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1. 发明申请

WO2006012013A3 ADJUSTABLE CARDIAC VALVE IMPLANT WITH SELECTIVE DIMENSIONAL ADJUSTMENT 审中-公开
标题翻译：可调心脏瓣膜植入物选择性尺寸调整
公开(公告)号：WO2006012013A3
公开(公告)日：2006-12-28
申请号：PCT/US2005021141
申请日：2005-06-15
申请人： MICARDIA CORP , RHEE RICHARD , SHAOULIAN EMANUEL , MOADDEB SHAHRAM , SHAOLIAN SAMUEL
发明人： RHEE RICHARD , SHAOULIAN EMANUEL , MOADDEB SHAHRAM , SHAOLIAN SAMUEL
IPC分类号： A61F2/24 , A61F2/00 , A61F2/02
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement. In one embodiment, an annuloplasty ring (1826) includes an anterior portion, a posterior portion and two lateral portions corresponding to intersections of the anterior portion and the posterior portion. The annuloplasty ring (1826) has a first shape in a first configuration and a second shape in a second configuration and is configured to transform from the first configuration to the second configuration in response to an activation energy applied thereto. The transformation is configured to reduce a distance between the anterior portion and the posterior portion without substantially decreasing a distance between the two lateral portions.
摘要翻译：提供了用于支持身体结构的方法和设备。可以以微创或非侵入方式在患者身体内调整装置，例如通过经皮或外部施加能量到患者身体。能量可以包括例如声能，射频能量，光能和磁能。因此，随着身体结构改变尺寸和/或形状，可以调整装置的尺寸和/或形状以提供连续的增强。在一个实施例中，瓣环成形术环（1826）包括前部，后部和对应于前部和后部的交点的两个侧部。瓣环成形术环（1826）具有第一构型的第一形状和第二构型的第二形状，并且构造成响应于施加到其上的激活能量从第一构型转变为第二构型。该变换被配置成减小前部和后部之间的距离而基本上不减小两个侧部之间的距离。

2. 发明申请

WO2006012068A2 THERMAL CONDUCTOR FOR ADJUSTABLE CARDIAC IMPLANT 审中-公开
标题翻译：用于可调节心脏植入物的导热体
公开(公告)号：WO2006012068A2
公开(公告)日：2006-02-02
申请号：PCT/US2005021597
申请日：2005-06-17
申请人： MICARDIA CORP , RHEE RICHARD , SHAOULIAN EMANUEL , MOADDEB SHAHRAM , SHAOLIAN SAMUEL
发明人： RHEE RICHARD , SHAOULIAN EMANUEL , MOADDEB SHAHRAM , SHAOLIAN SAMUEL
IPC分类号： A61F2/24 , A61F2/00 , A61F2/02
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement. In one embodiment, an annuloplasty ring (2600) includes a body member (800) including a shape memory material. The shape memory material is configured to transform the body member 800 from a first shape to a second shape in response to being heated. The annuloplasty ring (2600) also includes a thermally insulative material (912) at least partially covering the body member (800) and a thermally conductive material (2610, 2612, 2614) extending into the thermally insulative material (912). The thermally conductive material (2610, 2612, 2614) is configured to communicate thermal energy to the body member (800).
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，当身体结构改变尺寸和/或形状时，可以调节装置的尺寸和/或形状以提供持续的加强。在一个实施例中，瓣膜成形术环（2600）包括包括形状记忆材料的主体构件（800）。形状记忆材料被配置为响应于加热而将本体构件800从第一形状转变为第二形状。瓣膜成形术环（2600）还包括至少部分地覆盖主体构件（800）的热绝缘材料（912）和延伸到绝热材料（912）中的导热材料（2610,2612,2614）。导热材料（2610,2612,2614）构造成将热能传递到主体部件（800）。

