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1. 发明申请

US20090174143A1 Learning System and Method and Pattern Matching Design Game Implementing Same 审中-公开
标题翻译：学习系统与方法与模式匹配设计游戏实现相同
公开(公告)号：US20090174143A1
公开(公告)日：2009-07-09
申请号：US12348056
申请日：2009-01-02
申请人： Geoffrey Cox
发明人： Geoffrey Cox
IPC分类号： A63F3/04 , G09B19/00 , G09B19/22
CPC分类号： A63F11/0074 , A63F2011/0083 , A63F2250/12 , A63F2250/21 , A63F2250/605
摘要： A set of different metal and rope components can be used by groups or individuals to match a pre-determined pattern. A game operator can provide the individual or team with individual assembly components and a pre-determined pattern diagram. The team is then required to configure the different available components so as to match the diagram. In one embodiment of the present invention, the diagram is provided in black-and-white and the assembly components are in color. In one embodiment, a game is provided whereby a team uses trial and error to first build the assembly of pieces to match the diagram. Next, the team must plan and rehearse a strategy for quickly re-assembling the pieces to match the diagram while being timed by a clock. The process in accordance with the present invention is self-checking in that there is only one unique solution to the pre-determined assembly.
摘要翻译：一组不同的金属和绳索组件可以由组或个人使用以匹配预定图案。游戏运营商可以向个人或团队提供单独的组装组件和预定模式图。然后，团队需要配置不同的可用组件，以便与图匹配。在本发明的一个实施例中，该图以黑白提供，并且组装部件是彩色的。在一个实施例中，提供游戏，由此团队使用试错来首先构建件的组合以匹配图。接下来，团队必须计划和排练一个策略，以便在按时钟定时的情况下快速重新组装这些部分以匹配该图。根据本发明的方法是自检，因为对于预定的组件只有一个唯一的解决方案。

2. 发明授权

US5952525A Manufacture of glyphosate salts 失效
标题翻译：草甘膦盐的制造
公开(公告)号：US5952525A
公开(公告)日：1999-09-14
申请号：US68381
申请日：1998-05-08
申请人： Brian Geoffrey Cox , Stephen Martin Brown , Thomas Gray
发明人： Brian Geoffrey Cox , Stephen Martin Brown , Thomas Gray
IPC分类号： C07C381/12 , C07F9/38 , C07F9/28
CPC分类号： C07C381/12 , C07F9/3813
摘要： The trimethylsulphonium salt of N-phosphonomethylglycine is prepared by reacting N-phosphonomethylglycine, preferably in the form of a solid, with an aqueous solution of trimethylsulphonium carbonate or trimethylsulphonium bicarbonate or a mixture thereof. The trimethylsulphonium carbonate or trimethylsulphonium bicarbonate may be prepared by bubbling carbon dioxide through an aqueous solution of trimethylsulphonium hydroxide. It is possible to manufacture trimethylsulphonium carbonate or bicarbonate at one site and then transport them to a different site for local manufacture of N-phosphonomethylglycine in a relatively unsophisticated plant which produces minimal effluent.
摘要翻译： PCT No.PCT / GB96 / 02988第 371日期1998年5月8日 102（e）日期1998年5月8日PCT提交1996年12月4日PCT公布。公开号WO97 / 22612 PCT 日期：1997年6月26日N-膦酰基甲基甘氨酸的三甲基锍盐通过N-膦酰基甲基甘氨酸，优选为固体形式与碳酸三甲基锍或三甲基锍碳酸氢盐或其混合物的水溶液反应来制备。碳酸三甲基锍或三甲基锍碳酸氢盐可以通过将二氧化碳鼓泡通过氢氧化三甲基锍的水溶液来制备。可以在一个位置制造碳酸三甲基锍或碳酸氢盐，然后将它们运输到不同的位置，以便在相对不成熟的植物中局部制造N-膦酰基甲基甘氨酸，从而产生最少的流出物。

