专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP3391058A1 SYSTEMS AND METHODS FOR AUTOMATED ANALYSIS 无效转让
公开(公告)号：EP3391058A1
公开(公告)日：2018-10-24
申请号：EP16876536.0
申请日：2016-12-14
申请人： Abbott Laboratories , Accurso, Roger W. , Wu, Jiong , Kendall, Richard G. , Janik, James A. , Shanafelter, Ronald J. , Tabey, Roger , Berezhna, Svitlana Y. , Shields, Trevor D. , Janbakhsh, Mahmoud , Wong, Daryl , Haro, Jorge , Kennedy, Michael J.
发明人： ACCURSO, Roger W. , WU, Jiong , KENDALL, Richard G. , JANIK, James A. , SHANAFELTER, Ronald J. , TABEY, Roger , BEREZHNA, Svitlana Y. , SHIELDS, Trevor D. , JANBAKHSH, Mahmoud , WONG, Daryl , HARO, Jorge , KENNEDY, Michael J.
IPC分类号： G01N35/04 , G01N35/02 , G01N35/00
CPC分类号： G01N35/021 , G01D5/342 , G01N1/312 , G01N21/13 , G01N35/00029 , G01N35/00732 , G01N35/00871 , G01N35/0099 , G01N35/04 , G01N2035/00138 , G01N2035/00326 , G01N2035/00801 , G01N2035/0412 , G01N2035/0493 , G01N2201/0438
摘要： Aspects of the present disclosure include systems and methods. According to certain embodiments, provided is an integrated analysis system that includes a first module including a sample analysis component and a first internal container conveyor system. The integrated analysis system further includes a second module including a second internal container conveyor system. The first and second modules are positioned adjacent each other such that the first and second internal container conveyor systems are aligned and adapted to transport containers from the first module to the second module. Also provided are methods of analyzing and preparing samples (e.g., blood and body fluid samples), as well as components that find use within the analysis systems of the present disclosure.

2. 发明申请

WO2012158826A3 METHOD AND APPARATUS FOR DETECTION, ANALYSIS, AND COLLECTION OF RARE CELLULAR EVENTS 审中-公开
标题翻译：用于检测，分析和收集稀有细胞活性的方法和装置
公开(公告)号：WO2012158826A3
公开(公告)日：2014-05-08
申请号：PCT/US2012038189
申请日：2012-05-16
申请人： ABBOTT LAB , WU JIONG , JUNNARKAR MAHESH , VACCA GIACOMO
发明人： WU JIONG , JUNNARKAR MAHESH , VACCA GIACOMO
IPC分类号： G01N33/48 , G01N33/50
CPC分类号： G01N15/1459 , G01N15/1434 , G01N21/05 , G01N21/53 , G01N21/6428 , G01N21/645 , G01N2021/0346 , G01N2021/6482 , G01N2021/6493
摘要： Systems and methods for the detection, analysis, and collection of rare cellular events, wherein rare cellular events are defined by events comprising less than 5% of a total number of cells in a sample. The systems and methods generally include: (1) a flow cell dimensioned so as to permit a flow of a sample through the flow cell at a flow rate greater than 300,000 cells per second; (2) a laser positioned to emit a laser beam directed to the flow cell; (3) one or more deflector components disposed between the laser and the flow cell, wherein the deflector component is configured to affect a position of the laser beam relative to the sample flow; (4) one or more fluorescence emission detectors; and (5) one or more processor configured to detect rare cellular events based on fluorescence emission from cell-binding surface markers introduced into the sample prior to the sample being flowed through the flow cell.
摘要翻译：用于检测，分析和收集罕见细胞事件的系统和方法，其中罕见的细胞事件由包含小于样品中总细胞数量的5％的事件定义。系统和方法通常包括：（1）流动池，其尺寸设计成允许样品以大于每秒300,000个细胞的流速流过流动池; （2）定位成发射指向流动池的激光束的激光器; （3）设置在所述激光器和所述流动池之间的一个或多个偏转器部件，其中所述偏转器部件被配置为影响所述激光束相对于所述样品流的位置; （4）一个或多个荧光发射检测器; 以及（5）一个或多个处理器，被配置为基于在样品流过所述流动池之前引入到样品中的来自细胞结合表面标记物的荧光发射来检测罕见的细胞事件。

