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1. 发明申请

WO2003088948A3 MICROEMULSIONS FOR SELECTIVE MOLECULAR SEPARATION 审中-公开
公开(公告)号：WO2003088948A3
公开(公告)日：2003-10-30
申请号：PCT/US2003/013570
申请日：2003-04-22
申请人： UNIVERSITY OF FLORIDA , DENNIS, Donn, M. , MOREY, Timothy, E. , PARTCH, Richard, E. , SHAH, Dinesh, O. , VARSHNEY, Manoj
发明人： DENNIS, Donn, M. , MOREY, Timothy, E. , PARTCH, Richard, E. , SHAH, Dinesh, O. , VARSHNEY, Manoj
IPC分类号： A61K9/107
摘要： The subject invention provides unique materials and methods for selectively removing molecules from a medium. In a preferred embodiment of the subject invention, microemulsions are specifically designed to facilitate effective separation of even closely related chemical entities.

2. 发明申请

WO2009100011A3 TARGETED CELLULAR SELECTIVITY OF SURFACE ACTIVE MOLECULES 审中-公开
公开(公告)号：WO2009100011A3
公开(公告)日：2009-08-13
申请号：PCT/US2009/032851
申请日：2009-02-02
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , MOUDGIL, Brij, M. , VARSHNEY, Manoj , GROBMYER, Stephen, R.
发明人： MOUDGIL, Brij, M. , VARSHNEY, Manoj , GROBMYER, Stephen, R.
IPC分类号： A61K31/765 , A61P35/00 , A61K35/413 , A61K49/06
摘要： A method for the treatment of cancer involves delivering a surface active agent to an organism, where the surface active agent selectively partitions to and kills cancer cells as opposed to healthy cells. The surface active agent can be an ionic or a non-ionic surfactant with a HLB of less than 29 or a mixture of surface active agents with a HLB of less than 40, where the hydrophobic portion is a lesser fraction of the surface active agent than the hydrophilic portion. A fluorescence method of detecting and locating cancer cells in an organism involves delivering a surface active agent, where the surface active agent includes a fluorescence moiety that upon selective partitioning of the surface active agent to the cancer cells and irradiation by a radiation source to excite the fluorescence moiety, a fluorescence emission is observed permitting the detection and location of the cancerous tissue by local volumes of relatively high intensity emission.

3. 发明申请

WO2006135415A2 MICELLES AND NANOEMULSIONS FOR PREVENTATIVE AND REACTIVE TREATMENT OF ATHEROSCLEROSIS 审中-公开
标题翻译：用于预防和反应性治疗甲状腺功能亢进症的细胞和纳米抗体
公开(公告)号：WO2006135415A2
公开(公告)日：2006-12-21
申请号：PCT/US2005/031840
申请日：2005-09-08
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , VARSHNEY, Manoj , SHAH, Dinesh, O.
发明人： VARSHNEY, Manoj , SHAH, Dinesh, O.
CPC分类号： A61K9/1075
摘要： The subject invention is directed to microemulsion-based (ME) nanoparticles and methods of using same. The ME nanoparticles of the subject invention encompass self-assemblies of oil in water emulsions in the presence of at least two emulsifiers. One of the emulsifiers is a salt of a fatty acid, and the combined concentration of the at least two emulsifiers is sufficiently large to produce micelles, wherein the oil droplets are the hydrophobic core of the micelles. The subject invention also contemplates methods of modifying lipids, high density lipoprotein (HDL), and low density lipoprotein (LDL) in blood by contacting the blood with the ME nanoparticles of the subject invention. Another aspect concerns methods for treating atherosclerosis by administering the ME nanoparticles of the subject invention to a patient in need thereof.
摘要翻译：本发明涉及基于微乳液的（ME）纳米颗粒及其使用方法。本发明的ME纳米颗粒包括在至少两种乳化剂存在下的水包油乳液的自组装。乳化剂之一是脂肪酸的盐，并且至少两种乳化剂的组合浓度足够大以产生胶束，其中油滴是胶束的疏水核心。本发明还考虑通过使血液与本发明的ME纳米颗粒接触来改变血液中脂质，高密度脂蛋白（HDL）和低密度脂蛋白（LDL）的方法。另一方面涉及通过将本发明的ME纳米颗粒给予有需要的患者来治疗动脉粥样硬化的方法。

