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1. 发明申请

WO2006019520A2 MAGNETIC DEVICES AND METHODS FOR RESHAPING HEART ANATOMY 审中-公开
标题翻译：磁性装置和用于重新整理心脏解剖的方法
公开(公告)号：WO2006019520A2
公开(公告)日：2006-02-23
申请号：PCT/US2005/022461
申请日：2005-06-23
申请人： MICARDIA CORPORATION , MOADDEB, Shahram , SHAOLIAN, Samuel, M. , SHAOULIAN, Emanuel , RHEE, Richard , ANDERSON, Seteven, C.
发明人： MOADDEB, Shahram , SHAOLIAN, Samuel, M. , SHAOULIAN, Emanuel , RHEE, Richard , ANDERSON, Seteven, C.
IPC分类号： A61F2/00
CPC分类号： A61F2/2478 , A61B17/3468 , A61B2017/00876 , A61F2/2481 , A61F2/2487 , A61F2002/249 , A61F2210/009
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Heart dilation treated by reshaping the heart anatomy with the use of magnetic forces. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The magnetic forces are applied with the use of one or more magnetic elements which are implanted within the heart tissue or attached externally and/or internally to a surface of the heart. The various charges of the magnetic forces interact causing the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the force of the magnetic elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
摘要翻译：提供用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。通过使用磁力重塑心脏解剖结构来治疗心脏扩张。这种再成形改变了心脏部分，特别是右心室或左心室的几何形状，以增加心室的收缩性，从而增加心搏量，这又增加了心脏的心输出量。通过使用一个或多个磁性元件来施加磁力，所述磁性元件植入心脏组织内或附着在心脏表面的外部和/或内部。磁力的各种电荷相互作用导致相关的心脏组织区域重新调整位置，例如以减小心室的宽度。这种重新定位通过磁性元件的力持续保持一段时间，允许心脏扩张的破坏性作用减缓进展或逆转。

2. 发明申请

WO2006019521A2 SHAPE MEMORY DEVICES AND METHODS FOR RESHAPING HEART ANATOMY 审中-公开
标题翻译：形状记忆装置和用于重建心脏解剖的方法
公开(公告)号：WO2006019521A2
公开(公告)日：2006-02-23
申请号：PCT/US2005/022462
申请日：2005-06-23
申请人： MICARDIA CORPORATION , MOADDEB, Shahram , SHAOLIAN, Samuel, M. , SHAOULIAN, Emanuel , RHEE, Richard , ANDERSON, Seteven, C.
发明人： MOADDEB, Shahram , SHAOLIAN, Samuel, M. , SHAOULIAN, Emanuel , RHEE, Richard , ANDERSON, Seteven, C.
IPC分类号： A61F2/00
CPC分类号： A61F2/2478 , A61B17/3468 , A61B2017/00876 , A61F2/2481 , A61F2/2487 , A61F2002/249 , A61F2210/009
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Such heart dilation is treated by reshaping the heart anatomy with the use of shape memory elements. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The shape memory elements have an original shape and at least one memory shape. The elements are implanted within the heart tissue or attached externally and/or internally to a surface of the heart when in the original shape. The elements are then activated to transition from the original shape to one of the at least one memory shapes. Transitioning of the elements cause the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
摘要翻译：提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。通过使用形状记忆元件重建心脏解剖结构来治疗这种心脏扩张。这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加脑室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。形状记忆元件具有原始形状和至少一种存储器形状。当原始形状时，将元件植入心脏组织内或外部和/或内部附着到心脏的表面。元件然后被激活以从原始形状转换到至少一个存储器形状之一。元件的过渡导致相关的心脏组织区域重新调整位置，例如减小心室的宽度。这种重新定位由元素随时间推移而维持，从而允许心脏扩张的破坏性影响进展缓慢或逆转。

3. 发明申请

WO2006012068A3 THERMAL CONDUCTOR FOR ADJUSTABLE CARDIAC IMPLANT 审中-公开
公开(公告)号：WO2006012068A3
公开(公告)日：2006-02-02
申请号：PCT/US2005/021597
申请日：2005-06-17
申请人： MICARDIA CORPORATION , RHEE, Richard , SHAOULIAN, Emanuel , MOADDEB, Shahram , SHAOLIAN, Samuel
发明人： RHEE, Richard , SHAOULIAN, Emanuel , MOADDEB, Shahram , SHAOLIAN, Samuel
IPC分类号： A61F2/24
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement. In one embodiment, an annuloplasty ring (2600) includes a body member (800) including a shape memory material. The shape memory material is configured to transform the body member 800 from a first shape to a second shape in response to being heated. The annuloplasty ring (2600) also includes a thermally insulative material (912) at least partially covering the body member (800) and a thermally conductive material (2610, 2612, 2614) extending into the thermally insulative material (912). The thermally conductive material (2610, 2612, 2614) is configured to communicate thermal energy to the body member (800).

