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1. 发明专利

BR9912185A 未知
公开(公告)号：BR9912185A
公开(公告)日：2001-04-10
申请号：BR9912185
申请日：1999-06-11
申请人： PETER VISCOR , NIELS OLE NIELSEN , ARMIN DELONGT , KOLARIK VLADIMIR
发明人： VISCOR PETR , NIELSEN NIELS OLE , DELONG ARMIN , KOLARIK VLADIMIR
IPC分类号： H01J9/02 , H01J1/304 , H01J1/312 , H01J29/04 , H01J29/10 , H01J29/44 , H01J31/12 , H01J37/073 , H01J63/06 , H01J63/08 , H01L29/76 , H01L31/10 , H01L33/00 , H01J1/30
摘要： A planar electron emitter, based on the existence of quasi-ballistic transport of electrons is disclosed. In its preferred embodiment the planar electron emitter structure consists of a body of finite gap pure semiconductor or insulator, the said body of macroscopic thickness (~1 mm) being terminated by two parallel surfaces and of a set of two electrodes deposited/grown on the said two free surfaces such that when a low external electrical field (~100 V/cm) is applied to this structure, consisting of two electrodes and the said semiconductor or insulating body sandwiched between them, a large fraction of electrons injected into the said semiconductor or insulator body from the negatively charged electrode (cathode) is quasi-ballistic in nature, that is this fraction of injected electrons is accelerated within the said semiconductor or insulator body without suffering any appreciable inelastic energy losses, thereby achieving sufficient energy and appropriate momentum at the positively charged electrode (anode) to be able to traverse through the said anode and to escape from the said structure into empty space (vacuum), said semiconductor or insulator body comprises a material or material system having a predetermined crystal orientation.

2. 发明专利

AT320422B 未知
公开(公告)号：AT320422B
公开(公告)日：1975-02-10
申请号：AT732370
申请日：1970-08-11
申请人： OLE NIELSEN , MAX BEIDIL
IPC分类号： B29C51/08 , B29C51/22 , B31F1/07 , D21H5/24
摘要： 1312359 Embossing O NIELSEN and M BEIDIL 7 Aug 1970 [13 Aug 1969] 38090/70 Heading B6J A method of embossing sheet material comprises passing it through a nip between a pair of complementary rollers, each roller having a plurality of projections 40, Fig. 3, each of generally frusto-pyramidal configuration with a four sided base, extending outwardly therefrom and each projection of each roller engaging, in the nip, between projections of the other roller, and wherein each projection has one pair of opposite corners thereof aligned parallel to the axes of the rollers. The projections may be of convex cross-section, Fig. 5. The upper roller may be arranged in vertically slidable bearings 12 and 13 and the rollers may be driven from a motor 11 through sprockets 8 and 10 and chain 9. A gear 5 transmits the drive to the upper roller through a gear 6 which is in two sections to permit adjustment for elimination of play.

3. 发明授权

US08227607B2 Processes for 4-((1R,35)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine or a salt thereof 有权
标题翻译： 4 - （（1R，35）-6-氯-3-苯基茚-1-基）-1,2,2-三甲基哌嗪或其盐的方法
公开(公告)号：US08227607B2
公开(公告)日：2012-07-24
申请号：US12820392
申请日：2010-06-22
申请人： Heidi Lopez de Diego , Ole Nielsen , Lone Munch Ringgard , Henrik Svane , Allan Carsten Dahl , Mark Howells , Benny Bang-Andersen , Lars Ole Lyngsø , Sherry Lynn Collier
发明人： Heidi Lopez de Diego , Ole Nielsen , Lone Munch Ringgard , Henrik Svane , Allan Carsten Dahl , Mark Howells , Benny Bang-Andersen , Lars Ole Lyngsø , Sherry Lynn Collier
IPC分类号： C07D295/073 , C07C35/32
CPC分类号： C07D295/073 , C07B2200/07 , C07C17/16 , C07C25/22 , C07C29/143 , C07C35/32 , C07C2602/08 , C07D241/04 , C12P7/22 , C12P41/004 , C07C35/52
摘要： Methods for the preparation of 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and salts thereof are described.
摘要翻译：描述了制备4 - （（1R，3S）-6-氯-3-苯基茚-1-基）-1,2,2-三甲基哌嗪及其盐的方法。

