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1. 发明申请

WO0209671A3 MICROEMULSION AND MICELLE SYSTEMS FOR SOLUBILIZING DRUGS 审中-公开
标题翻译：用于溶解药物的微乳液和微凝胶系统
公开(公告)号：WO0209671A3
公开(公告)日：2002-05-16
申请号：PCT/US0124167
申请日：2001-07-31
申请人： UNIV FLORIDA , DENNIS DONN M , GRAVENSTEIN NIKOLAUS , MODELL JEROME H , MOREY TIMOTHY E , SHAH DINESH
发明人： DENNIS DONN M , GRAVENSTEIN NIKOLAUS , MODELL JEROME H , MOREY TIMOTHY E , SHAH DINESH
IPC分类号： A61K9/107 , A61K47/12 , A61K47/34 , A61K31/05
CPC分类号： A61K9/1075
摘要： A microemulsion delivery system for water insoluble or sparingly water soluble drugs that comprise a long polymer chain surfactant component and a short fatty acid sufractant component, with the amount of each being selected to provide stable microemulsion or micellar systems.
摘要翻译：一种用于水不溶性或微溶水性药物的微乳液递送系统，其包含长的聚合物链表面活性剂组分和短的脂肪酸补充剂组分，其中每种组分的量被选择以提供稳定的微乳液或胶束体系。

2. 发明申请

WO02080885B1 DETOXIFICATION AND DECONTAMINATION USING NANOTECHNOLOGY THERAPY 审中-公开
标题翻译：使用纳米技术治疗的脱氧和去除
公开(公告)号：WO02080885B1
公开(公告)日：2003-01-03
申请号：PCT/US0206114
申请日：2002-02-28
申请人： UNIV FLORIDA , DENNIS DONN M , MARTIN CHARLES R , MOREY TIMOTHY E , PARTCH RICHARD E , SHAH DINESH O
发明人： DENNIS DONN M , MARTIN CHARLES R , MOREY TIMOTHY E , PARTCH RICHARD E , SHAH DINESH O
IPC分类号： A61K9/51 , A61K9/14
CPC分类号： A61K9/0092 , A61K9/1075 , A61K9/51
摘要： A method for removing a target chemical from a region comprising the steps of: adding nanoparticle to the region and partitioning at least a portion of the target chemical into or onto the bioparticle. A composition comprising bioparticles having a surface adopted for toxic drug attachment is also provided.
摘要翻译：一种用于从区域除去目标化学物质的方法，包括以下步骤：向该区域添加纳米颗粒并将至少一部分目标化学品分配到生物颗粒中或其上。还提供了包含具有用于有毒药物附着的表面的生物颗粒的组合物。

3. 发明申请

WO02080885A8 DETOXIFICATION AND DECONTAMINATION USING NANOTECHNOLOGY THERAPY 审中-公开
标题翻译：使用纳米技术治疗的脱氧和去除
公开(公告)号：WO02080885A8
公开(公告)日：2003-01-30
申请号：PCT/US0206114
申请日：2002-02-28
申请人： UNIV FLORIDA , DENNIS DONN M , MARTIN CHARLES R , MOREY TIMOTHY E , PARTCH RICHARD E , SHAH DINESH O
发明人： DENNIS DONN M , MARTIN CHARLES R , MOREY TIMOTHY E , PARTCH RICHARD E , SHAH DINESH O
IPC分类号： A61K9/51 , A61K9/14
CPC分类号： A61K9/0092 , A61K9/1075 , A61K9/51
摘要： A method for removing a target chemical from a region comprising the steps of: adding nanoparticle size bioparticle to the region and partitioning at least a portion of the target chemical into or onto the bioparticle. A composition comprising bioparticles having a surface adopted for toxic drug attachment is also provided.
摘要翻译：一种用于从区域去除目标化学物质的方法，包括以下步骤：向该区域添加纳米颗粒尺寸的生物颗粒并将至少一部分目标化学品分配到生物颗粒中或其上。还提供了包含具有用于有毒药物附着的表面的生物颗粒的组合物。

