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1. 发明授权

US5928164A Apparatus for automated biopsy and collection of soft tissue 失效
标题翻译：用于自动活检和收集软组织的装置
公开(公告)号：US5928164A
公开(公告)日：1999-07-27
申请号：US4737
申请日：1998-01-09
申请人： Fred H. Burbank , Thomas J. Fogarty , Wayne E. Manska , Mark A. Ritchart , Timothy J. Ryan , Elias A. Zerhouni
发明人： Fred H. Burbank , Thomas J. Fogarty , Wayne E. Manska , Mark A. Ritchart , Timothy J. Ryan , Elias A. Zerhouni
IPC分类号： A61B10/02 , A61B10/00 , A61B17/22 , A61B17/30 , A61B17/34 , A61B5/00
CPC分类号： A61B10/0266 , A61B10/0275 , A61B10/0283 , A61B17/221 , A61B2010/0208 , A61B2010/0225 , A61B2017/303
摘要： A method and device for the automated biopsy and collection of soft tissue having a piercing needle with a receiving port to trap tissue prior to cutting. A motor drive directs and positions the tissue receiving port at a lesion site in arbitrary positions about and along the longitudinal axis of the device. A cutter advances into the receiving chamber and severs tissue which has prolapsed into the receiving port. The severed tissue is then removed from the receiving port without removing the piercing needle receiving port from the lesion site, thus allowing for the accurate, rapid removal of an arbitrary number of core samples with only one insertion. A tissue sample cassette provides storage for the samples as well as a means for coding and decoding the location from which the samples were obtained. Together, these features allow for more accurate and complete sampling of large lesions, for the complete removal of small lesions or removal of other tissue for a variety of reasons.
摘要翻译：一种用于自动活检和收集软组织的方法和装置，其具有带有接收端口的穿刺针，以在切割之前捕获组织。马达驱动器将组织接收端口引导并定位在病变位置处，并且沿着装置的纵向轴线的任意位置。切割器进入接收室并切断已经脱垂到接收端口中的组织。然后将切断的组织从接收端口移除而不从病变部位移除穿刺针接收端口，从而允许仅用一个插入准确，快速地去除任意数量的芯样品。组织样品盒为样品提供储存，以及用于编码和解码获得样品的位置的装置。一起，这些特征允许对于大的病变进行更准确和完整的取样，用于由于各种原因完全去除小损伤或去除其他组织。

2. 发明授权

US4646334A Radiographic test phantom for computed tomographic lung nodule analysis 失效
标题翻译：用于计算机断层扫描肺结节分析的射线照相测试体模
公开(公告)号：US4646334A
公开(公告)日：1987-02-24
申请号：US818804
申请日：1986-01-14
申请人： Elias A. Zerhouni
发明人： Elias A. Zerhouni
IPC分类号： A61B6/00 , G09B23/28 , G03B42/02
CPC分类号： A61B6/583 , A61B6/508 , G09B23/286
摘要： Disclosed is a test phantom for evaluating a computed tomographic scan of nodules in a lung of a human or non-human animal comprising a device which simulates a 15 to 40 mm thick transverse section of said animal the tissue simulating portions of said device are constructed of materials having radiographic densities substantially identical to those of the corresponding tissue in said simulated transverse section of said animal and contain voids therein which simulate, in size and shape, the lung cavities in said transverse section. At least one of the voids has positioned therein a test reference device constructed of a material of predetermined radiographic density which simulates a lung nodule.
摘要翻译：公开了一种用于评估人或非人动物的肺中的结节的计算机断层扫描的测试体模，包括模拟所述动物的15至40mm厚的横截面的装置，所述装置的组织模拟部分由具有与所述动物的所述模拟横截面中的相应组织基本相同的射线照相密度的材料，并且在其中包含在其中模拟所述横截面中的肺腔的尺寸和形状的空隙。至少一个空隙已经在其中定位了由模拟肺结节的预定放射照相密度的材料构成的测试参考装置。