4. 发明申请

US20110046218A1 CRYSTALLINE BASE OF ESCITALOPRAM AND ORODISPERSIBLE TABLETS COMPRISING ESCITALOPRAM BASE 审中-公开
标题翻译：包括ESCITALOPRAM基板的晶圆和可折叠片
公开(公告)号：US20110046218A1
公开(公告)日：2011-02-24
申请号：US12916750
申请日：2010-11-01
申请人： Robert Dancer , Hans Petersen , Ole Nielsen , Michael Harold Rock , Helle Eliasen , Ken Liljegren
发明人： Robert Dancer , Hans Petersen , Ole Nielsen , Michael Harold Rock , Helle Eliasen , Ken Liljegren
IPC分类号： A61K31/343 , C07D307/87 , A61P25/24
CPC分类号： C07D307/81
摘要： The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile, formulations of said base, a process for the preparation of purified salts of escitalopram, such as the oxalate, using the base, the salts obtained by said process and formulations containing such salts, and a process for the preparation of purified escitalopram free base or salts of escitalopram, such as the oxalate, using the hydrobromide, the salts obtained by said process and formulations containing such salts. Finally the present invention relates to an orodispersible tablet having a hardness of at least 22 N and an oral-disintegration time of less than 120 s and comprising an active pharmaceutical ingredient adsorbed onto a water soluble filler wherein the active pharmaceutical ingredient has a melting point in the range of 40-100° C., as well as a method for making such an orodispersible tablet.
摘要翻译：本发明涉及众所周知的抗抑郁药物依他普仑S-1- [3-（二甲基氨基）丙基] -1-（4-氟苯基）-1,3-二氢-5-异苯并呋喃甲腈的结晶碱，所述制剂为碱，使用碱，草酸盐的纯化盐的制备方法，通过所述方法获得的盐和含有这些盐的制剂的方法，以及制备纯化的依他普仑游离碱或依他普仑的盐的方法，例如草酸盐，使用氢溴酸盐，通过所述方法获得的盐和含有这些盐的制剂。最后，本发明涉及硬度至少为22N，口服崩解时间小于120秒的可分散片剂，其包含吸附在水溶性填料上的活性药物成分，其中活性药物成分的熔点为 40-100℃的范围，以及制造这种可分散片剂的方法。

5. 发明授权

US07367965B2 Ostomy appliance with multiple openings for preventing filter input blockage 有权
标题翻译：具有多个开口的造口术器具可防止过滤器输入堵塞
公开(公告)号：US07367965B2
公开(公告)日：2008-05-06
申请号：US10499823
申请日：2003-02-26
申请人： Lars Bo Poulsen , Per Ole Nielsen
发明人： Lars Bo Poulsen , Per Ole Nielsen
IPC分类号： A61M1/00 , A61F5/44
CPC分类号： A61F5/441
摘要： An ostomy appliance with a front wall and a rear wall of flexible material forming a bag, the rear wall having an opening into the bag by which waste material can enter the bag. The bag has two or more vents through which gas may escape from the bag and a filter device covering each vent. Each filter device has gas inlet and outlet openings in communication with a respective filter body so that in use gas flows through the filter device from the inlet opening through the filter body to the outlet opening. The inlet openings communicate with the inner space of the bag and are located near the border of the bag, being spaced at an angle of at least 45 degrees along radii of a circle of reference having a perimeter concentric with the waste opening of the bag.
摘要翻译：一种具有形成袋的柔性材料的前壁和后壁的造口术器具，所述后壁具有通过所述袋的开口，废料可以通过该开口进入袋中。该袋具有两个或更多个通风口，气体可以从该通气口从袋中逸出，并且覆盖每个排气口的过滤装置。每个过滤装置具有与相应的过滤器主体连通的气体入口和出口，使得在使用中气体通过过滤器装置从入口通过过滤器主体流到出口。入口开口与袋的内部空间连通并且位于袋的边界附近，沿着具有与袋的废物开口同心的周边的参考圆的半径以至少45度的角度间隔开。