4. 发明申请

WO2006034370A2 SYSTEMS AND METHODS FOR EVALUATING ENZYME COMPETENCY 审中-公开
标题翻译：用于评估酶能力的系统和方法
公开(公告)号：WO2006034370A2
公开(公告)日：2006-03-30
申请号：PCT/US2005033883
申请日：2005-09-20
申请人： UNIV FLORIDA , MELKER RICHARD J , MOREY TIMOTHY E , PROKAI LASZLO , DENNIS DONN M
发明人： MELKER RICHARD J , MOREY TIMOTHY E , PROKAI LASZLO , DENNIS DONN M
IPC分类号： C12Q1/26 , C12Q1/00
CPC分类号： C12Q1/00 , C12Q1/26
摘要： The present invention provides systems and methods for determining enzymatic competency, which is important in determining whether a patient may suffer an adverse drug reaction, has a disease associated with defects in specific enzymatic function, and/or has an enzyme defect that is likely to cause pathophysiology. As contemplated herein, a parent molecular entity is administered to a patient in whom enzymatic competency is to be determined. A sample of the patient's bodily fluid is exposed to a sensor of the invention to distinguish, detect, and quantify a detectable entity in the bodily fluid. Sensor-acquired data regarding the detectable entity is used to determine enzymatic competency. Preferably, a sample of a patient's exhaled breath is collected and exposed to the sensor of the invention. Types of sensor systems of the invention include, but are not limited to, surface resonance arrays; microelectromechanical sensors (such as microcantilever-based technology); molecularly imprinted polymer sensors; amplifying fluorescent sensor technology; aptamer-based sensor technology; SAW sensors; infrared sensors; fuel cells; chemical reactors; and pH sensitive sensors.
摘要翻译：本发明提供了用于确定酶能力的系统和方法，其在确定患者是否可能遭受不良药物反应，具有与特定酶功能缺陷相关的疾病和/或具有可能引起酶缺陷的酶缺陷病理生理学。如本文所考虑的，母体分子实体被施用于待确定酶促能力的患者。将患者体液的样本暴露于本发明的传感器以区分，检测和量化体液中的可检测实体。使用传感器获取的关于可检测实体的数据来确定酶促能力。优选地，患者呼出气的样本被收集并暴露于本发明的传感器。本发明的传感器系统的类型包括但不限于表面共振阵列; 微机电传感器（如基于微悬臂梁的技术）; 分子印迹聚合物传感器; 放大荧光传感器技术; 基于适配子的传感器技术; 声表面波传感器; 红外传感器; 燃料电池; 化学反应器; 和pH敏感传感器。

5. 发明申请

WO2012024401A2 INTELLIGENT DRUG AND/OR FLUID DELIVERY SYSTEM TO OPTIMIZING MEDICAL TREATMENT OR THERAPY USING PHARMACODYNAMIC AND/OR PHARMACOKINETIC DATA 审中-公开
标题翻译：智能药物和/或流体输送系统优化药物治疗或使用药物动力学和/或药代动力学数据的治疗
公开(公告)号：WO2012024401A2
公开(公告)日：2012-02-23
申请号：PCT/US2011048083
申请日：2011-08-17
申请人： UNIV FLORIDA , MELKER RICHARD J , DENNIS DONN M , MELKER JEREMY , RICE MARK , HURLEY ROBERT
发明人： MELKER RICHARD J , DENNIS DONN M , MELKER JEREMY , RICE MARK , HURLEY ROBERT
IPC分类号： A61M5/14 , A61M5/142 , A61M5/172 , A61M39/08 , A61M39/22 , G05B13/02 , G06F19/00 , G06Q50/00
CPC分类号： A61M5/1723 , A61B5/0205 , A61B5/02416 , A61B5/0261 , A61B5/036 , A61B5/0408 , A61B5/0816 , A61B5/1455 , A61B5/4839 , A61M5/142 , A61M5/168 , A61M5/16854 , A61M5/172 , A61M5/31511 , G06F19/3468 , G06Q50/22 , G16H20/17
摘要： A pharmacodynamic (PD), pharmacokinetic (PK), or both and PK guided infusion device, system and method optimizes the safety and efficacy of various forms of treatment or therapy (e.g., drug and/or fluid) in a variety of health-care and other settings.
摘要翻译：药物动力学（PD），药代动力学（PK）或两者和PK引导的输注装置，系统和方法优化各种形式的治疗或疗法（例如药物和/或流体）在各种保健中的安全性和功效和其他设置。

