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1. 发明申请

WO2006019520A3 MAGNETIC DEVICES AND METHODS FOR RESHAPING HEART ANATOMY 审中-公开
标题翻译：磁性装置和用于重建心脏解剖的方法
公开(公告)号：WO2006019520A3
公开(公告)日：2006-12-21
申请号：PCT/US2005022461
申请日：2005-06-23
申请人： MICARDIA CORP , MOADDEB SHAHRAM , SHAOLIAN SAMUEL M , SHAOULIAN EMANUEL , RHEE RICHARD , ANDERSON SETEVEN C
发明人： MOADDEB SHAHRAM , SHAOLIAN SAMUEL M , SHAOULIAN EMANUEL , RHEE RICHARD , ANDERSON SETEVEN C
IPC分类号： A61F2/00 , A61M1/12
CPC分类号： A61F2/2478 , A61B17/3468 , A61B2017/00876 , A61F2/2481 , A61F2/2487 , A61F2002/249 , A61F2210/009
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Heart dilation treated by reshaping the heart anatomy with the use of magnetic forces. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The magnetic forces are applied with the use of one or more magnetic elements which are implanted within the heart tissue or attached externally and/or internally to a surface of the heart. The various charges of the magnetic forces interact causing the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the force of the magnetic elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
摘要翻译：提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。通过使用磁力重塑心脏解剖结构治疗的心脏扩张。这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加脑室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。使用一个或多个植入心脏组织内或附着在心脏外表面和/或内部的磁性元件施加磁力。磁力的各种电荷相互作用，使相关的心脏组织区域重新调整位置，例如减小心室的宽度。这种重新定位通过磁性元件的力量随着时间的推移而保持，从而允许心脏扩张的破坏性作用在进展或反转中缓慢。

2. 发明申请

WO2006019521A3 SHAPE MEMORY DEVICES AND METHODS FOR RESHAPING HEART ANATOMY 审中-公开
标题翻译：形状记忆装置和用于重建心脏解剖的方法
公开(公告)号：WO2006019521A3
公开(公告)日：2006-12-21
申请号：PCT/US2005022462
申请日：2005-06-23
申请人： MICARDIA CORP , MOADDEB SHAHRAM , SHAOLIAN SAMUEL M , SHAOULIAN EMANUEL , RHEE RICHARD , ANDERSON SETEVEN C
发明人： MOADDEB SHAHRAM , SHAOLIAN SAMUEL M , SHAOULIAN EMANUEL , RHEE RICHARD , ANDERSON SETEVEN C
IPC分类号： A61F2/00
CPC分类号： A61F2/2478 , A61B17/3468 , A61B2017/00876 , A61F2/2481 , A61F2/2487 , A61F2002/249 , A61F2210/009
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Such heart dilation is treated by reshaping the heart anatomy with the use of shape memory elements. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The shape memory elements have an original shape and at least one memory shape. The elements are implanted within the heart tissue or attached externally and/or internally to a surface of the heart when in the original shape. The elements are then activated to transition from the original shape to one of the at least one memory shapes. Transitioning of the elements cause the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles
摘要翻译：提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。通过使用形状记忆元件重建心脏解剖结构来治疗这种心脏扩张。这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加脑室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。形状记忆元件具有原始形状和至少一种存储器形状。当原始形状时，将元件植入心脏组织内或外部和/或内部附着到心脏的表面。元件然后被激活以从原始形状转换到至少一个存储器形状之一。元件的过渡导致相关的心脏组织区域重新调整位置，例如减小心室的宽度

