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1. 发明申请

WO2008021617A8 CONDENSATE GLUCOSE ANALYZER 审中-公开
标题翻译：冷凝葡萄糖分析仪
公开(公告)号：WO2008021617A8
公开(公告)日：2008-04-24
申请号：PCT/US2007071469
申请日：2007-06-18
申请人： UNIV FLORIDA , MELKER RICHARD J , BJORAKER DAVID G , DENNIS DONN MICHAEL , STEWART JON DALE , BATICH CHRISTOPHER D , BOOTH MATTHEW M , HORN JOHN FREDERICK , YOUNGBLOOD RONALD , MOREY TIMOTHY E
发明人： MELKER RICHARD J , BJORAKER DAVID G , DENNIS DONN MICHAEL , STEWART JON DALE , BATICH CHRISTOPHER D , BOOTH MATTHEW M , HORN JOHN FREDERICK , YOUNGBLOOD RONALD , MOREY TIMOTHY E
IPC分类号： A61B5/00 , A61B5/083
CPC分类号： A61B5/083 , A61B5/1486 , A61B5/413 , Y10T436/144444
摘要： Systems and methods for analyzing glucose present m exhaled breath condensate (EBC). Electr
摘要翻译：用于分析葡萄糖的系统和方法，用于呼出呼气浓缩物（EBC）。 ELECTR

2. 发明申请

WO2006034370A3 SYSTEMS AND METHODS FOR EVALUATING ENZYME COMPETENCY 审中-公开
公开(公告)号：WO2006034370A3
公开(公告)日：2006-03-30
申请号：PCT/US2005/033883
申请日：2005-09-20
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , MELKER, Richard, J. , MOREY, Timothy, E. , PROKAI, laszlo , DENNIS, Donn, M.
发明人： MELKER, Richard, J. , MOREY, Timothy, E. , PROKAI, laszlo , DENNIS, Donn, M.
IPC分类号： C12Q1/26 , C12Q1/00
摘要： The present invention provides systems and methods for determining enzymatic competency, which is important in determining whether a patient may suffer an adverse drug reaction, has a disease associated with defects in specific enzymatic function, and/or has an enzyme defect that is likely to cause pathophysiology. As contemplated herein, a parent molecular entity is administered to a patient in whom enzymatic competency is to be determined. A sample of the patient’s bodily fluid is exposed to a sensor of the invention to distinguish, detect, and quantify a detectable entity in the bodily fluid. Sensor-acquired data regarding the detectable entity is used to determine enzymatic competency. Preferably, a sample of a patient’s exhaled breath is collected and exposed to the sensor of the invention. Types of sensor systems of the invention include, but are not limited to, surface resonance arrays; microelectromechanical sensors (such as microcantilever-based technology); molecularly imprinted polymer sensors; amplifying fluorescent sensor technology; aptamer-based sensor technology; SAW sensors; infrared sensors; fuel cells; chemical reactors; and pH sensitive sensors.

3. 发明申请

WO02080885A8 DETOXIFICATION AND DECONTAMINATION USING NANOTECHNOLOGY THERAPY 审中-公开
标题翻译：使用纳米技术治疗的脱氧和去除
公开(公告)号：WO02080885A8
公开(公告)日：2003-01-30
申请号：PCT/US0206114
申请日：2002-02-28
申请人： UNIV FLORIDA , DENNIS DONN M , MARTIN CHARLES R , MOREY TIMOTHY E , PARTCH RICHARD E , SHAH DINESH O
发明人： DENNIS DONN M , MARTIN CHARLES R , MOREY TIMOTHY E , PARTCH RICHARD E , SHAH DINESH O
IPC分类号： A61K9/51 , A61K9/14
CPC分类号： A61K9/0092 , A61K9/1075 , A61K9/51
摘要： A method for removing a target chemical from a region comprising the steps of: adding nanoparticle size bioparticle to the region and partitioning at least a portion of the target chemical into or onto the bioparticle. A composition comprising bioparticles having a surface adopted for toxic drug attachment is also provided.
摘要翻译：一种用于从区域去除目标化学物质的方法，包括以下步骤：向该区域添加纳米颗粒尺寸的生物颗粒并将至少一部分目标化学品分配到生物颗粒中或其上。还提供了包含具有用于有毒药物附着的表面的生物颗粒的组合物。

