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1. 发明专利

AT462373T 未知
公开(公告)号：AT462373T
公开(公告)日：2010-04-15
申请号：AT05763622
申请日：2005-06-23
申请人： MICARDIA CORP
发明人： MOADDEB SHAHRAM , SHAOLIAN SAMUEL , SHAOULIAN EMANUEL , RHEE RICHARD , ANDERSON SETEVEN
IPC分类号： A61F2/00

2. 发明申请

WO2007111972A3 ACTIVATION DEVICE FOR DYNAMIC RING MANIPULATION 审中-公开
标题翻译：用于动态环控制的激活装置
公开(公告)号：WO2007111972A3
公开(公告)日：2008-08-07
申请号：PCT/US2007007194
申请日：2007-03-23
申请人： MICARDIA CORP , SHAOLIAN SAMUEL , TRAN JASON , MOADDEB SHAHRAM , BUCHBINDER MAURICE , ZARBATANY DAVID
发明人： SHAOLIAN SAMUEL , TRAN JASON , MOADDEB SHAHRAM , BUCHBINDER MAURICE , ZARBATANY DAVID
IPC分类号： A61N1/00
CPC分类号： A61F2/2445 , A61F2/2466 , A61F2250/0001
摘要： An activation device for applying energy to an implanted annuloplasty ring is described. The activation device includes an outer elongate member having an outer elongate member distal end and an outer elongate member proximal end, and a lumen therebetween, wherein the inner elongate member is slidably insertable through the lumen of the outer member. The activation device further includes at least one adjustable spline having spline proximal and spline distal ends, the spline distal end connected to the inner tubular member distal end and the spline proximal end connected to the outer tubular member distal end, wherein the adjustable spline is configured to flex as the inner tubular member distal end is drawn proximally toward the outer tubular member distal end while the inner elongate member resides in the lumen of the outer elongate member. The activation device further includes at least one energy-transfer element coupled to the adjustable spline.
摘要翻译：描述了一种用于向植入的瓣膜成形术环施加能量的激活装置。激活装置包括具有外部细长构件远端和外部细长构件近端的外部细长构件和其间的内腔，其中内部细长构件可滑动地插入通过外部构件的内腔。激活装置还包括具有花键近端和花键远端的至少一个可调节花键，所述花键远端连接到内管状构件远端，花键近端连接到外管状构件远端，其中可调节花键配置当内部细长构件位于外部细长构件的内腔中时，内部管状构件远端朝向外侧管状构件远端被拉近。激活装置还包括耦合到可调节花键的至少一个能量传递元件。

3. 发明申请

WO2007033360A2 LEFT ATRIAL BALLOON CATHETER 审中-公开
标题翻译：左侧气囊导管
公开(公告)号：WO2007033360A2
公开(公告)日：2007-03-22
申请号：PCT/US2006035981
申请日：2006-09-13
申请人： MICARDIA CORP , MOADDEB SHAWN , RHEE RICHARD , ANDERSON STEVE
发明人： MOADDEB SHAWN , RHEE RICHARD , ANDERSON STEVE
IPC分类号： A61F2/24 , A61F2/958
CPC分类号： A61F2/2448 , A61F2/2466 , A61F2250/0004
摘要： Systems, methods and devices are provided for activation of an adjustable annuloplasty device. The devices may include a catheter system (3020) for percutaneously activating an adjustable annuloplasty device (3000), including a handle assembly (3052), a shaft assembly (3050) having at least one fluid lumen (3084), and a distal element (3004). The shaft assembly (3050) extends between the handle assembly (3052) and the distal element (3004), the distal element (3004) being in fluid communication with the handle assembly (3052) via the at least one fluid lumen (3084). The distal element (3004) includes an elongated core (3074) having a first port (3381) and an expandable member (3070). The core (3074) extends through the expandable member (3070) and the expandable member (3070) is movable between a collapsed position and an inflated position.
摘要翻译：提供了用于激活可调节瓣环成形术装置的系统，方法和装置。装置可以包括用于经皮激活可调节瓣环成形术装置（3000）的导管系统（3020），包括手柄组件（3052），具有至少一个流体腔（3084）的轴组件（3050）和远端元件 3004）。轴组件（3050）在手柄组件（3052）和远侧元件（3004）之间延伸，远端元件（3004）经由至少一个流体腔（3084）与手柄组件（3052）流体连通。远侧元件（3004）包括具有第一端口（3381）和可膨胀构件（3070）的细长芯（3074）。芯（3074）延伸穿过可膨胀构件（3070），并且可膨胀构件（3070）可在折叠位置和膨胀位置之间移动。

