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1. 发明授权

US07204797B2 Delivery methods, systems and components for use with hazardous pharmaceutical substances 有权
标题翻译：用于危险药物的输送方法，系统和组件
公开(公告)号：US07204797B2
公开(公告)日：2007-04-17
申请号：US10893591
申请日：2004-07-16
申请人： David M. Reilly , Alan D. Hirschman , David M. Griffiths , Currie Crookston
发明人： David M. Reilly , Alan D. Hirschman , David M. Griffiths , Currie Crookston
IPC分类号： A61N5/00
CPC分类号： A61K51/1282 , A61M5/007 , A61M5/1407 , A61M5/1452 , A61M5/14546 , A61M5/1785 , G06F19/00 , G16H20/17
摘要： A method of dispensing a hazardous pharmaceutical comprising the steps of: connecting a source of flushing fluid to a first port of a fluid delivery set; connecting a pressurizing unit of a powered injector system (including a powered injector and the pressurizing unit) to a second port of the fluid delivery set; purging air from the fluid delivery set; and, after purging air from the fluid delivery set, connecting a third port of the fluid delivery set to a source of the hazardous pharmaceutical. The fluid delivery set can, for example, include a valve system or assembly to control flow of fluid through the fluid delivery set. A system for delivery of a hazardous pharmaceutical includes: a syringe in operative connection with a powered injector; a protective container to enclose the syringe during operation thereof; the protective container being adapted to protect personnel from detrimental effects of the pharmaceutical; at least one source of flushing fluid; a fluid path adapted to connect to a patient; at least one source of the pharmaceutical; and a fluid delivery set including a valve assembly to which the syringe, the source of flushing fluid, the fluid path and the source of pharmaceutical are removably connectable. The valve assembly provides flow control through the fluid delivery set such that operator contact with the fluid delivery set is not required after connection of the source of pharmaceutical to the fluid delivery set.
摘要翻译：一种分配危险药物的方法，包括以下步骤：将冲洗流体源连接到流体输送装置的第一端口; 将动力注射器系统（包括动力注射器和加压单元）的加压单元连接到流体输送组的第二端口; 从流体输送装置吹扫空气; 并且在从流体输送装置吹扫空气之后，将流体输送装置的第三端口连接到危险药物源。流体输送装置可以例如包括阀系统或组件以控制通过流体输送组的流体的流动。用于递送危险药物的系统包括：与动力注射器可操作地连接的注射器; 在操作期间包围注射器的保护容器; 保护容器适于保护人员免受药物的不利影响; 至少一个冲洗液源; 适于连接到患者的流体路径; 至少一种药物来源; 以及包括阀组件的流体输送组件，注射器，冲洗流体源，流体路径和药物源可拆卸地连接到该组件。阀组件通过流体输送组件提供流量控制，使得在将药物源连接到流体输送装置之后，操作者不需要与流体输送装置接触。

