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1. 发明公开

EP1044051A1 NOVEL METHODS AND APPARATUS FOR IMPROVED FILTRATION OF SUBMICRON PARTICLES 审中-公开
标题翻译：方法和装置过滤微粒
公开(公告)号：EP1044051A1
公开(公告)日：2000-10-18
申请号：EP99946750.9
申请日：1999-09-03
申请人： UNIVERSITY OF FLORIDA , Farrah, Samuel R. , Shah, Dinesh O.
发明人： LUKASIK, Jerzy , FARRAH, Samuel, R. , SHAH, Dinesh, O. , KANG, Peter K. , KOOPMAN, Ben, L.
IPC分类号： B01D37/02
CPC分类号： B01D46/0028 , B01D39/00 , B01D39/18 , B01D39/2017 , B01D46/0035 , B01D2239/0414 , B01D2239/0428 , B01D2239/0471 , B01D2239/0613 , B01D2239/0618 , B01D2239/10
摘要： The subject invention pertains to novel methods of filtration, novel methods for production of filters, and novel filters, for the efficient filtration of particles. The materials and methods of the subject invention are particularly advantageous for the filtration of submicron particles, for example, nanoparticles, and can utilize the electrostatic attraction between particles and the fibers of microporous filters, for example, polypropylenefilters. The subject methods of filtration can lower the energy barrier between the particles and the filter surface and thus increase the deposition of particles on the surface of the filter. The methods and apparatus of the subject invention can be used to filter particles from many fluids including water and air. Advantageously, the subject surface modified filters can result in increased fluid flow, for the same pressure drop, compared to conventional filters.

2. 发明申请

WO2008051782A1 METHODS FOR THE DETECTION AND DIAGNOSIS OF TRYPANOSOMA CRUZI INFECTION 审中-公开
标题翻译： TRYPANOSOMA CRUZI感染的检测和诊断方法
公开(公告)号：WO2008051782A1
公开(公告)日：2008-05-02
申请号：PCT/US2007/081735
申请日：2007-10-18
申请人： ABBOTT LABORATORIES , SHAH, Dinesh O , CHANG, Chi-deu , SCHOCHETMAN, Gerald , CHENG, Kevin Y
发明人： SHAH, Dinesh O , CHANG, Chi-deu , SCHOCHETMAN, Gerald , CHENG, Kevin Y
IPC分类号： G01N33/553
CPC分类号： G01N33/56905 , G01N33/543
摘要： The present invention relates to the diagnosis of Trypanosoma cruzi infection.
摘要翻译：本发明涉及克氏锥虫感染的诊断。

3. 发明申请

WO02080885A8 DETOXIFICATION AND DECONTAMINATION USING NANOTECHNOLOGY THERAPY 审中-公开
标题翻译：使用纳米技术治疗的脱氧和去除
公开(公告)号：WO02080885A8
公开(公告)日：2003-01-30
申请号：PCT/US0206114
申请日：2002-02-28
申请人： UNIV FLORIDA , DENNIS DONN M , MARTIN CHARLES R , MOREY TIMOTHY E , PARTCH RICHARD E , SHAH DINESH O
发明人： DENNIS DONN M , MARTIN CHARLES R , MOREY TIMOTHY E , PARTCH RICHARD E , SHAH DINESH O
IPC分类号： A61K9/51 , A61K9/14
CPC分类号： A61K9/0092 , A61K9/1075 , A61K9/51
摘要： A method for removing a target chemical from a region comprising the steps of: adding nanoparticle size bioparticle to the region and partitioning at least a portion of the target chemical into or onto the bioparticle. A composition comprising bioparticles having a surface adopted for toxic drug attachment is also provided.
摘要翻译：一种用于从区域去除目标化学物质的方法，包括以下步骤：向该区域添加纳米颗粒尺寸的生物颗粒并将至少一部分目标化学品分配到生物颗粒中或其上。还提供了包含具有用于有毒药物附着的表面的生物颗粒的组合物。