3. 发明授权

US5980469A Method and apparatus for automated biopsy and collection of soft tissue 失效
标题翻译：用于软组织自动活检和收集的方法和装置
公开(公告)号：US5980469A
公开(公告)日：1999-11-09
申请号：US4782
申请日：1998-01-09
申请人： Fred H. Burbank , Thomas J. Fogarty , Wayne E. Manska , Mark A. Ritchart , Timothy J. Ryan , Elias A. Zerhouni
发明人： Fred H. Burbank , Thomas J. Fogarty , Wayne E. Manska , Mark A. Ritchart , Timothy J. Ryan , Elias A. Zerhouni
IPC分类号： A61B10/02 , A61B10/00 , A61B17/22 , A61B17/30 , A61B17/34
CPC分类号： A61B10/0266 , A61B10/0275 , A61B10/0283 , A61B17/221 , A61B2010/0208 , A61B2010/0225 , A61B2017/303
摘要： A method and device for the automated biopsy and collection of soft tissue having a piercing needle with a receiving port to trap tissue prior to cutting. A motor drive directs and positions the tissue receiving port at a lesion site in arbitrary positions about and along the longitudinal axis of the device. A cutter advances into the receiving chamber and severs tissue which has prolapsed into the receiving port. The severed tissue is then removed from the receiving port without removing the piercing needle receiving port from the lesion site, thus allowing for the accurate, rapid removal of an arbitrary number of core samples with only one insertion. A tissue sample cassette provides storage for the samples as well as a means for coding and decoding the location from which the samples were obtained. Together, these features allow for more accurate and complete sampling of large lesions, for the complete removal of small lesions or removal of other tissue for a variety of reasons.
摘要翻译：一种用于自动活检和收集软组织的方法和装置，其具有带有接收端口的穿刺针，以在切割之前捕获组织。马达驱动器将组织接收端口引导并定位在病变位置处，并且沿着装置的纵向轴线的任意位置。切割器进入接收室并切断已经脱垂到接收端口中的组织。然后将切断的组织从接收端口移除而不从病变部位移除穿刺针接收端口，从而允许仅用一个插入准确，快速地去除任意数量的芯样品。组织样品盒为样品提供储存，以及用于编码和解码获得样品的位置的装置。一起，这些特征允许对于大的病变进行更准确和完整的取样，用于由于各种原因完全去除小损伤或去除其他组织。

4. 发明授权

US5775333A Apparatus for automated biopsy and collection of soft tissue 失效
公开(公告)号：US5775333A
公开(公告)日：1998-07-07
申请号：US645225
申请日：1996-05-13
申请人： Fred H. Burbank , Thomas J. Fogarty , Wayne E. Manska , Mark A. Ritchart , Timothy J. Ryan , Elias A. Zerhouni
发明人： Fred H. Burbank , Thomas J. Fogarty , Wayne E. Manska , Mark A. Ritchart , Timothy J. Ryan , Elias A. Zerhouni
IPC分类号： A61B10/02 , A61B10/00 , A61B17/22 , A61B17/30 , A61B17/34
CPC分类号： A61B10/0266 , A61B10/0275 , A61B10/0283 , A61B17/221 , A61B2010/0208 , A61B2010/0225 , A61B2017/303
摘要： A method and device for the automated biopsy and collection of soft tissue having a piercing needle with a receiving port to trap tissue prior to cutting. A motor drive directs and positions the tissue receiving port at a lesion site in arbitrary positions about and along the longitudinal axis of the device. A cutter advances into the receiving chamber and severs tissue which has prolapsed into the receiving port. The severed tissue is then removed from the receiving port without removing the piercing needle receiving port from the lesion site, thus allowing for the accurate, rapid removal of an arbitrary number of core samples with only one insertion. A tissue sample cassette provides storage for the samples as well as a means for coding and decoding the location from which the samples were obtained. Together, these features allow for more accurate and complete sampling of large lesions, for the complete removal of small lesions or removal of other tissue for a variety of reasons.

