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1. 发明申请

WO2006019943A1 IMPLANTS AND METHODS FOR RESHAPING HEART VALVES 审中-公开
标题翻译：用于修复心脏瓣膜的植入物和方法
公开(公告)号：WO2006019943A1
公开(公告)日：2006-02-23
申请号：PCT/US2005/025044
申请日：2005-07-14
申请人： MICARDIA CORPORATION , MOADDEB, Shahram , SHAOULIAN, Emanuel , SHAOLIAN, Samuel , HENSON, Michael, R. , RHEE, Richard, S. , ANDERSON, Steven, C.
发明人： MOADDEB, Shahram , SHAOULIAN, Emanuel , SHAOLIAN, Samuel , HENSON, Michael, R. , RHEE, Richard, S. , ANDERSON, Steven, C.
IPC分类号： A61F2/06
CPC分类号： A61F2/2442 , A61B17/3468 , A61B2017/00243 , A61F2/2451 , A61F2002/249 , A61F2210/0076
摘要： Tissue shaping methods and devices are provided for reinforcing and/or remodeling heart valves. Magnetic tissue shaping devices (302) are implanted in tissue adjacent heart valve leaflets (204, 206). The devices (302) are mutually attractive or repulsive to remodel the heart tissue, improving heart valve function. In other embodiments, one or more tissue shaping devices are implanted in a patient's body adjacent a heart valve leaflet (204, 206). The shape memory material of the devices can be activated within the patient less invasively, such as by applying energy percutaneously or external to the patient. The shape memory devices (502) are implanted in a first configuration and then activated, remembering a second configuration that displaces tissue that remodels heart valve geometry. In other embodiments, a brace (1900) is crimped to the base of a heart valve leaflet (204, 206) to support the leaflet and improve valve closure.
摘要翻译：提供组织成形方法和装置用于加强和/或改造心脏瓣膜。将磁组织成形装置（302）植入邻近心脏瓣膜小叶（204,206）的组织中。装置（302）相互吸引或排斥以改善心脏组织，改善心脏瓣膜功能。在其它实施例中，将一个或多个组织成形装置植入患者体内邻近心脏瓣膜小叶（204,206）。装置的形状记忆材料可以在患者内较少侵入地被激活，例如通过经皮或外部施加能量。形状记忆装置（502）以第一构型植入，然后被激活，记住移位重塑心脏瓣膜几何形状的组织的第二构型。在其他实施例中，将支架（1900）卷曲到心脏瓣膜小叶（204,206）的底部以支撑小叶并改善瓣膜关闭。

2. 发明申请

WO2006012068A3 THERMAL CONDUCTOR FOR ADJUSTABLE CARDIAC IMPLANT 审中-公开
公开(公告)号：WO2006012068A3
公开(公告)日：2006-02-02
申请号：PCT/US2005/021597
申请日：2005-06-17
申请人： MICARDIA CORPORATION , RHEE, Richard , SHAOULIAN, Emanuel , MOADDEB, Shahram , SHAOLIAN, Samuel
发明人： RHEE, Richard , SHAOULIAN, Emanuel , MOADDEB, Shahram , SHAOLIAN, Samuel
IPC分类号： A61F2/24
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement. In one embodiment, an annuloplasty ring (2600) includes a body member (800) including a shape memory material. The shape memory material is configured to transform the body member 800 from a first shape to a second shape in response to being heated. The annuloplasty ring (2600) also includes a thermally insulative material (912) at least partially covering the body member (800) and a thermally conductive material (2610, 2612, 2614) extending into the thermally insulative material (912). The thermally conductive material (2610, 2612, 2614) is configured to communicate thermal energy to the body member (800).

3. 发明申请

WO2006012013A2 ADJUSTABLE CARDIAC VALVE IMPLANT WITH SELECTIVE DIMENSIONAL ADJUSTMENT 审中-公开
标题翻译：可调节心脏瓣膜植入物，具有选择性的尺寸调整
公开(公告)号：WO2006012013A2
公开(公告)日：2006-02-02
申请号：PCT/US2005/021141
申请日：2005-06-15
申请人： MICARDIA CORPORATION , RHEE, Richard , SHAOULIAN, Emanuel , MOADDEB, Shahram , SHAOLIAN, Samuel
发明人： RHEE, Richard , SHAOULIAN, Emanuel , MOADDEB, Shahram , SHAOLIAN, Samuel
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement. In one embodiment, an annuloplasty ring (1826) includes an anterior portion, a posterior portion and two lateral portions corresponding to intersections of the anterior portion and the posterior portion. The annuloplasty ring (1826) has a first shape in a first configuration and a second shape in a second configuration and is configured to transform from the first configuration to the second configuration in response to an activation energy applied thereto. The transformation is configured to reduce a distance between the anterior portion and the posterior portion without substantially decreasing a distance between the two lateral portions.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，当身体结构改变尺寸和/或形状时，可以调节装置的尺寸和/或形状以提供持续的加强。在一个实施例中，瓣膜成形术环（1826）包括前部，后部和对应于前部和后部的交叉点的两个侧部。瓣膜成形术环（1826）具有第一构造的第一形状和第二构造的第二形状，并且被配置为响应于施加到其上的活化能量而从第一构型变换到第二构造。该变换被配置为减小前部和后部之间的距离，而基本上不减小两个侧部之间的距离。

