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1. 发明授权

US4854324A Processor-controlled angiographic injector device 失效
标题翻译：处理器控制的血管造影注射器装置
公开(公告)号：US4854324A
公开(公告)日：1989-08-08
申请号：US161434
申请日：1988-02-24
申请人： Alan D. Hirschman , David M. Reilly , Ross H. Potter , John A. Stulen , Eric M. Toft , John G. Clark
发明人： Alan D. Hirschman , David M. Reilly , Ross H. Potter , John A. Stulen , Eric M. Toft , John G. Clark
IPC分类号： A61M5/172
CPC分类号： A61M5/14546 , A61M5/172 , A61M2230/04 , Y10S128/01
摘要： An angiographic injector device for use in x-ray photography for delivering contrast media to a patient at controlled rates and pressures. A processor elicits injection parameters from an operator or a pre-programmed injection module, and on the basis of the injection parameters, calculates appropriate control signals for use in a closed-loop servo system to actuate the plunger of a syringe containing the contrast media. Injection parameters includes flow rate, volume, duration, pressure limit and rise-fall time of flow rate. The device also includes control circuits for inhibiting the injection device in response to a contrast media pressure limit, failure in the processor or injection control system, or upon reaching a predetermined volume of injected media. A mechanical stop member cooperates with the control circuit for blocking movement of the syringe plunger upon reaching the predetermined injected volume. Further, the device includes a self-test feature for checking the status of operational components thereof and a self-calibration feature for calibrating the servo system and position monitors. To improve reliability and to provide immunity from data corruption due to line power interruption, injection parameters are stored in battery-powered primary and secondary memories, and are compared and verified prior to an injection. To assist in coordinating an injection in synchronism with cardiac activity, the device monitors the ECG waveform of the patient's heart and injects a small bolus of contrast media at a given interval, such as the distolic interval. An interface also is provided for providing remote transfer of status and control information with the angiographic injector device.
摘要翻译：一种用于x射线摄影的血管造影注射器装置，用于以受控的速率和压力向患者输送造影剂。处理器从操作者或预编程的注射模块引出注射参数，并且基于注射参数，计算用于闭环伺服系统中的合适的控制信号以致动含有造影剂的注射器的柱塞。注射参数包括流量，体积，持续时间，压力极限和流速上升时间。该装置还包括用于响应于造影剂压力极限，处理器或注射控制系统中的故障或达到预定体积的注射介质而抑制注射装置的控制电路。机械止动构件与控制电路配合，以阻止注射器柱塞达到预定注射体积时的运动。此外，该装置包括用于检查其操作部件的状态的自检特征和用于校准伺服系统和位置监视器的自校准特征。为了提高可靠性并提供由于线路电源中断引起的数据损坏的免疫力，注入参数存储在电池供电的初级和次级存储器中，并在注入之前进行比较和验证。为了协调与心脏活动同步的注射，该装置监测患者心脏的心电图波形，并以给定的时间间隔（例如恶心间隔）注入小量的造影剂。还提供了用于提供与血管造影注射器装置的状态和控制信息的远程传送的界面。