5. 发明授权

US5699801A Method of internal magnetic resonance imaging and spectroscopic analysis and associated apparatus 失效
标题翻译：内部磁共振成像和光谱分析方法及相关设备
公开(公告)号：US5699801A
公开(公告)日：1997-12-23
申请号：US457833
申请日：1995-06-01
申请人： Ergin Atalar , Paul A. Bottomley , Elias A. Zerhouni
发明人： Ergin Atalar , Paul A. Bottomley , Elias A. Zerhouni
IPC分类号： A61B10/00 , A61B5/055 , A61B10/02 , A61B19/00 , G01R33/34
CPC分类号： G01R33/34084 , A61B5/055 , G01R33/341 , G01R33/3657 , G01R33/3678 , G01R33/34007
摘要： The invention provides a method for magnetic resonance imaging and spectroscopic analysis of the interior of a specimen which includes positioning the specimen within a main magnetic field, introducing an invasive probe having an elongated receiver coil into or adjacent to the specimen with the coil having at least one pair of elongated electrical conductors, preferably, generally parallel to each other disposed within a dielectric material and having a pair of ends electrically connected to each other. RF pulses are provided to the region of interest to excite magnetic resonance signals, gradient magnetic pulses are applied to the region of interest with the receiver coil receiving magnetic resonance signals and emitting responsive output signals which may be processed by a computer to provide image information for display in a desired manner. The method in a preferred form involves employing a flexible receiver coil which has uniform sensitivity along the coil and may be operated even when the magnetic resonance signal is in an oblique position. Tuning capacitance may be distributed along the length of the coil and/or a Faraday screen provided to minimize dielectric losses between the coil and the surrounding material of the specimen. The method may be used on a wide variety of specimens and in a preferred use is introduced into small blood vessels of a patient to facilitate determination of atherosclerotic plaque. Medical intervention procedures, such as plaque removal, may be employed generally simultaneously with the imaging of the present invention. Corresponding apparatus is provided.
摘要翻译：本发明提供了一种用于磁共振成像和样品内部光谱分析的方法，其包括将样品定位在主磁场内，将具有细长的接收器线圈的侵入性探针引入到试样中或与样品相邻，线圈至少具有一对细长的电导体，优选地大致彼此平行地设置在电介质材料内并且具有彼此电连接的一对端部。将RF脉冲提供给感兴趣的区域以激励磁共振信号，梯度磁脉冲被施加到感兴趣的区域，接收器线圈接收磁共振信号并且发出可由计算机处理的响应输出信号，以提供图像信息以期望的方式显示。优选形式的方法涉及使用具有沿线圈的均匀灵敏度的柔性接收器线圈，并且即使当磁共振信号处于倾斜位置时也可以进行操作。调谐电容可以沿着线圈的长度和/或法拉第屏幕分布，以最小化线圈和样品的周围材料之间的介电损耗。该方法可以用于各种各样的样品，并且优选的用途被引入到患者的小血管中以便于确定动脉粥样硬化斑块。医疗干预程序，例如除斑，可以与本发明的成像通常同时使用。提供相应的设备。

6. 发明授权

US5526822A Method and apparatus for automated biopsy and collection of soft tissue 失效
公开(公告)号：US5526822A
公开(公告)日：1996-06-18
申请号：US217246
申请日：1994-03-24
申请人： Fred H. Burbank , Thomas J. Fogarty , Wayne E. Manska , Mark A. Ritchart , Timothy J. Ryan , Elias A. Zerhouni
发明人： Fred H. Burbank , Thomas J. Fogarty , Wayne E. Manska , Mark A. Ritchart , Timothy J. Ryan , Elias A. Zerhouni
IPC分类号： A61B10/02 , A61B10/00 , A61B17/22 , A61B17/30 , A61B17/34
CPC分类号： A61B10/0266 , A61B10/0275 , A61B10/0283 , A61B17/221 , A61B2010/0208 , A61B2010/0225 , A61B2017/303
摘要： A method and device for the automated biopsy and collection of soft tissue having a piercing needle with a receiving port to trap tissue prior to cutting. A motor drive directs and positions the tissue receiving port at a lesion site in arbitrary positions about and along the longitudinal axis of the device. A cutter advances into the receiving chamber and severs tissue which has prolapsed into the receiving port. The severed tissue is then removed from the receiving port without removing the piercing needle receiving port from the lesion site, thus allowing for the accurate, rapid removal of an arbitrary number of core samples with only one insertion. A tissue sample cassette provides storage for the samples as well as a means for coding and decoding the location from which the samples were obtained. Together, these features allow for more accurate and complete sampling of large lesions, for the complete removal of small lesions or removal of other tissue for a variety of reasons.