6. 发明申请

US20070021499A1 CRYSTALLINE BASE OF ESCITALOPRAM AND ORODISPERSIBLE TABLETS COMPRISING ESCITALOPRAM BASE 有权
标题翻译：包括ESCITALOPRAM基板的晶圆和可折叠片
公开(公告)号：US20070021499A1
公开(公告)日：2007-01-25
申请号：US11425522
申请日：2006-06-21
申请人： Robert Dancer , Hans Petersen , Ole Nielsen , Michael Rock , Helle Eliasen , Ken Liljegren
发明人： Robert Dancer , Hans Petersen , Ole Nielsen , Michael Rock , Helle Eliasen , Ken Liljegren
IPC分类号： A61K31/343 , C07D307/02
CPC分类号： C07D307/81
摘要： The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile, formulations of said base, a process for the preparation of purified salts of escitalopram, such as the oxalate, using the base, the salts obtained by said process and formulations containing such salts, and a process for the preparation of purified escitalopram free base or salts of escitalopram, such as the oxalate, using the hydrobromide, the salts obtained by said process and formulations containing such salts. Finally the present invention relates to an orodispersible tablet having a hardness of at least 22 N and an oral-disintegration time of less than 120 s and comprising an active pharmaceutical ingredient adsorbed onto a water soluble filler wherein the active pharmaceutical ingredient has a melting point in the range of 40-100° C., as well as a method for making such an orodispersible tablet.
摘要翻译：本发明涉及众所周知的抗抑郁药物依他普仑S-1- [3-（二甲基氨基）丙基] -1-（4-氟苯基）-1,3-二氢-5-异苯并呋喃甲腈的结晶碱，所述制剂为碱，使用碱，草酸盐的纯化盐的制备方法，通过所述方法获得的盐和含有这些盐的制剂的方法，以及制备纯化的依他普仑游离碱或依他普仑的盐的方法，例如草酸盐，使用氢溴酸盐，通过所述方法获得的盐和含有这些盐的制剂。最后，本发明涉及硬度至少为22N，口服崩解时间小于120秒的可分散片剂，其包含吸附在水溶性填料上的活性药物成分，其中活性药物成分的熔点为 40-100℃的范围，以及制造这种可分散片剂的方法。

7. 发明申请

US20060281759A1 Succinate and malonate salt of trans 4-(ir,3s)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and the use as a medicament 有权
标题翻译：反式4-（ir，3s）-6-氯-3-苯基茚基-1-基）-1,2,2-三甲基哌嗪的琥珀酸盐和丙二酸盐和用作药物的用途
公开(公告)号：US20060281759A1
公开(公告)日：2006-12-14
申请号：US10568572
申请日：2004-08-18
申请人： Heidi de Diego , Ole Nielsen , Lone Ringgard , Henrik Svane , Allan Dahl , Mark Howells , Benny Bang-Andersen , Lars Lyngso
发明人： Heidi de Diego , Ole Nielsen , Lone Ringgard , Henrik Svane , Allan Dahl , Mark Howells , Benny Bang-Andersen , Lars Lyngso
IPC分类号： A61K31/495 , C07D241/04
CPC分类号： C07D295/073 , C07B2200/07 , C07C17/16 , C07C25/22 , C07C29/143 , C07C35/32 , C07C2602/08 , C07D241/04 , C12P7/22 , C12P41/004 , C07C35/52
摘要： 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine hydrogen succinate or hydrogen malonate, pharmaceutical compositions containing these salts and the medical use thereof, including for the treatment of schizophrenia and other psychotic disorders. Also described are methods for the preparation of 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and medical uses thereof.
摘要翻译： 4 - （（1R，3S）-6-氯-3-苯基茚基-1-基）-1,2,2-三甲基哌嗪氢化琥珀酸盐或丙二酸氢盐，含有这些盐的药物组合物及其医疗用途，包括用于治疗的精神分裂症和其他精神障碍。还描述了制备4 - （（1R，3S）-6-氯-3-苯基茚-1-基）-1,2,2-三甲基哌嗪的方法及其医疗用途。