4. 发明申请

WO2006012038A3 SELECTIVELY ADJUSTABLE CARDIAC VALVE IMPLANTS 审中-公开
标题翻译：选择性可调节的心脏瓣膜植入物
公开(公告)号：WO2006012038A3
公开(公告)日：2006-10-26
申请号：PCT/US2005021324
申请日：2005-06-16
申请人： MICARDIA CORP , SHAOULIAN EMANUEL , SHAOLIAN SAMUEL , MOADDEB SHAHRAM
发明人： SHAOULIAN EMANUEL , SHAOLIAN SAMUEL , MOADDEB SHAHRAM
IPC分类号： A61F2/28 , A61F2/00 , A61F2/02 , A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by apply energy to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过将能量施加于患者身体。能量可以包括例如声能，射频能量，光能和磁能。因此，当身体结构改变尺寸和/或形状时，可以调节装置的尺寸和/或形状以提供持续的加强。

5. 发明申请

WO2012019052A3 PERCUTANEOUS TRANSCATHETER REPAIR OF HEART VALVES 审中-公开
标题翻译： PERCUTANEOUS TRANSCATHETER维修心脏瓣膜
公开(公告)号：WO2012019052A3
公开(公告)日：2012-07-26
申请号：PCT/US2011046659
申请日：2011-08-04
申请人： MICARDIA CORP , TSUKASHIMA ROSS , SHAOLIAN SAMUEL M , BUCHBINDER MAURICE , GRAY BRIAN C , PACKHAM VICTOR S , CAO HUNG H
发明人： TSUKASHIMA ROSS , SHAOLIAN SAMUEL M , BUCHBINDER MAURICE , GRAY BRIAN C , PACKHAM VICTOR S , CAO HUNG H
IPC分类号： A61F2/24 , A61M25/01 , A61M31/00
CPC分类号： A61F2/2466 , A61F2/2442 , A61F2/2445 , A61F2/2448 , A61F2210/0014 , A61F2220/0016 , A61F2220/0033 , A61F2220/0075 , A61F2250/0004 , A61F2250/001 , A61F2250/0067 , A61F2250/0096
摘要： Apparatus, systems, and methods are provided for repairing heart valves through percutaneous transcatheter delivery and fixation of annuloplasty rings to heart valves. An annuloplasty ring includes an outer hollow member including a plurality of segments. Adjacent segments cooperate with one another to change the outer hollow member from an elongate insertion geometry to an annular operable geometry. The annuloplasty ring also includes an internal anchor member located at least partially within the outer hollow member. The internal anchor member includes a plurality of anchors configured to attach the annuloplasty ring to tissue of a heart valve annulus. The internal anchor member is configured to move the plurality of anchors with respect to a plurality of windows in the outer hollow member to selectively deploy the plurality of anchors through the respective windows.
摘要翻译：提供装置，系统和方法用于通过经皮经导管递送和瓣膜成形术环固定到心脏瓣膜来修复心脏瓣膜。瓣膜成形术环包括包括多个段的外部中空构件。相邻的部分彼此协作以将外部空心构件从细长的插入几何形状改变为环形可操作的几何形状。瓣膜成形术环还包括至少部分地位于外部中空构件内部的内部锚定构件。内部锚固构件包括构造成将瓣环成形术环附接到心脏瓣膜环的组织的多个锚固件。内部锚固构件被构造成相对于外部中空构件中的多个窗口移动多个锚固件，以选择性地将多个锚定件展开通过相应的窗口。

