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    • 1. 发明申请
    • USE OF A GALECTIN-1-TRAGETED RNAI-BASED APPROACH FOR THE TREATMENT OF CANCER
    • GALECTIN-1-TRAGETED基于RNAi的方法在治疗癌症中的应用
    • WO2006108474A2
    • 2006-10-19
    • PCT/EP2006/002170
    • 2006-03-09
    • UNIVERSITE LIBRE DE BRUXELLESUNIVERSITE CATHOLIQUE DE LOUVAINCAMBY, IsabelleHENRIET, PatrickLEFRANC, FlorenceCOURTOY, PierreKISS, Robert
    • CAMBY, IsabelleHENRIET, PatrickLEFRANC, FlorenceCOURTOY, PierreKISS, Robert
    • C12N15/11A61K48/00
    • C12N15/1138C12N15/113C12N2310/111C12N2310/14C12N2310/53
    • The present invention relates to an RNAi molecule suitable for reducing the expression of galectin-1 containing any of the sequences of SEQ ID NOs: 1-33, and preferably the sequences of SEQ ID NO: 2, 3, or 4, and to the use thereof as a medicament, or for the manufacture of a medicament for treating and/or for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma. The present invention also relates to compositions and methods for treating and for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, for reducing the migration of tumor cells, preferably cells of glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, and/or for enhancing the efficacy of cancer therapies for the treatment of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, selected from the group comprising chemotherapy, radiation therapy, immunotherapy, and/or gene therapy.
    • 本发明涉及适用于减少包含SEQ ID NO:1-33的任何序列,并且优选SEQ ID NO:2的序列的半乳糖凝集素-1的表达的RNAi分子, 3或4的化合物,以及其作为药物的用途,或用于制造治疗和/或延缓癌症进展的药物,优选神经胶质瘤,胰腺癌,头颈癌,黑素瘤,非小细胞肺癌, 细胞肺癌和非霍奇金淋巴瘤。 本发明还涉及用于治疗和延缓癌症进展的组合物和方法,所述癌症优选神经胶质瘤,胰腺癌,头颈癌,黑素瘤,非小细胞肺癌和非霍奇金淋巴瘤,用于减少 肿瘤细胞,优选神经胶质瘤细胞,胰腺癌,头颈癌,黑素瘤,非小细胞肺癌和非霍奇金淋巴瘤,和/或用于增强癌症疗法治疗癌症,优选神经胶质瘤的效力, 胰腺癌,头颈癌,黑素瘤,非小细胞肺癌和非何杰金氏淋巴瘤,其选自包括化学疗法,放射疗法,免疫疗法和/或基因疗法的组。
    • 3. 发明申请
    • USE OF A GALECTIN-1-TRAGETED RNAI-BASED APPROACH FOR THE TREATMENT OF CANCER
    • 用于治疗癌症的GALECTIN-1-TRAGETED基于RNAi的方法的应用
    • WO2006108474A3
    • 2006-12-21
    • PCT/EP2006002170
    • 2006-03-09
    • UNIV BRUXELLESUNIV LOUVAINCAMBY ISABELLEHENRIET PATRICKLEFRANC FLORENCECOURTOY PIERREKISS ROBERT
    • CAMBY ISABELLEHENRIET PATRICKLEFRANC FLORENCECOURTOY PIERREKISS ROBERT
    • A61K48/00C12N15/113
    • C12N15/1138C12N15/113C12N2310/111C12N2310/14C12N2310/53
    • The present invention relates to an RNAi molecule suitable for reducing the expression of galectin-1 containing any of the sequences of SEQ ID NOs: 1-33, and preferably the sequences of SEQ ID NO: 2, 3, or 4, and to the use thereof as a medicament, or for the manufacture of a medicament for treating and/or for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma. The present invention also relates to compositions and methods for treating and for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, for reducing the migration of tumor cells, preferably cells of glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, and/or for enhancing the efficacy of cancer therapies for the treatment of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, selected from the group comprising chemotherapy, radiation therapy, immunotherapy, and/or gene therapy.
    • 本发明涉及适用于降低含有SEQ ID NO:1-33的任何序列,优选SEQ ID NO:2,3或4的序列的半乳凝素-1的表达的RNAi分子,并且涉及 或用于制备用于治疗和/或延迟癌症进展的药物,优选神经胶质瘤,胰腺癌,头颈癌,黑素瘤,非小细胞肺癌和非霍奇金淋巴瘤 。 本发明还涉及用于治疗和延迟癌症,优选神经胶质瘤,胰腺癌,头颈癌,黑素瘤,非小细胞肺癌和非霍奇金淋巴瘤的进展的组合物和方法,用于减少 肿瘤细胞,优选胶质瘤细胞,胰腺癌,头颈癌,黑素瘤,非小细胞肺癌和非霍奇金淋巴瘤,和/或用于增强癌症疗法治疗癌症的功效,优选神经胶质瘤, 胰腺癌,头颈癌,黑素瘤,非小细胞肺癌和非霍奇金淋巴瘤,选自化疗,放射治疗,免疫治疗和/或基因治疗。