3. 发明申请

US20050065207A1 Method for the preparation of escitalopram 审中-公开
标题翻译：艾司西酞普兰的制备方法
公开(公告)号：US20050065207A1
公开(公告)日：2005-03-24
申请号：US10483824
申请日：2002-07-12
申请人： Michael Sommer , Ole Nielsen , Hans Petersen , Haleh Ahmadian , Henrik Pedersen , Peter Brosen , Fiona Geiser , James Lee , Geoffrey Cox , Olivier Dapremont , Christina Suteu , Sebastian Assenza , Shankar Hariharan , Usha Nair
发明人： Michael Sommer , Ole Nielsen , Hans Petersen , Haleh Ahmadian , Henrik Pedersen , Peter Brosen , Fiona Geiser , James Lee , Geoffrey Cox , Olivier Dapremont , Christina Suteu , Sebastian Assenza , Shankar Hariharan , Usha Nair
IPC分类号： A61K31/343 , A61P25/24 , C07B20060101 , C07C215/32 , C07C215/34 , C07D20060101 , C07D307/87
CPC分类号： C07C215/32 , C07D307/87
摘要： A novel method is provided for the manufacture of escitalopram. The method comprises chromatographic separation of the enantiomers of citalopram or an intermediate in the production of citalopram using a chiral stationary phase such as Chiralpak™ or Chiralcel™ OD. Novel chiral intermediates for the synthesis of Escitalopram made by said method are also provided.
摘要翻译：提供了一种制备依他普仑的新方法。该方法包括使用手性固定相（例如Chiralpak TM或Chiralcel TM OD）对西酞普兰对映异构体或西酞普兰生产中的中间体进行色谱分离。还提供了通过所述方法制备的用于合成依他普仑的新型手性中间体。

4. 发明申请

US20050027450A1 Altitude aiding in a satellite positioning system 审中-公开
标题翻译：高度协助卫星定位系统
公开(公告)号：US20050027450A1
公开(公告)日：2005-02-03
申请号：US10633488
申请日：2003-08-01
申请人： Geoffrey Cox , Lionel Garin , Makarand Phatak
发明人： Geoffrey Cox , Lionel Garin , Makarand Phatak
IPC分类号： G01S1/00 , G01S5/00 , G01S5/14 , G01S19/05 , G01S19/29 , G01S19/30 , G01S19/50
CPC分类号： G01S19/50 , G01S5/0036 , G01S5/0054 , G01S19/05
摘要： A satellite position system with a plurality of satellites transmitting spread spectrum signals to a satellite position system receiver that is able to determine location using three spread spectrum signals and a polynomial surface fit to digital altitude data that approximates the altitude of the satellite position system receiver.
摘要翻译：具有多个卫星的卫星定位系统向能够使用三个扩展频谱信号确定位置的卫星定位系统接收机发射扩频信号，以及对近似于卫星定位系统接收机的高度的数字高度数据进行多项式曲面拟合。

5. 发明授权

US6040452A Process for making benzisothiazolin-3-ones 失效
标题翻译：制备苯并异噻唑啉-3-酮的方法
公开(公告)号：US6040452A
公开(公告)日：2000-03-21
申请号：US331241
申请日：1999-06-18
申请人： Brian Geoffrey Cox , Thomas Gray
发明人： Brian Geoffrey Cox , Thomas Gray
IPC分类号： C07D275/04
CPC分类号： C07D275/04
摘要： A process for making a 1,2-benzisothiazolin-3-one by cycling a bisamide precursor under alkaline conditions in the presence of oxygen or an oxygen-release compound in the presence of a nitrogen, sulphur or phosphorus nucelophile. Preferred nucelophiles are ammonia, primary, secondary and tertiary amines, amides, pyridines and quinolines
摘要翻译： PCT No.PCT / GB97 / 03130 Sec。 371日期：1999年6月18日 102（e）1999年6月18日PCT 1997年11月13日PCT PCT。 WO98 / 28283 PCT出版物日期1998年7月2日制备1,2-苯并异噻唑啉-3-酮的方法是通过在氮气，硫或磷酸盐存在下，在氧气或氧气释放化合物的存在下，在碱性条件下使双酰胺前体循环来制备1,2-苯并异噻唑啉-3-酮的方法。优选的生菜碱是氨，伯，仲和叔胺，酰胺，吡啶和喹啉