4. 发明申请

WO2008021617A1 CONDENSATE GLUCOSE ANALYZER 审中-公开
标题翻译：冷凝葡萄糖分析仪
公开(公告)号：WO2008021617A1
公开(公告)日：2008-02-21
申请号：PCT/US2007/071469
申请日：2007-06-18
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , MELKER, Richard, J. , BJORAKER, David, G. , DENNIS, Donn, Michael , STEWART, Jon, Dale , BATICH, Christopher, D. , BOOTH, Matthew, M. , HORN, John, Frederick , YOUNGBLOOD, Ronald , MOREY, Timothy, E.
发明人： MELKER, Richard, J. , BJORAKER, David, G. , DENNIS, Donn, Michael , STEWART, Jon, Dale , BATICH, Christopher, D. , BOOTH, Matthew, M. , HORN, John, Frederick , YOUNGBLOOD, Ronald , MOREY, Timothy, E.
IPC分类号： A61B5/00 , A61B5/083
CPC分类号： A61B5/083 , A61B5/1486 , A61B5/413 , Y10T436/144444
摘要： Systems and methods for analyzing glucose present m exhaled breath condensate (EBC). Electrochemical- or coulometric-based sensing technologies are used to analyze EBC for the presence and/or concentration of glucose.
摘要翻译：用于分析葡萄糖的系统和方法，用于呼出呼气浓缩物（EBC）。使用基于电化学或电量法的感测技术来分析葡萄糖的存在和/或浓度。

5. 发明申请

WO2006034370A2 SYSTEMS AND METHODS FOR EVALUATING ENZYME COMPETENCY 审中-公开
标题翻译：用于评估酶能力的系统和方法
公开(公告)号：WO2006034370A2
公开(公告)日：2006-03-30
申请号：PCT/US2005033883
申请日：2005-09-20
申请人： UNIV FLORIDA , MELKER RICHARD J , MOREY TIMOTHY E , PROKAI LASZLO , DENNIS DONN M
发明人： MELKER RICHARD J , MOREY TIMOTHY E , PROKAI LASZLO , DENNIS DONN M
IPC分类号： C12Q1/26 , C12Q1/00
CPC分类号： C12Q1/00 , C12Q1/26
摘要： The present invention provides systems and methods for determining enzymatic competency, which is important in determining whether a patient may suffer an adverse drug reaction, has a disease associated with defects in specific enzymatic function, and/or has an enzyme defect that is likely to cause pathophysiology. As contemplated herein, a parent molecular entity is administered to a patient in whom enzymatic competency is to be determined. A sample of the patient's bodily fluid is exposed to a sensor of the invention to distinguish, detect, and quantify a detectable entity in the bodily fluid. Sensor-acquired data regarding the detectable entity is used to determine enzymatic competency. Preferably, a sample of a patient's exhaled breath is collected and exposed to the sensor of the invention. Types of sensor systems of the invention include, but are not limited to, surface resonance arrays; microelectromechanical sensors (such as microcantilever-based technology); molecularly imprinted polymer sensors; amplifying fluorescent sensor technology; aptamer-based sensor technology; SAW sensors; infrared sensors; fuel cells; chemical reactors; and pH sensitive sensors.
摘要翻译：本发明提供了用于确定酶能力的系统和方法，其在确定患者是否可能遭受不良药物反应，具有与特定酶功能缺陷相关的疾病和/或具有可能引起酶缺陷的酶缺陷病理生理学。如本文所考虑的，母体分子实体被施用于待确定酶促能力的患者。将患者体液的样本暴露于本发明的传感器以区分，检测和量化体液中的可检测实体。使用传感器获取的关于可检测实体的数据来确定酶促能力。优选地，患者呼出气的样本被收集并暴露于本发明的传感器。本发明的传感器系统的类型包括但不限于表面共振阵列; 微机电传感器（如基于微悬臂梁的技术）; 分子印迹聚合物传感器; 放大荧光传感器技术; 基于适配子的传感器技术; 声表面波传感器; 红外传感器; 燃料电池; 化学反应器; 和pH敏感传感器。

6. 发明申请

WO0209671A3 MICROEMULSION AND MICELLE SYSTEMS FOR SOLUBILIZING DRUGS 审中-公开
标题翻译：用于溶解药物的微乳液和微凝胶系统
公开(公告)号：WO0209671A3
公开(公告)日：2002-05-16
申请号：PCT/US0124167
申请日：2001-07-31
申请人： UNIV FLORIDA , DENNIS DONN M , GRAVENSTEIN NIKOLAUS , MODELL JEROME H , MOREY TIMOTHY E , SHAH DINESH
发明人： DENNIS DONN M , GRAVENSTEIN NIKOLAUS , MODELL JEROME H , MOREY TIMOTHY E , SHAH DINESH
IPC分类号： A61K9/107 , A61K47/12 , A61K47/34 , A61K31/05
CPC分类号： A61K9/1075
摘要： A microemulsion delivery system for water insoluble or sparingly water soluble drugs that comprise a long polymer chain surfactant component and a short fatty acid sufractant component, with the amount of each being selected to provide stable microemulsion or micellar systems.
摘要翻译：一种用于水不溶性或微溶水性药物的微乳液递送系统，其包含长的聚合物链表面活性剂组分和短的脂肪酸补充剂组分，其中每种组分的量被选择以提供稳定的微乳液或胶束体系。

7. 发明申请

WO2003088948A3 MICROEMULSIONS FOR SELECTIVE MOLECULAR SEPARATION 审中-公开
公开(公告)号：WO2003088948A3
公开(公告)日：2003-10-30
申请号：PCT/US2003/013570
申请日：2003-04-22
申请人： UNIVERSITY OF FLORIDA , DENNIS, Donn, M. , MOREY, Timothy, E. , PARTCH, Richard, E. , SHAH, Dinesh, O. , VARSHNEY, Manoj
发明人： DENNIS, Donn, M. , MOREY, Timothy, E. , PARTCH, Richard, E. , SHAH, Dinesh, O. , VARSHNEY, Manoj
IPC分类号： A61K9/107
摘要： The subject invention provides unique materials and methods for selectively removing molecules from a medium. In a preferred embodiment of the subject invention, microemulsions are specifically designed to facilitate effective separation of even closely related chemical entities.