2. 发明授权

US08747358B2 Injector system with a manual control device 有权
标题翻译：注射器系统带手动控制装置
公开(公告)号：US08747358B2
公开(公告)日：2014-06-10
申请号：US11238666
申请日：2005-09-29
申请人： Frederick W. Trombley, III , Robert M. Schmidt , David M. Reilly , Alan D. Hirschman , David M. Griffiths , Gerald W. Callan , Luis A. Pedraza , Jennie Kwo , Christopher T. Zirps , Roderick H. Beaulieu
发明人： Frederick W. Trombley, III , Robert M. Schmidt , David M. Reilly , Alan D. Hirschman , David M. Griffiths , Gerald W. Callan , Luis A. Pedraza , Jennie Kwo , Christopher T. Zirps , Roderick H. Beaulieu
IPC分类号： A61M1/00
CPC分类号： A61M5/007 , A61M5/14546 , A61M5/16827 , A61M31/005 , A61M39/22 , A61M2005/1403 , A61M2205/582 , A61M2209/01 , Y10T137/7727
摘要： An injector system includes a powered injector, a pressurizing chamber in operative connection with the powered injection, a fluid path in fluid communication with the pressurizing chamber, and a manual control in fluid connection with the fluid path. The manual control includes at least one actuator for controlling the injector through application of force by an operator. The actuator provides tactile feedback of pressure in the fluid path to the operator via a fluid connection therewith. An injection system for use in angiography includes a source of saline, a pump in fluid connection with the source of saline to pressurized the saline, a source of contrast, a contrast valve in fluid connection with the source of contrast, a powered injector in fluid connection with the contrast valve, and a pressure isolation mechanism.
摘要翻译：注射器系统包括动力注射器，与动力注射操作连接的加压室，与加压室流体连通的流体路径，以及与流体路径流体连接的手动控制。手动控制包括至少一个执行器，用于通过操作者施加力来控制喷射器。致动器通过与其的流体连接提供到操作者的流体路径中的压力的触觉反馈。用于血管造影术的注射系统包括盐水源，与盐水源流体连接的泵以加压盐水，对比源，与对比源流体连接的对比阀，流体中的动力注射器与对比度阀的连接，以及压力隔离机构。

3. 发明申请

US20100185040A1 FLUID DELIVERY SYSTEMS, DEVICES AND METHODS FOR DELIVERY OF HAZARDOUS FLUIDS 有权
标题翻译：流体输送系统，用于输送危险液体的装置和方法
公开(公告)号：US20100185040A1
公开(公告)日：2010-07-22
申请号：US12748682
申请日：2010-03-29
申请人： Arthur E. Uber, III , Alan D. Hirschman , David M. Griffiths , Frederick W. Trombley , David M. Reilly
发明人： Arthur E. Uber, III , Alan D. Hirschman , David M. Griffiths , Frederick W. Trombley , David M. Reilly
IPC分类号： A61M36/08 , A61M5/31
CPC分类号： A61M25/0045 , A61J1/2096 , A61M5/007 , A61M5/1408 , A61M5/142 , A61M5/1452 , A61M5/44 , A61M2202/049 , A61N5/1001
摘要： A system for injecting a patient, includes a container enclosing a hazardous pharmaceutical; a first pump to deliver a hazardous pharmaceutical to a patient and a fluid path operably connected to the first pump, the container, and the patient. The system further includes a hazardous material containment suitable to confine the hazardous pharmaceutical during connection of the hazardous pharmaceutical container to the fluid path.
摘要翻译：一种用于注射患者的系统，包括容纳危险药物的容器; 向患者输送危险药物的第一泵和可操作地连接到第一泵，容器和患者的流体路径。该系统还包括适合于在将危险药物容器连接到流体路径期间限制危险药物的危险材料容纳物。

4. 发明授权

US07204797B2 Delivery methods, systems and components for use with hazardous pharmaceutical substances 有权
标题翻译：用于危险药物的输送方法，系统和组件
公开(公告)号：US07204797B2
公开(公告)日：2007-04-17
申请号：US10893591
申请日：2004-07-16
申请人： David M. Reilly , Alan D. Hirschman , David M. Griffiths , Currie Crookston
发明人： David M. Reilly , Alan D. Hirschman , David M. Griffiths , Currie Crookston
IPC分类号： A61N5/00
CPC分类号： A61K51/1282 , A61M5/007 , A61M5/1407 , A61M5/1452 , A61M5/14546 , A61M5/1785 , G06F19/00 , G16H20/17
摘要： A method of dispensing a hazardous pharmaceutical comprising the steps of: connecting a source of flushing fluid to a first port of a fluid delivery set; connecting a pressurizing unit of a powered injector system (including a powered injector and the pressurizing unit) to a second port of the fluid delivery set; purging air from the fluid delivery set; and, after purging air from the fluid delivery set, connecting a third port of the fluid delivery set to a source of the hazardous pharmaceutical. The fluid delivery set can, for example, include a valve system or assembly to control flow of fluid through the fluid delivery set. A system for delivery of a hazardous pharmaceutical includes: a syringe in operative connection with a powered injector; a protective container to enclose the syringe during operation thereof; the protective container being adapted to protect personnel from detrimental effects of the pharmaceutical; at least one source of flushing fluid; a fluid path adapted to connect to a patient; at least one source of the pharmaceutical; and a fluid delivery set including a valve assembly to which the syringe, the source of flushing fluid, the fluid path and the source of pharmaceutical are removably connectable. The valve assembly provides flow control through the fluid delivery set such that operator contact with the fluid delivery set is not required after connection of the source of pharmaceutical to the fluid delivery set.
摘要翻译：一种分配危险药物的方法，包括以下步骤：将冲洗流体源连接到流体输送装置的第一端口; 将动力注射器系统（包括动力注射器和加压单元）的加压单元连接到流体输送组的第二端口; 从流体输送装置吹扫空气; 并且在从流体输送装置吹扫空气之后，将流体输送装置的第三端口连接到危险药物源。流体输送装置可以例如包括阀系统或组件以控制通过流体输送组的流体的流动。用于递送危险药物的系统包括：与动力注射器可操作地连接的注射器; 在操作期间包围注射器的保护容器; 保护容器适于保护人员免受药物的不利影响; 至少一个冲洗液源; 适于连接到患者的流体路径; 至少一种药物来源; 以及包括阀组件的流体输送组件，注射器，冲洗流体源，流体路径和药物源可拆卸地连接到该组件。阀组件通过流体输送组件提供流量控制，使得在将药物源连接到流体输送装置之后，操作者不需要与流体输送装置接触。

