专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008055530A1 TARGETING OF ALPHA-1 OR ALPHA-3 SUBUNIT OF NA+, K+-ATPASE IN THE TREATMENT OF PROLIFERATIVE DISEASES 审中-公开
标题翻译： NA +，K + -ATPASE在治疗增殖性疾病中的ALPHA-1或ALPHA-3亚型的靶向
公开(公告)号：WO2008055530A1
公开(公告)日：2008-05-15
申请号：PCT/EP2006/010739
申请日：2006-11-09
申请人： UNIBIOSCREEN S.A. , MIJATOVIC, Tatjana , VAN QUAQUEBEKE, Eric , DENÈVE, Nancy , VAN DEN HOVE, Laurent , DARRO, Francis , KISS, Robert
发明人： MIJATOVIC, Tatjana , VAN QUAQUEBEKE, Eric , DENÈVE, Nancy , VAN DEN HOVE, Laurent , DARRO, Francis , KISS, Robert
IPC分类号： C12N15/11 , A61K31/429 , A61P35/00
CPC分类号： C12N15/1137 , C12N2310/14 , C12Y306/03009
摘要： The present invention provides methods, reagents, pharmaceutical formulations and kits for the treatment of proliferative diseases, such as tumours and cancers. The invention teaches to target select subunits of the Na + ,K + -ATPase, and especially the alpha-1 subunit and/or the alpha-3 subunit thereof.
摘要翻译：本发明提供了用于治疗增殖性疾病如肿瘤和癌症的方法，试剂，药物制剂和试剂盒。本发明教导了靶向Na +，K + +， - ATP酶，特别是α-1亚基和/或其α-3亚基的选择亚基。

2. 发明申请

WO2007054292A3 AZONAFIDE DERIVATIVES, METHODS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS THEREFROM 审中-公开
标题翻译： AZONAFIDE衍生物，其生产方法及其药物组合物
公开(公告)号：WO2007054292A3
公开(公告)日：2007-07-26
申请号：PCT/EP2006010727
申请日：2006-11-09
申请人： UNIBIOSCREEN SA , VAN QUAQUEBEKE ERIC , TUTI JEROME , VAN DEN HOVE LAURENT , KISS ROBERT , DARRO FRANCIS
发明人： VAN QUAQUEBEKE ERIC , TUTI JEROME , VAN DEN HOVE LAURENT , KISS ROBERT , DARRO FRANCIS
IPC分类号： C07D221/18 , A61K31/473 , A61P35/00 , C07D401/12 , C07D405/12 , C07D417/12
CPC分类号： C07D405/12 , C07D221/18 , C07D401/12 , C07D417/12
摘要： Azonafide derivatives are obtained by reacting azonafide with aldehydes, acyl halides, thioacyl halides, monoisocyanates, isothiocyanates, sulfonyl halides, monohalogenoalkanes, monohalogenoalkenes or monohalogenoalkynes, and are useful as active ingredients of pharmaceutical compositions for the prevention and treament of cell proliferative disorders, in particular several forms of Cancer.
摘要翻译：通过使azonafide与醛，酰基卤，硫代酰卤，单异氰酸酯，异硫氰酸酯，磺酰卤，单卤代烷烃，单卤代烯烃或单卤代炔反应，可以将Azonafide衍生物作为药物组合物的有效成分，特别是用于预防和治疗细胞增殖性疾病几种形式的癌症。

