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1. 发明申请

US20110065938A1 METHOD FOR THE PREPARATION OF ESCITALOPRAM 审中-公开
标题翻译：用于制备ESCITALOPRAM的方法
公开(公告)号：US20110065938A1
公开(公告)日：2011-03-17
申请号：US12781048
申请日：2010-05-17
申请人： Michael B. Sommer , Ole Nielsen , Hans Petersen , Haleh Ahmadian , Henrik Pedersen , Peter Brosen , Fiona Geiser , James Lee , Geoffrey Cox , Olivier Dapremont , Christina Suteu , Sebastian P. Assenza , Shankar Hariharan , Usha Nair
发明人： Michael B. Sommer , Ole Nielsen , Hans Petersen , Haleh Ahmadian , Henrik Pedersen , Peter Brosen , Fiona Geiser , James Lee , Geoffrey Cox , Olivier Dapremont , Christina Suteu , Sebastian P. Assenza , Shankar Hariharan , Usha Nair
IPC分类号： C07D307/87 , C07C215/32
CPC分类号： C07C215/32 , C07D307/87
摘要： A novel method is provided for the manufacture of escitalopram. The method comprises chromatographic separation of the enantiomers of citalopram or an intermediate in the production of citalopram using a chiral stationary phase such as Chiralpak™ AD or Chiralcel™ OD. Novel chiral intermediates for the synthesis of Escitalopram made by said method are also provided.
摘要翻译：提供了一种制备依他普仑的新方法。该方法包括使用手性固定相如Chiralpak TM AD或Chiralcel TM OD，对西酞普兰对映异构体或西酞普兰生产中的中间体进行色谱分离。还提供了通过所述方法制备的用于合成依他普仑的新型手性中间体。

2. 发明授权

US06717431B2 Method for semiconductor yield loss calculation 失效
标题翻译：半导体屈服损失计算方法
公开(公告)号：US06717431B2
公开(公告)日：2004-04-06
申请号：US10137142
申请日：2002-05-02
申请人： Dieter Rathei , Joerg Wohlfahrt , Luis G. Andrade , Robert Petter , Thomas S. Taylor , Babatunde Ashiru , Mark E. Luzar , Michael B. Sommer , Ulrich K. Zimmermann
发明人： Dieter Rathei , Joerg Wohlfahrt , Luis G. Andrade , Robert Petter , Thomas S. Taylor , Babatunde Ashiru , Mark E. Luzar , Michael B. Sommer , Ulrich K. Zimmermann
IPC分类号： G01R3126
CPC分类号： H01L22/20
摘要： A method of calculating yield loss of semiconductor wafers which are tested with a test sequence to derive a total fail region count for each of the wafers, the semiconductor wafers having multiple chips thereon. The method comprises calculating a fail region count for each of the tests in the test sequence, calculating the test sequence limited yield loss for each of the wafers, and apportioning the test sequence limited yield loss to selected ones of the test based upon the absolute or cumulative number of fails identified by the tests of the test sequence. In some embodiments, core parametric test data is correlated with the test sequence limited yield and analyzed to determine reparability.
摘要翻译：一种计算半导体晶片的屈服损耗的方法，其通过测试序列测试以导出每个晶片的总失败区域计数，半导体晶片具有多个芯片。该方法包括计算测试序列中的每个测试的失败区域计数，计算每个晶片的测试序列受限产量损失，以及基于绝对值或绝对值的测试序列限制产量损失分配给选定的测试通过测试序列的测试识别的故障累积次数。在一些实施例中，核心参数测试数据与测试序列限制产量相关，并进行分析以确定可修复性。