3. 发明申请

WO2006116129A2 DYNAMICALLY ADJUSTABLE IMPLANTS AND METHODS FOR RESHAPING TISSUE 审中-公开
标题翻译：动态可调节的植入物和用于修复组织的方法
公开(公告)号：WO2006116129A2
公开(公告)日：2006-11-02
申请号：PCT/US2006015165
申请日：2006-04-21
申请人： MICARDIA CORP , SHAOULIAN EMANUEL , MOADDEB SHAHRAM , SHAOLIAN SAMUEL M
发明人： SHAOULIAN EMANUEL , MOADDEB SHAHRAM , SHAOLIAN SAMUEL M
IPC分类号： A61F2/24 , A61F2/86
CPC分类号： A61F2/2451 , A61F2250/0001 , A61F2250/0039
摘要： Tissue shaping devices and methods are provided. The devices (120) can be adjusted within the body of a patient in a less invasive or non-invasive manner, such as by applying energy percutaneously or external (1300) to the patient's body. In one example, the device (120) is positioned within the coronary sinus (104) of the patient so as to effect changes in at least one dimension of the mitral valve annulus (116). The device (120) may also advantageously include a shape memory material that is responsive to changes in temperature and/or exposure to a magnetic field. In one example, the shape memory material is responsive to energy, such as electromagnetic or acoustic energy, applied from an energy source located outside the coronary sinus (104). A material having enhanced absorption characteristics with respect to the desired heating energy may also be used to facilitate heating and adjustment of the tissue shaping device (120).
摘要翻译：提供组织整形装置和方法。装置（120）可以以较少侵入性或非侵入性方式在患者体内调节，例如通过经皮或外部（1300）将能量施加到患者身体。在一个示例中，装置（120）定位在患者的冠状窦（104）内，以便实现二尖瓣环（116）的至少一个维度的变化。装置（120）还可以有利地包括响应温度变化和/或暴露于磁场的形状记忆材料。在一个示例中，形状记忆材料响应于从位于冠状窦（104）外部的能量源施加的能量，例如电磁或声能。相对于期望的加热能量具有增强的吸收特性的材料也可用于促进组织整形装置（120）的加热和调节。

4. 发明申请

WO2007030417A3 SLOTTED ANNULOPLASTY RING 审中-公开
标题翻译：缝合ANNULOPLASTY环
公开(公告)号：WO2007030417A3
公开(公告)日：2009-04-16
申请号：PCT/US2006034428
申请日：2006-09-01
申请人： MICARDIA CORP , SHAOLIAN SAMUEL M , RHEE RICHARD S , SHAOULIAN EMANUEL , MOADDEB SHAHRAM
发明人： RHEE RICHARD S , SHAOULIAN EMANUEL , MOADDEB SHAHRAM
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2250/0001 , A61F2250/0004
摘要： Methods and devices are provided for support of a body structure. The device can be adjusted within the patient's body in a minimally or non-invasive manner, by applying energy percutaneously or externally to the body. The energy may include: acoustic, light, magnetic, or radio frequency energy. As the body structure changes the size and/or shape of the annuloplasty rings adjusts to provide continued reinforcement. In certain embodiments, the device (3500) includes a body member (3502) and an insert member (3504). Th body member (3502) has a slot (3506) that extends at least partially along the circumference of the body (3502). The insert member (3504) extends at least partially along the circumference of the body (3502). The device (3500) has a first shape in a first configuration which transforms to a second shape in a second configuration in response to an activation energy applied thereto.
摘要翻译：提供了用于支撑身体结构的方法和装置。通过将能量经皮或外部施加于身体，该装置可以以最低限度或非侵入性的方式在患者体内进行调节。能量可以包括：声，光，磁或射频能量。随着身体结构改变，瓣环成形术环的尺寸和/或形状调整以提供持续的加强。在某些实施例中，装置（3500）包括主体构件（3502）和插入构件（3504）。本体构件（3502）具有至少部分地沿主体（3502）的圆周延伸的狭槽（3506）。插入构件（3504）至少部分地沿主体（3502）的圆周延伸。装置（3500）具有第一构造的第一形状，其响应于施加到其上的活化能而以第二构造转变为第二形状。