6. 发明申请

WO2004037316A3 NANOPARTICLE DELIVERY SYSTEM 审中-公开
标题翻译：纳米颗粒传递系统
公开(公告)号：WO2004037316A3
公开(公告)日：2004-10-07
申请号：PCT/US0332355
申请日：2003-10-10
申请人： UNIV FLORIDA , DENNIS DONN M , MARTIN CHARLES R , ROGERS RICHARD J , STEWART JON D
发明人： DENNIS DONN M , MARTIN CHARLES R , ROGERS RICHARD J , STEWART JON D
IPC分类号： A61K9/51 , A61K47/48 , A61F2/02 , A61K9/14 , A61K9/50 , A61K33/44
CPC分类号： A61K9/0092 , A61K47/6849 , A61K47/6923 , B82Y5/00 , Y10T428/2984 , Y10T428/2987
摘要： The invention relates to the nanotubes of various sizes and composed of a wide variety of materials, or combination of materials . The invention also describes the use of such nanotubes for the delivery of various payloads and, in particular, for the in vivo delivery of bioactive substances.
摘要翻译：本发明涉及各种尺寸的纳米管，并且由多种材料或材料组合组成。本发明还描述了这种纳米管用于递送各种有效载荷的用途，并且特别是用于体内递送生物活性物质。

7. 发明申请

WO2012024106A3 CENTRAL SITE PHOTOPLETHYSMOGRAPHY, MEDICATION ADMINISTRATION, AND SAFETY 审中-公开
标题翻译：中心地点光电子学，药物管理和安全
公开(公告)号：WO2012024106A3
公开(公告)日：2012-06-14
申请号：PCT/US2011046943
申请日：2011-08-08
申请人： UNIV FLORIDA , XHALE INC , MELKER RICHARD J , DENNIS DONN M , MELKER JEREMY , RICE MARK , HURLEY ROBERT , GOLD MARK , ALLEN RICHARD
发明人： MELKER RICHARD J , DENNIS DONN M , MELKER JEREMY , RICE MARK , HURLEY ROBERT , GOLD MARK , ALLEN RICHARD
IPC分类号： A61B5/02 , A61B5/0205 , A61B5/087 , A61B5/145
CPC分类号： A61M5/1723 , A61B5/002 , A61B5/0205 , A61B5/024 , A61B5/0402 , A61B5/0816 , A61B5/0826 , A61B5/0836 , A61B5/14551 , A61B5/4818 , A61B5/4821 , A61B5/4839 , A61B5/6803 , A61B5/7246 , A61M16/00 , A61M16/0051 , A61M16/026 , A61M16/0666 , A61M16/0677 , A61M16/10 , A61M16/161 , A61M2016/0027 , A61M2205/3368 , A61M2230/04 , A61M2230/205 , A61M2230/432 , G06F19/3456 , G06F19/3468
摘要： A monitoring and control system, apparatus and method for safe administration, reduction or cessation of administration of at least on medication, fluid or both, which includes at least one Central Source Site (CSS) Photoplethysmography (PPG) sensor coupled to means for control of delivery of the at least one medication, fluid or both.
摘要翻译：用于至少在药物，流体或两者上施用的安全管理，减少或停止的监测和控制系统，装置和方法，所述监测和控制系统，装置和方法包括至少一个中央源站点（CSS）Photoplethysmography（PPG）传感器，耦合到用于控制递送至少一种药物，流体或两者。