8. 发明授权

US09176057B2 Apparatus and method for measuring retroreflectivity of a surface 有权
标题翻译：用于测量表面的后向反射率的装置和方法
公开(公告)号：US09176057B2
公开(公告)日：2015-11-03
申请号：US13576044
申请日：2011-02-04
申请人： Kaj Sørensen , Asbjørn Mejnertsen , Jan Harries Hansen , Hans Ole Nielsen
发明人： Kaj Sørensen , Asbjørn Mejnertsen , Jan Harries Hansen , Hans Ole Nielsen
IPC分类号： G01N21/55
CPC分类号： G01N21/55 , G01N2021/551
摘要： An apparatus for measuring the retroreflectivity of a surface. The apparatus comprises a light source for illuminating an area of said surface at an incident angle relative to the surface; a detector for detecting light reflected back from the surface at an observation angle relative to the surface; a signal processing unit adapted to receive a detector signal from the detector and to determine, from at least the received detector signal, a measure of retro reflectivity of the surface; a range finder for measuring a distance between the apparatus and the illuminated area. The signal processing unit is further adapted to adjust the measure of retroreflectivity responsive to the measured distance.
摘要翻译：用于测量表面的后向反射率的装置。该装置包括用于以相对于该表面入射的角度照射所述表面的区域的光源; 用于检测从表面以相对于表面观察角度反射回的光的检测器; 信号处理单元，适于从所述检测器接收检测器信号，并且从至少所接收的检测器信号确定所述表面的复现反射率的量度; 用于测量设备和照明区域之间的距离的测距仪。信号处理单元还适于响应于测量的距离来调节后向反射率的测量。

9. 发明授权

US08076342B2 Malonate salt of 4-((1R,3S)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and uses of same 有权
标题翻译： 4 - （（1R，3S）-6-氯-3-苯基茚满-1-基）-1,2,2-三甲基哌嗪的丙二酸盐及其用途
公开(公告)号：US08076342B2
公开(公告)日：2011-12-13
申请号：US12939904
申请日：2010-11-04
申请人： Heidi Lopez de Diego , Ole Nielsen , Lone Munch Ringgard , Henrik Svane , Allan Carsten Dahl , Mark Howells , Benny Bang-Andersen , Lars Ole Lyngso
发明人： Heidi Lopez de Diego , Ole Nielsen , Lone Munch Ringgard , Henrik Svane , Allan Carsten Dahl , Mark Howells , Benny Bang-Andersen , Lars Ole Lyngso
IPC分类号： A61K31/495 , C07D241/04
CPC分类号： C07D295/073 , C07B2200/07 , C07C17/16 , C07C25/22 , C07C29/143 , C07C35/32 , C07C2602/08 , C07D241/04 , C12P7/22 , C12P41/004 , C07C35/52
摘要： 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine hydrogen malonate salt and pharmaceutical comprising and uses of the same, including for the treatment of schizophrenia and other psychotic disorders are described.
摘要翻译： 4 - （（1R，3S）-6-氯-3-苯基茚基-1-基）-1,2,2-三甲基哌嗪氢丙二酸盐和包含其用途的药物，包括用于治疗精神分裂症和其他精神病描述疾病。

10. 发明授权

US08076320B2 Crystalline forms of a pharmaceutical compound 有权
标题翻译：药物化合物的结晶形式
公开(公告)号：US08076320B2
公开(公告)日：2011-12-13
申请号：US10597977
申请日：2005-02-24
申请人： Michael Harold Rock , Heidi Lopez De Diego , Kim Lasse Christensen , Ole Nielsen , Anders Buur , Mark Howells
发明人： Michael Harold Rock , Heidi Lopez De Diego , Kim Lasse Christensen , Ole Nielsen , Anders Buur , Mark Howells
IPC分类号： A61P25/16 , A61K31/7056 , C07H19/23
CPC分类号： C07H19/23 , C07D491/22
摘要： Described are crystalline forms of the pharmaceutical compound “[9S-(9α,10β,12α)]-5,16-Bis[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9, 12-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester”, as well as methods for their use and preparation.
摘要翻译：描述了药物化合物“[9S-（9α，10α，12α）] -5,16-双[（乙硫基）甲基] -2,3,9,10,11,12-六氢-10- -4-羟基-9-甲基-1-氧代-9,12-环氧基-1H-二吲哚并[1,2,3-fg：3'，2'，1'-k]吡咯并[3,4-i] 6]苯并二氮辛-10-羧酸甲酯“，以及它们的使用和制备方法。

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