4. 发明申请

WO2006086627A2 DYNAMICALLY ADJUSTABLE GASTRIC IMPLANTS AND METHODS OF TREATING OBESITY USING DYNAMICALLY ADJUSTABLE GASTRIC IMPLANTS 审中-公开
标题翻译：动态可调节的植入式植入物和使用动态可调节的植入物处理肥胖的方法
公开(公告)号：WO2006086627A2
公开(公告)日：2006-08-17
申请号：PCT/US2006/004728
申请日：2006-02-10
申请人： MICARDIA CORPORATION , LEMBO, Nicholas, J. , MOADDEB, Shahram , SHAOULIAN, Emanuel , SHAOLIAN, Samuel , HENSON, Michael, R.
发明人： LEMBO, Nicholas, J. , MOADDEB, Shahram , SHAOULIAN, Emanuel , SHAOLIAN, Samuel , HENSON, Michael, R.
IPC分类号： A61C8/00
CPC分类号： A61F5/0079 , A61F5/0053 , A61F5/0086 , A61F2002/044
摘要： Implants for treatment of obesity may be placed within the stomach and/or esophagus or around the outside surface of the stomach and/or esophagus. The implants comprise at least a portion constructed of a shape memory material. The implants are thus adapted to be implanted in a deformed shape, and then to be transformed through the application of activation energy into a memorized shape. The shape and/or size transformation induces a change in shape of the stomach and/or esophagus, thus altering the normal digestive path of food entering the patient's gastrointestinal tract.
摘要翻译：用于治疗肥胖的植入物可以放置在胃和/或食道内或胃和/或食道的外表面周围。植入物包括由形状记忆材料构成的至少一部分。因此，植入物适于以变形的形状植入，然后通过将活化能量施加到记忆形状中而变形。形状和/或尺寸转换引起胃和/或食道的形状变化，从而改变进入患者胃肠道的食物的正常消化道。

5. 发明申请

WO2006012038A2 SELECTIVELY ADJUSTABLE CARDIAC VALVE IMPLANTS 审中-公开
标题翻译：选择性可调节的心脏瓣膜植入物
公开(公告)号：WO2006012038A2
公开(公告)日：2006-02-02
申请号：PCT/US2005/021324
申请日：2005-06-16
申请人： MICARDIA CORPORATION , SHAOULIAN, Emanuel , SHAOLIAN, Samuel , MOADDEB, Shahram
发明人： SHAOULIAN, Emanuel , SHAOLIAN, Samuel , MOADDEB, Shahram
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement. In one embodiment, a body member (2100) of an annuloplasty ring includes a first shape memory material (2114) configured to transform the body member (2100) from a first configuration having a first size of a dimension to a second configuration having a second size of the dimension. The second size is less than said first size in septal lateral distance. The body member (2100) also includes a second shape memory material (2116) configured to transform the body member (2100) from the second configuration to a third configuration having a third size of the dimension, wherein the second size is less than the third size in septal lateral distance.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给予患者身体的能量。能量可以包括例如声能，射频能量，光能和磁能。因此，随着身体结构改变尺寸和/或形状，可以调节装置的尺寸和/或形状以提供持续的加强。在一个实施例中，瓣膜成形术环的主体部件（2100）包括第一形状记忆材料（2114），其被配置为将主体部件（2100）从具有第一尺寸尺寸的第一构造转换成具有第二构造的第二构造尺寸尺寸。第二尺寸小于所述第一尺寸的间隔横向距离。主体构件（2100）还包括构造成将主体构件（2100）从第二构造转换成具有尺寸的第三尺寸的第三构造的第二形状记忆材料（2116），其中第二尺寸小于第三尺寸大小间隔横向距离。