3. 发明申请

WO2010126838A1 METHOD FOR DISCRIMINATING RED BLOOD CELLS FROM WHITE BLOOD CELLS BY USING FORWARD SCATTERING FROM A LASER IN AN AUTOMATED HEMATOLOGY ANALYZER 审中-公开
标题翻译：用于通过使用来自自动化学分析仪中的激光的前向散射来鉴别来自白血球细胞的红细胞的方法
公开(公告)号：WO2010126838A1
公开(公告)日：2010-11-04
申请号：PCT/US2010/032429
申请日：2010-04-26
申请人： ABBOTT LABORATORIES , KROCKENBERGER, Martin , WU, Jiong , ROEMER, Bodo , VACCA, Giacomo
发明人： KROCKENBERGER, Martin , WU, Jiong , ROEMER, Bodo , VACCA, Giacomo
IPC分类号： G01N33/48
CPC分类号： G01N15/1404 , G01N15/00 , G01N15/1429 , G01N15/1459 , G01N21/53 , G01N33/49 , G01N33/4915 , G01N33/492 , G01N2015/0073 , G01N2015/0076 , G01N2015/008 , G01N2015/0084 , G01N2015/1006 , G01N2015/1486 , G01N2800/22 , Y10T436/101666
摘要： A method for identifying, analyzing, and quantifying the cellular components of whole blood by means of an automated hematology analyzer and the detection of the light scattered, absorbed, and fluorescently emitted by each cell. More particularly, the aforementioned method involves identifying, analyzing, and quantifying the cellular components of whole blood by means of a light source having a wavelength ranging from about 400 nm to about 450 nm and multiple in-flow optical measurements and staining without the need for lysing red blood cells.
摘要翻译：一种通过自动血液分析仪识别，分析和定量全血细胞成分的方法，以及每个细胞散射，吸收和荧光发射的光的检测。更具体地，上述方法包括通过具有波长范围为约400nm至约450nm的光源和多次流入光学测量和染色来鉴定，分析和定量全血的细胞组分，并且不需要裂解红细胞。

4. 发明申请

WO2006110339A1 CELLULAR STANDARDS FOR GLYCATED HEMOGLOBIN AlC DETERMINATION 审中-公开
标题翻译：用于糖化HEMOGLOBIN AlC测定的细胞标准品
公开(公告)号：WO2006110339A1
公开(公告)日：2006-10-19
申请号：PCT/US2006/011884
申请日：2006-03-30
申请人： STRECK LABORATORIES, INC. , RYAN, Wayne , WU, Jiong
发明人： RYAN, Wayne , WU, Jiong
IPC分类号： G01N33/72 , C07K14/805
CPC分类号： G01N33/723 , Y10T436/10 , Y10T436/105831 , Y10T436/108331 , Y10T436/25 , Y10T436/25125
摘要： Disclosed are cellular hemoglobin AIc (Hb AIc ) normal and abnormal (high) controls for use in detecting Hb AIc levels. The present invention also relates to methods for generating cellular Hb AIc controls using red blood cells and methods for using the cellular controls. The present invention encompasses several methods for the preparation of Hb AIc cellular controls including: (1) a boronate method where the glycation occurs non-specif ically; (2) a stabilized diabetic blood method where the glycation occurs specifically on Hb AIc, and (3) the glycation of normal blood method that is achieved by controlling conditions such that glycation occurs predominantly on Hb AIc. These methods produce cellular Hb AIc controls with desirable stability and that can be detected on a variety of instruments. In preferred embodiments, the control contains intact erythrocytes .
摘要翻译：公开了用于检测Hb AIc水平的细胞血红蛋白AIc（Hb AIc）正常和异常（高）对照。本发明还涉及使用红细胞产生细胞Hb AIc对照的方法和使用细胞对照的方法。本发明包括几种用于制备HbA1c细胞对照的方法，包括：（1）硼酸盐法，其中糖化发生非特异性; （2）稳定的糖尿病血液法，其中糖化特异性地发生在HbA1c上，和（3）通过控制使糖基化主要发生在HbA1c上的病症来实现的正常血液法糖化。这些方法产生具有期望稳定性的细胞Hb AIc对照，并且可以在各种仪器上检测。在优选的实施方案中，对照含有完整的红细胞。

