测量信号电平具有X，Y和Z方向上的分量，因此可用于在三维空间中定义方向矢量。该向量表示IMD的方向。通过将指示当前IMD位置的方向矢量与指示参考取向的向量进行比较，可以检测IMD的移位。在一个实施例中，参考取向可以与其中IMD远端基本上垂直于组织的位置相关联。可以通过计算两个相关联的向量之间的角度来执行参考取向与随后的IMD取向之间的比较。如果角度超过预定的最大角度，则表示移动。

3. 发明授权

US06772001B2 Medical examination and/or treatment system 有权
标题翻译：体检和/或治疗系统
公开(公告)号：US06772001B2
公开(公告)日：2004-08-03
申请号：US10346612
申请日：2003-01-17
申请人： Michael Maschke
发明人： Michael Maschke
IPC分类号： A61B505
CPC分类号： A61B1/00156 , A61B5/02007 , A61B5/065 , A61B6/12 , A61B8/0833 , A61B8/0841 , A61B8/12 , A61B34/20 , A61B2034/2051 , A61B2090/376 , A61B2090/378 , A61B2090/3782
摘要： A medical examination and/or treatment system has an X-ray image exposure system with a radiation source, a radiation receiver as well as a control and processing device that controls them, a catheter system with a catheter with at least one element in the catheter tip that generates a magnetic field and a device for generating an external magnetic field for guiding the movement of the catheter introduced into a patient by interaction with the magnetic field generated by the element at the catheter tip, as well as an ultrasound image exposure system having a device integrated in the catheter tip for generating and for receiving ultrasound and having a control and processing device that controls this device.
摘要翻译：医疗检查和/或治疗系统具有具有辐射源的X射线图像曝光系统，辐射接收器以及控制它们的控制和处理装置，具有在导管中具有至少一个元件的导管的导管系统产生磁场的尖端和用于产生外部磁场的装置，用于通过与由导管尖端处的元件产生的磁场相互作用来引导引入患者的导管的移动，以及具有集成在导管末端中用于生成和接收超声波并且具有控制该装置的控制和处理装置的装置。

4. 发明授权

US06768921B2 Electrical impedance method and apparatus for detecting and diagnosing diseases 有权
公开(公告)号：US06768921B2
公开(公告)日：2004-07-27
申请号：US09749613
申请日：2000-12-28
申请人： Leslie W. Organ , Kenneth C. Smith , Reza Safaee-Rad , Milan Graovac , George P. Darmos , Ilya Gavrilov
发明人： Leslie W. Organ , Kenneth C. Smith , Reza Safaee-Rad , Milan Graovac , George P. Darmos , Ilya Gavrilov
IPC分类号： A61B505
CPC分类号： A61B5/0536 , A61B5/04085 , A61B2562/0209 , A61B2562/046
摘要： The present invention relates to an improved method and apparatus for detecting and diagnosing disease states in a living organism by using a plurality of electrical impedance measurements. In particular, the invention provides for an improved electrode array for diagnosing the presence of a disease state in the human breast, and discloses a method of application of the array to the breast that ensures that the multiplicity of impedance measurements obtained from a first body part correspond as precisely and reproducibly as possible to the multiplicity of impedance measurements that are obtained from another, homologous, second body part. A number of diagnostic methods based on homologous electrical difference analysis are disclosed, including the calculation of a number of metrics used to indicate disease states by comparison with pre-established threshold values, and the construction of a number of graphical displays for indicating the location of disease to a body part sector.

