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1. 发明授权

US09056200B2 Apparatus and methods for delivery of fluid injection boluses to patients and handling harmful fluids 有权
标题翻译：用于向患者输送流体注射剂并处理有害流体的装置和方法
公开(公告)号：US09056200B2
公开(公告)日：2015-06-16
申请号：US12996520
申请日：2009-06-05
申请人： Arthur E. Uber, III , Mark Trocki , Marc A. Mabie , Larry McCutchan , L. George Siddoway , Kevin P. Cowan , Lisa M. Coates , John F. Kalafut , Aaron Hughes , David M. Griffiths , Peter Twichell , Julie Gulick , Frederick W. Trombley, III
发明人： Arthur E. Uber, III , Mark Trocki , Marc A. Mabie , Larry McCutchan , L. George Siddoway , Kevin P. Cowan , Lisa M. Coates , John F. Kalafut , Aaron Hughes , David M. Griffiths , Peter Twichell , Julie Gulick , Frederick W. Trombley, III
IPC分类号： A61N5/00 , A61N5/10 , A61M5/00 , A61M5/168 , A61M5/178 , A61M5/14
CPC分类号： A61N5/1007 , A61M5/007 , A61M5/16827 , A61M5/1785 , A61M2005/1402 , A61M2202/0225 , A61M2202/049 , A61M2206/11 , A61M2206/18 , Y10T137/0318
摘要： A hazardous fluid transport container and a hazardous fluid delivery system are disclosed. The hazardous fluid transport container includes a housing enclosing an at least partially shielded enclosure. First and second fluid path elements are disposed within the housing, with the first fluid path element and second fluid path element fluidly coupled together. A pump unit may be provided for dispensing fluid from the first and second fluid path elements optionally into a third fluid path element. Also, methods for priming the hazardous fluid transport container and for mitigating laminar flow injection bolus spreading are disclosed. Additionally, disclosed is a radioactive fluid transport container for a syringe or other container. The radioactive fluid transport container allows the syringe or container to be used in an injection procedure without removal from the container.
摘要翻译：公开了一种危险流体输送容器和危险流体输送系统。危险流体输送容器包括封闭至少部分屏蔽的外壳的壳体。第一和第二流体通道元件设置在壳体内，第一流体路径元件和第二流体路径元件流体耦合在一起。可以提供泵单元，用于将流体从第一和第二流体路径元件任选地分配到第三流体路径元件中。此外，公开了用于引燃危险流体输送容器和减轻层流注射团块扩散的方法。此外，公开了一种用于注射器或其他容器的放射性流体输送容器。放射性流体输送容器允许注射器或容器在注射过程中使用而不从容器中取出。

2. 发明申请

US20150058038A1 SYSTEMS HAVING A CENTRALIZED DATABASE FOR USE IN THE COLLECTION, MANAGEMENT AND DISSEMINATION OF INFORMATION RELATING TO MEDICAL PROCEDURES 审中-公开
标题翻译：具有集中数据库的系统用于收集，管理和发布与医疗程序有关的信息
公开(公告)号：US20150058038A1
公开(公告)日：2015-02-26
申请号：US13975290
申请日：2013-08-24
申请人： Arthur E. Uber, III , John P. Friel , David M. Griffiths
发明人： Arthur E. Uber, III , John P. Friel , David M. Griffiths
IPC分类号： G06F19/00
CPC分类号： G06F19/325 , G06F19/321 , G06F19/324 , G06Q10/10 , G06Q50/22 , G06Q50/24 , G16H10/60 , Y10S707/915 , Y10S707/99933 , Y10S707/99942 , Y10S707/99943 , Y10S707/99944 , Y10S707/99945
摘要： A system for the collection, management, and dissemination of information relating at least to a medical procedure is disclosed. The system includes a user interface adapted to provide raw data information at least about one of a patient, the medical procedure, and a result of the medical procedure. A medical device communicates with the user interface, receives the raw data information from the user interface, and generates operational information during use. A central database communicates at least with the medical device and receives data from the medical device. The central database is used to create related entries based on the raw data information and the operational information and optionally transmits the related entry to the medical device or the medical device user. The related entry includes information that provides guidance based on previously tabulated, related medical procedures. A system for the iterative analysis of medical standards is also disclosed along with methods for the evaluation of medical procedures and standards.
摘要翻译：公开了收集，管理和传播至少涉及医疗程序的信息的系统。该系统包括适于提供至少约一个患者，医疗程序和医疗程序结果的原始数据信息的用户界面。医疗设备与用户界面通信，从用户界面接收原始数据信息，并在使用过程中生成操作信息。中央数据库至少与医疗设备通信并从医疗设备接收数据。中央数据库用于基于原始数据信息和操作信息创建相关条目，并且可选地将相关条目发送到医疗设备或医疗设备用户。相关条目包括基于以前列出的相关医疗程序提供指导的信息。还公开了用于医疗标准的迭代分析的系统以及用于评估医疗程序和标准的方法。

