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1. 发明申请

WO2009126306A2 COMPOSITIONS AND METHODS FOR DETECTING EGFR MUTATIONS IN CANCER 审中-公开
标题翻译：用于检测癌症中EGFR突变的组合物和方法
公开(公告)号：WO2009126306A2
公开(公告)日：2009-10-15
申请号：PCT/US2009/002247
申请日：2009-04-10
申请人： CELL SIGNALING TECHNOLOGY, INC. , GU, Ting-Lei , WU, Jiong , KANE, Susan , HAACK, Herbert , WIELER, James , CAI, Jun-ming , RIMKUNAS, Victoria , YU, Jian
发明人： GU, Ting-Lei , WU, Jiong , KANE, Susan , HAACK, Herbert , WIELER, James , CAI, Jun-ming , RIMKUNAS, Victoria , YU, Jian
IPC分类号： A61K48/00
CPC分类号： C07K16/2863 , C07K14/4703 , C07K14/485 , C07K2317/20 , C07K2317/34 , C07K2317/56 , C07K2317/565 , G01N33/57423 , G01N33/57484 , G01N2800/52
摘要： The invention discloses binding agents to the E746 - A750 deletion and the L858R point mutations in the epidermal growth factor receptor (EGFR) molecule, and methods for use thereof, including methods for the diagnosis and treatment of cancer.
摘要翻译：本发明公开了表皮生长因子受体（EGFR）分子中E746-A750缺失和L858R点突变的结合剂及其使用方法，包括诊断和治疗癌症的方法。

2. 发明申请

WO2006099005A1 METHOD FOR IDENTIFYING AGENTS WHICH MODULATE GTPASE ACTIVITY INVOLVED IN INSULIN-STIMULATED GLUT4 TRANSLOCATION 审中-公开
标题翻译：用于鉴定胰岛素刺激的GLUT4转录中涉及的调节蛋白酶活性的试剂的方法
公开(公告)号：WO2006099005A1
公开(公告)日：2006-09-21
申请号：PCT/US2006/008336
申请日：2006-03-08
申请人： TRUSTEES OF DARTMOUTH COLLEGE , LIENHARD, Gustav, E. , KANE, Susan , MINEA, Christinel, P. , SANO, Hiroyuki
发明人： LIENHARD, Gustav, E. , KANE, Susan , MINEA, Christinel, P. , SANO, Hiroyuki
IPC分类号： C12Q1/00
CPC分类号： C12Q1/48 , G01N33/566
摘要： The present invention is a method for identifying agents that modulate the GTPase activity of AS160. In the instant assay, AS160 or the GAP domain thereof is contacted with a test agent, in the presence of GTP-bound Rab (2A, 8A, 8B, 10, or 14), and the AS160 GAP domain-mediated hydrolysis of GTP to GDP is monitored.
摘要翻译：本发明是鉴定调节AS160的GTP酶活性的试剂的方法。在本试验中，在GTP结合的Rab（2A，8A，8B，10或14）的存在下，将AS160或其GAP结构域与测试试剂接触，并将AS160GAP结构域介导的GTP水解监测国内生产总值。

3. 发明申请

WO2009126306A8 COMPOSITIONS AND METHODS FOR DETECTING EGFR MUTATIONS IN CANCER 审中-公开
标题翻译：用于检测癌症中EGFR突变的组合物和方法
公开(公告)号：WO2009126306A8
公开(公告)日：2010-01-14
申请号：PCT/US2009002247
申请日：2009-04-10
申请人： CELL SIGNALING TECHNOLOGY INC , GU TING-LEI , WU JIONG , KANE SUSAN , HAACK HERBERT , WIELER JAMES , CAI JUN-MING , RIMKUNAS VICTORIA , YU JIAN
发明人： GU TING-LEI , WU JIONG , KANE SUSAN , HAACK HERBERT , WIELER JAMES , CAI JUN-MING , RIMKUNAS VICTORIA , YU JIAN
IPC分类号： A61K48/00
CPC分类号： C07K16/2863 , C07K14/4703 , C07K14/485 , C07K2317/20 , C07K2317/34 , C07K2317/56 , C07K2317/565 , G01N33/57423 , G01N33/57484 , G01N2800/52
摘要： The invention discloses binding agents to the E746 - A750 deletion and the L858R point mutations in the epidermal growth factor receptor (EGFR) molecule, and methods for use thereof, including methods for the diagnosis and treatment of cancer.
摘要翻译：本发明公开了表皮生长因子受体（EGFR）分子中E746-A750缺失和L858R点突变的结合剂及其使用方法，包括诊断和治疗癌症的方法。