5. 发明授权

US06768916B2 Patient-supporting apparatus for a piece of medical equipment 失效
标题翻译：用于一件医疗设备的患者支持装置
公开(公告)号：US06768916B2
公开(公告)日：2004-07-27
申请号：US10026693
申请日：2001-12-27
申请人： Michael Heinold , Wilhelm Strasser , Matthias Seufert
发明人： Michael Heinold , Wilhelm Strasser , Matthias Seufert
IPC分类号： A61B505
CPC分类号： A61B5/0555 , Y10S5/943
摘要： A patient-supporting apparatus (1) for a piece of medical equipment (15), in particular for an MRI tomograph, has a panel (5) for supporting a patient (3) or for bearing a separate supporting panel. Also provided is a guide element (7) on which the panel (5) is arranged in a displaceable manner such that it can be introduced into an accommodating region (13) of the piece of medical equipment (15). The patient-supporting apparatus (1) is distinguished in that a handle (21) provided for displacing the panel (5) is of pivotable configuration. Preferably integrated in the handle (21) is an actuating element (31) which can bring about an operation for braking the panel (5) in relation to the guide element (7).
摘要翻译：用于一件医疗设备（15）的患者支持设备（1），特别是用于MRI断层摄影机，具有用于支撑患者（3）或用于支撑单独的支撑面板的面板（5）。还设置有引导元件（7），面板（5）以可移位的方式布置在该引导元件（7）上，使得其可以被引入到医疗设备（15）的容纳区域（13）中。患者支撑装置（1）的特征在于，用于移动面板（5）的手柄（21）是可枢转的构造。最好集成在手柄（21）中的是致动元件（31），该致动元件可以引起相对于引导元件（7）制动面板（5）的操作。

6. 发明授权

US06766184B2 Methods and apparatus for diagnostic multispectral digital imaging 有权
标题翻译：诊断多光谱数字成像的方法和装置
公开(公告)号：US06766184B2
公开(公告)日：2004-07-20
申请号：US09821786
申请日：2001-03-28
申请人： Urs Utzinger , Rebecca Richards-Kortum , Calum MacAuldy , Michele Follen
发明人： Urs Utzinger , Rebecca Richards-Kortum , Calum MacAuldy , Michele Follen
IPC分类号： A61B505
CPC分类号： A61B1/00186 , A61B1/043 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B1/303 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086
摘要： Methods and apparatus for generating multispectral images of tissue. The multispectral images may be used as a diagnostic tool for conditions such as cervical cancer detection and diagnosis. Primary radiation is produced with an illumination source. The primary radiation is filtered to select a first wavelength and a first polarization. Tissue is illuminated with the filtered primary radiation to generate secondary radiation, which is filtered to select a second wavelength and a second polarization. The filtered secondary radiation is collected with a detector, and a plurality of multispectral images of the tissue is generated according to different combinations of first and second wavelengths and first and second polarization with an analysis unit in operable relation with the detector. Apparatus utilizing the invention include endoscopes and colposcopes.
摘要翻译：用于生成组织多光谱图像的方法和装置。多光谱图像可以用作诸如宫颈癌检测和诊断的诊断工具。主要辐射是用照明源产生的。对主辐射进行滤波以选择第一波长和第一偏振。组织用经滤波的主辐射照射以产生二次辐射，其被滤波以选择第二波长和第二极化。用检测器收集滤波后的二次辐射，根据第一和第二波长的不同组合以及与检测器可操作的分析单元产生第一和第二极化的组织的多个多光谱图像。利用本发明的装置包括内窥镜和阴道镜。

7. 发明授权

US06760616B2 Tissue discrimination and applications in medical procedures 有权
标题翻译：组织歧视和医疗程序中的应用
公开(公告)号：US06760616B2
公开(公告)日：2004-07-06
申请号：US09860648
申请日：2001-05-18
申请人： Michael F. Hoey , Corbett W. Stone , Kevin Foley
发明人： Michael F. Hoey , Corbett W. Stone , Kevin Foley
IPC分类号： A61B505
CPC分类号： A61B5/4869 , A61B5/0537 , A61B5/0538 , A61B5/4893 , A61B17/7001 , A61B18/02 , A61B18/04 , A61B2017/00022
摘要： A method and system for discriminating tissue types, controlling the level of therapy to tissue, and determining the health of a known tissue by measuring the characteristics an electrical signal applied to conductive element located within or by the tissue. Additionally, the method and system may be used for determining whether the conductive tip of a pedicle probe or pedicle screw is located in one of cortical bone, cancellous bone, and cortical bone near a boundary with soft tissue, whether the conductive tip of a cannula is located adjacent to one of nerve tissue and annulus tissue, and whether the conductive tip of a cathode is located adjacent to one of nerve tissue and prostate gland tissue.
摘要翻译：用于区分组织类型，控制组织的治疗水平以及通过测量施加到位于组织内部或通过组织的导电元件的电信号的特性来确定已知组织的健康的方法和系统。此外，该方法和系统可用于确定椎弓根探针或椎弓根螺钉的导电尖端是否位于与软组织边界附近的皮层骨，松质骨和皮质骨之一中，不管导管的导电末端位于神经组织和环带组织之间，以及阴极的导电末端是否位于神经组织和前列腺组织之一附近。