8. 发明申请

WO02080885B1 DETOXIFICATION AND DECONTAMINATION USING NANOTECHNOLOGY THERAPY 审中-公开
标题翻译：使用纳米技术治疗的脱氧和去除
公开(公告)号：WO02080885B1
公开(公告)日：2003-01-03
申请号：PCT/US0206114
申请日：2002-02-28
申请人： UNIV FLORIDA , DENNIS DONN M , MARTIN CHARLES R , MOREY TIMOTHY E , PARTCH RICHARD E , SHAH DINESH O
发明人： DENNIS DONN M , MARTIN CHARLES R , MOREY TIMOTHY E , PARTCH RICHARD E , SHAH DINESH O
IPC分类号： A61K9/51 , A61K9/14
CPC分类号： A61K9/0092 , A61K9/1075 , A61K9/51
摘要： A method for removing a target chemical from a region comprising the steps of: adding nanoparticle to the region and partitioning at least a portion of the target chemical into or onto the bioparticle. A composition comprising bioparticles having a surface adopted for toxic drug attachment is also provided.
摘要翻译：一种用于从区域除去目标化学物质的方法，包括以下步骤：向该区域添加纳米颗粒并将至少一部分目标化学品分配到生物颗粒中或其上。还提供了包含具有用于有毒药物附着的表面的生物颗粒的组合物。

9. 发明申请

WO2008022183A1 CONDENSATE GLUCOSE ANALYZER 审中-公开
标题翻译：冷凝葡萄糖分析仪
公开(公告)号：WO2008022183A1
公开(公告)日：2008-02-21
申请号：PCT/US2007/075985
申请日：2007-08-15
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , XHALE DIAGNOSTICS, INC. , MELKER, Richard, J. , BJORAKER, David, G. , DENNIS, Donn, Michael , STEWART, Jon, Dale , BATICH, Christopher, D. , BOOTH, Matthew, M. , HORN, John, Frederick , YOUNGBLOOD, Ronald , MOREY, Timothy, E.
发明人： MELKER, Richard, J. , BJORAKER, David, G. , DENNIS, Donn, Michael , STEWART, Jon, Dale , BATICH, Christopher, D. , BOOTH, Matthew, M. , HORN, John, Frederick , YOUNGBLOOD, Ronald , MOREY, Timothy, E.
IPC分类号： A61B5/00 , A61B5/083
CPC分类号： A61B5/14532 , A61B5/083 , A61B5/1486 , A61B5/413
摘要： Systems and methods for analyzing glucose present in exhaled breath condensate (EBC). In certain embodiments, electrochemical- or coulometnc-based sensing technologies are used to analyze EBC for the presence and/or concentration of glucose. Based on the detected glucose m EBC, the subject invention provides systems and methods for non-mvasive, accurate assessment of blood glucose levels.
摘要翻译：用于分析呼出气凝缩物（EBC）中存在的葡萄糖的系统和方法。在某些实施方案中，使用基于电化学或库仑法的感测技术来分析葡萄糖的存在和/或浓度。基于检测到的葡萄糖EBC，本发明提供了用于非侵入性，准确评估血糖水平的系统和方法。

10. 发明申请

WO2003088948A2 MICROEMULSIONS FOR SELECTIVE MOLECULAR SEPARATION 审中-公开
标题翻译：用于选择性分子分离的微乳液
公开(公告)号：WO2003088948A2
公开(公告)日：2003-10-30
申请号：PCT/US2003/013570
申请日：2003-04-22
申请人： UNIVERSITY OF FLORIDA , DENNIS, Donn, M. , MOREY, Timothy, E. , PARTCH, Richard, E. , SHAH, Dinesh, O. , VARSHNEY, Manoj
发明人： DENNIS, Donn, M. , MOREY, Timothy, E. , PARTCH, Richard, E. , SHAH, Dinesh, O. , VARSHNEY, Manoj
IPC分类号： A61K9/00
CPC分类号： A61K31/55 , A61K9/1075 , A61K31/445 , B01J20/28
摘要： The subject invention provides unique materials and methods for selectively removing molecules from a medium. In a preferred embodiment of the subject invention, microemulsions are specifically designed to facilitate effective separation of even closely related chemical entities.
摘要翻译：本发明提供了用于从介质中选择性去除分子的独特材料和方法。在本发明的一个优选实施方案中，微乳液被特别设计以促进甚至密切相关的化学实体的有效分离。

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