3. 发明授权

US08876754B2 Catheter with filtering and sensing elements 有权
标题翻译：带过滤和感应元件的导管
公开(公告)号：US08876754B2
公开(公告)日：2014-11-04
申请号：US11469054
申请日：2006-08-31
申请人： Arun Ranchod , David M. Griffiths , Alan D. Hirschman
发明人： Arun Ranchod , David M. Griffiths , Alan D. Hirschman
IPC分类号： A61M31/00 , A61M25/00
CPC分类号： A61M25/007 , A61F2/013
摘要： A delivery apparatus useful for infusing a therapeutic agent into a body lumen, the apparatus including a lumenal body defining at least one infusion port for infusing the therapeutic agent into the body lumen, and a sensing element which is distal of the at least one infusion port and adapted to sense the amount of infused therapeutic agent or any compound derived therefrom in the body lumen. Another embodiment of the apparatus includes a lumenal body defining at least one infusion port for infusing the therapeutic agent into the body lumen, and a filtration element which is distal of the at least one infusion port and adapted to deliver a reaction agent which may react with the therapeutic agent in the body lumen. A sensing element may be provided distal of the filtration element for sensing the amount of infused therapeutic agent or compounds derived therefrom in the body lumen.
摘要翻译：一种用于将治疗剂注入体腔中的输送装置，所述装置包括限定用于将治疗剂注入体腔的至少一个输注端口的腔体，以及位于至少一个输注端口的远端的感测元件并且适于感测输注的治疗剂或其体内衍生的任何化合物的量。该装置的另一实施例包括限定用于将治疗剂注入体腔的至少一个输注端口的腔体，以及位于该至少一个输注端口的远端的适于输送可与治疗剂在体腔内。感测元件可以设置在过滤元件的远侧，用于感测在体腔中输注的治疗剂或其衍生的化合物的量。

4. 发明申请

US20110270633A1 INTERFACE DEVICES AND METHODS FOR AUTOMATED BENCHMARKING OF BEST MEDICAL PRACTICES AND PRODUCTS 有权
标题翻译：用于自动化的最佳医疗实践和产品的界面装置和方法
公开(公告)号：US20110270633A1
公开(公告)日：2011-11-03
申请号：US13180175
申请日：2011-07-11
申请人： Arthur E. Uber III , John P. Friel , David M. Griffiths
发明人： Arthur E. Uber III , John P. Friel , David M. Griffiths
IPC分类号： G06Q50/00
CPC分类号： G06F19/325 , G06F19/00 , G06F19/321 , G06F19/324 , G06Q10/10 , G06Q50/22 , G06Q50/24 , G16H10/60 , Y10S707/915 , Y10S707/99933 , Y10S707/99942 , Y10S707/99943 , Y10S707/99944 , Y10S707/99945
摘要： A system for the collection, management, and dissemination of information relating at least to a medical procedure is disclosed. The system includes a user interface adapted to provide raw data information at least about one of a patient, the medical procedure, and a result of the medical procedure. A medical device communicates with the user interface, receives the raw data information from the user interface, and generates operational information during use. A central database communicates at least with the medical device and receives data from the medical device. The central database is used to create related entries based on the raw data information and the operational information and optionally transmits the related entry to the medical device or the medical device user. The related entry includes information that provides guidance based on previously tabulated, related medical procedures. A system for the iterative analysis of medical standards is also disclosed along with methods for the evaluation of medical procedures and standards.
摘要翻译：公开了收集，管理和传播至少涉及医疗程序的信息的系统。该系统包括适于提供至少约一个患者，医疗程序和医疗程序结果的原始数据信息的用户界面。医疗设备与用户界面通信，从用户界面接收原始数据信息，并在使用过程中生成操作信息。中央数据库至少与医疗设备通信并从医疗设备接收数据。中央数据库用于基于原始数据信息和操作信息创建相关条目，并且可选地将相关条目发送到医疗设备或医疗设备用户。相关条目包括基于以前列出的相关医疗程序提供指导的信息。还公开了用于医疗标准的迭代分析的系统以及用于评估医疗程序和标准的方法。