8. 发明授权

US06757559B2 System for and method of detecting polygraph countermeasures 失效
标题翻译：测谎对策的系统及方法
公开(公告)号：US06757559B2
公开(公告)日：2004-06-29
申请号：US10040760
申请日：2002-01-09
申请人： Emmanuel Cohen
发明人： Emmanuel Cohen
IPC分类号： A61B505
CPC分类号： A61B5/164 , A61B5/0533
摘要： A system for, and method of identifying a use of countermeasures by a subject of a polygraph test, the method including the steps of: (a) posing a plurality of questions to the subject; (b) determining, for each question, a time interval between an end of the question and a start of an answer by the subject to the question, thereby generating a plurality of time intervals, and (c) comparing the time intervals to identify the countermeasures.
摘要翻译：一种用于通过测谎测试的对象识别使用对策的系统和方法，所述方法包括以下步骤：（a）向所述对象提供多个问题; （b）针对每个问题，确定问题结束与受试者对问题的回答开始之间的时间间隔，从而产生多个时间间隔，以及（c）比较时间间隔以识别对策。

9. 发明授权

US06748258B1 Method and devices for heart treatment 有权
标题翻译：心脏治疗方法和装置
公开(公告)号：US06748258B1
公开(公告)日：2004-06-08
申请号：US09706584
申请日：2000-11-03
申请人： Richard L. Mueller , U. Hiram Chee
发明人： Richard L. Mueller , U. Hiram Chee
IPC分类号： A61B505
CPC分类号： A61B17/32053 , A61B17/3417 , A61B17/3478 , A61B18/1492 , A61B18/22 , A61B2017/00247 , A61B2018/00392 , A61B2090/036
摘要： Various methods and devices for treating a patient who has lost, or is at risk of losing cardiac function by cardiac ischemia are disclosed. Treatment includes first imaging a patient's heart, or a portion thereof, to identify underperfused regions of cardiac muscle, and a source of oxygenated blood that is proximate to the underperfused region. Between the underperfused regions and the oxygenated blood source, a target area is selected where thermal or mechanical injury is introduced, and optionally reintroduced, to convert initial capillary blush, resulting from the injury.
摘要翻译：公开了用于治疗由于心脏缺血而失去或有丧失心脏功能风险的患者的各种方法和装置。治疗包括首先对患者的心脏或其一部分进行成像以识别心肌的不足灌注区域，以及接近欠灌注区域的充氧血液源。在欠灌注区域和氧合血液源之间，选择引入热或机械损伤的目标区域，并且可选地重新引入，以转化由损伤引起的初始毛细血管腮红。

10. 发明授权

US06748257B2 Detection of ribcage boundary from digital chest image 失效
标题翻译：从数字胸部图像检测胸腔边界
公开(公告)号：US06748257B2
公开(公告)日：2004-06-08
申请号：US09983613
申请日：2001-10-25
申请人： Osamu Ozaki
发明人： Osamu Ozaki
IPC分类号： A61B505
CPC分类号： A61B5/1075 , A61B5/103 , Y10S128/92 , Y10S128/922 , Y10S128/925
摘要： To prevent erroneous detection of a ribcage boundary from a chest image, an outer search limit point is decided with precision. A profile of smoothed pixel-value integrated averages in each of right and left lung field of the image is obtained, a threshold for each of the right and left lung fields with the profile taken as a reference is decided, and each of the right and left lung fields is searched from a central part of each lung field outwardly on the image so that a position exceeding the threshold is determined. The position is set as the outer search limit point for a series of a upper lung ribcage boundary candidate points. In the search, in cases the position exceeding the threshold is not found, a first derivative of the profile is used to decide the outer search limit point.
摘要翻译：为了防止胸部图像中的胸腔边界的错误检测，精确地确定外部搜索极限点。得到图像右，左肺场平均像素值整合平均曲线，确定以该轮廓作为参照的左右肺野中每一个的阈值，右侧和右侧从图像上的每个肺区域的中心部分搜索左肺区域，从而确定超过阈值的位置。该位置被设置为一系列上肺胸腔边界候选点的外部搜索极限点。在搜索中，如果未找到超过阈值的位置，则使用轮廓的一阶导数来确定外部搜索极限点。

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