3. 发明授权

US4873344A Cyano containing indene derivatives 失效
标题翻译：含氰基的茚衍生物
公开(公告)号：US4873344A
公开(公告)日：1989-10-10
申请号：US124820
申请日：1987-11-24
申请人： Klaus P. Bogeso , Michael B. Sommer
发明人： Klaus P. Bogeso , Michael B. Sommer
IPC分类号： C07C255/47 , C07C45/65 , C07C45/67 , C07C49/617 , C07C49/67 , C07C49/693 , C07C49/697 , C07C49/755 , C07C62/38 , C07C67/00 , C07C253/00 , C07C253/30 , C07C255/45 , C07C255/58 , C07C311/37 , C07C315/04 , C07C317/14 , C07C317/48 , C07C319/20 , C07C323/38 , C07C323/63 , C07D207/32 , C07D207/337 , C07D207/416 , C07D213/57 , C07D317/06 , C07D317/60 , C07D333/24
CPC分类号： C07D207/337 , C07C255/00 , C07C45/676 , C07C49/697 , C07C62/38 , C07D213/57 , C07D317/60 , C07D333/24
摘要： The present invention relates to novel indene derivatives with the general formula I: ##STR1## wherein R.sup.1 is (a) a phenyl group optionally substituted with one or two groups selected from halogen, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulfonyl, dilower alkylamino, acylamino such as acetylamino, cyano, trifluoromethyl, trifluoromethoxy, pyrrole and dilower alkylpyrrole,(b) a polycyclic aromatic or heteroaromatic group, such as naphthalene or quinoline,(c) a heteroaromatic group such as thiophene, pyridine, and pyrrole, optionally substituted with one or more groups selected from halogen, lower alkyl, lower alkoxy, lower alkylthio, trifluoromethyl or trifluoromethoxy,R.sub.2 is selected from H, halogen, lower alkyl, benzyl, lower alkylthio, methoxy, lower alkylsulfonyl, dilower alkylsulfamoyl, acylamino such as acetylamino, benzylamino, dilower alkylamino, cyano, pyrrole, dilower alkylpyrrole, trifluoromethyl and trifluoromethoxy,R.sup.3 is CN, COOR.sup.4, --CON(R.sup.4).sub.2 or COR.sup.4, where R.sup.4 is a lower alkyl group, and "n" is an integer of from 1-3 inclusive.The indene derivatives of formula I are, when R.sup.1 is as defined under (a) above, valuable intermediates which are useful in the preparation of pharmacologically effective indane and indene derivatives known from e.g. U.S. Pat. Nos. 4,443,448 and 4,525,360.Moreover, the invention relates to a method for the preparation of the compounds of formula I and to a method for the preparation of compounds of the following formula IV: ##STR2## wherein R.sup.1, R.sup.2 and "n" are as defined above.
摘要翻译：本发明涉及具有通式I的新颖的茚衍生物：其中R 1是（a）任选被一个或两个选自卤素，低级烷基，低级烷氧基，低级烷硫基，低级烷基磺酰基，二氯烷基氨基，酰氨基如乙酰氨基，氰基，三氟甲基，三氟甲氧基，吡咯和二烯烷基吡咯，（b）多环芳族或杂芳族基团如萘或喹啉，（c）杂芳基如噻吩，吡啶和吡咯，任选被一个或多个选自卤素，低级烷基，低级烷氧基，低级烷硫基，三氟甲基或三氟甲氧基的基团取代，R 2选自H，卤素，低级烷基，苄基，低级烷硫基，甲氧基，低级烷基磺酰基，二低级烷基氨磺酰基，作为乙酰氨基，苄氨基，二元烷基氨基，氰基，吡咯，二元烷基吡咯，三氟甲基和三氟甲氧基，R3是CN，COOR4，-CON（R4）2或COR4，其中 R4是低级烷基，“n”是1-3的整数。当R1如上述（a）中所定义时，式I的茚衍生物是有用的中间体，它们可用于制备药物学有效的二氢化茚和茚衍生物，其从例如，美国专利第4,443,448号和第4,525,360号。此外，本发明涉及制备式I化合物的方法和制备下式IV化合物的方法：其中R 1，R 2和“n”如上所定义。

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