4. 发明申请

WO2009100011A2 TARGETED CELLULAR SELECTIVITY OF SURFACE ACTIVE MOLECULES 审中-公开
标题翻译：表面活性分子的靶向细胞选择性
公开(公告)号：WO2009100011A2
公开(公告)日：2009-08-13
申请号：PCT/US2009032851
申请日：2009-02-02
申请人： UNIV FLORIDA , MOUDGIL BRIJ M , VARSHNEY MANOJ , GROBMYER STEPHEN R
发明人： MOUDGIL BRIJ M , VARSHNEY MANOJ , GROBMYER STEPHEN R
IPC分类号： A61K31/765 , A61K49/06 , A61P35/00
CPC分类号： A61K49/0017 , A61K31/765 , A61K47/543 , A61K47/60
摘要： A method for the treatment of cancer involves delivering a surface active agent to an organism, where the surface active agent selectively partitions to and kills cancer cells as opposed to healthy cells. The surface active agent can be an ionic or a non-ionic surfactant with a HLB of less than 29 or a mixture of surface active agents with a HLB of less than 40, where the hydrophobic portion is a lesser fraction of the surface active agent than the hydrophilic portion. A fluorescence method of detecting and locating cancer cells in an organism involves delivering a surface active agent, where the surface active agent includes a fluorescence moiety that upon selective partitioning of the surface active agent to the cancer cells and irradiation by a radiation source to excite the fluorescence moiety, a fluorescence emission is observed permitting the detection and location of the cancerous tissue by local volumes of relatively high intensity emission.
摘要翻译：用于治疗癌症的方法包括将表面活性剂递送至生物体，其中表面活性剂选择性分配并杀死癌细胞而非健康细胞。表面活性剂可以是HLB小于29的离子或非离子表面活性剂或HLB小于40的表面活性剂的混合物，其中疏水部分是表面活性剂的较少部分亲水部分。检测和定位生物体中的癌细胞的荧光方法涉及递送表面活性剂，其中表面活性剂包括荧光部分，所述荧光部分在表面活性剂选择性分配到癌细胞上并通过辐射源辐射以激发荧光部分，观察到荧光发射，允许通过相对高强度发射的局部体积检测和定位癌组织。

5. 发明申请

WO2006135415A3 MICELLES AND NANOEMULSIONS FOR PREVENTATIVE AND REACTIVE TREATMENT OF ATHEROSCLEROSIS 审中-公开
标题翻译：用于预防和反应性治疗甲状腺功能亢进症的细胞和纳米抗体
公开(公告)号：WO2006135415A3
公开(公告)日：2007-03-01
申请号：PCT/US2005031840
申请日：2005-09-08
申请人： UNIV FLORIDA , VARSHNEY MANOJ , SHAH DINESH O
发明人： VARSHNEY MANOJ , SHAH DINESH O
IPC分类号： A61K9/107
CPC分类号： A61K9/1075
摘要： The subject invention is directed to microemulsion-based (ME) nanoparticles and methods of using same. The ME nanoparticles of the subject invention encompass self-assemblies of oil in water emulsions in the presence of at least two emulsifiers. One of the emulsifiers is a salt of a fatty acid, and the combined concentration of the at least two emulsifiers is sufficiently large to produce micelles, wherein the oil droplets are the hydrophobic core of the micelles. The subject invention also contemplates methods of modifying lipids, high density lipoprotein (HDL), and low density lipoprotein (LDL) in blood by contacting the blood with the ME nanoparticles of the subject invention. Another aspect concerns methods for treating atherosclerosis by administering the ME nanoparticles of the subject invention to a patient in need thereof.
摘要翻译：本发明涉及基于微乳液的（ME）纳米颗粒及其使用方法。本发明的ME纳米颗粒包括在至少两种乳化剂存在下的水包油乳液的自组装。乳化剂之一是脂肪酸的盐，并且至少两种乳化剂的组合浓度足够大以产生胶束，其中油滴是胶束的疏水核心。本发明还考虑通过使血液与本发明的ME纳米颗粒接触来改变血液中脂质，高密度脂蛋白（HDL）和低密度脂蛋白（LDL）的方法。另一方面涉及通过将本发明的ME纳米颗粒给予有需要的患者来治疗动脉粥样硬化的方法。

6. 发明申请

WO2003088948A2 MICROEMULSIONS FOR SELECTIVE MOLECULAR SEPARATION 审中-公开
标题翻译：用于选择性分子分离的微乳液
公开(公告)号：WO2003088948A2
公开(公告)日：2003-10-30
申请号：PCT/US2003/013570
申请日：2003-04-22
申请人： UNIVERSITY OF FLORIDA , DENNIS, Donn, M. , MOREY, Timothy, E. , PARTCH, Richard, E. , SHAH, Dinesh, O. , VARSHNEY, Manoj
发明人： DENNIS, Donn, M. , MOREY, Timothy, E. , PARTCH, Richard, E. , SHAH, Dinesh, O. , VARSHNEY, Manoj
IPC分类号： A61K9/00
CPC分类号： A61K31/55 , A61K9/1075 , A61K31/445 , B01J20/28
摘要： The subject invention provides unique materials and methods for selectively removing molecules from a medium. In a preferred embodiment of the subject invention, microemulsions are specifically designed to facilitate effective separation of even closely related chemical entities.
摘要翻译：本发明提供了用于从介质中选择性去除分子的独特材料和方法。在本发明的一个优选实施方案中，微乳液被特别设计以促进甚至密切相关的化学实体的有效分离。

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