3. 发明申请

WO2006012038A3 SELECTIVELY ADJUSTABLE CARDIAC VALVE IMPLANTS 审中-公开
标题翻译：选择性可调节的心脏瓣膜植入物
公开(公告)号：WO2006012038A3
公开(公告)日：2006-10-26
申请号：PCT/US2005021324
申请日：2005-06-16
申请人： MICARDIA CORP , SHAOULIAN EMANUEL , SHAOLIAN SAMUEL , MOADDEB SHAHRAM
发明人： SHAOULIAN EMANUEL , SHAOLIAN SAMUEL , MOADDEB SHAHRAM
IPC分类号： A61F2/28 , A61F2/00 , A61F2/02 , A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by apply energy to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过将能量施加于患者身体。能量可以包括例如声能，射频能量，光能和磁能。因此，当身体结构改变尺寸和/或形状时，可以调节装置的尺寸和/或形状以提供持续的加强。

4. 发明申请

WO2006086627A3 DYNAMICALLY ADJUSTABLE GASTRIC IMPLANTS AND METHODS OF TREATING OBESITY USING DYNAMICALLY ADJUSTABLE GASTRIC IMPLANTS 审中-公开
标题翻译：动态可调节的植入式植入物和使用动态可调节的植入物处理肥胖的方法
公开(公告)号：WO2006086627A3
公开(公告)日：2007-10-04
申请号：PCT/US2006004728
申请日：2006-02-10
申请人： MICARDIA CORP , LEMBO NICHOLAS J , MOADDEB SHAHRAM , SHAOULIAN EMANUEL , SHAOLIAN SAMUEL , HENSON MICHAEL R
发明人： LEMBO NICHOLAS J , MOADDEB SHAHRAM , SHAOULIAN EMANUEL , SHAOLIAN SAMUEL , HENSON MICHAEL R
IPC分类号： A61B17/04 , A61B17/12
CPC分类号： A61F5/0079 , A61F5/0053 , A61F5/0086 , A61F2002/044
摘要： Implants for treatment of obesity may be placed within the stomach and/or esophagus or around the outside surface of the stomach and/or esophagus. The implants comprise at least a portion constructed of a shape memory material. The implants are thus adapted to be implanted in a deformed shape, and then to be transformed through the application of activation energy into a memorized shape. The shape and/or size transformation induces a change in shape of the stomach and/or esophagus, thus altering the normal digestive path of food entering the patient's gastrointestinal tract.
摘要翻译：用于治疗肥胖的植入物可以放置在胃和/或食道内或胃和/或食道的外表面周围。植入物包括由形状记忆材料构成的至少一部分。因此，植入物适于以变形的形状植入，然后通过将活化能量施加到记忆形状中而变形。形状和/或尺寸转换引起胃和/或食道的形状变化，从而改变进入患者胃肠道的食物的正常消化道。

5. 发明申请

WO2006012011A3 ADJUSTABLE CARDIAC VALVE IMPLANT WITH COUPLING MECHANISM 审中-公开
标题翻译：可调心脏瓣膜植入联合机制
公开(公告)号：WO2006012011A3
公开(公告)日：2006-03-09
申请号：PCT/US2005021136
申请日：2005-06-15
申请人： MICARDIA CORP , SHAOULIAN EMANUEL , SHAOLIAN SAMUEL , MOADDEB SHAHRAM
发明人： SHAOULIAN EMANUEL , SHAOLIAN SAMUEL , MOADDEB SHAHRAM
IPC分类号： A61F2/06 , A61F2/00 , A61F2/02 , A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement. In one embodiment, an annuloplasty ring (100) includes a tubular member (112) configured to be attached to or near a cardiac valve annulus. The tubular member (112) includes a receptacle end (114) and an insert end (116) configured to couple with the receptacle end (114) of the tubular member (112) such that the tubular member (112) substantially forms a shape of a ring. The insert end (116) is configured to move with respect to the receptacle end (114) to change a circumference of the ring.
摘要翻译：提供了用于支持身体结构的方法和设备。可以以微创或非侵入方式在患者身体内调整装置，例如通过经皮或外部施加能量到患者身体。能量可以包括例如声能，射频能量，光能和磁能。因此，随着身体结构改变尺寸和/或形状，可以调整装置的尺寸和/或形状以提供连续的增强。在一个实施例中，瓣环成形术环（100）包括管状构件（112），该管状构件构造成附接到心脏瓣膜环上或其附近。管状部件（112）包括容器端部（114）和配置成与管状部件（112）的容器端部（114）连接的插入端部（116），使得管状部件（112）基本上形成戒指。插入端（116）构造成相对于插座端（114）移动以改变环的周长。