3. 发明申请

WO2006108474A3 USE OF A GALECTIN-1-TRAGETED RNAI-BASED APPROACH FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的GALECTIN-1-TRAGETED基于RNAi的方法的应用
公开(公告)号：WO2006108474A3
公开(公告)日：2006-12-21
申请号：PCT/EP2006002170
申请日：2006-03-09
申请人： UNIV BRUXELLES , UNIV LOUVAIN , CAMBY ISABELLE , HENRIET PATRICK , LEFRANC FLORENCE , COURTOY PIERRE , KISS ROBERT
发明人： CAMBY ISABELLE , HENRIET PATRICK , LEFRANC FLORENCE , COURTOY PIERRE , KISS ROBERT
IPC分类号： A61K48/00 , C12N15/113
CPC分类号： C12N15/1138 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to an RNAi molecule suitable for reducing the expression of galectin-1 containing any of the sequences of SEQ ID NOs: 1-33, and preferably the sequences of SEQ ID NO: 2, 3, or 4, and to the use thereof as a medicament, or for the manufacture of a medicament for treating and/or for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma. The present invention also relates to compositions and methods for treating and for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, for reducing the migration of tumor cells, preferably cells of glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, and/or for enhancing the efficacy of cancer therapies for the treatment of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, selected from the group comprising chemotherapy, radiation therapy, immunotherapy, and/or gene therapy.
摘要翻译：本发明涉及适用于降低含有SEQ ID NO：1-33的任何序列，优选SEQ ID NO：2,3或4的序列的半乳凝素-1的表达的RNAi分子，并且涉及或用于制备用于治疗和/或延迟癌症进展的药物，优选神经胶质瘤，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤。本发明还涉及用于治疗和延迟癌症，优选神经胶质瘤，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤的进展的组合物和方法，用于减少肿瘤细胞，优选胶质瘤细胞，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤，和/或用于增强癌症疗法治疗癌症的功效，优选神经胶质瘤，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤，选自化疗，放射治疗，免疫治疗和/或基因治疗。

4. 发明申请

WO1994025439A1 NOVEL 3-DIMETHYLAMINO ACRIDINE DERIVATIVES, THEIR PREPARATION AND APPLICATION IN THERAPY 审中-公开
标题翻译：新型3-二甲氨基嘌呤衍生物，其制备和应用于治疗
公开(公告)号：WO1994025439A1
公开(公告)日：1994-11-10
申请号：PCT/FR1994000501
申请日：1994-05-02
申请人： PIERRE FABRE MEDICAMENT , LHOMME, Jean , BIGG, Denis , DUFLOS, Alain , BONNAUD, Bernard , DEMEUNYNCK, Martine , ETIEVANT, Chantal , KISS, Robert
发明人： PIERRE FABRE MEDICAMENT
IPC分类号： C07D219/08
CPC分类号： C07D219/08
摘要： Novel 3-dimethylamino acridine derivatives of general formula (1) and the therapeutically acceptable salts of these molecules. The invention also concerns the application of these compounds in therapy and methods for their preparation.
摘要翻译：通式（1）的新型3-二甲基氨基吖啶衍生物和这些分子的治疗上可接受的盐。本发明还涉及这些化合物在治疗中的应用及其制备方法。

5. 发明申请

WO1994021648A1 NOVEL CARPAINE MONOAMIDES, THEIR PREPARATION AND THEIR USE AS DRUGS 审中-公开
标题翻译：新型卡波单宁，其制备及其作为药物使用
公开(公告)号：WO1994021648A1
公开(公告)日：1994-09-29
申请号：PCT/FR1994000268
申请日：1994-03-14
申请人： PIERRE FABRE MEDICAMENT , FAHY, Jacques , MAMATAS, Stylianos , BIGG, Dennis , KRUCZYNSKI, Anna , KISS, Robert
发明人： PIERRE FABRE MEDICAMENT
IPC分类号： C07D498/18
CPC分类号： C07D498/18
摘要： Novel carpaine derivatives of general formula (2), wherein A is a direct bond, a -(CH2)n- chain wherein n is 1, 2 or 3, or a -CH2-X- chain wherein X is an oxygen or sulphur atom; and Aryl represents a phenyl, naphthyl, furyl, thienyl, benzofuryl or benzothienyl ring optionally substituted by one or more substituents selected from a halogen atom, a C1-14 alkyl group, a C1-4 alkoxy group, a nitro group, a cyano group, a trifluoromethyl group or a trifluoromethoxy group; and therapeutically acceptable salts of such molecules. The therapeutical uses of such compounds and a method for preparing same are also disclosed.
摘要翻译：通式（2）的新型卡潘仁衍生物，其中A为直接键，其中n为1,2或3的 - （CH 2）n - 链，或其中X为氧或硫原子的-CH 2 -X-链 ; 芳基表示任选被一个或多个选自卤素原子，C 1-14烷基，C 1-4烷氧基，硝基，氰基的取代基取代的苯基，萘基，呋喃基，噻吩基，苯并呋喃基或苯并噻吩基三氟甲基或三氟甲氧基; 和这些分子的治疗上可接受的盐。还公开了这些化合物的治疗用途及其制备方法。