4. 发明申请

WO2004055260A1 USE OF MULTIMOLECULAR LAYERS TO REDUCE EVAPORATION OF WATER 审中-公开
标题翻译：使用多层分子减少水分蒸发
公开(公告)号：WO2004055260A1
公开(公告)日：2004-07-01
申请号：PCT/US2003/039614
申请日：2003-12-12
申请人： UNIVERSITY OF FLORIDA , BAGWE, Rahul, Prabhakar , SHAH, Dinesh, O.
发明人： BAGWE, Rahul, Prabhakar , SHAH, Dinesh, O.
IPC分类号： D06M15/00
CPC分类号： A61K9/0048
摘要： Methods and compositions for the retardation of evaporation of water from a water/ air interface. The methods comprise applying a multimolecular oil/ surfactant layer to the surface. Preferably the surfactant is BRIJ-93.
摘要翻译：阻止水/空气界面蒸发水的方法和组成。所述方法包括将多分子油/表面活性剂层施加到表面。表面活性剂优选为BRIJ-93。

5. 发明申请

WO2003088948A2 MICROEMULSIONS FOR SELECTIVE MOLECULAR SEPARATION 审中-公开
标题翻译：用于选择性分子分离的微乳液
公开(公告)号：WO2003088948A2
公开(公告)日：2003-10-30
申请号：PCT/US2003/013570
申请日：2003-04-22
申请人： UNIVERSITY OF FLORIDA , DENNIS, Donn, M. , MOREY, Timothy, E. , PARTCH, Richard, E. , SHAH, Dinesh, O. , VARSHNEY, Manoj
发明人： DENNIS, Donn, M. , MOREY, Timothy, E. , PARTCH, Richard, E. , SHAH, Dinesh, O. , VARSHNEY, Manoj
IPC分类号： A61K9/00
CPC分类号： A61K31/55 , A61K9/1075 , A61K31/445 , B01J20/28
摘要： The subject invention provides unique materials and methods for selectively removing molecules from a medium. In a preferred embodiment of the subject invention, microemulsions are specifically designed to facilitate effective separation of even closely related chemical entities.
摘要翻译：本发明提供了用于从介质中选择性去除分子的独特材料和方法。在本发明的一个优选实施方案中，微乳液被特别设计以促进甚至密切相关的化学实体的有效分离。

6. 发明申请

WO2002080885A1 DETOXIFICATION AND DECONTAMINATION USING NANOTECHNOLOGY THERAPY 审中-公开
标题翻译：使用纳米技术治疗的脱氧和去除
公开(公告)号：WO2002080885A1
公开(公告)日：2002-10-17
申请号：PCT/US2002/006114
申请日：2002-02-28
申请人： UNIVERSITY OF FLORIDA , DENNIS, Donn, M. , MARTIN, Charles, R. , MOREY, Timothy, E. , PARTCH, Richard, E. , SHAH, Dinesh, O.
发明人： DENNIS, Donn, M. , MARTIN, Charles, R. , MOREY, Timothy, E. , PARTCH, Richard, E. , SHAH, Dinesh, O.
IPC分类号： A61K9/14
CPC分类号： A61K9/0092 , A61K9/1075 , A61K9/51
摘要： A method for detoxification and decontamination comprising the steps of: adding nanoparticle size bioparticles having at least one enzyme incorporated therein to a solution and biotransforming the target chemical into inactive metabolites.
摘要翻译：一种用于从区域去除目标化学物质的方法，包括以下步骤：向该区域添加纳米颗粒尺寸的生物颗粒并将至少一部分目标化学品分配到生物颗粒中或其上。还提供了包含具有用于有毒药物附着的表面的生物颗粒的组合物。

7. 发明申请

WO2006135415A3 MICELLES AND NANOEMULSIONS FOR PREVENTATIVE AND REACTIVE TREATMENT OF ATHEROSCLEROSIS 审中-公开
标题翻译：用于预防和反应性治疗甲状腺功能亢进症的细胞和纳米抗体
公开(公告)号：WO2006135415A3
公开(公告)日：2007-03-01
申请号：PCT/US2005031840
申请日：2005-09-08
申请人： UNIV FLORIDA , VARSHNEY MANOJ , SHAH DINESH O
发明人： VARSHNEY MANOJ , SHAH DINESH O
IPC分类号： A61K9/107
CPC分类号： A61K9/1075
摘要： The subject invention is directed to microemulsion-based (ME) nanoparticles and methods of using same. The ME nanoparticles of the subject invention encompass self-assemblies of oil in water emulsions in the presence of at least two emulsifiers. One of the emulsifiers is a salt of a fatty acid, and the combined concentration of the at least two emulsifiers is sufficiently large to produce micelles, wherein the oil droplets are the hydrophobic core of the micelles. The subject invention also contemplates methods of modifying lipids, high density lipoprotein (HDL), and low density lipoprotein (LDL) in blood by contacting the blood with the ME nanoparticles of the subject invention. Another aspect concerns methods for treating atherosclerosis by administering the ME nanoparticles of the subject invention to a patient in need thereof.
摘要翻译：本发明涉及基于微乳液的（ME）纳米颗粒及其使用方法。本发明的ME纳米颗粒包括在至少两种乳化剂存在下的水包油乳液的自组装。乳化剂之一是脂肪酸的盐，并且至少两种乳化剂的组合浓度足够大以产生胶束，其中油滴是胶束的疏水核心。本发明还考虑通过使血液与本发明的ME纳米颗粒接触来改变血液中脂质，高密度脂蛋白（HDL）和低密度脂蛋白（LDL）的方法。另一方面涉及通过将本发明的ME纳米颗粒给予有需要的患者来治疗动脉粥样硬化的方法。