6. 发明申请

WO2010036793A3 DYNAMIC HEART HARNESS 审中-公开
标题翻译：动态心脏线束
公开(公告)号：WO2010036793A3
公开(公告)日：2010-07-01
申请号：PCT/US2009058204
申请日：2009-09-24
申请人： MICARDIA CORP , SHAOLIAN SAMUEL M , TSUKASHIMA ROSS , POOL SCOTT L
发明人： SHAOLIAN SAMUEL M , TSUKASHIMA ROSS , POOL SCOTT L
IPC分类号： A61N2/10 , A61F2/24
CPC分类号： A61F2/2481 , A61N2/06
摘要： A reversibly adjustable heart harness is configured to surround at least a portion of a heart and to provide a compressive force to the heart during at least a portion of a cardiac cycle. The heart harness includes a plurality of wires forming a mesh structure, and one or more tensioning motors connected to the mesh structure. The one or more tensioning motors are configured to selectively increase or reduce tension in the mesh structure to readjust the compressive force provided that the heart harness provides to the heart.
摘要翻译：可逆调节的心脏线束构造成围绕心脏的至少一部分并且在心脏周期的至少一部分期间向心脏提供压缩力。心形线束包括多个形成网状结构的线，以及连接到网状结构的一个或多个张紧马达。一个或多个张紧马达构造成选择性地增加或减小网状结构中的张力，以重新调整心脏线束提供给心脏的压缩力。

7. 发明申请

WO2006019520A3 MAGNETIC DEVICES AND METHODS FOR RESHAPING HEART ANATOMY 审中-公开
标题翻译：磁性装置和用于重建心脏解剖的方法
公开(公告)号：WO2006019520A3
公开(公告)日：2006-12-21
申请号：PCT/US2005022461
申请日：2005-06-23
申请人： MICARDIA CORP , MOADDEB SHAHRAM , SHAOLIAN SAMUEL M , SHAOULIAN EMANUEL , RHEE RICHARD , ANDERSON SETEVEN C
发明人： MOADDEB SHAHRAM , SHAOLIAN SAMUEL M , SHAOULIAN EMANUEL , RHEE RICHARD , ANDERSON SETEVEN C
IPC分类号： A61F2/00 , A61M1/12
CPC分类号： A61F2/2478 , A61B17/3468 , A61B2017/00876 , A61F2/2481 , A61F2/2487 , A61F2002/249 , A61F2210/009
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Heart dilation treated by reshaping the heart anatomy with the use of magnetic forces. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The magnetic forces are applied with the use of one or more magnetic elements which are implanted within the heart tissue or attached externally and/or internally to a surface of the heart. The various charges of the magnetic forces interact causing the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the force of the magnetic elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
摘要翻译：提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。通过使用磁力重塑心脏解剖结构治疗的心脏扩张。这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加脑室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。使用一个或多个植入心脏组织内或附着在心脏外表面和/或内部的磁性元件施加磁力。磁力的各种电荷相互作用，使相关的心脏组织区域重新调整位置，例如减小心室的宽度。这种重新定位通过磁性元件的力量随着时间的推移而保持，从而允许心脏扩张的破坏性作用在进展或反转中缓慢。

8. 发明专利

AT429194T 未知
公开(公告)号：AT429194T
公开(公告)日：2009-05-15
申请号：AT06255867
申请日：2006-11-16
申请人： MICARDIA CORP
发明人： MOADDEB SHAHRAM
IPC分类号： A61F2/24
摘要： A system for reshaping or reforming a heart valve annulus, the system comprising: a catheter configured to deliver energy to an implant, a magnet located in or on a catheter, the magnet configured to engage an annuloplasty device implanted at or near the heart valve annulus; an energy transfer module configured to change at least one dimension of the heart valve annulus while transforming the annuloplasty device from a first to second configuration and while the catheter is engaged to the annuloplasty device. The annuloplasty device may comprise one or more energy conductors.