6. 发明申请

WO2006012011B1 ADJUSTABLE CARDIAC VALVE IMPLANT WITH COUPLING MECHANISM 审中-公开
公开(公告)号：WO2006012011B1
公开(公告)日：2006-11-02
申请号：PCT/US2005021136
申请日：2005-06-15
申请人： MICARDIA CORP , SHAOULIAN EMANUEL , SHAOLIAN SAMUEL , MOADDEB SHAHRAM
发明人： SHAOULIAN EMANUEL , SHAOLIAN SAMUEL , MOADDEB SHAHRAM
IPC分类号： A61F2/06 , A61F2/00 , A61F2/02 , A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement. In one embodiment, an annuloplasty ring (100) includes a tubular member (112) configured to be attached to or near a cardiac valve annulus. The tubular member (112) includes a receptacle end (114) and an insert end (116) configured to couple with the receptacle end (114) of the tubular member (112) such that the tubular member (112) substantially forms a shape of a ring. The insert end (116) is configured to move with respect to the receptacle end (114) to change a circumference of the ring.

7. 发明申请

WO2007111972A3 ACTIVATION DEVICE FOR DYNAMIC RING MANIPULATION 审中-公开
标题翻译：用于动态环控制的激活装置
公开(公告)号：WO2007111972A3
公开(公告)日：2008-08-07
申请号：PCT/US2007007194
申请日：2007-03-23
申请人： MICARDIA CORP , SHAOLIAN SAMUEL , TRAN JASON , MOADDEB SHAHRAM , BUCHBINDER MAURICE , ZARBATANY DAVID
发明人： SHAOLIAN SAMUEL , TRAN JASON , MOADDEB SHAHRAM , BUCHBINDER MAURICE , ZARBATANY DAVID
IPC分类号： A61N1/00
CPC分类号： A61F2/2445 , A61F2/2466 , A61F2250/0001
摘要： An activation device for applying energy to an implanted annuloplasty ring is described. The activation device includes an outer elongate member having an outer elongate member distal end and an outer elongate member proximal end, and a lumen therebetween, wherein the inner elongate member is slidably insertable through the lumen of the outer member. The activation device further includes at least one adjustable spline having spline proximal and spline distal ends, the spline distal end connected to the inner tubular member distal end and the spline proximal end connected to the outer tubular member distal end, wherein the adjustable spline is configured to flex as the inner tubular member distal end is drawn proximally toward the outer tubular member distal end while the inner elongate member resides in the lumen of the outer elongate member. The activation device further includes at least one energy-transfer element coupled to the adjustable spline.
摘要翻译：描述了一种用于向植入的瓣膜成形术环施加能量的激活装置。激活装置包括具有外部细长构件远端和外部细长构件近端的外部细长构件和其间的内腔，其中内部细长构件可滑动地插入通过外部构件的内腔。激活装置还包括具有花键近端和花键远端的至少一个可调节花键，所述花键远端连接到内管状构件远端，花键近端连接到外管状构件远端，其中可调节花键配置当内部细长构件位于外部细长构件的内腔中时，内部管状构件远端朝向外侧管状构件远端被拉近。激活装置还包括耦合到可调节花键的至少一个能量传递元件。