4. 发明申请

WO2006099005A8 METHOD FOR IDENTIFYING AGENTS WHICH MODULATE GTPASE ACTIVITY INVOLVED IN INSULIN-STIMULATED GLUT4 TRANSLOCATION 审中-公开
标题翻译：用于鉴定胰岛素刺激的GLUT4转录中涉及的调节蛋白酶活性的试剂的方法
公开(公告)号：WO2006099005A8
公开(公告)日：2007-08-30
申请号：PCT/US2006008336
申请日：2006-03-08
申请人： DARTMOUTH COLLEGE , LIENHARD GUSTAV E , KANE SUSAN , MIINEA CHRISTINEL P , SANO HIROYUKI
发明人： LIENHARD GUSTAV E , KANE SUSAN , MIINEA CHRISTINEL P , SANO HIROYUKI
IPC分类号： C12Q1/00
CPC分类号： C12Q1/48 , G01N33/566
摘要： The present invention is a method for identifying agents that modulate the GTPase activity of AS160. In the instant assay, AS160 or the GAP domain thereof is contacted with a test agent, in the presence of GTP-bound Rab (2A, 8A, 8B, 10, or 14), and the AS160 GAP domain-mediated hydrolysis of GTP to GDP is monitored.
摘要翻译：本发明是鉴定调节AS160的GTPase活性的试剂的方法。在本试验中，在GTP结合的Rab（2A，8A，8B，10或14）存在下，将AS160或其GAP结构域与测试试剂接触，并将AS160GAP结构域介导的GTP水解监测国内生产总值。

5. 发明申请

WO2009126306A3 COMPOSITIONS AND METHODS FOR DETECTING EGFR MUTATIONS IN CANCER 审中-公开
标题翻译：检测癌症中EGFR突变的组合物和方法
公开(公告)号：WO2009126306A3
公开(公告)日：2010-04-22
申请号：PCT/US2009002247
申请日：2009-04-10
申请人： CELL SIGNALING TECHNOLOGY INC , GU TING-LEI , WU JIONG , KANE SUSAN , HAACK HERBERT , WIELER JAMES , CAI JUN-MING , RIMKUNAS VICTORIA , YU JIAN
发明人： GU TING-LEI , WU JIONG , KANE SUSAN , HAACK HERBERT , WIELER JAMES , CAI JUN-MING , RIMKUNAS VICTORIA , YU JIAN
IPC分类号： C12P21/08 , C07K16/00 , G01N33/574
CPC分类号： C07K16/2863 , C07K14/4703 , C07K14/485 , C07K2317/20 , C07K2317/34 , C07K2317/56 , C07K2317/565 , G01N33/57423 , G01N33/57484 , G01N2800/52
摘要： The invention discloses binding agents to the E746 - A750 deletion and the L858R point mutations in the epidermal growth factor receptor (EGFR) molecule, and methods for use thereof, including methods for the diagnosis and treatment of cancer.
摘要翻译：本发明公开了表皮生长因子受体（EGFR）分子中E746-A750缺失和L858R点突变的结合剂及其使用方法，包括诊断和治疗癌症的方法。

6. 发明申请

WO1996038318A1 LOAD BEARING AUTOMOTIVE BENCH SEAT ASSEMBLY 审中-公开
标题翻译：负载轴承汽车座椅组件
公开(公告)号：WO1996038318A1
公开(公告)日：1996-12-05
申请号：PCT/US1996008442
申请日：1996-06-03
申请人： ALUMINUM COMPANY OF AMERICA , NOVAK, Miloslav , TRAGESER, Andrew, B. , SUMME, Isabel, M. , KANE, Susan, L.
发明人： ALUMINUM COMPANY OF AMERICA
IPC分类号： B60N02/44
CPC分类号： B60N2/242 , B60N2/68 , B60N2/688
摘要： An automotive bench seat assembly which may be removable from a vehicle, has a seat (2), a seatback (4) adjacent to the seat, a pair of relatively spaced stanchions (6, 8) having an upper portion secured to the seat, and a lower floor engaging portion. The seat has a front rail (12), a rear rail (10), and a pair of side members (14, 16) connecting the front and rear rails. A pair of belt supporting towers (72, 74) are operatively associated with shoulder belts and serve to transmit impact loads to the floor through the stanchions (6, 8). The stanchions have upper portions supportingly secured to towers (72, 74) or the rear rail (10) intermediate the ends thereof and to the front rail (12) intermediate the ends thereof. The stanchions have the floor engaging portion positioned inwardly of the side members (14, 16). Lap belts also transmit impact loads through the stanchions to the floor. The stanchions may be generally V-shaped and have sidewalls composed of reinforced sheet members. Reinforced sheet members may be provided in the seatback (4) and seat (2).
摘要翻译：可以从车辆移除的汽车座椅组件具有座椅（2），与座椅相邻的座椅靠背（4），一对相对间隔的支柱（6,8），其具有固定到座椅的上部部分，和下层接合部。座椅具有前导轨（12），后导轨（10）和连接前导轨和后导轨的一对侧构件（14,16）。一对带支撑塔（72,74）可操作地与肩带相关联并且用于通过支柱（6,8）将冲击载荷传递到地板。支柱具有支撑地固定到塔（72,74）或后轨道（10）的上部，其中间在其端部之间并且在其端部之间的前轨道（12）之间。支柱具有位于侧构件（14,16）内侧的地板接合部分。搭接带还将穿过支柱的冲击载荷传递到地板上。支柱通常为V形并且具有由加强板构件组成的侧壁。可以在座椅靠背（4）和座椅（2）中设置加强片材。

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