9. 发明申请

WO2008006002A3 METHODS AND SYSTEMS FOR CARDIAC REMODELING VIA RESYNCHRONIZATION 审中-公开
标题翻译：通过再次心脏再造的方法和系统
公开(公告)号：WO2008006002A3
公开(公告)日：2008-12-31
申请号：PCT/US2007072786
申请日：2007-07-03
申请人： MICARDIA CORP , MOADDEB SHAHRAM , SHAOLIAN SAMUEL M , SHAOULIAN EMANUEL
发明人： MOADDEB SHAHRAM , SHAOLIAN SAMUEL M , SHAOULIAN EMANUEL
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/0597 , A61N1/3622 , A61N1/3968
摘要： Systems, methods and devices are provided for improving the hemodynamic efficiency of a patient's heart by implanting one or more reinforcement elements on or with the heart and providing electrical stimulation to the heart. The reinforcement elements may include magnetic and/or shape memory material and are configured to reshape the heart so as to boost the heart's mechanical energy during a response to the electrical stimulation. In some embodiments, at least one reinforcement element includes an electrode configured to sense electrocardiogram signals within the heart. An electrical stimulation device such as an implantable or external pacemaker/defibrillator may be configured to control delivery of electrical pulses to the heart based on the sensed electrocardiogram signals. In addition, or in other embodiments, at least one reinforcement element includes an electrode configured to deliver the electrical pulses to the heart.
摘要翻译：提供了系统，方法和装置，用于通过在心脏上或与心脏一起植入一个或多个增强元件并向心脏提供电刺激来改善患者心脏的血液动力学效率。加强元件可以包括磁性和/或形状的记忆材料，并且被配置成重塑心脏，以便在对电刺激的响应期间增强心脏的机械能。在一些实施例中，至少一个加强元件包括被配置为感测心脏内的心电图信号的电极。诸如植入式或外部起搏器/除颤器之类的电刺激装置可以被配置成基于感测到的心电图信号来控制向心脏的电脉冲的传递。另外或在其它实施例中，至少一个加强元件包括被配置为将电脉冲传送到心脏的电极。

10. 发明申请

WO2006012013A3 ADJUSTABLE CARDIAC VALVE IMPLANT WITH SELECTIVE DIMENSIONAL ADJUSTMENT 审中-公开
标题翻译：可调心脏瓣膜植入物选择性尺寸调整
公开(公告)号：WO2006012013A3
公开(公告)日：2006-12-28
申请号：PCT/US2005021141
申请日：2005-06-15
申请人： MICARDIA CORP , RHEE RICHARD , SHAOULIAN EMANUEL , MOADDEB SHAHRAM , SHAOLIAN SAMUEL
发明人： RHEE RICHARD , SHAOULIAN EMANUEL , MOADDEB SHAHRAM , SHAOLIAN SAMUEL
IPC分类号： A61F2/24 , A61F2/00 , A61F2/02
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement. In one embodiment, an annuloplasty ring (1826) includes an anterior portion, a posterior portion and two lateral portions corresponding to intersections of the anterior portion and the posterior portion. The annuloplasty ring (1826) has a first shape in a first configuration and a second shape in a second configuration and is configured to transform from the first configuration to the second configuration in response to an activation energy applied thereto. The transformation is configured to reduce a distance between the anterior portion and the posterior portion without substantially decreasing a distance between the two lateral portions.
摘要翻译：提供了用于支持身体结构的方法和设备。可以以微创或非侵入方式在患者身体内调整装置，例如通过经皮或外部施加能量到患者身体。能量可以包括例如声能，射频能量，光能和磁能。因此，随着身体结构改变尺寸和/或形状，可以调整装置的尺寸和/或形状以提供连续的增强。在一个实施例中，瓣环成形术环（1826）包括前部，后部和对应于前部和后部的交点的两个侧部。瓣环成形术环（1826）具有第一构型的第一形状和第二构型的第二形状，并且构造成响应于施加到其上的激活能量从第一构型转变为第二构型。该变换被配置成减小前部和后部之间的距离而基本上不减小两个侧部之间的距离。

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