2. 发明授权

US06767319B2 Delivery methods, systems and components for use with hazardous pharmaceutical substances 有权
标题翻译：用于危险药物的输送方法，系统和组件
公开(公告)号：US06767319B2
公开(公告)日：2004-07-27
申请号：US10201880
申请日：2002-07-24
申请人： David M. Reilly , Alan D. Hirschman , David M. Griffiths , Currie Crookston
发明人： David M. Reilly , Alan D. Hirschman , David M. Griffiths , Currie Crookston
IPC分类号： A61N500
CPC分类号： A61K51/1282 , A61M5/007 , A61M5/1407 , A61M5/1452 , A61M5/14546 , A61M5/1785 , G06F19/00 , G16H20/17
摘要： A method of dispensing a hazardous pharmaceutical includes the steps of: connecting a source of flushing fluid to a first port of a fluid delivery set; connecting a pressurizing unit of a powered injector system (including a powered injector and the pressurizing unit) to a second port of the fluid delivery set; purging air from the fluid delivery set; and, after purging air from the fluid delivery set, connecting a third port of the fluid delivery set to a source of the hazardous pharmaceutical. The fluid delivery set can, for example, include a valve system or assembly to control flow of fluid through the fluid delivery set. A system for delivery of a hazardous pharmaceutical includes: a syringe in operative connection with a powered injector; a protective container to enclose the syringe during operation thereof, the protective container being adapted to protect personnel from detrimental effects of the pharmaceutical; at least one source of flushing fluid; a fluid path adapted to connect to a patient; at least one source of the pharmaceutical; and a fluid delivery set including a valve assembly to which the syringe, the source of flushing fluid, the fluid path and the source of pharmaceutical are removably connectable. The valve assembly provides flow control through the fluid delivery set such that operator contact with the fluid delivery set is not required after connection of the source of pharmaceutical to the fluid delivery set.
摘要翻译：分配危险药物的方法包括以下步骤：将冲洗流体源连接到流体输送装置的第一端口; 将动力注射器系统（包括动力注射器和加压单元）的加压单元连接到流体输送组的第二端口; 从流体输送装置吹扫空气; 并且在从流体输送装置吹扫空气之后，将流体输送装置的第三端口连接到危险药物源。流体输送装置可以例如包括阀系统或组件以控制通过流体输送组的流体的流动。用于递送危险药物的系统包括：与动力注射器可操作地连接的注射器; 保护容器在操作期间封闭注射器，保护容器适于保护人员免受药物的不利影响; 至少一个冲洗液源; 适于连接到患者的流体路径; 至少一种药物来源; 以及包括阀组件的流体输送组件，注射器，冲洗流体源，流体路径和药物源可拆卸地连接到该组件。阀组件通过流体输送组件提供流量控制，使得在将药物源连接到流体输送装置之后，操作者不需要与流体输送装置接触。

3. 发明授权

US08747358B2 Injector system with a manual control device 有权
标题翻译：注射器系统带手动控制装置
公开(公告)号：US08747358B2
公开(公告)日：2014-06-10
申请号：US11238666
申请日：2005-09-29
申请人： Frederick W. Trombley, III , Robert M. Schmidt , David M. Reilly , Alan D. Hirschman , David M. Griffiths , Gerald W. Callan , Luis A. Pedraza , Jennie Kwo , Christopher T. Zirps , Roderick H. Beaulieu
发明人： Frederick W. Trombley, III , Robert M. Schmidt , David M. Reilly , Alan D. Hirschman , David M. Griffiths , Gerald W. Callan , Luis A. Pedraza , Jennie Kwo , Christopher T. Zirps , Roderick H. Beaulieu
IPC分类号： A61M1/00
CPC分类号： A61M5/007 , A61M5/14546 , A61M5/16827 , A61M31/005 , A61M39/22 , A61M2005/1403 , A61M2205/582 , A61M2209/01 , Y10T137/7727
摘要： An injector system includes a powered injector, a pressurizing chamber in operative connection with the powered injection, a fluid path in fluid communication with the pressurizing chamber, and a manual control in fluid connection with the fluid path. The manual control includes at least one actuator for controlling the injector through application of force by an operator. The actuator provides tactile feedback of pressure in the fluid path to the operator via a fluid connection therewith. An injection system for use in angiography includes a source of saline, a pump in fluid connection with the source of saline to pressurized the saline, a source of contrast, a contrast valve in fluid connection with the source of contrast, a powered injector in fluid connection with the contrast valve, and a pressure isolation mechanism.
摘要翻译：注射器系统包括动力注射器，与动力注射操作连接的加压室，与加压室流体连通的流体路径，以及与流体路径流体连接的手动控制。手动控制包括至少一个执行器，用于通过操作者施加力来控制喷射器。致动器通过与其的流体连接提供到操作者的流体路径中的压力的触觉反馈。用于血管造影术的注射系统包括盐水源，与盐水源流体连接的泵以加压盐水，对比源，与对比源流体连接的对比阀，流体中的动力注射器与对比度阀的连接，以及压力隔离机构。