6. 发明申请

WO2012107262A1 DIHYDROBENZOPYRAN, THIOCHROMAN, TETRAHYDROQUINOLEINE AND TETRAHYDRONAPHTALENE DERIVATIVES AND THEIR USE IN ANTICANCER THERAPY 审中-公开
标题翻译：二氢苯并噻吩，噻吗啉，四氢喹诺酮和四氢吡喃衍生物及其在抗生素治疗中的应用
公开(公告)号：WO2012107262A1
公开(公告)日：2012-08-16
申请号：PCT/EP2012/050733
申请日：2012-01-18
申请人： UNIVERSITE DE LIEGE , UNIVERSITE LIBRE DE BRUXELLES , GOFFIN, Eric , DE TULLIO, Pascal , FLORENCE, Xavier , PIROTTE, Bernard , ROGISTER, Bernard , LAMORAL-THEYS, Delphine , LEFRANC, Florence , KISS, Robert
发明人： GOFFIN, Eric , DE TULLIO, Pascal , FLORENCE, Xavier , PIROTTE, Bernard , ROGISTER, Bernard , LAMORAL-THEYS, Delphine , LEFRANC, Florence , KISS, Robert
IPC分类号： C07D311/68 , C07D311/70 , C07D335/06 , A61K31/382 , A61K31/366 , A61P35/00
CPC分类号： C07D311/68 , C07D311/70 , C07D335/06
摘要： New dihydrobenzopyran, thiochroman, tetrahydroquinoleine and tetrahydronaphthalene derivatives and their use in anti-cancer therapy with the general formula (I).
摘要翻译：新二氢苯并吡喃，二氢苯并噻喃，四氢喹啉和四氢萘衍生物及其在抗癌治疗中的用途与通式（I）。

7. 发明申请

WO2008043846A3 NEW ISOCARBOSTYRIL ALKALOID DERIVATIVES HAVING ANTI-PROLIFERATIVE AND ANTI-MIGRATORY ACTIVITIES 审中-公开
标题翻译：具有抗增殖活性和抗活性活性的新型异烟肼碱性衍生物
公开(公告)号：WO2008043846A3
公开(公告)日：2008-05-29
申请号：PCT/EP2007060906
申请日：2007-10-12
申请人： UNIBIOSCREEN SA , INGRASSIA LAURENT , WLODARCZAK LISE , THOMAS STEPHANIE , VAN QUAQUEBEKE ERIC , VAN DEN HOVE LAURENT , KISS ROBERT , DARRO FRANCIS
发明人： INGRASSIA LAURENT , WLODARCZAK LISE , THOMAS STEPHANIE , VAN QUAQUEBEKE ERIC , VAN DEN HOVE LAURENT , KISS ROBERT , DARRO FRANCIS
IPC分类号： C07D491/06 , A61K31/4355 , A61P35/00
CPC分类号： C07D491/06
摘要： The present invention relates to novel isocarbostyril alkaloid derivatives having an anti-proliferative and anti-migratory activities, in particular to compounds of formula (I) or (II), stereoisomers, tautomers, racemates, prodrugs, metabolites thereof, or a pharmaceutically acceptable salt and/or solvate thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 have the same meaning as that defined in the claims. The present invention also relates to a method for the preparation of said compounds, to compositions, in particular pharmaceuticals, comprising such compounds, and to uses of such compounds in the treatment and prophylaxis of cancer.
摘要翻译：本发明涉及具有抗增殖和抗迁移活性的新型异卡波姆特生物碱衍生物，特别涉及式（I）或（II）的化合物，立体异构体，互变异构体，外消旋体，前药，其代谢物或药学上可接受的盐和/或其溶剂化物，其中R 1，R 2，R 3，R 4，R SUP > 5 ，R 6和R 7具有与权利要求中所定义相同的含义。本发明还涉及制备所述化合物的方法，组合物，特别是包含这些化合物的药物，以及这些化合物在治疗和预防癌症中的用途。

