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1. 发明申请

WO2007030417A3 SLOTTED ANNULOPLASTY RING 审中-公开
标题翻译：缝合ANNULOPLASTY环
公开(公告)号：WO2007030417A3
公开(公告)日：2009-04-16
申请号：PCT/US2006034428
申请日：2006-09-01
申请人： MICARDIA CORP , SHAOLIAN SAMUEL M , RHEE RICHARD S , SHAOULIAN EMANUEL , MOADDEB SHAHRAM
发明人： RHEE RICHARD S , SHAOULIAN EMANUEL , MOADDEB SHAHRAM
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2250/0001 , A61F2250/0004
摘要： Methods and devices are provided for support of a body structure. The device can be adjusted within the patient's body in a minimally or non-invasive manner, by applying energy percutaneously or externally to the body. The energy may include: acoustic, light, magnetic, or radio frequency energy. As the body structure changes the size and/or shape of the annuloplasty rings adjusts to provide continued reinforcement. In certain embodiments, the device (3500) includes a body member (3502) and an insert member (3504). Th body member (3502) has a slot (3506) that extends at least partially along the circumference of the body (3502). The insert member (3504) extends at least partially along the circumference of the body (3502). The device (3500) has a first shape in a first configuration which transforms to a second shape in a second configuration in response to an activation energy applied thereto.
摘要翻译：提供了用于支撑身体结构的方法和装置。通过将能量经皮或外部施加于身体，该装置可以以最低限度或非侵入性的方式在患者体内进行调节。能量可以包括：声，光，磁或射频能量。随着身体结构改变，瓣环成形术环的尺寸和/或形状调整以提供持续的加强。在某些实施例中，装置（3500）包括主体构件（3502）和插入构件（3504）。本体构件（3502）具有至少部分地沿主体（3502）的圆周延伸的狭槽（3506）。插入构件（3504）至少部分地沿主体（3502）的圆周延伸。装置（3500）具有第一构造的第一形状，其响应于施加到其上的活化能而以第二构造转变为第二形状。

2. 发明申请

WO2006019943A1 IMPLANTS AND METHODS FOR RESHAPING HEART VALVES 审中-公开
标题翻译：用于修复心脏瓣膜的植入物和方法
公开(公告)号：WO2006019943A1
公开(公告)日：2006-02-23
申请号：PCT/US2005/025044
申请日：2005-07-14
申请人： MICARDIA CORPORATION , MOADDEB, Shahram , SHAOULIAN, Emanuel , SHAOLIAN, Samuel , HENSON, Michael, R. , RHEE, Richard, S. , ANDERSON, Steven, C.
发明人： MOADDEB, Shahram , SHAOULIAN, Emanuel , SHAOLIAN, Samuel , HENSON, Michael, R. , RHEE, Richard, S. , ANDERSON, Steven, C.
IPC分类号： A61F2/06
CPC分类号： A61F2/2442 , A61B17/3468 , A61B2017/00243 , A61F2/2451 , A61F2002/249 , A61F2210/0076
摘要： Tissue shaping methods and devices are provided for reinforcing and/or remodeling heart valves. Magnetic tissue shaping devices (302) are implanted in tissue adjacent heart valve leaflets (204, 206). The devices (302) are mutually attractive or repulsive to remodel the heart tissue, improving heart valve function. In other embodiments, one or more tissue shaping devices are implanted in a patient's body adjacent a heart valve leaflet (204, 206). The shape memory material of the devices can be activated within the patient less invasively, such as by applying energy percutaneously or external to the patient. The shape memory devices (502) are implanted in a first configuration and then activated, remembering a second configuration that displaces tissue that remodels heart valve geometry. In other embodiments, a brace (1900) is crimped to the base of a heart valve leaflet (204, 206) to support the leaflet and improve valve closure.
摘要翻译：提供组织成形方法和装置用于加强和/或改造心脏瓣膜。将磁组织成形装置（302）植入邻近心脏瓣膜小叶（204,206）的组织中。装置（302）相互吸引或排斥以改善心脏组织，改善心脏瓣膜功能。在其它实施例中，将一个或多个组织成形装置植入患者体内邻近心脏瓣膜小叶（204,206）。装置的形状记忆材料可以在患者内较少侵入地被激活，例如通过经皮或外部施加能量。形状记忆装置（502）以第一构型植入，然后被激活，记住移位重塑心脏瓣膜几何形状的组织的第二构型。在其他实施例中，将支架（1900）卷曲到心脏瓣膜小叶（204,206）的底部以支撑小叶并改善瓣膜关闭。