5. 发明申请

WO2003070899A2 PHOSPHO-SPECIFIC ANTIBODIES TO FLT3 AND USES THEREOF 审中-公开
标题翻译：磷酸化特异性抗体FLT3及其用途
公开(公告)号：WO2003070899A2
公开(公告)日：2003-08-28
申请号：PCT/US2003/004758
申请日：2003-02-19
申请人： CELL SIGNALING TECHNOLOGY, INC. , COMB, Michael, J. , WETZEL, Randall, K. , WU, Jiong , CROSBY, Katherine
发明人： COMB, Michael, J. , WETZEL, Randall, K. , WU, Jiong , CROSBY, Katherine
IPC分类号： C12N
CPC分类号： C07K16/44 , C07K16/2896 , C07K16/40 , C07K2317/34 , G01N33/573 , G01N33/57426
摘要： The invention discloses two newly-discovered Flt3 phosphorylation sites, tyrosine 589 (Tyr589) and tyrosine 591 (Tyr591) in the intracellular domain, and provides antibodies, both polyclonal and monoclonal, that selectively bind to Flt3 when phosphorylated at these novel sites. Also provided are assays utilizing these reagents, including methods for determining the phosphorylation of Flt3 in a biological sample, selecting a patient suitable for Flt3 inhibitor therapy, profiling Flt3 activation in a test tissue, and identifying a compound that modulates phosphorylation of Flt3 in a test tissue, by using a detectable reagent, such as the disclosed antibodies, that binds to Flt3 when phosphorylated at Tyr589 or Tyr591. The sample or test tissue may be taken from a subject suspected of having cancer, such as acute myelogenous leukemia (AML).
摘要翻译：本发明公开了两个新发现的Flt3磷酸化位点，即细胞内结构域中的酪氨酸589（Tyr589）和酪氨酸591（Tyr591），并且提供了在这些新位点磷酸化时选择性结合Flt3的抗体，多克隆和单克隆抗体。还提供了使用这些试剂的测定法，包括用于测定生物样品中Flt3的磷酸化的方法，选择适合Flt3抑制剂治疗的患者，在测试组织中分析Flt3活化，以及鉴定在测试中调节Flt3的磷酸化的化合物通过使用在Tyr589或Tyr591磷酸化时与Flt3结合的可检测试剂，例如所公开的抗体。样品或测试组织可以从疑似患有癌症的受试者中获取，例如急性骨髓性白血病（AML）。

6. 发明申请

WO2012151105A2 BASOPHIL ANALYSIS SYSTEM AND METHOD 审中-公开
标题翻译： BASOPHIL分析系统和方法
公开(公告)号：WO2012151105A2
公开(公告)日：2012-11-08
申请号：PCT/US2012035163
申请日：2012-04-26
申请人： ABBOTT LAB , WU JIONG , BUHL MICHAEL R , VACCA GIACOMO
发明人： WU JIONG , BUHL MICHAEL R , VACCA GIACOMO
IPC分类号： C12M1/42 , G01N21/64
CPC分类号： G01N15/1434 , G01N15/1459 , G01N21/6428 , G01N33/49 , G01N2015/0069 , G01N2015/008 , G01N2015/1006 , G01N2015/1402 , G01N2015/1477 , G01N2015/1486 , G01N2015/1488 , G01N2021/6439
摘要： Provided herein are systems and methods for analyzing blood samples, and more specifically for performing a basophil analysis. In one embodiment, the systems and methods include: (a) staining a blood sample with an exclusive cell membrane permeable fluorescent dye; and then (b) using measurements of light scatter and fluorescence emission to distinguish basophils from other WBC sub-populations. In one embodiment, the systems and methods include performing a basophil cluster analysis of the blood sample, based on the combination of light scatter and fluorescence measurements.
摘要翻译：本文提供了用于分析血液样品的系统和方法，并且更具体地用于进行嗜碱性粒细胞分析。在一个实施方案中，系统和方法包括：（a）用专用细胞膜可渗透荧光染料染色血液样品; 然后（b）使用光散射和荧光发射的测量来区分嗜碱性粒细胞与其他WBC亚种群。在一个实施方案中，系统和方法包括基于光散射和荧光测量的组合来进行血液样品的嗜碱性粒细胞聚类分析。