5. 发明授权

US07632245B1 Devices, systems and methods for delivery of a fluid into a patient during a magnetic resonance procedure 有权
标题翻译：用于在磁共振程序期间将流体输送到患者体内的装置，系统和方法
公开(公告)号：US07632245B1
公开(公告)日：2009-12-15
申请号：US10921083
申请日：2004-08-18
申请人： Kevin P. Cowan , Frederick W. Trombley, III , David M. Reilly , David M. Griffiths , George J. Misic , Keith Callan
发明人： Kevin P. Cowan , Frederick W. Trombley, III , David M. Reilly , David M. Griffiths , George J. Misic , Keith Callan
IPC分类号： A61M5/19
CPC分类号： A61M5/14526 , A61M5/007 , A61M2039/0009 , A61M2205/3362
摘要： A device for injection of a fluid into a patient includes a container adapted to hold the fluid and defining an outlet through which the fluid can exit the container. A pressurizing mechanism is in connection with the container for pressurizing the fluid, and an actuator is in fluid connection with the outlet. The actuator has a first state in which fluid is prevented from flowing through the outlet and a second state in which fluid can flow through the outlet. The injection device further includes a flow regulator to control the flow rate of fluid in fluid connection with the outlet. The container, the pressurizing mechanism, the actuator and the flow regulator can be MR compatible, thereby making the device suitable for use in or near the bore of an MR scanner.
摘要翻译：用于向患者注射流体的装置包括适于保持流体并限定出口的容器，流体可通过该出口离开容器。加压机构与用于对流体加压的容器连接，并且致动器与出口流体连接。致动器具有防止流体流过出口的第一状态和流体可以流过出口的第二状态。注射装置还包括流量调节器以控制与出口流体连接的流体的流速。容器，加压机构，致动器和流量调节器可以是MR兼容的，从而使得该装置适合于在MR扫描器的孔中或附近使用。

6. 发明授权

US07540854B2 Method of substituting a first fluid delivery device with a second fluid delivery device 有权
标题翻译：用第二流体输送装置代替第一流体输送装置的方法
公开(公告)号：US07540854B2
公开(公告)日：2009-06-02
申请号：US10190361
申请日：2002-07-03
申请人： Frederick W. Trombley, III , Francis J. Sciulli, Jr. , David M. Griffiths , Arthur E. Uber, III
发明人： Frederick W. Trombley, III , Francis J. Sciulli, Jr. , David M. Griffiths , Arthur E. Uber, III
IPC分类号： A61M37/00 , A61B6/00
CPC分类号： A61M5/142 , A61M39/08 , A61M39/10
摘要： A method of substituting an MRI incompatible pump for delivering fluid to a patient with an MRI compatible pump, both pumps being microprocessor controlled. The first pump operates upon administration tubing for pumping fluid from a source thereof to the patient. The method includes the steps of: providing the second pump to be substituted for the first pump; providing second tubing having a portion thereof that is operable to function with the second pump; connecting the second tubing to the administration tubing to establish an altered fluid path from the source to the patient, the altered path including portions of both the administration and second tubing; placing the second pump for operation upon the second tubing to enable the second pump to pump the fluid through the altered path according to programming thereof; and disconnecting the first pump from the administration tubing before bringing the patient into the MRI environment.
摘要翻译：用MRI兼容的泵代替MRI不相容的泵将流体输送到具有MRI兼容泵的患者的方法，两个泵都由微处理器控制。第一泵在管道管上操作，以将流体从源的泵送到患者。该方法包括以下步骤：提供要替代第一泵的第二泵; 提供第二管道，其具有可与第二泵一起起作用的部分; 将所述第二管道连接到所述管道管，以建立从所述源到所述患者的改变的流体路径，所述改变的路径包括所述施用和所述第二管道的两部分; 将第二泵放置在第二管上以使第二泵根据其编程使泵流体通过改变的路径; 并在将患者进入MRI环境之前将第一个泵与管线管连接起来。