3. 发明申请

WO2005122964A8 THREE-DIMENSIONAL ANULOPLASTY RING AND TEMPLATE 审中-公开
标题翻译：三维平滑肌环和模板
公开(公告)号：WO2005122964A8
公开(公告)日：2006-02-16
申请号：PCT/US2005020583
申请日：2005-06-10
申请人： EDWARDS LIFESCIENCES CORP , MCCARTHY PATRICK M , RHEE RICHARD S , SCHRECK STEFAN G
发明人： MCCARTHY PATRICK M , RHEE RICHARD S , SCHRECK STEFAN G
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2/2466 , A61M25/001 , A61M25/0032 , A61M25/0069 , A61M25/007 , A61M25/0071 , A61M25/0138 , A61M2025/0002 , A61M2025/0003 , A61M2025/0004 , A61M2025/0081
摘要： An annuloplasty ring (40) having a three-dimensional discontinuous form generally arranged about an axis (44) with two free ends (46a, 46b) that are axially offset. The ring is particularly suited for repair of the tricuspid valve, and more closely conforms to the annulus shape. The ring is more flexible in bending about radially extending axes than about the central axis. The ring may have an inner structural support (60) covered by a pliable sleeve and/or a fabric tube (64). The structural support may have a varying cross-section, such as a C-shaped cross-section in a mid-section between two free ends and a rectangular cross-section at the free ends. A delivery template (90) having a mounting ring (94) with about the same shape as the ring facilitates implant, and may be releasably attached to a delivery handle (92). The delivery template may include a plurality of cutting guides (126) for releasably attaching the annuloplasty ring thereto while presenting maximum outer surface area for the ring. The template may have an outwardly-facing groove (124) to receive and retain the ring.
摘要翻译：具有三维不连续形状的瓣环成形术环（40），其通常围绕轴向（44）布置，具有轴向偏移的两个自由端（46a，46b）。该环特别适用于修复三尖瓣，并且更接近于环形。环绕径向延伸的轴弯曲比围绕中心轴更弯曲。环可以具有由柔韧套筒和/或织物管（64）覆盖的内部结构支撑件（60）。结构支撑件可以具有变化的横截面，例如两个自由端之间的中间部分中的C形横截面和在自由端处的矩形横截面。具有与环具有大致相同形状的安装环（94）的输送模板（90）便于植入，并且可以可释放地附接到递送手柄（92）。输送模板可以包括多个切割引导件（126），用于将环形成形术环可释放地附接到其上，同时呈现环的最大外表面积。模板可以具有用于接收和保持环的向外的凹槽（124）。

4. 发明申请

WO2006012068A3 THERMAL CONDUCTOR FOR ADJUSTABLE CARDIAC IMPLANT 审中-公开
公开(公告)号：WO2006012068A3
公开(公告)日：2006-02-02
申请号：PCT/US2005/021597
申请日：2005-06-17
申请人： MICARDIA CORPORATION , RHEE, Richard , SHAOULIAN, Emanuel , MOADDEB, Shahram , SHAOLIAN, Samuel
发明人： RHEE, Richard , SHAOULIAN, Emanuel , MOADDEB, Shahram , SHAOLIAN, Samuel
IPC分类号： A61F2/24
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement. In one embodiment, an annuloplasty ring (2600) includes a body member (800) including a shape memory material. The shape memory material is configured to transform the body member 800 from a first shape to a second shape in response to being heated. The annuloplasty ring (2600) also includes a thermally insulative material (912) at least partially covering the body member (800) and a thermally conductive material (2610, 2612, 2614) extending into the thermally insulative material (912). The thermally conductive material (2610, 2612, 2614) is configured to communicate thermal energy to the body member (800).

5. 发明申请

WO2006012013A2 ADJUSTABLE CARDIAC VALVE IMPLANT WITH SELECTIVE DIMENSIONAL ADJUSTMENT 审中-公开
标题翻译：可调节心脏瓣膜植入物，具有选择性的尺寸调整
公开(公告)号：WO2006012013A2
公开(公告)日：2006-02-02
申请号：PCT/US2005/021141
申请日：2005-06-15
申请人： MICARDIA CORPORATION , RHEE, Richard , SHAOULIAN, Emanuel , MOADDEB, Shahram , SHAOLIAN, Samuel
发明人： RHEE, Richard , SHAOULIAN, Emanuel , MOADDEB, Shahram , SHAOLIAN, Samuel
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement. In one embodiment, an annuloplasty ring (1826) includes an anterior portion, a posterior portion and two lateral portions corresponding to intersections of the anterior portion and the posterior portion. The annuloplasty ring (1826) has a first shape in a first configuration and a second shape in a second configuration and is configured to transform from the first configuration to the second configuration in response to an activation energy applied thereto. The transformation is configured to reduce a distance between the anterior portion and the posterior portion without substantially decreasing a distance between the two lateral portions.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，当身体结构改变尺寸和/或形状时，可以调节装置的尺寸和/或形状以提供持续的加强。在一个实施例中，瓣膜成形术环（1826）包括前部，后部和对应于前部和后部的交叉点的两个侧部。瓣膜成形术环（1826）具有第一构造的第一形状和第二构造的第二形状，并且被配置为响应于施加到其上的活化能量而从第一构型变换到第二构造。该变换被配置为减小前部和后部之间的距离，而基本上不减小两个侧部之间的距离。