7. 发明申请

WO2009126306A2 COMPOSITIONS AND METHODS FOR DETECTING EGFR MUTATIONS IN CANCER 审中-公开
标题翻译：用于检测癌症中EGFR突变的组合物和方法
公开(公告)号：WO2009126306A2
公开(公告)日：2009-10-15
申请号：PCT/US2009/002247
申请日：2009-04-10
申请人： CELL SIGNALING TECHNOLOGY, INC. , GU, Ting-Lei , WU, Jiong , KANE, Susan , HAACK, Herbert , WIELER, James , CAI, Jun-ming , RIMKUNAS, Victoria , YU, Jian
发明人： GU, Ting-Lei , WU, Jiong , KANE, Susan , HAACK, Herbert , WIELER, James , CAI, Jun-ming , RIMKUNAS, Victoria , YU, Jian
IPC分类号： A61K48/00
CPC分类号： C07K16/2863 , C07K14/4703 , C07K14/485 , C07K2317/20 , C07K2317/34 , C07K2317/56 , C07K2317/565 , G01N33/57423 , G01N33/57484 , G01N2800/52
摘要： The invention discloses binding agents to the E746 - A750 deletion and the L858R point mutations in the epidermal growth factor receptor (EGFR) molecule, and methods for use thereof, including methods for the diagnosis and treatment of cancer.
摘要翻译：本发明公开了表皮生长因子受体（EGFR）分子中E746-A750缺失和L858R点突变的结合剂及其使用方法，包括诊断和治疗癌症的方法。

8. 发明申请

WO2004039963A3 ANTIBODIES SPECIFIC FOR PHOSPHORYLATED INSULIN RECEPTOR SUBSTRATE-1/2 (SER 1101/SER1149) AND USES THEREOF 审中-公开
标题翻译：磷酸化胰岛素受体基质-1/2（SER 1101 / SER1149）的特异性抗体及其用途
公开(公告)号：WO2004039963A3
公开(公告)日：2005-03-17
申请号：PCT/US0334861
申请日：2003-10-29
申请人： CELL SIGNALING TECHNOLOGY INC , POLAKIEWICZ ROBERTO , WU JIONG , LI YU
发明人： POLAKIEWICZ ROBERTO , WU JIONG , LI YU
IPC分类号： C07K16/18 , C12P21/08 , G01N33/74 , G01N33/53 , C07K16/00
CPC分类号： C07K16/44 , C07K16/18 , G01N33/74
摘要： The invention discloses newly-discovered phosphorylation sites in human IRS-1 and IRS-2, serine 1101 (Serl101) and serine 1149 (Ser1149) respectively, and provides antibodies, both polyclonal and monoclonal, that selectively bind to IRS-1 and/or IRS-2 when phosphorylated at these respective sites, but do not bind to IRS-1 and/or IRS-2 when not phosphorylated at these respective sites. The sites are relevant to insulin-resistance in type 2 diabetes. Also provided are methods for determining the phosphorylation of IRS-1/2 or activity of PKC theta in a biological sample, by using a detectable reagent, such as the disclosed antibodies, that binds to IRS-1/2 only when phosphorylated at Ser1101/Ser1149. Kits comprising the phosphoIRS-1/2 (Ser1101/1149) antibodies of the invention are also provided.
摘要翻译：本发明公开了分别在人IRS-1和IRS-2，丝氨酸1101（Ser1101）和丝氨酸1149（Ser1149）中新发现的磷酸化位点，并提供选择性结合IRS-1和/或 IRS-2在这些相应位点处磷酸化，但当不在这些相应位点被磷酸化时不结合IRS-1和/或IRS-2。这些部位与2型糖尿病中的胰岛素抵抗有关。还提供了通过使用可检测的试剂，例如所公开的抗体，其仅在Ser1101 / 1细胞磷酸化时与IRS-1/2结合才能确定生物样品中IRS-1/2的磷酸化或PKCθ的活性的方法， Ser1149。还提供了包含本发明的磷酸化IRS-1/2（Ser1101 / 1149）抗体的试剂盒。