5. 发明授权

US08702649B2 Multiple lumen diffusion catheter 有权
标题翻译：多腔扩散导管
公开(公告)号：US08702649B2
公开(公告)日：2014-04-22
申请号：US12515981
申请日：2007-11-28
申请人： Robert S. Schwartz , Robert A. Van Tassel , Eugene A. Gelblum , Alan D. Hirschman , John F. Kalafut , David M. Reilly , Frederick W. Trombley, III , Arthur E. Uber, III
发明人： Robert S. Schwartz , Robert A. Van Tassel , Eugene A. Gelblum , Alan D. Hirschman , John F. Kalafut , David M. Reilly , Frederick W. Trombley, III , Arthur E. Uber, III
IPC分类号： A61M29/00
CPC分类号： A61M25/007 , A61M25/003
摘要： A method and device for the simultaneous or sequential introduction of multiple fluids into the bloodstream including a multiple lumen catheter with corresponding multiple hole sets. By introducing a second fluid such as saline, the concentration and bolus of a first fluid, such as a contrast agent, can be controlled and optimized.
摘要翻译：一种用于同时或顺序地将多种流体引入血流中的方法和装置，包括具有相应多孔组的多腔导管。通过引入诸如盐水的第二流体，可以控制和优化第一流体如造影剂的浓度和推注。

6. 发明申请

US20130253254A1 FLUID DELIVERY SYSTEMS, DEVICES AND METHODS FOR DELIVERY OF HAZARDOUS FLUIDS 有权
标题翻译：流体输送系统，用于输送危险液体的装置和方法
公开(公告)号：US20130253254A1
公开(公告)日：2013-09-26
申请号：US13898680
申请日：2013-05-21
申请人： Arthur E. Uber, III , Alan D. Hirschman , David M. Griffiths , Frederick W. Trombley, III , David M. Reilly
发明人： Arthur E. Uber, III , Alan D. Hirschman , David M. Griffiths , Frederick W. Trombley, III , David M. Reilly
IPC分类号： A61M5/142 , A61J1/20 , A61N5/10 , A61M5/44
CPC分类号： A61M25/0045 , A61J1/2096 , A61M5/007 , A61M5/1408 , A61M5/142 , A61M5/1452 , A61M5/44 , A61M2202/049 , A61N5/1001
摘要： A system for delivering fluid to a patient includes a container suitable for holding a fluid and an enclosure to shield the fluid. The system further includes a pump device capable of pumping fluid from the container and delivering the fluid to the patient, and the container adapted to be attachable to the pump device.
摘要翻译：用于将流体输送到患者的系统包括适于保持流体的容器和用于屏蔽流体的外壳。该系统还包括能够从容器泵送流体并将流体输送到患者的泵装置，以及适于附接到泵装置的容器。