4. 发明申请

US20100185040A1 FLUID DELIVERY SYSTEMS, DEVICES AND METHODS FOR DELIVERY OF HAZARDOUS FLUIDS 有权
标题翻译：流体输送系统，用于输送危险液体的装置和方法
公开(公告)号：US20100185040A1
公开(公告)日：2010-07-22
申请号：US12748682
申请日：2010-03-29
申请人： Arthur E. Uber, III , Alan D. Hirschman , David M. Griffiths , Frederick W. Trombley , David M. Reilly
发明人： Arthur E. Uber, III , Alan D. Hirschman , David M. Griffiths , Frederick W. Trombley , David M. Reilly
IPC分类号： A61M36/08 , A61M5/31
CPC分类号： A61M25/0045 , A61J1/2096 , A61M5/007 , A61M5/1408 , A61M5/142 , A61M5/1452 , A61M5/44 , A61M2202/049 , A61N5/1001
摘要： A system for injecting a patient, includes a container enclosing a hazardous pharmaceutical; a first pump to deliver a hazardous pharmaceutical to a patient and a fluid path operably connected to the first pump, the container, and the patient. The system further includes a hazardous material containment suitable to confine the hazardous pharmaceutical during connection of the hazardous pharmaceutical container to the fluid path.
摘要翻译：一种用于注射患者的系统，包括容纳危险药物的容器; 向患者输送危险药物的第一泵和可操作地连接到第一泵，容器和患者的流体路径。该系统还包括适合于在将危险药物容器连接到流体路径期间限制危险药物的危险材料容纳物。

5. 发明申请

US20080294096A1 Delivery of Agents Such as Cells to Tissue 有权
标题翻译：将细胞递送给组织
公开(公告)号：US20080294096A1
公开(公告)日：2008-11-27
申请号：US12092448
申请日：2006-11-06
申请人： Arthur E. Uber, III , Alan D. Hirschman , Evan Facher , Eugene A. Gelblum , David M. Griffiths , Edward J. Rhinehart , David M. Reilly , Kevin P. Cowan , Page Cedarholm , Barry L. Tucker , Mark Trocki , David Mishler , Henry E. Bartony, JR. , Robert Parks
发明人： Arthur E. Uber, III , Alan D. Hirschman , Evan Facher , Eugene A. Gelblum , David M. Griffiths , Edward J. Rhinehart , David M. Reilly , Kevin P. Cowan , Page Cedarholm , Barry L. Tucker , Mark Trocki , David Mishler , Henry E. Bartony, JR. , Robert Parks
IPC分类号： A61M5/168
CPC分类号： A61M5/142 , A61M5/1452 , A61M5/1723 , A61M5/3291 , A61M25/007 , A61M25/04 , A61M31/005 , A61M2025/0089 , A61M2025/009 , A61M2025/0092
摘要： A system for delivering a fluid comprising cells to tissue of a patient, includes: a least a first container for holding an injection fluid in which the agent is carried; a first powered drive in operative connection with the container, the first powered drive being operable to pressurize contents of the container; a control system in operative connection with the first powered drive and operative to control the first powered drive; a fluid path in fluid connection with the container, the fluid path including a patient interface adapted to deposit the cells within tissue of the patient; a sensor system; and a communication system in connection with at least the control system and the sensor system. The communication system is adapted to provide information to the control system. The control system in adapted to transmit a control signal to at least the first powered drive based at least in part on information provided to the control system. The cells can for example be pregenitor cells or stem cells.
摘要翻译：一种用于将包含细胞的流体输送到患者的组织的系统，包括：用于保持其中携带有药剂的注射液体的至少第一容器; 与容器操作性连接的第一动力驱动器，第一动力驱动器可操作以对容器的内容物进行加压; 控制系统，其与第一动力驱动器操作连接并且可操作以控制第一动力驱动; 与容器流体连接的流体路径，流体路径包括适于将细胞沉积在患者组织内的患者界面; 传感器系统; 以及至少与控制系统和传感器系统相关的通信系统。通信系统适于向控制系统提供信息。控制系统适于至少部分地基于提供给控制系统的信息将控制信号发送到至少第一动力驱动器。细胞可以例如是前体细胞或干细胞。