6. 发明申请

WO2006012011A2 ADJUSTABLE CARDIAC VALVE IMPLANT WITH COUPLING MECHANISM 审中-公开
标题翻译：可调节心脏瓣膜植入与联合机制
公开(公告)号：WO2006012011A2
公开(公告)日：2006-02-02
申请号：PCT/US2005/021136
申请日：2005-06-15
申请人： MICARDIA CORPORATION , SHAOULIAN, Emanuel , SHAOLIAN, Samuel , MOADDEB, Shahram
发明人： SHAOULIAN, Emanuel , SHAOLIAN, Samuel , MOADDEB, Shahram
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement. In one embodiment, an annuloplasty ring (100) includes a tubular member (112) configured to be attached to or near a cardiac valve annulus. The tubular member (112) includes a receptacle end (114) and an insert end (116) configured to couple with the receptacle end (114) of the tubular member (112) such that the tubular member (112) substantially forms a shape of a ring. The insert end (116) is configured to move with respect to the receptacle end (114) to change a circumference of the ring.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，当身体结构改变尺寸和/或形状时，可以调节装置的尺寸和/或形状以提供持续的加强。在一个实施例中，瓣膜成形术环（100）包括构造成附接到心脏瓣膜环上或附近的管状构件（112）。管状构件（112）包括容置端（114）和插入端（116），其被配置为与管状构件（112）的容置端（114）联接，使得管状构件（112）基本上形成戒指。插入端（116）构造成相对于插座端（114）移动以改变环的圆周。

7. 发明申请

WO2007111972A2 ACTIVATION DEVICE FOR DYNAMIC RING MANIPULATION 审中-公开
标题翻译：用于动态环控制的激活装置
公开(公告)号：WO2007111972A2
公开(公告)日：2007-10-04
申请号：PCT/US2007/007194
申请日：2007-03-23
申请人： MICARDIA CORPORATION , SHAOLIAN, Samuel , TRAN, Jason , MOADDEB, Shahram , BUCHBINDER, Maurice , ZARBATANY, David
发明人： SHAOLIAN, Samuel , TRAN, Jason , MOADDEB, Shahram , BUCHBINDER, Maurice , ZARBATANY, David
IPC分类号： A61F2/24 , A61B18/18
CPC分类号： A61F2/2445 , A61F2/2466 , A61F2250/0001
摘要： An activation device for applying energy to an implanted annuloplasty ring is described. In some embodiments, the activation device includes an outer elongate member having an outer elongate member distal end and an outer elongate member proximal end, and a lumen therebetween. In some embodiments, the activation device further includes an inner elongate member having a inner elongate member distal end and a inner elongate member proximal end, and a lumen therebetween, wherein the inner elongate member is slidably insertable through the lumen of the outer elongate member. In some embodiments, the activation device further includes at least one adjustable spline having spline proximal and spline distal ends, the spline distal end connected to the inner tubular member distal end and the spline proximal end connected to the outer tubular member distal end, wherein the adjustable spline is configured to flex as the inner tubular member distal end is drawn proximally toward the outer tubular member distal end while the inner elongate member resides in the lumen of the outer elongate member. In some embodiments, the activation device further includes at least one energy-transfer element coupled to the adjustable spline.
摘要翻译：描述了一种用于向植入的瓣膜成形术环施加能量的激活装置。在一些实施例中，激活装置包括具有外部细长构件远端和外部细长构件近端的外部细长构件和其间的内腔。在一些实施例中，激活装置还包括具有内部细长构件远端和内部细长构件近端的内部细长构件和其间的内腔，其中内部细长构件可滑动地插入穿过外部细长构件的内腔。在一些实施例中，激活装置还包括具有花键近端和花键远端的至少一个可调节花键，花键远端连接到内部管状构件远端，花键近端连接到外部管状构件远端，其中，当内部细长构件驻留在外部细长构件的内腔中时，可调节花键构造成随着内部管状构件远端朝向外部管状构件远端被拉近而弯曲。在一些实施例中，激活装置还包括耦合到可调节花键的至少一个能量传递元件。