7. 发明申请

US20130172811A1 Systems and Methods of Delivering a Dilated Slurry to a Patient 有权
标题翻译：向患者提供稀释的浆液的系统和方法
公开(公告)号：US20130172811A1
公开(公告)日：2013-07-04
申请号：US13772849
申请日：2013-02-21
申请人： Arthur E. Uber, III , David M. Griffiths , David M. Reilly , Alan D. Hirschman , Kevin P. Cowan , Mark Trocki
发明人： Arthur E. Uber, III , David M. Griffiths , David M. Reilly , Alan D. Hirschman , Kevin P. Cowan , Mark Trocki
IPC分类号： A61M5/14 , A61M5/172
CPC分类号： A61M5/1407 , A61M5/14216 , A61M5/14236 , A61M5/1723 , A61M2202/09 , B01F7/00258 , B01F7/00566 , B01F7/00908 , B01F7/086 , B01F9/103 , B01F11/0071 , B01F11/0074 , B01F11/0082 , B01F11/025 , B01F13/002 , B01F13/0023 , B01F13/0818 , G06F19/00
摘要： A system for delivering a slurry to a patient includes a fluid, a material that is non-dissolvable or immiscible in the fluid, thereby forming a slurry, a container adapted to contain the slurry and a supernate of the slurry, the container defining an outlet through which the slurry is delivered to the patient, a fluidizing system associated with the container, a pressurizing mechanism adapted to create a pressure to cause the slurry contained within the container to flow for delivery to the patient and a control unit in communication with and adapted to control the fluidizing system and the pressurizing mechanism. The fluidizing system is adapted to effect dilation of the slurry while maintaining at least a portion of the supernate.
摘要翻译：用于将浆料递送到患者的系统包括流体，在流体中不可溶或不混溶的材料，从而形成浆料，适于容纳浆料的容器和浆料的上清液，容器限定出口通过其将浆料输送到患者，与容器相关联的流化系统，适于产生压力以使容纳在容器内的浆液流动以输送到患者的加压机构，以及与该患者连接并适应的控制单元以控制流化系统和加压机构。流化系统适于在保持至少一部分上清液的同时实现浆料的扩张。

8. 发明授权

US07713239B2 System for delivery of hazardous pharmaceuticals 有权
标题翻译：交付危险药品的系统
公开(公告)号：US07713239B2
公开(公告)日：2010-05-11
申请号：US10821210
申请日：2004-04-08
申请人： Arthur E. Uber, III , Alan D. Hirschman , David M. Griffiths , Frederick W. Trombley , David M. Reilly
发明人： Arthur E. Uber, III , Alan D. Hirschman , David M. Griffiths , Frederick W. Trombley , David M. Reilly
IPC分类号： A61M37/00
CPC分类号： A61M25/0045 , A61J1/2096 , A61M5/007 , A61M5/1408 , A61M5/142 , A61M5/1452 , A61M5/44 , A61M2202/049 , A61N5/1001
摘要： A system for injecting a patient, includes a container enclosing a hazardous pharmaceutical; a first pump to deliver a hazardous pharmaceutical to a patient and a fluid path operably connected to the first pump, the container, and the patient. The system further includes a hazardous material containment suitable to confine the hazardous pharmaceutical during connection of the hazardous pharmaceutical container to the fluid path.
摘要翻译：一种用于注射患者的系统，包括容纳危险药物的容器; 向患者输送危险药物的第一泵和可操作地连接到第一泵，容器和患者的流体路径。该系统还包括适合于在将危险药物容器连接到流体路径期间限制危险药物的危险材料容纳物。

