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1. 发明申请

WO2006108474A2 USE OF A GALECTIN-1-TRAGETED RNAI-BASED APPROACH FOR THE TREATMENT OF CANCER 审中-公开
标题翻译： GALECTIN-1-TRAGETED基于RNAi的方法在治疗癌症中的应用
公开(公告)号：WO2006108474A2
公开(公告)日：2006-10-19
申请号：PCT/EP2006/002170
申请日：2006-03-09
申请人： UNIVERSITE LIBRE DE BRUXELLES , UNIVERSITE CATHOLIQUE DE LOUVAIN , CAMBY, Isabelle , HENRIET, Patrick , LEFRANC, Florence , COURTOY, Pierre , KISS, Robert
发明人： CAMBY, Isabelle , HENRIET, Patrick , LEFRANC, Florence , COURTOY, Pierre , KISS, Robert
IPC分类号： C12N15/11 , A61K48/00
CPC分类号： C12N15/1138 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to an RNAi molecule suitable for reducing the expression of galectin-1 containing any of the sequences of SEQ ID NOs: 1-33, and preferably the sequences of SEQ ID NO: 2, 3, or 4, and to the use thereof as a medicament, or for the manufacture of a medicament for treating and/or for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma. The present invention also relates to compositions and methods for treating and for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, for reducing the migration of tumor cells, preferably cells of glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, and/or for enhancing the efficacy of cancer therapies for the treatment of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, selected from the group comprising chemotherapy, radiation therapy, immunotherapy, and/or gene therapy.
摘要翻译：本发明涉及适用于减少包含SEQ ID NO：1-33的任何序列，并且优选SEQ ID NO：2的序列的半乳糖凝集素-1的表达的RNAi分子， 3或4的化合物，以及其作为药物的用途，或用于制造治疗和/或延缓癌症进展的药物，优选神经胶质瘤，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌，细胞肺癌和非霍奇金淋巴瘤。本发明还涉及用于治疗和延缓癌症进展的组合物和方法，所述癌症优选神经胶质瘤，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤，用于减少肿瘤细胞，优选神经胶质瘤细胞，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤，和/或用于增强癌症疗法治疗癌症，优选神经胶质瘤的效力，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非何杰金氏淋巴瘤，其选自包括化学疗法，放射疗法，免疫疗法和/或基因疗法的组。

2. 发明公开

EP1874930A2 USE OF A GALECTIN-1-TRAGETED RNAI-BASED APPROACH FOR THE TREATMENT OF CANCER 有权
标题翻译：使用APPROACH ON RNAI-BASED半乳糖凝集素1作为靶的癌症治疗
公开(公告)号：EP1874930A2
公开(公告)日：2008-01-09
申请号：EP06707489.8
申请日：2006-03-09
申请人： UNIVERSITE LIBRE DE BRUXELLES , UNIVERSITE CATHOLIQUE DE LOUVAIN
发明人： CAMBY, Isabelle , HENRIET, Patrick , LEFRANC, Florence , COURTOY, Pierre , KISS, Robert
IPC分类号： C12N15/11 , A61K48/00
CPC分类号： C12N15/1138 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to an RNAi molecule suitable for reducing the expression of galectin-1 containing any of the sequences of SEQ ID NOs: 1-33, and preferably the sequences of SEQ ID NO: 2, 3, or 4, and to the use thereof as a medicament, or for the manufacture of a medicament for treating and/or for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma. The present invention also relates to compositions and methods for treating and for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, for reducing the migration of tumor cells, preferably cells of glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, and/or for enhancing the efficacy of cancer therapies for the treatment of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, selected from the group comprising chemotherapy, radiation therapy, immunotherapy, and/or gene therapy.

3. 发明授权

EP1874930B1 USE OF A GALECTIN-1-TRAGETED RNAI-BASED APPROACH FOR THE TREATMENT OF CANCER 有权
标题翻译：使用APPROACH ON RNAI-BASED半乳糖凝集素1作为靶的癌症治疗
公开(公告)号：EP1874930B1
公开(公告)日：2011-09-07
申请号：EP06707489.8
申请日：2006-03-09
申请人： Université Libre de Bruxelles , UNIVERSITE CATHOLIQUE DE LOUVAIN
发明人： CAMBY, Isabelle , HENRIET, Patrick , LEFRANC, Florence , COURTOY, Pierre , KISS, Robert
IPC分类号： C12N15/11 , A61K48/00
CPC分类号： C12N15/1138 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to an RNAi molecule suitable for reducing the expression of galectin-1 containing any of the sequences of SEQ ID NOs: 1-33, and preferably the sequences of SEQ ID NO: 2, 3, or 4, and to the use thereof as a medicament, or for the manufacture of a medicament for treating and/or for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma. The present invention also relates to compositions and methods for treating and for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, for reducing the migration of tumor cells, preferably cells of glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, and/or for enhancing the efficacy of cancer therapies for the treatment of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, selected from the group comprising chemotherapy, radiation therapy, immunotherapy, and/or gene therapy.

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