9. 发明申请

WO2004039963A2 ANTIBODIES SPECIFIC FOR PHOSPHORYLATED INSULIN RECEPTOR SUBSTRATE-1/2 (SER 1101/SER1149) AND USES THEREOF 审中-公开
标题翻译：磷酸化胰岛素受体基质-1/2（SER 1101 / SER1149）的特异性抗体及其用途
公开(公告)号：WO2004039963A2
公开(公告)日：2004-05-13
申请号：PCT/US2003/034861
申请日：2003-10-29
申请人： CELL SIGNALING TECHNOLOGY, INC. , POLAKIEWICZ, Roberto , WU, Jiong , LI, Yu
发明人： POLAKIEWICZ, Roberto , WU, Jiong , LI, Yu
IPC分类号： C12N
CPC分类号： C07K16/44 , C07K16/18 , G01N33/74
摘要： The invention discloses newly-discovered phosphorylation sites in human IRS-1 and IRS-2, serine 1101 (Serl101) and serine 1149 (Ser1149) respectively, and provides antibodies, both polyclonal and monoclonal, that selectively bind to IRS-1 and/or IRS-2 when phosphorylated at these respective sites, but do not bind to IRS-1 and/or IRS-2 when not phosphorylated at these respective sites. The sites are relevant to insulin-resistance in type 2 diabetes. Also provided are methods for determining the phosphorylation of IRS-1/2 or activity of PKC theta in a biological sample, by using a detectable reagent, such as the disclosed antibodies, that binds to IRS-1/2 only when phosphorylated at Ser1101/Ser1149. Kits comprising the phosphoIRS-1/2 (Ser1101/1149) antibodies of the invention are also provided.
摘要翻译：本发明公开了分别在人IRS-1和IRS-2，丝氨酸1101（Ser1101）和丝氨酸1149（Ser1149）中新发现的磷酸化位点，并提供选择性结合IRS-1和/或 IRS-2在这些相应位点处磷酸化，但当不在这些相应位点被磷酸化时不结合IRS-1和/或IRS-2。这些部位与2型糖尿病中的胰岛素抵抗有关。还提供了通过使用可检测的试剂，例如所公开的抗体，其仅在Ser1101 / 1细胞磷酸化时与IRS-1/2结合才能确定生物样品中IRS-1/2的磷酸化或PKCθ的活性的方法， Ser1149。还提供了包含本发明的磷酸化IRS-1/2（Ser1101 / 1149）抗体的试剂盒。

10. 发明申请

WO2012158826A2 METHOD AND APPARATUS FOR DETECTION, ANALYSIS, AND COLLECTION OF RARE CELLULAR EVENTS 审中-公开
标题翻译：检测，分析和收集稀有细胞活性的方法和装置
公开(公告)号：WO2012158826A2
公开(公告)日：2012-11-22
申请号：PCT/US2012/038189
申请日：2012-05-16
申请人： ABBOTT LABORATORIES , WU, Jiong , JUNNARKAR, Mahesh , VACCA, Giacomo
发明人： WU, Jiong , JUNNARKAR, Mahesh , VACCA, Giacomo
IPC分类号： C12M1/42 , C12M1/36
CPC分类号： G01N15/1459 , G01N15/1434 , G01N21/05 , G01N21/53 , G01N21/6428 , G01N21/645 , G01N2021/0346 , G01N2021/6482 , G01N2021/6493
摘要： Systems and methods for the detection, analysis, and collection of rare cellular events, wherein rare cellular events are defined by events comprising less than 5% of a total number of cells in a sample. The systems and methods generally include: (1) a flow cell dimensioned so as to permit a flow of a sample through the flow cell at a flow rate greater than 300,000 cells per second; (2) a laser positioned to emit a laser beam directed to the flow cell; (3) one or more deflector components disposed between the laser and the flow cell, wherein the deflector component is configured to affect a position of the laser beam relative to the sample flow; (4) one or more fluorescence emission detectors; and (5) one or more processor configured to detect rare cellular events based on fluorescence emission from cell-binding surface markers introduced into the sample prior to the sample being flowed through the flow cell.
摘要翻译：用于检测，分析和收集稀有细胞事件的系统和方法，其中罕见的细胞事件由包含小于样品中总细胞数的5％的事件定义。系统和方法通常包括：（1）流动池，其尺寸设计成允许样品以大于每秒300,000个细胞的流速流过流动池; （2）定位成发射指向流动池的激光束的激光器; （3）设置在激光器和流动池之间的一个或多个偏转器部件，其中偏转器部件被配置为影响激光束相对于样品流的位置; （4）一个或多个荧光发射检测器; 以及（5）一个或多个处理器，被配置为基于在样品流过所述流动池之前引入到所述样品中的来自细胞结合表面标记的荧光发射来检测罕见的细胞事件。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式