8. 发明申请

WO2004033465B1 2" OXO-VORUSCHARIN AND DERIVATIVES THEREOF 审中-公开
标题翻译： 2“OXO-VORUSCHARIN及其衍生物
公开(公告)号：WO2004033465B1
公开(公告)日：2004-06-17
申请号：PCT/EP0311194
申请日：2003-10-09
申请人： UNIBIOSCREEN SA , VAN QUAQUEBEKE ERIC , BRAEKMAN JEAN-CLAUDE , SIMON GENTIANE , GUISSOU PIERRE , NACOULMA ODILE GERMAINE , DEWELLE JANIQUE , DARRO FRANCIS , KISS ROBERT
发明人： VAN QUAQUEBEKE ERIC , BRAEKMAN JEAN-CLAUDE , SIMON GENTIANE , GUISSOU PIERRE , NACOULMA ODILE GERMAINE , DEWELLE JANIQUE , DARRO FRANCIS , KISS ROBERT
IPC分类号： A61K31/429 , A61P35/00 , C07D513/20 , C07F7/18
CPC分类号： C07D513/20 , C07F7/1856 , C07J21/00
摘要： The present invention relates to the novel compound 2'' oxo-voruscharin and derivatives. In addition, the present invention relates to pharmaceutical compositions comprising the novel 2'' oxo-voruscharin or derivatives. The present invention further relates to the 2'' oxo-voruscharin and derivatives for use as a medicament and for use in the preparation of a medicament for treating cancer. The present invention also relates to a method of treating cancer.
摘要翻译：本发明涉及新型化合物2“氧代 - 葡萄糖胺及其衍生物。另外，本发明涉及包含新的2“氧代 - 葡萄糖胺或其衍生物的药物组合物。本发明还涉及用作药物并用于制备用于治疗癌症的药物的2“氧代 - 葡萄糖胺及其衍生物。本发明还涉及治疗癌症的方法。

9. 发明申请

WO0222074A3 USE OF 2- AND 4- QUINOLONES FOR INHIBITING INTIMAL NEO-PROLIFERATION 审中-公开
标题翻译：使用2-和4-喹啉抑制实际的近期增殖
公开(公告)号：WO0222074A3
公开(公告)日：2002-06-20
申请号：PCT/FR0102849
申请日：2001-09-13
申请人： LAFON LABOR , DARRO FRANCIS , JOSEPH BENOIT , KISS ROBERT , FRYDMAN ARMAND , GUILLAUMET GERALD
发明人： DARRO FRANCIS , JOSEPH BENOIT , KISS ROBERT , FRYDMAN ARMAND , GUILLAUMET GERALD
IPC分类号： A61K31/47 , A61K31/4704 , A61P9/10
CPC分类号： A61K31/4704 , A61K31/47
摘要： The invention concerns the use of 3-aryl-2 and 4-quinolones for making a medicine inhibiting intimal neo-proliferation, in particular, to prevent post-angioplasty intraluminal restenosis.
摘要翻译：本发明涉及3-芳基-2-和4-喹诺酮用于制备抑制内膜新增殖的药物，特别是防止血管内成形术管腔内再狭窄。

10. 发明申请

WO2010102673A1 HELLEBRIN AND HELLEBRIGENIN DERIVATIVES 审中-公开
标题翻译： HELLEBRIN和HELLEBRIGENIN衍生物
公开(公告)号：WO2010102673A1
公开(公告)日：2010-09-16
申请号：PCT/EP2009/052985
申请日：2009-03-13
申请人： Unibioscreen S.A. , DEWELLE, Janique , EL YAZIDI, Mohamed , VAN QUAQUEBEKE, Eric , DE NEVE, Nancy , MIJATOVIC, Tatjana , INGRASSIA, Laurent , KISS, Robert , VAN VYNCKT, Frank , HEUREUX, Nicolas
发明人： DEWELLE, Janique , EL YAZIDI, Mohamed , VAN QUAQUEBEKE, Eric , DE NEVE, Nancy , MIJATOVIC, Tatjana , INGRASSIA, Laurent , KISS, Robert , VAN VYNCKT, Frank , HEUREUX, Nicolas
IPC分类号： C07J19/00 , C07J41/00 , C07J43/00 , A61K31/58 , A61P35/00
CPC分类号： C07J19/00 , C07J19/005 , C07J41/0055 , C07J43/003
摘要： The present invention relates to new cardiotonic Steroid Compounds of Formula (I) or (II) wherein X 1 , X 2 , X 3 , L, R 1 , R 2 , R 3 , R 4 , and R 5 have the same meaning as that defined in the Claims. The invention also relates to the use of said Compounds as medicaments, in particular in the treatment of Cancer.
摘要翻译：本发明涉及式（I）或（II）的新的强心型类固醇化合物，其中X 1，X 2，X 3，L，R 1，R 2，R 3，R 4和R 5具有与权利要求中所定义相同的含义。本发明还涉及所述化合物作为药物，特别是用于治疗癌症的用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式