8. 发明申请

WO2007038336A2 METHOD AND APPARATUS FOR ADJUSTING BODY LUMENS 审中-公开
标题翻译：用于调节身体照明的方法和设备
公开(公告)号：WO2007038336A2
公开(公告)日：2007-04-05
申请号：PCT/US2006/037095
申请日：2006-09-22
申请人： ELLIPSE TECHNOLOGIES, INC. , KICK, George, F. , LENKER, Jay, A. , SHAOLIAN, Samuel , MOADDEB, Shawn , HENSON, Mike
发明人： KICK, George, F. , LENKER, Jay, A. , SHAOLIAN, Samuel , MOADDEB, Shawn , HENSON, Mike
IPC分类号： A61F2/02
CPC分类号： A61B17/12 , A61B17/12009 , A61B17/12013 , A61B17/3468 , A61B2017/00827 , A61B2017/22054 , A61B2017/22069 , A61B2017/306 , A61B2017/3486
摘要： Disclosed is a device and method for accessing the lower esophageal sphincter through the esophagus. In one embodiment, a catheter is inserted through the mouth or nose of a patient and advanced to the region of the diaphragm. Under fluoroscopy or endoscopy, a hollow needle at the distal end of the catheter punctures the wall of the esophagus from the inside so that the distal end of the needle is positioned outside the esophagus. An implant is next advanced out through the hollow needle to the region outside the sphincter where it is deflected and coerced to bluntly dissect around the circumference of the esophagus, where the implant is left in place to heal. The hollow needle is removed and the esophageal wall is allowed to heal. Subsequent diametric adjustment of the implant allows for tightening or loosening of the sphincter to minimize gastric reflux. The device and method can also be used to treat the pyloric or other body sphincters, hollow organs, or ducts.
摘要翻译：公开了一种通过食管进入食管下括约肌的装置和方法。在一个实施例中，导管通过患者的口或鼻插入并推进至隔膜的区域。在透视或内窥镜检查下，导管远端的中空针从内侧穿刺食管壁，使针的远端位于食管外。然后通过中空针将植入物推进到括约肌外部的区域，在该区域中，其被偏转并被强制钝性地解剖食道的周围，植入物留在原处以愈合。空心针被移除并且食道壁被允许愈合。随后对植入物进行直径调整允许收紧或松开括约肌以使胃反流最小化。该装置和方法也可以用于治疗幽门或其他身体括约肌，中空器官或导管。

9. 发明申请

WO2005062940A2 METHOD AND APPARATUS FOR IN VIVO COLLECTION AND SURVEILLANCE OF CIRCULATING BIOLOGICAL COMPONENTS 审中-公开
标题翻译：循环生物组分收集和监测的方法和装置
公开(公告)号：WO2005062940A2
公开(公告)日：2005-07-14
申请号：PCT/US2004/043376
申请日：2004-12-22
申请人： JOHN WAYNE CANCER INSTITUTE , HOON, David , TABACK, Bret , SHAOLIAN, Samuel
发明人： HOON, David , TABACK, Bret , SHAOLIAN, Samuel
IPC分类号： C12Q1/68
CPC分类号： G01N33/54366 , B82Y30/00
摘要： The invention relates generally to in vivo collection of circulating molecules, tumor cells and other biological markers using a collecting probe. The probe is configured for placement within a living organism for an extended period of time to provide sufficient yield of biological marker for analysis. In some embodiments of the invention, active attraction of biological markers is provided. A combination of detection methods may be provided on the same probe or probe system. A partial or complete analytic/detection assembly may also be integrated with the probe.
摘要翻译：本发明一般涉及使用收集探针体内收集循环分子，肿瘤细胞和其他生物学标记物。探针配置为在活体内长时间放置以提供足够的生物标志物用于分析。在本发明的一些实施方案中，提供了生物标志物的主动吸引。可以在相同的探针或探针系统上提供检测方法的组合。部分或完整的分析/检测组件也可以与探头集成。

10. 发明申请

WO2009102580A1 ADJUSTABLE CARDIAC VALVE IMPLANT WITH SELECTIVE DIMENSIONAL ADJUSTMENT 审中-公开
标题翻译：可调节心脏瓣膜植入物，具有选择性的尺寸调整
公开(公告)号：WO2009102580A1
公开(公告)日：2009-08-20
申请号：PCT/US2009/032974
申请日：2009-02-03
申请人： MICARDIA CORPORATION
发明人： SHAOLIAN, Samuel , MOADDEB, Shahram , RHEE, Richard, S.
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2448 , A61F2210/0014 , A61F2210/0023 , A61F2210/009 , A61F2250/0001 , A61F2250/0004
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include an anterior portion, a posterior portion and two lateral portions corresponding to intersections of the anterior portion and the posterior portion. The devices have a first shape in a first configuration and a second shape in a second configuration and are configured to transform from the first configuration to the second configuration in response to an activation energy applied thereto. The transformation is configured to reduce a distance between the anterior portion and the posterior portion more than a distance between the two lateral portions.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。在某些实施例中，装置包括前部，后部和对应于前部和后部的交叉点的两个侧部。这些装置具有第一配置中的第一形状和第二配置的第二形状，并且被配置为响应于施加到其上的激活能量而从第一配置变换到第二配置。该变换被配置为减小前部和后部之间的距离超过两个侧部之间的距离。

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