6. 发明授权

US5847138A Chemical process 失效
标题翻译：化学工艺
公开(公告)号：US5847138A
公开(公告)日：1998-12-08
申请号：US479242
申请日：1995-06-07
申请人： John David Jones , Gareth Andrew DeBoos , Paul Wilkinson , Brian Geoffrey Cox , Jan Michael Fielden
发明人： John David Jones , Gareth Andrew DeBoos , Paul Wilkinson , Brian Geoffrey Cox , Jan Michael Fielden
IPC分类号： C07D20060101 , C07D239/34 , C07D239/52 , C07D307/28 , C07D307/83 , C07D307/86 , C07D311/12
CPC分类号： C07D239/34 , C07D307/83 , C07D311/12
摘要： A process for the preparing agrochemical intermediates of formula (I): ##STR1## wherein W is (CH.sub.3 O) CH.CHCO.sub.2 CH.sub.3 or CH.sub.3 O.CH.dbd.CCO.sub.2 CH.sub.3 ; Z.sup.1 is a halogen atom; and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, acetoxy or acyl; the process comprising the steps of: (a) reacting a compound of formula (II): ##STR2## wherein X, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined above, with a compound of formula ROCH.sub.3, wherein R is a metal; and, (b) reacting the product of (a) with a compound of formula (III): ##STR3## wherein Z.sup.1 and Z.sup.2 are halogen atom. A process for the preparation of compounds of formula (II) and compounds of formula (II) themselves. A process for obtaining, in substantially pure form, a compound of formula (II) wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are all hydrogen.
摘要翻译：制备式（I）的农药中间体的方法：其中W是（CH 3 O）CH.CHCO 2 CH 3或CH 3 O.CH = CCO 2 CH 3; Z1是卤原子; 且R 1，R 2，R 3和R 4独立地为氢，卤素，C 1-4烷基，C 1-4烷氧基，乙酰氧基或酰基; 该方法包括以下步骤：（a）使式（II）化合物：其中X，R 1，R 2，R 3和R 4如上定义的式（II）化合物与式ROCH 3的化合物反应，其中R为金属和（b）使（a）的产物与式（III）的化合物反应：其中Z1和Z2是卤素原子。制备式（II）化合物和式（II）化合物本身的方法。以基本上纯的形式获得其中R 1，R 2，R 3和R 4全部为氢的式（II）化合物的方法。

7. 发明授权

US07543819B2 Learning system and method and trivia game implementing same 有权
标题翻译：学习系统和方法和琐事游戏实现相同
公开(公告)号：US07543819B2
公开(公告)日：2009-06-09
申请号：US11642259
申请日：2006-12-20
申请人： Geoffrey Cox
发明人： Geoffrey Cox
IPC分类号： A63F1/00
CPC分类号： A63F1/00 , A63F9/18 , A63F2003/00025
摘要： The present invention provides a progressive fact or trivia game. In one embodiment, the present invention is implemented as a series of cards, each having a unique multiple choice question as well as a unique number or other identifying indicia placed conspicuously thereon. After each possible answer to the question, another number or identifying indicia appears referencing a separate card in the series. When a player answers a question from a given card, the number or other indicia placed beside the player's answer indicates the next card to which the player should proceed. The next card holds the next question for the player to answer. The present invention can be implemented through physical cards or electronically over a network, for example.
摘要翻译：本发明提供了渐进的事实或琐事游戏。在一个实施例中，本发明被实现为一系列卡，每个卡具有唯一的多项选择问题以及明显放置在其上的唯一号码或其他识别标记。在问题的每个可能的答案之后，出现另一个数字或识别标记，引用该系列中的单独的卡。当玩家从给定的卡片中回答问题时，放置在玩家答案旁边的数字或其他标记表示玩家应该继续进行的下一张牌。下一张卡持有玩家回答的下一个问题。例如，本发明可以通过物理卡或通过网络电子地实现。