7. 发明申请

US20090070342A1 SYSTEM AND METHOD FOR AUTOMATED BENCHMARKING FOR THE RECOGNITION OF BEST MEDICAL PRACTICES AND PRODUCTS AND FOR ESTABLISHING STANDARDS FOR MEDICAL PROCEDURES 有权
标题翻译：用于自动识别最佳医疗实践和产品并建立医疗程序标准的系统和方法
公开(公告)号：US20090070342A1
公开(公告)日：2009-03-12
申请号：US12254318
申请日：2008-10-20
申请人： Arthur E. Uber, III , John P. Friel , David M. Griffiths
发明人： Arthur E. Uber, III , John P. Friel , David M. Griffiths
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F19/325 , G06F19/00 , G06F19/321 , G06F19/324 , G06Q10/10 , G06Q50/22 , G06Q50/24 , G16H10/60 , Y10S707/915 , Y10S707/99933 , Y10S707/99942 , Y10S707/99943 , Y10S707/99944 , Y10S707/99945
摘要： A system for the collection, management, and dissemination of information relating at least to a medical procedure is disclosed. The system includes a user interface adapted to provide raw data information at least about one of a patient, the medical procedure, and a result of the medical procedure. A medical device communicates with the user interface, receives the raw data information from the user interface, and generates operational information during use. A central database communicates at least with the medical device and receives data from the medical device. The central database is used to create related entries based on the raw data information and the operational information and optionally transmits the related entry to the medical device or the medical device user. The related entry includes information that provides guidance based on previously tabulated, related medical procedures. A system for the iterative analysis of medical standards is also disclosed along with methods for the evaluation of medical procedures and standards.
摘要翻译：公开了收集，管理和传播至少涉及医疗程序的信息的系统。该系统包括适于提供至少约一个患者，医疗程序和医疗程序结果的原始数据信息的用户界面。医疗设备与用户界面通信，从用户界面接收原始数据信息，并在使用过程中生成操作信息。中央数据库至少与医疗设备通信并从医疗设备接收数据。中央数据库用于基于原始数据信息和操作信息创建相关条目，并且可选地将相关条目发送到医疗设备或医疗设备用户。相关条目包括基于以前列出的相关医疗程序提供指导的信息。还公开了用于医疗标准的迭代分析的系统以及用于评估医疗程序和标准的方法。

8. 发明申请

US20080294096A1 Delivery of Agents Such as Cells to Tissue 有权
标题翻译：将细胞递送给组织
公开(公告)号：US20080294096A1
公开(公告)日：2008-11-27
申请号：US12092448
申请日：2006-11-06
申请人： Arthur E. Uber, III , Alan D. Hirschman , Evan Facher , Eugene A. Gelblum , David M. Griffiths , Edward J. Rhinehart , David M. Reilly , Kevin P. Cowan , Page Cedarholm , Barry L. Tucker , Mark Trocki , David Mishler , Henry E. Bartony, JR. , Robert Parks
发明人： Arthur E. Uber, III , Alan D. Hirschman , Evan Facher , Eugene A. Gelblum , David M. Griffiths , Edward J. Rhinehart , David M. Reilly , Kevin P. Cowan , Page Cedarholm , Barry L. Tucker , Mark Trocki , David Mishler , Henry E. Bartony, JR. , Robert Parks
IPC分类号： A61M5/168
CPC分类号： A61M5/142 , A61M5/1452 , A61M5/1723 , A61M5/3291 , A61M25/007 , A61M25/04 , A61M31/005 , A61M2025/0089 , A61M2025/009 , A61M2025/0092
摘要： A system for delivering a fluid comprising cells to tissue of a patient, includes: a least a first container for holding an injection fluid in which the agent is carried; a first powered drive in operative connection with the container, the first powered drive being operable to pressurize contents of the container; a control system in operative connection with the first powered drive and operative to control the first powered drive; a fluid path in fluid connection with the container, the fluid path including a patient interface adapted to deposit the cells within tissue of the patient; a sensor system; and a communication system in connection with at least the control system and the sensor system. The communication system is adapted to provide information to the control system. The control system in adapted to transmit a control signal to at least the first powered drive based at least in part on information provided to the control system. The cells can for example be pregenitor cells or stem cells.
摘要翻译：一种用于将包含细胞的流体输送到患者的组织的系统，包括：用于保持其中携带有药剂的注射液体的至少第一容器; 与容器操作性连接的第一动力驱动器，第一动力驱动器可操作以对容器的内容物进行加压; 控制系统，其与第一动力驱动器操作连接并且可操作以控制第一动力驱动; 与容器流体连接的流体路径，流体路径包括适于将细胞沉积在患者组织内的患者界面; 传感器系统; 以及至少与控制系统和传感器系统相关的通信系统。通信系统适于向控制系统提供信息。控制系统适于至少部分地基于提供给控制系统的信息将控制信号发送到至少第一动力驱动器。细胞可以例如是前体细胞或干细胞。