5. 发明申请

WO2008006002A3 METHODS AND SYSTEMS FOR CARDIAC REMODELING VIA RESYNCHRONIZATION 审中-公开
标题翻译：通过再次心脏再造的方法和系统
公开(公告)号：WO2008006002A3
公开(公告)日：2008-12-31
申请号：PCT/US2007072786
申请日：2007-07-03
申请人： MICARDIA CORP , MOADDEB SHAHRAM , SHAOLIAN SAMUEL M , SHAOULIAN EMANUEL
发明人： MOADDEB SHAHRAM , SHAOLIAN SAMUEL M , SHAOULIAN EMANUEL
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/0597 , A61N1/3622 , A61N1/3968
摘要： Systems, methods and devices are provided for improving the hemodynamic efficiency of a patient's heart by implanting one or more reinforcement elements on or with the heart and providing electrical stimulation to the heart. The reinforcement elements may include magnetic and/or shape memory material and are configured to reshape the heart so as to boost the heart's mechanical energy during a response to the electrical stimulation. In some embodiments, at least one reinforcement element includes an electrode configured to sense electrocardiogram signals within the heart. An electrical stimulation device such as an implantable or external pacemaker/defibrillator may be configured to control delivery of electrical pulses to the heart based on the sensed electrocardiogram signals. In addition, or in other embodiments, at least one reinforcement element includes an electrode configured to deliver the electrical pulses to the heart.
摘要翻译：提供了系统，方法和装置，用于通过在心脏上或与心脏一起植入一个或多个增强元件并向心脏提供电刺激来改善患者心脏的血液动力学效率。加强元件可以包括磁性和/或形状的记忆材料，并且被配置成重塑心脏，以便在对电刺激的响应期间增强心脏的机械能。在一些实施例中，至少一个加强元件包括被配置为感测心脏内的心电图信号的电极。诸如植入式或外部起搏器/除颤器之类的电刺激装置可以被配置成基于感测到的心电图信号来控制向心脏的电脉冲的传递。另外或在其它实施例中，至少一个加强元件包括被配置为将电脉冲传送到心脏的电极。

6. 发明申请

WO2006012038A3 SELECTIVELY ADJUSTABLE CARDIAC VALVE IMPLANTS 审中-公开
标题翻译：选择性可调节的心脏瓣膜植入物
公开(公告)号：WO2006012038A3
公开(公告)日：2006-10-26
申请号：PCT/US2005021324
申请日：2005-06-16
申请人： MICARDIA CORP , SHAOULIAN EMANUEL , SHAOLIAN SAMUEL , MOADDEB SHAHRAM
发明人： SHAOULIAN EMANUEL , SHAOLIAN SAMUEL , MOADDEB SHAHRAM
IPC分类号： A61F2/28 , A61F2/00 , A61F2/02 , A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by apply energy to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过将能量施加于患者身体。能量可以包括例如声能，射频能量，光能和磁能。因此，当身体结构改变尺寸和/或形状时，可以调节装置的尺寸和/或形状以提供持续的加强。

7. 发明申请

WO2006012013A3 ADJUSTABLE CARDIAC VALVE IMPLANT WITH SELECTIVE DIMENSIONAL ADJUSTMENT 审中-公开
标题翻译：可调心脏瓣膜植入物选择性尺寸调整
公开(公告)号：WO2006012013A3
公开(公告)日：2006-12-28
申请号：PCT/US2005021141
申请日：2005-06-15
申请人： MICARDIA CORP , RHEE RICHARD , SHAOULIAN EMANUEL , MOADDEB SHAHRAM , SHAOLIAN SAMUEL
发明人： RHEE RICHARD , SHAOULIAN EMANUEL , MOADDEB SHAHRAM , SHAOLIAN SAMUEL
IPC分类号： A61F2/24 , A61F2/00 , A61F2/02
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement. In one embodiment, an annuloplasty ring (1826) includes an anterior portion, a posterior portion and two lateral portions corresponding to intersections of the anterior portion and the posterior portion. The annuloplasty ring (1826) has a first shape in a first configuration and a second shape in a second configuration and is configured to transform from the first configuration to the second configuration in response to an activation energy applied thereto. The transformation is configured to reduce a distance between the anterior portion and the posterior portion without substantially decreasing a distance between the two lateral portions.
摘要翻译：提供了用于支持身体结构的方法和设备。可以以微创或非侵入方式在患者身体内调整装置，例如通过经皮或外部施加能量到患者身体。能量可以包括例如声能，射频能量，光能和磁能。因此，随着身体结构改变尺寸和/或形状，可以调整装置的尺寸和/或形状以提供连续的增强。在一个实施例中，瓣环成形术环（1826）包括前部，后部和对应于前部和后部的交点的两个侧部。瓣环成形术环（1826）具有第一构型的第一形状和第二构型的第二形状，并且构造成响应于施加到其上的激活能量从第一构型转变为第二构型。该变换被配置成减小前部和后部之间的距离而基本上不减小两个侧部之间的距离。