6. 发明申请

WO2006012013A3 ADJUSTABLE CARDIAC VALVE IMPLANT WITH SELECTIVE DIMENSIONAL ADJUSTMENT 审中-公开
标题翻译：可调心脏瓣膜植入物选择性尺寸调整
公开(公告)号：WO2006012013A3
公开(公告)日：2006-12-28
申请号：PCT/US2005021141
申请日：2005-06-15
申请人： MICARDIA CORP , RHEE RICHARD , SHAOULIAN EMANUEL , MOADDEB SHAHRAM , SHAOLIAN SAMUEL
发明人： RHEE RICHARD , SHAOULIAN EMANUEL , MOADDEB SHAHRAM , SHAOLIAN SAMUEL
IPC分类号： A61F2/24 , A61F2/00 , A61F2/02
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement. In one embodiment, an annuloplasty ring (1826) includes an anterior portion, a posterior portion and two lateral portions corresponding to intersections of the anterior portion and the posterior portion. The annuloplasty ring (1826) has a first shape in a first configuration and a second shape in a second configuration and is configured to transform from the first configuration to the second configuration in response to an activation energy applied thereto. The transformation is configured to reduce a distance between the anterior portion and the posterior portion without substantially decreasing a distance between the two lateral portions.
摘要翻译：提供了用于支持身体结构的方法和设备。可以以微创或非侵入方式在患者身体内调整装置，例如通过经皮或外部施加能量到患者身体。能量可以包括例如声能，射频能量，光能和磁能。因此，随着身体结构改变尺寸和/或形状，可以调整装置的尺寸和/或形状以提供连续的增强。在一个实施例中，瓣环成形术环（1826）包括前部，后部和对应于前部和后部的交点的两个侧部。瓣环成形术环（1826）具有第一构型的第一形状和第二构型的第二形状，并且构造成响应于施加到其上的激活能量从第一构型转变为第二构型。该变换被配置成减小前部和后部之间的距离而基本上不减小两个侧部之间的距离。

7. 发明申请

WO2006012068A2 THERMAL CONDUCTOR FOR ADJUSTABLE CARDIAC IMPLANT 审中-公开
标题翻译：用于可调节心脏植入物的导热体
公开(公告)号：WO2006012068A2
公开(公告)日：2006-02-02
申请号：PCT/US2005021597
申请日：2005-06-17
申请人： MICARDIA CORP , RHEE RICHARD , SHAOULIAN EMANUEL , MOADDEB SHAHRAM , SHAOLIAN SAMUEL
发明人： RHEE RICHARD , SHAOULIAN EMANUEL , MOADDEB SHAHRAM , SHAOLIAN SAMUEL
IPC分类号： A61F2/24 , A61F2/00 , A61F2/02
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement. In one embodiment, an annuloplasty ring (2600) includes a body member (800) including a shape memory material. The shape memory material is configured to transform the body member 800 from a first shape to a second shape in response to being heated. The annuloplasty ring (2600) also includes a thermally insulative material (912) at least partially covering the body member (800) and a thermally conductive material (2610, 2612, 2614) extending into the thermally insulative material (912). The thermally conductive material (2610, 2612, 2614) is configured to communicate thermal energy to the body member (800).
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，当身体结构改变尺寸和/或形状时，可以调节装置的尺寸和/或形状以提供持续的加强。在一个实施例中，瓣膜成形术环（2600）包括包括形状记忆材料的主体构件（800）。形状记忆材料被配置为响应于加热而将本体构件800从第一形状转变为第二形状。瓣膜成形术环（2600）还包括至少部分地覆盖主体构件（800）的热绝缘材料（912）和延伸到绝热材料（912）中的导热材料（2610,2612,2614）。导热材料（2610,2612,2614）构造成将热能传递到主体部件（800）。