6. 发明授权

US09326742B2 Systems for integrated radiopharmaceutical generation, preparation, transportation and administration 有权
标题翻译：综合放射性药物生成，制备，运输和管理系统
公开(公告)号：US09326742B2
公开(公告)日：2016-05-03
申请号：US12595165
申请日：2007-12-28
申请人： Alan D. Hirschman , Arthur E. Uber, III , David M. Reilly , John Kalafut , Frederick W. Trombley, III , Steven J. Remis , Scott Griffith , Douglas Descalzi , Richard Dewit , David M. Griffiths , Marc A. Mabie , Mark Trocki
发明人： Alan D. Hirschman , Arthur E. Uber, III , David M. Reilly , John Kalafut , Frederick W. Trombley, III , Steven J. Remis , Scott Griffith , Douglas Descalzi , Richard Dewit , David M. Griffiths , Marc A. Mabie , Mark Trocki
IPC分类号： A61M3/00 , A61B6/00 , A61B6/03 , A61B6/04 , A61M5/172 , G06F19/00 , G21G4/08 , A61B6/10 , A61B5/0205 , A61B5/00 , A61M5/00 , A61M5/145 , A61M5/168 , A61M5/178
CPC分类号： A61N5/1001 , A61B5/0205 , A61B5/055 , A61B5/7289 , A61B6/032 , A61B6/037 , A61B6/0478 , A61B6/107 , A61B6/4057 , A61B6/4258 , A61B6/4423 , A61B6/507 , A61B6/508 , A61B6/5288 , A61B6/548 , A61M5/007 , A61M5/14546 , A61M5/1456 , A61M5/16827 , A61M5/16881 , A61M5/1723 , A61M5/1785 , A61M2205/3576 , A61N5/1071 , A61N2005/1021 , A61N2005/1094 , G06F19/00 , G06F19/3468 , G16H20/17 , G21F5/015 , G21G4/08
摘要： A hazardous fluid handling system which includes a housing having a radiation shielded internal chamber disposed therein which may accommodate a container holding a radioactive fluid, one or more radioactivity detectors positioned within the shielded internal chamber in operational proximity to the radioactive fluid in the container, and a dosimeter control device electronically coupled to the radioactivity detector(s) is disclosed. The dosimeter control device is operational for determining information regarding the radioactive fluid in the container based on individual measurements received from the one or more radioactivity detectors. The hazardous fluid handling system may be integrated into a patient support platform which includes a patient stimulus apparatus, an imager proximate the patient support platform, a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient, a patient monitor to be associated with the patient, and an integrated system controller.
摘要翻译：一种危险的流体处理系统，其包括具有设置在其中的辐射屏蔽内部室的壳体，其可以容纳容纳放射性流体的容器，位于屏蔽内部室内的一个或多个放射性检测器，其操作接近容器中的放射性流体;以及公开了一种电子耦合到放射性检测器的剂量计控制装置。剂量计控制装置可操作用于基于从一个或多个放射性检测器接收的各个测量值来确定关于容器中的放射性流体的信息。有害流体处理系统可以集成到患者支撑平台中，该患者支撑平台包括患者刺激装置，靠近患者支撑平台的成像器，用于将放射性药物流体输入患者的放射性药物流体输送系统，病人和一个集成的系统控制器。