8. 发明申请

WO2006012011B1 ADJUSTABLE CARDIAC VALVE IMPLANT WITH COUPLING MECHANISM 审中-公开
公开(公告)号：WO2006012011B1
公开(公告)日：2006-11-02
申请号：PCT/US2005021136
申请日：2005-06-15
申请人： MICARDIA CORP , SHAOULIAN EMANUEL , SHAOLIAN SAMUEL , MOADDEB SHAHRAM
发明人： SHAOULIAN EMANUEL , SHAOLIAN SAMUEL , MOADDEB SHAHRAM
IPC分类号： A61F2/06 , A61F2/00 , A61F2/02 , A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement. In one embodiment, an annuloplasty ring (100) includes a tubular member (112) configured to be attached to or near a cardiac valve annulus. The tubular member (112) includes a receptacle end (114) and an insert end (116) configured to couple with the receptacle end (114) of the tubular member (112) such that the tubular member (112) substantially forms a shape of a ring. The insert end (116) is configured to move with respect to the receptacle end (114) to change a circumference of the ring.

9. 发明申请

WO2006012068A2 THERMAL CONDUCTOR FOR ADJUSTABLE CARDIAC IMPLANT 审中-公开
标题翻译：用于可调节心脏植入物的导热体
公开(公告)号：WO2006012068A2
公开(公告)日：2006-02-02
申请号：PCT/US2005021597
申请日：2005-06-17
申请人： MICARDIA CORP , RHEE RICHARD , SHAOULIAN EMANUEL , MOADDEB SHAHRAM , SHAOLIAN SAMUEL
发明人： RHEE RICHARD , SHAOULIAN EMANUEL , MOADDEB SHAHRAM , SHAOLIAN SAMUEL
IPC分类号： A61F2/24 , A61F2/00 , A61F2/02
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement. In one embodiment, an annuloplasty ring (2600) includes a body member (800) including a shape memory material. The shape memory material is configured to transform the body member 800 from a first shape to a second shape in response to being heated. The annuloplasty ring (2600) also includes a thermally insulative material (912) at least partially covering the body member (800) and a thermally conductive material (2610, 2612, 2614) extending into the thermally insulative material (912). The thermally conductive material (2610, 2612, 2614) is configured to communicate thermal energy to the body member (800).
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，当身体结构改变尺寸和/或形状时，可以调节装置的尺寸和/或形状以提供持续的加强。在一个实施例中，瓣膜成形术环（2600）包括包括形状记忆材料的主体构件（800）。形状记忆材料被配置为响应于加热而将本体构件800从第一形状转变为第二形状。瓣膜成形术环（2600）还包括至少部分地覆盖主体构件（800）的热绝缘材料（912）和延伸到绝热材料（912）中的导热材料（2610,2612,2614）。导热材料（2610,2612,2614）构造成将热能传递到主体部件（800）。

10. 发明申请

WO2006086627A3 DYNAMICALLY ADJUSTABLE GASTRIC IMPLANTS AND METHODS OF TREATING OBESITY USING DYNAMICALLY ADJUSTABLE GASTRIC IMPLANTS 审中-公开
标题翻译：动态可调节的植入式植入物和使用动态可调节的植入物处理肥胖的方法
公开(公告)号：WO2006086627A3
公开(公告)日：2007-10-04
申请号：PCT/US2006004728
申请日：2006-02-10
申请人： MICARDIA CORP , LEMBO NICHOLAS J , MOADDEB SHAHRAM , SHAOULIAN EMANUEL , SHAOLIAN SAMUEL , HENSON MICHAEL R
发明人： LEMBO NICHOLAS J , MOADDEB SHAHRAM , SHAOULIAN EMANUEL , SHAOLIAN SAMUEL , HENSON MICHAEL R
IPC分类号： A61B17/04 , A61B17/12
CPC分类号： A61F5/0079 , A61F5/0053 , A61F5/0086 , A61F2002/044
摘要： Implants for treatment of obesity may be placed within the stomach and/or esophagus or around the outside surface of the stomach and/or esophagus. The implants comprise at least a portion constructed of a shape memory material. The implants are thus adapted to be implanted in a deformed shape, and then to be transformed through the application of activation energy into a memorized shape. The shape and/or size transformation induces a change in shape of the stomach and/or esophagus, thus altering the normal digestive path of food entering the patient's gastrointestinal tract.
摘要翻译：用于治疗肥胖的植入物可以放置在胃和/或食道内或胃和/或食道的外表面周围。植入物包括由形状记忆材料构成的至少一部分。因此，植入物适于以变形的形状植入，然后通过将活化能量施加到记忆形状中而变形。形状和/或尺寸转换引起胃和/或食道的形状变化，从而改变进入患者胃肠道的食物的正常消化道。

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