4. 发明申请

WO2006012013A2 ADJUSTABLE CARDIAC VALVE IMPLANT WITH SELECTIVE DIMENSIONAL ADJUSTMENT 审中-公开
标题翻译：可调节心脏瓣膜植入物，具有选择性的尺寸调整
公开(公告)号：WO2006012013A2
公开(公告)日：2006-02-02
申请号：PCT/US2005/021141
申请日：2005-06-15
申请人： MICARDIA CORPORATION , RHEE, Richard , SHAOULIAN, Emanuel , MOADDEB, Shahram , SHAOLIAN, Samuel
发明人： RHEE, Richard , SHAOULIAN, Emanuel , MOADDEB, Shahram , SHAOLIAN, Samuel
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement. In one embodiment, an annuloplasty ring (1826) includes an anterior portion, a posterior portion and two lateral portions corresponding to intersections of the anterior portion and the posterior portion. The annuloplasty ring (1826) has a first shape in a first configuration and a second shape in a second configuration and is configured to transform from the first configuration to the second configuration in response to an activation energy applied thereto. The transformation is configured to reduce a distance between the anterior portion and the posterior portion without substantially decreasing a distance between the two lateral portions.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，当身体结构改变尺寸和/或形状时，可以调节装置的尺寸和/或形状以提供持续的加强。在一个实施例中，瓣膜成形术环（1826）包括前部，后部和对应于前部和后部的交叉点的两个侧部。瓣膜成形术环（1826）具有第一构造的第一形状和第二构造的第二形状，并且被配置为响应于施加到其上的活化能量而从第一构型变换到第二构造。该变换被配置为减小前部和后部之间的距离，而基本上不减小两个侧部之间的距离。

5. 发明申请

WO2007033360A3 LEFT ATRIAL BALLOON CATHETER 审中-公开
公开(公告)号：WO2007033360A3
公开(公告)日：2007-03-22
申请号：PCT/US2006/035981
申请日：2006-09-13
申请人： MICARDIA CORPORATION , MOADDEB, Shawn , RHEE, Richard , ANDERSON, Steve
发明人： MOADDEB, Shawn , RHEE, Richard , ANDERSON, Steve
IPC分类号： A61M25/10
摘要： Systems, methods and devices are provided for activation of an adjustable annuloplasty device. The devices may include a catheter system (3020) for percutaneously activating an adjustable annuloplasty device (3000), including a handle assembly (3052), a shaft assembly (3050) having at least one fluid lumen (3084), and a distal element (3004). The shaft assembly (3050) extends between the handle assembly (3052) and the distal element (3004), the distal element (3004) being in fluid communication with the handle assembly (3052) via the at least one fluid lumen (3084). The distal element (3004) includes an elongated core (3074) having a first port (3381) and an expandable member (3070). The core (3074) extends through the expandable member (3070) and the expandable member (3070) is movable between a collapsed position and an inflated position.

6. 发明授权

EP1773239B1 SHAPE MEMORY DEVICES FOR RESHAPING HEART ANATOMY 有权
标题翻译：形状记忆器件形成心脏解剖
公开(公告)号：EP1773239B1
公开(公告)日：2010-03-31
申请号：EP05763622.7
申请日：2005-06-23
申请人： Micardia Corporation
发明人： MOADDEB, Shahram , SHAOLIAN, Samuel, M. , SHAOULIAN, Emanuel , RHEE, Richard , ANDERSON, Seteven, C.
IPC分类号： A61F2/00
CPC分类号： A61F2/2478 , A61B17/3468 , A61B2017/00876 , A61F2/2481 , A61F2/2487 , A61F2002/249 , A61F2210/009

7. 发明公开

EP1776067A2 THERMAL CONDUCTOR FOR ADJUSTABLE CARDIAC IMPLANT 审中-公开
标题翻译：热火头可调节心脏植入物
公开(公告)号：EP1776067A2
公开(公告)日：2007-04-25
申请号：EP05761832.4
申请日：2005-06-17
申请人： Micardia Corporation
发明人： RHEE, Richard , SHAOULIAN, Emanuel , MOADDEB, Shahram , SHAOLIAN, Samuel
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement. In one embodiment, an annuloplasty ring (2600) includes a body member (800) including a shape memory material. The shape memory material is configured to transform the body member 800 from a first shape to a second shape in response to being heated. The annuloplasty ring (2600) also includes a thermally insulative material (912) at least partially covering the body member (800) and a thermally conductive material (2610, 2612, 2614) extending into the thermally insulative material (912). The thermally conductive material (2610, 2612, 2614) is configured to communicate thermal energy to the body member (800).