7. 发明授权

US08277391B2 Methods and devices for defining and marking tissue 有权
标题翻译：用于定义和标记组织的方法和装置
公开(公告)号：US08277391B2
公开(公告)日：2012-10-02
申请号：US10213638
申请日：2002-08-07
申请人： Seth A. Foerster , Fred H. Burbank , Mark A. Ritchart , Elias A. Zerhouni
发明人： Seth A. Foerster , Fred H. Burbank , Mark A. Ritchart , Elias A. Zerhouni
IPC分类号： A61B10/00
CPC分类号： A61B19/54 , A61B10/0275 , A61B10/0283 , A61B90/39 , A61B2017/00004 , A61B2090/3908 , A61B2090/3987 , Y10T24/4501
摘要： In order to later identify the location of a biopsy or surgery, various means and methods for permanently and non-surgically marking selected tissue in the human body are used. Later visualization of the markers is readily accomplished using state-of-the-art imaging systems.
摘要翻译：为了稍后识别活组织检查或手术的位置，使用用于永久地和非手术地标记人体中的选定组织的各种手段和方法。使用最先进的成像系统，很容易实现标记的可视化。

8. 发明授权

US07044957B2 Devices for defining and marking tissue 失效
标题翻译：用于定义和标记组织的设备
公开(公告)号：US07044957B2
公开(公告)日：2006-05-16
申请号：US09776125
申请日：2001-02-02
申请人： Seth A. Foerster , Fred H. Burbank , Mark A. Ritchart , Elias A. Zerhouni
发明人： Seth A. Foerster , Fred H. Burbank , Mark A. Ritchart , Elias A. Zerhouni
IPC分类号： A61B17/34
CPC分类号： A61B19/54 , A61B10/0275 , A61B10/0283 , A61B90/39 , A61B2017/00004 , A61B2090/3908 , A61B2090/3987 , Y10T24/4501
摘要： In order to later identify the location of a biopsy or surgery, various means and methods for permanently and non-surgically marking selected tissue in the human body are used. Later visualization of the markers is readily accomplished using state-of-the-art imaging systems.
摘要翻译：为了稍后识别活组织检查或手术的位置，使用用于永久地和非手术地标记人体中的选定组织的各种手段和方法。使用最先进的成像系统，很容易实现标记的可视化。

9. 发明授权

US06228055B1 Devices for marking and defining particular locations in body tissue 失效
标题翻译：用于标记和定义身体组织中特定位置的装置
公开(公告)号：US06228055B1
公开(公告)日：2001-05-08
申请号：US08858389
申请日：1997-05-19
申请人： Seth A. Foerster , Fred H. Burbank , Mark A. Ritchart , Elias A. Zerhouni
发明人： Seth A. Foerster , Fred H. Burbank , Mark A. Ritchart , Elias A. Zerhouni
IPC分类号： A61M500
CPC分类号： A61B19/54 , A61B10/0275 , A61B10/0283 , A61B90/39 , A61B2017/00004 , A61B2090/3908 , A61B2090/3987 , Y10T24/4501
摘要： Implantable devices are disclosed for marking the location of a biopsy or surgery for the purpose of identification. The devices are remotely delivered, preferably percutaneously. Visualization of the markers is readily accomplished using various state of the art imaging systems. Using the inventive systems, it is possible to permanently mark the location or margins of a lesion or other tissue site, prior to removing or sampling same. The markers function to provide evidence of the location of the lesion after the procedure is completed, for reference during future examinations or procedures.
摘要翻译：公开了可植入装置，用于标识活检或手术的位置用于鉴定。这些装置被远程传送，优选经皮。使用各种现有技术的成像系统可以容易地实现标记的可视化。使用本发明的系统，可以在移除或取样之前永久地标记病变或其他组织部位的位置或边缘。标记功能用于在手术完成后提供病变位置的证据，以供将来检查或手术参考。

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