8. 发明申请

WO2005062940A3 METHOD AND APPARATUS FOR IN VIVO COLLECTION AND SURVEILLANCE OF CIRCULATING BIOLOGICAL COMPONENTS 审中-公开
标题翻译：用于体内循环生物组分收集和监测的方法和设备
公开(公告)号：WO2005062940A3
公开(公告)日：2005-09-09
申请号：PCT/US2004043376
申请日：2004-12-22
申请人： WAYNE JOHN CANCER INST , HOON DAVID , TABACK BRET , SHAOLIAN SAMUEL
发明人： HOON DAVID , TABACK BRET , SHAOLIAN SAMUEL
IPC分类号： C12Q1/68
CPC分类号： G01N33/54366 , B82Y30/00
摘要： The invention relates generally to in vivo collection of circulating molecules, tumor cells and other biological markers using a collecting probe. The probe is configured for placement within a living organism for an extended period of time to provide sufficient yield of biological marker for analysis. In some embodiments of the invention, active attraction of biological markers is provided. A combination of detection methods may be provided on the same probe or probe system. A partial or complete analytic/detection assembly may also be integrated with the probe.
摘要翻译：本发明一般涉及使用采集探针在体内收集循环分子，肿瘤细胞和其他生物标志物。探针被配置用于放置在活体内长时间以提供用于分析的足够产量的生物标记。在本发明的一些实施方式中，提供了生物标记的主动吸引。可以在相同的探针或探针系统上提供检测方法的组合。部分或完整的分析/检测组件也可以与探针集成。

9. 发明申请

WO2007038336A3 METHOD AND APPARATUS FOR ADJUSTING BODY LUMENS 审中-公开
标题翻译：调节身体的方法和装置
公开(公告)号：WO2007038336A3
公开(公告)日：2007-07-12
申请号：PCT/US2006037095
申请日：2006-09-22
申请人： ELLIPSE TECHNOLOGIES INC , KICK GEORGE F , LENKER JAY A , SHAOLIAN SAMUEL , MOADDEB SHAWN , HENSON MIKE
发明人： KICK GEORGE F , LENKER JAY A , SHAOLIAN SAMUEL , MOADDEB SHAWN , HENSON MIKE
IPC分类号： A61F2/02
CPC分类号： A61B17/12 , A61B17/12009 , A61B17/12013 , A61B17/3468 , A61B2017/00827 , A61B2017/22054 , A61B2017/22069 , A61B2017/306 , A61B2017/3486
摘要： Disclosed is a device and method for accessing the lower esophageal sphincter through the esophagus. In one embodiment, a catheter is inserted through the mouth or nose of a patient and advanced to the region of the diaphragm. Under fluoroscopy or endoscopy, a hollow needle at the distal end of the catheter punctures the wall of the esophagus from the inside so that the distal end of the needle is positioned outside the esophagus. An implant is next advanced out through the hollow needle to the region outside the sphincter where it is deflected and coerced to bluntly dissect around the circumference of the esophagus, where the implant is left in place to heal. The hollow needle is removed and the esophageal wall is allowed to heal. Subsequent diametric adjustment of the implant allows for tightening or loosening of the sphincter to minimize gastric reflux. The device and method can also be used to treat the pyloric or other body sphincters, hollow organs, or ducts.
摘要翻译：公开了一种通过食道进入下食管括约肌的装置和方法。在一个实施例中，导管穿过患者的嘴或鼻插入并前进到隔膜的区域。在荧光透视或内窥镜检查下，导管远端的中空针头从内侧穿刺食道的壁，使得针的远端位于食道外部。然后将植入物通过中空针前进到括约肌外部的区域，在那里它被偏转并胁迫以在食道周围钝化解剖，植入物留在原位以愈合。取出空心针，食管壁被治愈。随后的植入物的直径调整允许收缩或松开括约肌以最小化胃反流。该装置和方法还可用于治疗幽门或其他身体括约肌，中空器官或管道。

10. 发明专利

AT462373T 未知
公开(公告)号：AT462373T
公开(公告)日：2010-04-15
申请号：AT05763622
申请日：2005-06-23
申请人： MICARDIA CORP
发明人： MOADDEB SHAHRAM , SHAOLIAN SAMUEL , SHAOULIAN EMANUEL , RHEE RICHARD , ANDERSON SETEVEN
IPC分类号： A61F2/00

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