8. 发明公开

EP2605698A4 CENTRAL SITE PHOTOPLETHYSMOGRAPHY, MEDICATION ADMINISTRATION, AND SAFETY 有权转让
标题翻译： PHOTOPLETHYSMOGRAPHIE，MEDIKAMENTENABGABE UND SICHERHEITSHERSTELLUNG AN EINEM ZENTRALEN STANDORT
公开(公告)号：EP2605698A4
公开(公告)日：2017-05-10
申请号：EP11818556
申请日：2011-08-08
申请人： UNIV FLORIDA , XHALE INC
发明人： MELKER RICHARD J , DENNIS DONN M , MELKER JEREMY , RICE MARK , HURLEY ROBERT , GOLD MARK , ALLEN RICHARD
IPC分类号： A61B5/02 , A61B5/0205 , A61B5/087 , A61B5/145 , G06F19/00
CPC分类号： A61M5/1723 , A61B5/002 , A61B5/0205 , A61B5/024 , A61B5/0402 , A61B5/0816 , A61B5/0826 , A61B5/0836 , A61B5/14551 , A61B5/4818 , A61B5/4821 , A61B5/4839 , A61B5/6803 , A61B5/7246 , A61M16/00 , A61M16/0051 , A61M16/026 , A61M16/0666 , A61M16/0677 , A61M16/10 , A61M16/161 , A61M2016/0027 , A61M2205/3368 , A61M2230/04 , A61M2230/205 , A61M2230/432 , G06F19/3456 , G06F19/3468
摘要： A monitoring and control system, apparatus and method for safe administration, reduction or cessation of administration of at least on medication, fluid or both, which includes at least one Central Source Site (CSS) Photoplethysmography (PPG) sensor coupled to means for control of delivery of the at least one medication, fluid or both.
摘要翻译：一种用于安全施用，减少或停止施用至少一种药物，流体或两者的监测和控制系统，装置和方法，其包括至少一个中央源位点（CSS）光电容积脉搏波传感器（PPG）传感器，其耦合到用于控制输送至少一种药物，流体或两者。

9. 发明公开

EP1414497A4 NOVEL MICROEMULSION AND MICELLE SYSTEMS FOR SOLUBILIZING DRUGS 审中-公开
标题翻译：新的微乳液和胶束增溶的药物
公开(公告)号：EP1414497A4
公开(公告)日：2007-11-21
申请号：EP02761231
申请日：2002-08-05
申请人： UNIV FLORIDA
发明人： DENNIS DONN M , GRAVENSTEIN NIKOLAUS , MODELL JEROME H , MOREY TIMOTHY E , SHAH DINESH O
IPC分类号： A61K47/30 , A61K9/107 , A61K47/32 , A61K47/34
CPC分类号： A61K9/1075 , A61K47/12 , A61K47/34
摘要： A nicroemulsion delivery system for water insoluble or sparingly water soluble drugs that comprises a long polymer chain surfactant component and a short fatty acid surfactant component, with the amount of each being selected to providestable microemulsion or micellar systems.

10. 发明专利

CA2845712A1 SMARTTM SOLID ORAL DOSAGE FORMS 未知
公开(公告)号：CA2845712A1
公开(公告)日：2013-03-21
申请号：CA2845712
申请日：2012-09-14
申请人： UNIV FLORIDA
发明人： DENNIS DONN M , MELKER RICHARD J
IPC分类号： A61J3/07 , A61B5/08 , A61B5/083 , A61K9/48 , A61K47/08 , A61K47/10 , A61K49/00
摘要： Solid Oral Dosage Forms (SODFs) comprising Self Monitoring and Reporting Therapeutics (SMART) adherence technology are provided which require no or minimal modification of clinical trial materials (CTMs) or marketed drug while providing tamper resistant (literally foolproof) measurement of adherence that is highly accurate and without altering the chemical, manufacturing, and controls (CMC) of the CTM or marketed drug.

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