7. 发明授权

US09005166B2 Fluid delivery systems, devices and methods for delivery of hazardous fluids 有权
标题翻译：用于输送危险液体的流体输送系统，装置和方法
公开(公告)号：US09005166B2
公开(公告)日：2015-04-14
申请号：US13898680
申请日：2013-05-21
申请人： Arthur E. Uber, III , Alan D. Hirschman , David M. Griffiths , Frederick W. Trombley, III , David M. Reilly
发明人： Arthur E. Uber, III , Alan D. Hirschman , David M. Griffiths , Frederick W. Trombley, III , David M. Reilly
IPC分类号： A61M37/00 , A61M5/142 , A61M5/00 , A61M5/14 , A61M5/145 , A61J1/20 , A61M5/44 , A61N5/10
CPC分类号： A61M25/0045 , A61J1/2096 , A61M5/007 , A61M5/1408 , A61M5/142 , A61M5/1452 , A61M5/44 , A61M2202/049 , A61N5/1001
摘要： A system for delivering fluid to a patient includes a hazardous material enclosure suitable for holding a first container comprising a first fluid, and a pump device capable of pumping the first fluid from the first container and a second fluid from a second container. The hazardous materials enclosure has a cap which includes a flexible sealing member that cooperates with the first container to create a biohazard seal during connection of the first container to the cap. The system further includes a mixing device associated with the pump for mixing the first and second fluids for delivering the fluid mixture to the patient.
摘要翻译：用于将流体输送到患者的系统包括适于保持包括第一流体的第一容器的危险材料外壳和能够从第一容器泵送第一流体的泵装置和来自第二容器的第二流体的泵装置。危险材料外壳具有盖，该盖包括与第一容器配合的柔性密封构件，以在第一容器与盖连接期间产生生物危害密封。该系统还包括与泵相关联的混合装置，用于混合第一和第二流体以将流体混合物输送给患者。

8. 发明授权

US08192397B2 Medical fluid injection and inflation system 有权
标题翻译：医疗注射液和通气系统
公开(公告)号：US08192397B2
公开(公告)日：2012-06-05
申请号：US11425497
申请日：2006-06-21
申请人： David M. Griffiths , Rosemary Almon-Martin , Alan D. Hirschman , David M. Reilly , Frederick W. Trombley, III , Arthur E. Uber, III , William Jaecklein
发明人： David M. Griffiths , Rosemary Almon-Martin , Alan D. Hirschman , David M. Reilly , Frederick W. Trombley, III , Arthur E. Uber, III , William Jaecklein
IPC分类号： A61M29/00
CPC分类号： A61M25/10184 , A61M5/007 , A61M5/14566 , A61M5/16827 , A61M5/16854 , A61M25/007 , A61M25/104 , A61M2025/102 , A61M2025/1022
摘要： A combined fluid injection and inflation system is disclosed and includes a fluid delivery system including at least one pressurizing device, a fluid path, and a control unit. The fluid path is adapted to connect the pressurizing device to a patient via a catheter including a balloon and inserted in the patient. The control unit is operable to control the fluid delivery system. In operation, the control unit selectively actuates the fluid delivery system to operate in a fluid injection mode or in a balloon inflation mode. In the fluid injection mode the pressurizing device delivers fluid to the fluid path for a fluid injection procedure. In the balloon inflation mode, the pressurizing device delivers fluid to the fluid path for inflating the balloon associated with the catheter. An operator control may be connected to the control unit for controlling the fluid delivery system and may be a handheld device.
摘要翻译：公开了组合的流体注入和充气系统，并且包括包括至少一个加压装置，流体路径和控制单元的流体输送系统。流体路径适于经由包括球囊并且插入患者体内的导管将加压装置连接到患者。控制单元可操作以控制流体输送系统。在操作中，控制单元选择性地致动流体输送系统以流体注射模式或气球充气模式操作。在流体注射模式中，加压装置将流体输送到流体路径用于流体注射程序。在球囊膨胀模式中，加压装置将流体输送到流体路径，用于使与导管相关联的球囊膨胀。操作员控制可以连接到控制单元以控制流体输送系统，并且可以是手持装置。