8. 发明申请

WO2009086398A2 ANTI-T. CRUZI ANTIBODIES AND METHODS OF USE 审中-公开
标题翻译： ANTI-T。 CRUZI抗体和使用方法
公开(公告)号：WO2009086398A2
公开(公告)日：2009-07-09
申请号：PCT/US2008/088199
申请日：2008-12-23
申请人： ABBOTT LABORATORIES , TYNER, Lowell , BROPHY, Susan E. , HAWKSWORTH, David J. , SHAH, Dinesh O. , SIEGEL, Robert W. , TIEMAN, Bryan C. , TU, Bailin , ZIEMANN, Robert N.
发明人： BROPHY, Susan E. , HAWKSWORTH, David J. , SHAH, Dinesh O. , SIEGEL, Robert W. , TIEMAN, Bryan C. , TU, Bailin , ZIEMANN, Robert N.
IPC分类号： C07K16/20 , G01N33/569
CPC分类号： G01N33/56905 , C07K16/20 , C07K2317/24 , C07K2317/56 , C07K2317/92 , G01N2333/44 , G01N2469/10 , G01N2469/20 , G01N2496/00
摘要： The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.
摘要翻译：本公开涉及使用试剂检测克氏锥虫的表位的试剂和方法。

9. 发明申请

WO2003088948A3 MICROEMULSIONS FOR SELECTIVE MOLECULAR SEPARATION 审中-公开
公开(公告)号：WO2003088948A3
公开(公告)日：2003-10-30
申请号：PCT/US2003/013570
申请日：2003-04-22
申请人： UNIVERSITY OF FLORIDA , DENNIS, Donn, M. , MOREY, Timothy, E. , PARTCH, Richard, E. , SHAH, Dinesh, O. , VARSHNEY, Manoj
发明人： DENNIS, Donn, M. , MOREY, Timothy, E. , PARTCH, Richard, E. , SHAH, Dinesh, O. , VARSHNEY, Manoj
IPC分类号： A61K9/107
摘要： The subject invention provides unique materials and methods for selectively removing molecules from a medium. In a preferred embodiment of the subject invention, microemulsions are specifically designed to facilitate effective separation of even closely related chemical entities.

10. 发明申请

WO02080885B1 DETOXIFICATION AND DECONTAMINATION USING NANOTECHNOLOGY THERAPY 审中-公开
标题翻译：使用纳米技术治疗的脱氧和去除
公开(公告)号：WO02080885B1
公开(公告)日：2003-01-03
申请号：PCT/US0206114
申请日：2002-02-28
申请人： UNIV FLORIDA , DENNIS DONN M , MARTIN CHARLES R , MOREY TIMOTHY E , PARTCH RICHARD E , SHAH DINESH O
发明人： DENNIS DONN M , MARTIN CHARLES R , MOREY TIMOTHY E , PARTCH RICHARD E , SHAH DINESH O
IPC分类号： A61K9/51 , A61K9/14
CPC分类号： A61K9/0092 , A61K9/1075 , A61K9/51
摘要： A method for removing a target chemical from a region comprising the steps of: adding nanoparticle to the region and partitioning at least a portion of the target chemical into or onto the bioparticle. A composition comprising bioparticles having a surface adopted for toxic drug attachment is also provided.
摘要翻译：一种用于从区域除去目标化学物质的方法，包括以下步骤：向该区域添加纳米颗粒并将至少一部分目标化学品分配到生物颗粒中或其上。还提供了包含具有用于有毒药物附着的表面的生物颗粒的组合物。

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