8. 发明申请

WO2005122964A1 THREE-DIMENSIONAL ANULOPLASTY RING AND TEMPLATE 审中-公开
标题翻译：三维平滑肌环和模板
公开(公告)号：WO2005122964A1
公开(公告)日：2005-12-29
申请号：PCT/US2005/020583
申请日：2005-06-10
申请人： EDWARDS LIFESCIENCES CORPORATION , McCARTHY, Patrick, M. , RHEE, Richard, S. , SCHRECK, Stefan, G.
发明人： McCARTHY, Patrick, M. , RHEE, Richard, S. , SCHRECK, Stefan, G.
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2/2466 , A61M25/001 , A61M25/0032 , A61M25/0069 , A61M25/007 , A61M25/0071 , A61M25/0138 , A61M2025/0002 , A61M2025/0003 , A61M2025/0004 , A61M2025/0081
摘要： An annuloplasty ring (40) having a three-dimensional discontinuous form generally arranged about an axis (44) with two free ends (46a, 46b) that are axially offset. The ring is particularly suited for repair of the tricuspid valve, and more closely conforms to the annulus shape. The ring is more flexible in bending about radially extending axes than about the central axis. The ring may have an inner structural support (60) covered by a pliable sleeve and/or a fabric tube (64). The structural support may have a varying cross-section, such as a C-shaped cross-section in a mid-section between two free ends and a rectangular cross-section at the free ends. A delivery template (90) having a mounting ring (14) with about the same shape as the ring facilitates implant, and may be releasably attached to a delivery handle (92). The deliver template may include a plurality of cutting guides (126) for releasably attaching the annuloplasty ring thereto while presenting maximum outer surface area for the ring. The template may have an outwardly-facing groove (124) to receive and retain the ring.
摘要翻译：具有三维不连续形状的环形成形环（40），其通常围绕轴向（44）布置，具有轴向偏移的两个自由端（46a，46b）。该环特别适用于修复三尖瓣，并且更接近于环形。环绕径向延伸的轴弯曲比围绕中心轴更弯曲。环可以具有由柔韧套筒和/或织物管（64）覆盖的内部结构支撑件（60）。结构支撑件可以具有变化的横截面，例如两个自由端之间的中间部分中的C形横截面和在自由端处的矩形横截面。具有与环具有大致相同形状的安装环（14）的输送模板（90）便于植入，并且可以可释放地附接到输送手柄（92）。输送模板可以包括多个切割引导件（126），用于将环形成形术环可释放地附接到其上，同时呈现环的最大外表面积。模板可以具有用于接收和保持环的向外的凹槽（124）。

9. 发明申请

WO2007033360A3 LEFT ATRIAL BALLOON CATHETER 审中-公开
公开(公告)号：WO2007033360A3
公开(公告)日：2007-03-22
申请号：PCT/US2006/035981
申请日：2006-09-13
申请人： MICARDIA CORPORATION , MOADDEB, Shawn , RHEE, Richard , ANDERSON, Steve
发明人： MOADDEB, Shawn , RHEE, Richard , ANDERSON, Steve
IPC分类号： A61M25/10
摘要： Systems, methods and devices are provided for activation of an adjustable annuloplasty device. The devices may include a catheter system (3020) for percutaneously activating an adjustable annuloplasty device (3000), including a handle assembly (3052), a shaft assembly (3050) having at least one fluid lumen (3084), and a distal element (3004). The shaft assembly (3050) extends between the handle assembly (3052) and the distal element (3004), the distal element (3004) being in fluid communication with the handle assembly (3052) via the at least one fluid lumen (3084). The distal element (3004) includes an elongated core (3074) having a first port (3381) and an expandable member (3070). The core (3074) extends through the expandable member (3070) and the expandable member (3070) is movable between a collapsed position and an inflated position.

10. 发明申请

WO2006019520A3 MAGNETIC DEVICES AND METHODS FOR RESHAPING HEART ANATOMY 审中-公开
标题翻译：磁性装置和用于重建心脏解剖的方法
公开(公告)号：WO2006019520A3
公开(公告)日：2006-12-21
申请号：PCT/US2005022461
申请日：2005-06-23
申请人： MICARDIA CORP , MOADDEB SHAHRAM , SHAOLIAN SAMUEL M , SHAOULIAN EMANUEL , RHEE RICHARD , ANDERSON SETEVEN C
发明人： MOADDEB SHAHRAM , SHAOLIAN SAMUEL M , SHAOULIAN EMANUEL , RHEE RICHARD , ANDERSON SETEVEN C
IPC分类号： A61F2/00 , A61M1/12
CPC分类号： A61F2/2478 , A61B17/3468 , A61B2017/00876 , A61F2/2481 , A61F2/2487 , A61F2002/249 , A61F2210/009
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Heart dilation treated by reshaping the heart anatomy with the use of magnetic forces. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The magnetic forces are applied with the use of one or more magnetic elements which are implanted within the heart tissue or attached externally and/or internally to a surface of the heart. The various charges of the magnetic forces interact causing the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the force of the magnetic elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
摘要翻译：提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。通过使用磁力重塑心脏解剖结构治疗的心脏扩张。这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加脑室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。使用一个或多个植入心脏组织内或附着在心脏外表面和/或内部的磁性元件施加磁力。磁力的各种电荷相互作用，使相关的心脏组织区域重新调整位置，例如减小心室的宽度。这种重新定位通过磁性元件的力量随着时间的推移而保持，从而允许心脏扩张的破坏性作用在进展或反转中缓慢。

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