9. 发明申请

US20080147147A1 VEIN LOCATING DEVICE FOR VASCULAR ACCESS PROCEDURES 审中-公开
标题翻译： VEIN用于血管通路程序的定位装置
公开(公告)号：US20080147147A1
公开(公告)日：2008-06-19
申请号：US11612147
申请日：2006-12-18
申请人： David M. Griffiths , Arthur E. Uber , Page Cedarholm , Adrienne Fazio , Michael J. Yanniello
发明人： David M. Griffiths , Arthur E. Uber , Page Cedarholm , Adrienne Fazio , Michael J. Yanniello
IPC分类号： A61N5/06
CPC分类号： A61B5/0059 , A61B5/489
摘要： A device for detecting a venous structure or vessels in a patient or animal. The device includes an optical source for transmitting optical energy into the tissue of the patient, an optical detector for detecting at least a portion of the optical energy that is transmitted into and reflected by the tissue, and an indicator operably associated with the optical source and the optical detector. The indicator is adapted to indicate relative changes in the detected reflection or scattering of the optical energy transmitted into the tissue of the patient.
摘要翻译：用于检测患者或动物中的静脉结构或血管的装置。该装置包括用于将光能量传输到患者组织中的光源，用于检测透射到组织中并由其反射的光能的至少一部分的光学检测器，以及与光源可操作地相关联的指示器，光学检测器。指示符适于指示检测到的透射到患者组织中的光能的反射或散射的相对变化。

10. 发明申请

US20080097339A1 CATHETER WITH FILTERING AND SENSING ELEMENTS 有权
标题翻译：带过滤器和感应元件的过滤器
公开(公告)号：US20080097339A1
公开(公告)日：2008-04-24
申请号：US11469054
申请日：2006-08-31
申请人： Arun Ranchod , David M. Griffiths , Alan D. Hirschman
发明人： Arun Ranchod , David M. Griffiths , Alan D. Hirschman
IPC分类号： A61M5/168 , A61M29/00
CPC分类号： A61M25/007 , A61F2/013
摘要： In one form, the therapeutic agent delivery apparatus is used for infusing a therapeutic agent into a body lumen and includes a lumenal body defining a plurality of infusion ports for infusing the therapeutic agent into the body lumen, and a sensing element distal of the infusion ports and adapted to sense the amount of infused therapeutic agent or any compound derived from the therapeutic agent in the body lumen. In another form, the apparatus includes a lumenal body defining a plurality of infusion ports for infusing the therapeutic agent into the body lumen, and a filtration element distal of the infusion ports and adapted to deliver a reaction agent adapted to react with the therapeutic agent in the body lumen. A sensing element may be provided distal of the filtration element for sensing the amount of infused therapeutic agent or compounds derived therefrom in the body lumen.
摘要翻译：在一种形式中，治疗剂递送装置用于将治疗剂注入体腔，并且包括界定多个用于将治疗剂注入体腔的输注端口的腔体，以及位于输液端口远端的感测元件并且适于感测输注的治疗剂或源自体腔内的治疗剂的任何化合物的量。在另一种形式中，该装置包括限定用于将治疗剂注入体腔内的多个输注端口的腔体，以及位于输注端口远端的过滤元件，并适于递送适于与治疗剂反应的反应剂体腔。感测元件可以设置在过滤元件的远侧，用于感测在体腔中输注的治疗剂或其衍生的化合物的量。

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