8. 发明公开

EP1768601A2 MAGNETIC DEVICES AND METHODS FOR RESHAPING HEART ANATOMY 审中-公开
标题翻译：磁性装置和用于重新整理心脏解剖的方法
公开(公告)号：EP1768601A2
公开(公告)日：2007-04-04
申请号：EP05762115.3
申请日：2005-06-23
申请人： Micardia Corporation
发明人： MOADDEB, Shahram , SHAOLIAN, Samuel, M. , SHAOULIAN, Emanuel , RHEE, Richard , ANDERSON, Seteven, C.
IPC分类号： A61F2/00 , A61M1/12
CPC分类号： A61F2/2478 , A61B17/3468 , A61B2017/00876 , A61F2/2481 , A61F2/2487 , A61F2002/249 , A61F2210/009
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Heart dilation treated by reshaping the heart anatomy with the use of magnetic forces. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The magnetic forces are applied with the use of one or more magnetic elements which are implanted within the heart tissue or attached externally and/or internally to a surface of the heart. The various charges of the magnetic forces interact causing the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the force of the magnetic elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
摘要翻译：提供用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。通过使用磁力重塑心脏解剖结构来治疗心脏扩张。这种再成形改变了心脏部分，特别是右心室或左心室的几何形状，以增加心室的收缩性，从而增加心搏量，这又增加了心脏的心输出量。通过使用一个或多个磁性元件来施加磁力，所述磁性元件植入心脏组织内或附着在心脏表面的外部和/或内部。磁力的各种电荷相互作用导致相关的心脏组织区域重新调整位置，例如以减小心室的宽度。这种重新定位通过磁性元件的力随着时间的推移而保持，从而允许心脏扩张的损伤效应减缓进展或逆转。

9. 发明公开

EP1924314A2 LEFT ATRIAL BALLOON CATHETER 审中-公开
标题翻译： LINKSATRIALER BALLONKATHETER
公开(公告)号：EP1924314A2
公开(公告)日：2008-05-28
申请号：EP06814714.9
申请日：2006-09-13
申请人： Micardia Corporation
发明人： MOADDEB, Shawn , RHEE, Richard , ANDERSON, Steve
IPC分类号： A61M25/10
CPC分类号： A61F2/2448 , A61F2/2466 , A61F2250/0004
摘要： Systems, methods and devices are provided for activation of an adjustable annuloplasty device. The devices may include a catheter system (3020) for percutaneously activating an adjustable annuloplasty device (3000), including a handle assembly (3052), a shaft assembly (3050) having at least one fluid lumen (3084), and a distal element (3004). The shaft assembly (3050) extends between the handle assembly (3052) and the distal element (3004), the distal element (3004) being in fluid communication with the handle assembly (3052) via the at least one fluid lumen (3084). The distal element (3004) includes an elongated core (3074) having a first port (3381) and an expandable member (3070). The core (3074) extends through the expandable member (3070) and the expandable member (3070) is movable between a collapsed position and an inflated position.

10. 发明公开

EP1773239A2 SHAPE MEMORY DEVICES AND METHODS FOR RESHAPING HEART ANATOMY 有权
标题翻译：形状记忆器件形成心脏解剖
公开(公告)号：EP1773239A2
公开(公告)日：2007-04-18
申请号：EP05763622.7
申请日：2005-06-23
申请人： Micardia Corporation
发明人： MOADDEB, Shahram , SHAOLIAN, Samuel, M. , SHAOULIAN, Emanuel , RHEE, Richard , ANDERSON, Seteven, C.
IPC分类号： A61F2/00
CPC分类号： A61F2/2478 , A61B17/3468 , A61B2017/00876 , A61F2/2481 , A61F2/2487 , A61F2002/249 , A61F2210/009
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Such heart dilation is treated by reshaping the heart anatomy with the use of shape memory elements. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The shape memory elements have an original shape and at least one memory shape. The elements are implanted within the heart tissue or attached externally and/or internally to a surface of the heart when in the original shape. The elements are then activated to transition from the original shape to one of the at least one memory shapes. Transitioning of the elements cause the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles

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