8. 发明申请

US20070158909A1 Learning system and method and trivia game implementing same 有权
标题翻译：学习系统和方法和琐事游戏实现相同
公开(公告)号：US20070158909A1
公开(公告)日：2007-07-12
申请号：US11642259
申请日：2006-12-20
申请人： Geoffrey Cox
发明人： Geoffrey Cox
IPC分类号： A63F1/00 , A63F9/18
CPC分类号： A63F1/00 , A63F9/18 , A63F2003/00025
摘要： The present invention provides a progressive fact or trivia game. In one embodiment, the present invention is implemented as a series of cards, each having a unique multiple choice question as well as a unique number or other identifying indicia placed conspicuously thereon. After each possible answer to the question, another number or identifying indicia appears referencing a separate card in the series. When a player answers a question from a given card, the number or other indicia placed beside the player's answer indicates the next card to which the player should proceed. The next card holds the next question for the player to answer. The present invention can be implemented through physical cards or electronically over a network, for example.
摘要翻译：本发明提供了渐进的事实或琐事游戏。在一个实施例中，本发明被实现为一系列卡，每个卡具有唯一的多项选择问题以及明显放置在其上的唯一号码或其他识别标记。在问题的每个可能的答案之后，出现另一个数字或识别标记，引用该系列中的单独的卡。当玩家从给定的卡片中回答问题时，放置在玩家答案旁边的数字或其他标记表示玩家应该继续进行的下一张牌。下一张卡持有玩家回答的下一个问题。例如，本发明可以通过物理卡或通过网络电子地实现。

9. 发明申请

US20110065938A1 METHOD FOR THE PREPARATION OF ESCITALOPRAM 审中-公开
标题翻译：用于制备ESCITALOPRAM的方法
公开(公告)号：US20110065938A1
公开(公告)日：2011-03-17
申请号：US12781048
申请日：2010-05-17
申请人： Michael B. Sommer , Ole Nielsen , Hans Petersen , Haleh Ahmadian , Henrik Pedersen , Peter Brosen , Fiona Geiser , James Lee , Geoffrey Cox , Olivier Dapremont , Christina Suteu , Sebastian P. Assenza , Shankar Hariharan , Usha Nair
发明人： Michael B. Sommer , Ole Nielsen , Hans Petersen , Haleh Ahmadian , Henrik Pedersen , Peter Brosen , Fiona Geiser , James Lee , Geoffrey Cox , Olivier Dapremont , Christina Suteu , Sebastian P. Assenza , Shankar Hariharan , Usha Nair
IPC分类号： C07D307/87 , C07C215/32
CPC分类号： C07C215/32 , C07D307/87
摘要： A novel method is provided for the manufacture of escitalopram. The method comprises chromatographic separation of the enantiomers of citalopram or an intermediate in the production of citalopram using a chiral stationary phase such as Chiralpak™ AD or Chiralcel™ OD. Novel chiral intermediates for the synthesis of Escitalopram made by said method are also provided.
摘要翻译：提供了一种制备依他普仑的新方法。该方法包括使用手性固定相如Chiralpak TM AD或Chiralcel TM OD，对西酞普兰对映异构体或西酞普兰生产中的中间体进行色谱分离。还提供了通过所述方法制备的用于合成依他普仑的新型手性中间体。

10. 发明申请

US20060105347A1 Method for the production of fusion proteins in transgenic mammal milk 失效
公开(公告)号：US20060105347A1
公开(公告)日：2006-05-18
申请号：US10933854
申请日：2004-09-03
申请人： Harry Meade , Geoffrey Cox
发明人： Harry Meade , Geoffrey Cox
IPC分类号： C12Q1/68 , A01K67/027 , A61K38/16 , C07K14/16 , C12N1/18 , C12N15/74
CPC分类号： C12N15/62 , A01K2217/05 , A01K2217/052 , A01K2227/101 , A01K2267/01 , C12N15/8509 , C12N2830/008 , C12N2830/40 , C12N2830/85
摘要： Desirable fusion proteins can be produced in and purified from the milk of transgenic animals. The peptides are made as fusion proteins with a suitable fusion partner such as human alpha-fetoprotein. The fusion partner protein acts to promote and increase the half-life of the overall molecule as well as having therapeutic effects on its own. The fusion protein is typically produced through the use of transgenic animals and can be purified away from the now the milk or other bodily fluid of such an animal by an affinity purification method. A particular advantage of producing peptides via this route, in addition to the obvious advantages of high yield and biocompatibility, is that specific post-translational modifications, such as carboxy terminal amidation, can be performed in the mammary gland. Biologically active polypeptides comprising a therapeutically active polypeptide fused to human alpha-fetoprotein fragment or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.

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