9. 发明授权

US07094216B2 Injection system having a pressure isolation mechanism and/or a handheld controller 有权
标题翻译：具有压力隔离机构和/或手持控制器的注射系统
公开(公告)号：US07094216B2
公开(公告)日：2006-08-22
申请号：US09982518
申请日：2001-10-18
申请人： Frederick W. Trombley, III , Robert M. Schmidt , David M. Reilly , Alan D. Hirschman , David M. Griffiths , Gerald W. Callan , Luis A. Pedraza , Jennie Kwo , Christopher T. Zirps , Roderick H. Beaulieu
发明人： Frederick W. Trombley, III , Robert M. Schmidt , David M. Reilly , Alan D. Hirschman , David M. Griffiths , Gerald W. Callan , Luis A. Pedraza , Jennie Kwo , Christopher T. Zirps , Roderick H. Beaulieu
IPC分类号： A61M31/00
CPC分类号： A61M5/007 , A61M5/14546 , A61M5/16827 , A61M31/005 , A61M39/22 , A61M2005/1403 , A61M2205/582 , A61M2209/01 , Y10T137/7727
摘要： An injector system includes a powered injector, a pressurizing chamber in operative connection with the powered injector, a fluid path in fluid connection with the pressurizing chamber, and a manual control in fluid connection with the fluid path. The manual control includes at least one actuator for controlling the injector through application of force by an operator. The actuator provides tactile feedback of pressure in the fluid path to the operator via a fluid connection with the fluid path. An injection system for use in angiography includes a source of saline, a pump in fluid connection with the source of saline to pressurize the saline, a saline valve in fluid connection via a first port thereof with an outlet of the pump, a first connector in fluid connection with a second port of the saline valve, a source of contrast, a contrast valve in fluid connection with the source of contrast via a first port of the contrast valve, a powered injector in fluid connection with a second port of the contrast valve, a second connector in fluid connection with a third port of the contrast valve, and a pressure isolation mechanism.
摘要翻译：注射器系统包括动力注射器，与动力注射器可操作地连接的加压室，与加压室流体连接的流体路径，以及与流体路径流体连接的手动控制。手动控制包括至少一个执行器，用于通过操作者施加力来控制喷射器。致动器通过与流体路径的流体连接提供到操作者的流体路径中的压力的触觉反馈。用于血管造影术的注射系统包括盐水源，与盐水源流体连接以对盐水加压的泵，经由其第一端口与泵的出口流体连接的盐水阀，第一连接器与盐水阀的第二端口的流体连接，对比度源，通过对比度阀的第一端口与对比源流体连接的对比度阀，与对比度阀的第二端口流体连接的动力注射器与对比度阀的第三端口流体连接的第二连接器和压力隔离机构。

10. 发明授权

US06974443B2 Front loading injector system with pressure jacket assembly and syringe 失效
标题翻译：带压力套管组件和注射器的前部装载注射器系统
公开(公告)号：US06974443B2
公开(公告)日：2005-12-13
申请号：US10631079
申请日：2003-07-31
申请人： David M. Reilly , Arthur E. Uber, III , Alan D. Hirschman , Eugene A. Gelblum
发明人： David M. Reilly , Arthur E. Uber, III , Alan D. Hirschman , Eugene A. Gelblum
IPC分类号： A61M5/142 , A61M5/145 , A61M37/00 , B05C17/01
CPC分类号： B05C17/01 , A61M5/14546 , A61M5/14566 , A61M2005/14553 , Y10S128/01
摘要： An injector system includes a syringe and an injector. The syringe includes a body portion and a plunger movably disposed within the body portion. The injector includes a housing defining a front opening therein, a drive member extendible through the front opening of the housing for imparting motive force to the plunger disposed within the syringe, and a pressure jacket assembly associated with the housing for substantially enclosing the syringe during an injection procedure. The pressure jacket assembly includes a jacket cylinder having an open front end for receiving the syringe and a front member associated with the housing. The front member is pivotable between a closed position for retaining the syringe within the jacket cylinder and an open position for allowing the syringe to be inserted into and removed from the front end of the jacket cylinder.
摘要翻译：注射器系统包括注射器和注射器。注射器包括主体部分和可移动地设置在主体部分内的柱塞。注射器包括在其中限定前开口的壳体，可延伸穿过壳体的前开口的驱动构件，用于向设置在注射器内的柱塞赋予动力;以及与壳体相关联的压力套组件，用于在注射程序。所述压力套组件包括具有用于接收所述注射器的开口前端和与所述壳体相关联的前部构件的护套筒。前部构件在用于将注射器保持在护套筒内的关闭位置和用于允许注射器插入到护套筒的前端中并从套筒筒的前端移除的打开位置之间可枢转。

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