9. 发明申请

US20110178359A1 Systems For Integrated Radiopharmaceutical Generation, Preparation, Transportation and Administration 有权
标题翻译：综合放射性药物生成，制备，运输和管理系统
公开(公告)号：US20110178359A1
公开(公告)日：2011-07-21
申请号：US12595165
申请日：2007-12-28
申请人： Alan D. Hirschman , Arthur E. Uber, III , Kevin P. Cowan , David M. Reilly , Edward J. Rhinehart , John Kalafut , Bronwyn Uber , Frederick W. Trombley, III , Steven J. Remis , Paul D. Levin , Scott Griffith , Douglas Descalzi , Richard Dewit , David M. Griffiths
发明人： Alan D. Hirschman , Arthur E. Uber, III , Kevin P. Cowan , David M. Reilly , Edward J. Rhinehart , John Kalafut , Bronwyn Uber , Frederick W. Trombley, III , Steven J. Remis , Paul D. Levin , Scott Griffith , Douglas Descalzi , Richard Dewit , David M. Griffiths
IPC分类号： A61M36/06
CPC分类号： A61N5/1001 , A61B5/0205 , A61B5/055 , A61B5/7289 , A61B6/032 , A61B6/037 , A61B6/0478 , A61B6/107 , A61B6/4057 , A61B6/4258 , A61B6/4423 , A61B6/507 , A61B6/508 , A61B6/5288 , A61B6/548 , A61M5/007 , A61M5/14546 , A61M5/1456 , A61M5/16827 , A61M5/16881 , A61M5/1723 , A61M5/1785 , A61M2205/3576 , A61N5/1071 , A61N2005/1021 , A61N2005/1094 , G06F19/00 , G06F19/3468 , G16H20/17 , G21F5/015 , G21G4/08
摘要： An integrated radiopharmaceutical patient treatment system is disclosed including a patient support platform with an associated patient stimulus apparatus, an imager proximate the patient support platform, a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient, a patient monitor to be associated with a patient, and an integrated system controller operably associated with the patient stimulus apparatus, imager, radiopharmaceutical fluid delivery system, and patient monitor to control and coordinate their operations. Within the patient treatment system the radiopharmaceutical fluid delivery system may be included comprising a radionuclide supply module, a radiopharmaceutical processing module, a quality control module, a patient injection module, and a controller. A hazardous fluid handling system including a docking station and a hazardous fluid transport device adapted to detachably dock with the docking station is further disclosed.
摘要翻译：公开了一种集成的放射性药物患者治疗系统，其包括具有相关联的患者刺激装置的患者支撑平台，靠近患者支撑平台的成像器，用于将放射性药物流体输入患者的放射性药物流体输送系统，与患者以及与患者刺激装置，成像器，放射性药物流体输送系统和患者监护器可操作地相关联以控制和协调其操作的集成系统控制器。在患者治疗系统内，可以包括放射性药物流体递送系统，包括放射性核素供应模块，放射性药物处理模块，质量控制模块，患者注射模块和控制器。进一步公开了一种危险的流体处理系统，其包括对接站和适于与对接站可拆卸地对接的危险流体输送装置。

10. 发明申请

US20130253254A1 FLUID DELIVERY SYSTEMS, DEVICES AND METHODS FOR DELIVERY OF HAZARDOUS FLUIDS 有权
标题翻译：流体输送系统，用于输送危险液体的装置和方法
公开(公告)号：US20130253254A1
公开(公告)日：2013-09-26
申请号：US13898680
申请日：2013-05-21
申请人： Arthur E. Uber, III , Alan D. Hirschman , David M. Griffiths , Frederick W. Trombley, III , David M. Reilly
发明人： Arthur E. Uber, III , Alan D. Hirschman , David M. Griffiths , Frederick W. Trombley, III , David M. Reilly
IPC分类号： A61M5/142 , A61J1/20 , A61N5/10 , A61M5/44
CPC分类号： A61M25/0045 , A61J1/2096 , A61M5/007 , A61M5/1408 , A61M5/142 , A61M5/1452 , A61M5/44 , A61M2202/049 , A61N5/1001
摘要： A system for delivering fluid to a patient includes a container suitable for holding a fluid and an enclosure to shield the fluid. The system further includes a pump device capable of pumping fluid from the container and delivering the fluid to the patient, and the container adapted to be attachable to the pump device.
摘要翻译：用于将流体输送到患者的系统包括适于保持流体的容器和用于屏蔽流体的外壳。该系统还包括能够从容器泵送流体并将流体输送到患者的泵装置，以及适于附接到泵装置的容器。

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