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1. 发明申请

WO2012158826A3 METHOD AND APPARATUS FOR DETECTION, ANALYSIS, AND COLLECTION OF RARE CELLULAR EVENTS 审中-公开
标题翻译：用于检测，分析和收集稀有细胞活性的方法和装置
公开(公告)号：WO2012158826A3
公开(公告)日：2014-05-08
申请号：PCT/US2012038189
申请日：2012-05-16
申请人： ABBOTT LAB , WU JIONG , JUNNARKAR MAHESH , VACCA GIACOMO
发明人： WU JIONG , JUNNARKAR MAHESH , VACCA GIACOMO
IPC分类号： G01N33/48 , G01N33/50
CPC分类号： G01N15/1459 , G01N15/1434 , G01N21/05 , G01N21/53 , G01N21/6428 , G01N21/645 , G01N2021/0346 , G01N2021/6482 , G01N2021/6493
摘要： Systems and methods for the detection, analysis, and collection of rare cellular events, wherein rare cellular events are defined by events comprising less than 5% of a total number of cells in a sample. The systems and methods generally include: (1) a flow cell dimensioned so as to permit a flow of a sample through the flow cell at a flow rate greater than 300,000 cells per second; (2) a laser positioned to emit a laser beam directed to the flow cell; (3) one or more deflector components disposed between the laser and the flow cell, wherein the deflector component is configured to affect a position of the laser beam relative to the sample flow; (4) one or more fluorescence emission detectors; and (5) one or more processor configured to detect rare cellular events based on fluorescence emission from cell-binding surface markers introduced into the sample prior to the sample being flowed through the flow cell.
摘要翻译：用于检测，分析和收集罕见细胞事件的系统和方法，其中罕见的细胞事件由包含小于样品中总细胞数量的5％的事件定义。系统和方法通常包括：（1）流动池，其尺寸设计成允许样品以大于每秒300,000个细胞的流速流过流动池; （2）定位成发射指向流动池的激光束的激光器; （3）设置在所述激光器和所述流动池之间的一个或多个偏转器部件，其中所述偏转器部件被配置为影响所述激光束相对于所述样品流的位置; （4）一个或多个荧光发射检测器; 以及（5）一个或多个处理器，被配置为基于在样品流过所述流动池之前引入到样品中的来自细胞结合表面标记物的荧光发射来检测罕见的细胞事件。

2. 发明申请

WO2012158826A2 METHOD AND APPARATUS FOR DETECTION, ANALYSIS, AND COLLECTION OF RARE CELLULAR EVENTS 审中-公开
标题翻译：检测，分析和收集稀有细胞活性的方法和装置
公开(公告)号：WO2012158826A2
公开(公告)日：2012-11-22
申请号：PCT/US2012/038189
申请日：2012-05-16
申请人： ABBOTT LABORATORIES , WU, Jiong , JUNNARKAR, Mahesh , VACCA, Giacomo
发明人： WU, Jiong , JUNNARKAR, Mahesh , VACCA, Giacomo
IPC分类号： C12M1/42 , C12M1/36
CPC分类号： G01N15/1459 , G01N15/1434 , G01N21/05 , G01N21/53 , G01N21/6428 , G01N21/645 , G01N2021/0346 , G01N2021/6482 , G01N2021/6493
摘要： Systems and methods for the detection, analysis, and collection of rare cellular events, wherein rare cellular events are defined by events comprising less than 5% of a total number of cells in a sample. The systems and methods generally include: (1) a flow cell dimensioned so as to permit a flow of a sample through the flow cell at a flow rate greater than 300,000 cells per second; (2) a laser positioned to emit a laser beam directed to the flow cell; (3) one or more deflector components disposed between the laser and the flow cell, wherein the deflector component is configured to affect a position of the laser beam relative to the sample flow; (4) one or more fluorescence emission detectors; and (5) one or more processor configured to detect rare cellular events based on fluorescence emission from cell-binding surface markers introduced into the sample prior to the sample being flowed through the flow cell.
摘要翻译：用于检测，分析和收集稀有细胞事件的系统和方法，其中罕见的细胞事件由包含小于样品中总细胞数的5％的事件定义。系统和方法通常包括：（1）流动池，其尺寸设计成允许样品以大于每秒300,000个细胞的流速流过流动池; （2）定位成发射指向流动池的激光束的激光器; （3）设置在激光器和流动池之间的一个或多个偏转器部件，其中偏转器部件被配置为影响激光束相对于样品流的位置; （4）一个或多个荧光发射检测器; 以及（5）一个或多个处理器，被配置为基于在样品流过所述流动池之前引入到所述样品中的来自细胞结合表面标记的荧光发射来检测罕见的细胞事件。

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